Published in Nucleic Acids Res on August 09, 2004
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res (2012) 2.36
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes. Nucleic Acids Res (2008) 2.27
Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. J Biol Chem (2009) 1.72
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Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med Chem (2010) 1.44
Structural diversity of triplet repeat RNAs. J Biol Chem (2010) 1.29
Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target. Nucleic Acids Res (2011) 1.29
Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes. Nucleic Acids Res (2005) 1.20
Evidence for RNA-mediated toxicity in the fragile X-associated tremor/ataxia syndrome. Future Neurol (2009) 1.17
Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription. Nucleic Acids Res (2009) 1.16
Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. Nucleic Acids Res (2010) 1.13
The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA. Nucleic Acids Res (2009) 1.08
The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA. Nucleic Acids Res (2007) 1.08
Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome. Nucleic Acids Res (2011) 1.06
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res (2011) 1.04
DNA and RNA quadruplex-binding proteins. Int J Mol Sci (2014) 1.01
Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning. J Mol Biol (2011) 0.99
Hnrpab regulates neural development and neuron cell survival after glutamate stimulation. RNA (2012) 0.91
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region. J Biol Chem (2011) 0.90
Repeat-associated non-AUG translation and its impact in neurodegenerative disease. Neurotherapeutics (2014) 0.88
G-quadruplexes in pathogens: a common route to virulence control? PLoS Pathog (2015) 0.83
Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats. Nucleic Acids Res (2014) 0.82
The multiple molecular facets of fragile X-associated tremor/ataxia syndrome. J Neurodev Disord (2014) 0.80
RNA G-quadruplexes: emerging mechanisms in disease. Nucleic Acids Res (2016) 0.78
Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions. Front Cell Neurosci (2017) 0.75
The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes. Sci Rep (2017) 0.75
RNA G-quadruplexes in biology: Principles and molecular mechanisms. J Mol Biol (2017) 0.75
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A (2002) 9.60
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature (1988) 8.58
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell (2001) 8.04
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell (2001) 6.50
The Bloom's syndrome helicase unwinds G4 DNA. J Biol Chem (1998) 4.67
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res (2001) 4.47
Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell (1995) 4.35
DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res (1998) 4.09
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n. J Biol Chem (1999) 3.39
G-quadruplex DNA structures--variations on a theme. Biol Chem (2001) 3.36
Translational suppression by trinucleotide repeat expansion at FMR1. Science (1995) 2.73
The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure. Proc Natl Acad Sci U S A (1994) 2.72
Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell (1993) 2.52
Transcription of the FMR1 gene in individuals with fragile X syndrome. Am J Med Genet (2000) 2.46
The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res (1999) 2.21
CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro. Nucleic Acids Res (1995) 2.13
Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications. Proc Natl Acad Sci U S A (1995) 2.10
Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA. Am J Med Genet (2000) 1.85
Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15. Nucleic Acids Res (1995) 1.84
Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes. J Biol Chem (1995) 1.71
Solution structure of a DNA quadruplex containing the fragile X syndrome triplet repeat. J Mol Biol (1995) 1.59
Structure-function correlations of the insulin-linked polymorphic region. J Mol Biol (1996) 1.54
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. J Biol Chem (2001) 1.50
A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1 messenger RNA. J Med Genet (2001) 1.44
Functional and dysfunctional roles of quadruplex DNA in cells. Chem Biol (2001) 1.43
The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer. Nucleic Acids Res (2003) 1.35
A protein binding to CArG box motifs and to single-stranded DNA functions as a transcriptional repressor. Gene (1992) 1.35
The fragile X syndrome single strand d(CGG)n nucleotide repeats readily fold back to form unimolecular hairpin structures. J Biol Chem (1995) 1.23
MyoD binds to the guanine tetrad nucleic acid structure. J Biol Chem (1992) 1.12
The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n. Nucleic Acids Res (2003) 1.09
Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription. J Biol Chem (1998) 1.07
Tetrahelical forms of the fragile X syndrome expanded sequence d(CGG)(n) are destabilized by two heterogeneous nuclear ribonucleoprotein-related telomeric DNA-binding proteins. J Biol Chem (2000) 1.04
CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter. Nucleic Acids Res (2000) 1.02
The human insulin gene-linked polymorphic region adopts a G-quartet structure in chromatin assembled in vitro. J Mol Endocrinol (1993) 1.00
Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)n. Nucleic Acids Res (2002) 0.98
Purification and characterization of qTBP42, a new single-stranded and quadruplex telomeric DNA-binding protein from rat hepatocytes. J Biol Chem (1997) 0.97
Retracted Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue. Proc Natl Acad Sci U S A (2004) 0.97
Posttranscriptional regulation of insulin-like growth factor II mRNA. Scand J Clin Lab Invest Suppl (1995) 0.86
Telomeric and tetraplex DNA binding properties of qTBP42: a homologue of the CArG box binding protein CBF-A. Biochem Biophys Res Commun (1997) 0.85
Did quadruplex DNA play a role in the evolution of the eukaryotic linear chromosome? Mini Rev Med Chem (2003) 0.80
Characterization of CArG-binding protein A initially identified by differential display. Neuroscience (1999) 0.80
Changes in CArG-binding protein A expression levels following injection(s) of the D1-dopamine agonist SKF-82958 in the intact and 6-hydroxydopamine-lesioned rat. Neuroscience (2000) 0.80
Detection of ultra-rare mutations by next-generation sequencing. Proc Natl Acad Sci U S A (2012) 5.53
Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet (2007) 3.53
Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11
Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A (2004) 3.07
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation (2009) 2.96
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet (2008) 2.77
Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol (2004) 2.58
Environmental and chemical carcinogenesis. Semin Cancer Biol (2004) 2.50
Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol (2010) 2.02
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem (2005) 1.94
Quantification of random genomic mutations. Nat Methods (2005) 1.88
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol (2007) 1.74
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. Proc Natl Acad Sci U S A (2003) 1.67
Cancer genome sequencing--an interim analysis. Cancer Res (2009) 1.52
On mitochondria, mutations, and methodology. Cell Metab (2009) 1.52
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet (2013) 1.51
Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol (2007) 1.41
Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev (2011) 1.39
Genetic instability in cancer: theory and experiment. Semin Cancer Biol (2005) 1.34
Current advances in unraveling the function of the Werner syndrome protein. Mutat Res (2005) 1.32
Optimization of DNA polymerase mutation rates during bacterial evolution. Proc Natl Acad Sci U S A (2009) 1.28
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res (2002) 1.27
Lethal mutagenesis of HIV. Virus Res (2005) 1.26
Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci U S A (2006) 1.25
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
High fidelity and lesion bypass capability of human DNA polymerase delta. Biochimie (2009) 1.22
Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes. Nucleic Acids Res (2005) 1.20
Homodimeric MyoD preferentially binds tetraplex structures of regulatory sequences of muscle-specific genes. J Biol Chem (2005) 1.19
Generation of mutator mutants during carcinogenesis. DNA Repair (Amst) (2005) 1.18
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. J Biol Chem (2008) 1.18
Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci U S A (2009) 1.17
Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. J Biol Chem (2007) 1.15
Werner syndrome protein interacts functionally with translesion DNA polymerases. Proc Natl Acad Sci U S A (2007) 1.15
Quantification of random mutations in the mitochondrial genome. Methods (2008) 1.14
Negative clonal selection in tumor evolution. Genetics (2005) 1.13
APOBEC3B mutagenesis in cancer. Nat Genet (2013) 1.09
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet (2013) 1.09
The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n. Nucleic Acids Res (2003) 1.09
The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA. Nucleic Acids Res (2009) 1.08
Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461. PLoS One (2011) 1.08
The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA. Nucleic Acids Res (2007) 1.08
The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. J Biol Chem (2004) 1.08
Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. Mol Cell (2010) 1.07
Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen (2005) 1.06
Lethal mutagenesis: targeting the mutator phenotype in cancer. Semin Cancer Biol (2010) 1.05
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem (2002) 1.04
DNA polymerase delta in DNA replication and genome maintenance. Environ Mol Mutagen (2012) 1.02
Implications of genetic heterogeneity in cancer. Ann N Y Acad Sci (2012) 1.02
Critical role of R-loops in processing replication blocks. Front Biosci (2005) 1.01
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev (2003) 1.01
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) (2004) 0.99
Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression. J Biol Chem (2010) 0.99
Incorporation of reporter-labeled nucleotides by DNA polymerases. Biotechniques (2005) 0.98
Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)n. Nucleic Acids Res (2002) 0.98
Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase. Nucleic Acids Res (2003) 0.98
Mutator phenotype in cancer: origin and consequences. Semin Cancer Biol (2010) 0.98
Do mutator mutations fuel tumorigenesis? Cancer Metastasis Rev (2013) 0.96
Characterization of a novel form of X-linked incomplete achromatopsia. Vis Neurosci (2004) 0.96
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ. J Biol Chem (2012) 0.96
Quadruplex structures of muscle gene promoter sequences enhance in vivo MyoD-dependent gene expression. Nucleic Acids Res (2010) 0.95
The mutator phenotype in cancer: molecular mechanisms and targeting strategies. Curr Drug Targets (2010) 0.95
MyoD uses overlapping but distinct elements to bind E-box and tetraplex structures of regulatory sequences of muscle-specific genes. Nucleic Acids Res (2007) 0.95
Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication. Nucleic Acids Res (2011) 0.94
Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea. J Biol Chem (2004) 0.93
Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases. DNA Repair (Amst) (2005) 0.92
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures. PLoS One (2012) 0.92
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. J Biol Chem (2003) 0.92
Differential binding of quadruplex structures of muscle-specific genes regulatory sequences by MyoD, MRF4 and myogenin. Nucleic Acids Res (2008) 0.91
Ageing: mice and mitochondria. Nature (2004) 0.88
Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation. J Biol Chem (2013) 0.87
Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers. Transl Oncol (2013) 0.87
Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst) (2005) 0.87
A random mutation capture assay to detect genomic point mutations in mouse tissue. Nucleic Acids Res (2011) 0.86
Tumbling down a different pathway to genetic instability. J Clin Invest (2003) 0.86
Migratory birds and avian flu. Science (2006) 0.86
Detection of electrographic seizures by critical care providers using color density spectral array after cardiac arrest is feasible. Pediatr Crit Care Med (2015) 0.85
When pol I goes into high gear: processive DNA synthesis by pol I in the cell. Cell Cycle (2004) 0.84
Werner syndrome gene variants in human sarcomas. Mol Carcinog (2010) 0.84
Use of Pol I-deficient E. coli for functional complementation of DNA polymerase. Methods Mol Biol (2003) 0.83
Limits to the Human Cancer Genome Project? Science (2007) 0.81
Accuracy of Next Generation Sequencing Platforms. Next Gener Seq Appl (2015) 0.80
A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site. J Biol Chem (2013) 0.80
Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA Repair (Amst) (2008) 0.80
LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends Genet (2007) 0.80
Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis. Inflamm Bowel Dis (2013) 0.80
Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects. J Mol Med (Berl) (2010) 0.79
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. Int J Cancer (2006) 0.79
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther (2006) 0.78
The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum. J Mol Biol (2011) 0.78
Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells. Hum Gene Ther (2009) 0.78
Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site. J Biol Chem (2003) 0.77