Published in Proc Natl Acad Sci U S A on June 11, 2007
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Proc Natl Acad Sci U S A (2008) 2.70
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci (2008) 2.24
Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol (2010) 2.02
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle (2008) 1.83
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
DNA helicases involved in DNA repair and their roles in cancer. Nat Rev Cancer (2013) 1.58
Replication stress and cancer: it takes two to tango. Exp Cell Res (2014) 1.33
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Mol Carcinog (2009) 1.24
Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) (2008) 1.20
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Res (2009) 1.02
Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling. DNA Repair (Amst) (2012) 1.01
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ. J Biol Chem (2012) 0.96
Separate roles of structured and unstructured regions of Y-family DNA polymerases. Adv Protein Chem Struct Biol (2009) 0.93
WRN participates in translesion synthesis pathway through interaction with NBS1. Mech Ageing Dev (2010) 0.89
Biochemical analysis of active site mutations of human polymerase η. Mutat Res (2013) 0.89
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. J Proteome Res (2011) 0.88
Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication. J Mol Biol (2012) 0.88
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle (2013) 0.87
Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. J Biol Chem (2012) 0.86
Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. Ageing Res Rev (2016) 0.84
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Res (2012) 0.84
Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions. Ageing Res Rev (2016) 0.82
Telomeres do the (un)twist: helicase actions at chromosome termini. Biochim Biophys Acta (2009) 0.82
The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA. DNA Repair (Amst) (2010) 0.82
Clinical implications of the basic defects in Cockayne syndrome and xeroderma pigmentosum and the DNA lesions responsible for cancer, neurodegeneration and aging. Mech Ageing Dev (2008) 0.82
Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma (2016) 0.81
Escherichia coli Rep DNA helicase and error-prone DNA polymerase IV interact physically and functionally. Mol Microbiol (2011) 0.80
Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure. Int J Toxicol (2014) 0.79
Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA. Environ Mol Mutagen (2013) 0.79
Biochemical analysis of DNA polymerase η fidelity in the presence of replication protein A. PLoS One (2014) 0.77
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles. Genes (Basel) (2016) 0.75
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res (2014) 0.75
Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem (2005) 8.13
hRAD30 mutations in the variant form of xeroderma pigmentosum. Science (1999) 7.40
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest (1970) 6.44
RecQ helicases: caretakers of the genome. Nat Rev Cancer (2003) 5.83
Fidelity of human DNA polymerase eta. J Biol Chem (2000) 4.39
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat Immunol (2001) 4.00
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol (2001) 3.60
Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci U S A (1989) 3.55
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J (2000) 3.46
Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol (2001) 2.84
Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem (1999) 2.77
Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. Genes Dev (2001) 2.53
Analyzing fidelity of DNA polymerases. Methods Enzymol (1995) 2.52
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide. J Biol Chem (1998) 2.30
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc Natl Acad Sci U S A (2001) 2.26
Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro. Nucleic Acids Res (2000) 2.25
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
Homologous recombination resolution defect in werner syndrome. Mol Cell Biol (2002) 2.21
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol (2002) 2.15
Suffering in silence: the tolerance of DNA damage. Nat Rev Mol Cell Biol (2005) 2.01
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res (1992) 1.98
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease. J Biol Chem (1998) 1.90
Error rate and specificity of human and murine DNA polymerase eta. J Mol Biol (2001) 1.86
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet (1981) 1.85
Xeroderma pigmentosum: variants with normal DNA repair and normal sensitivity to ultraviolet light. J Invest Dermatol (1972) 1.84
Spontaneous and induced chromosomal instability in Werner syndrome. Hum Genet (1988) 1.80
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res (1998) 1.80
Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa. J Biol Chem (2004) 1.73
Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev (2001) 1.61
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. J Biol Chem (2001) 1.50
Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Biochemistry (2002) 1.47
Characterization of the human and mouse WRN 3'-->5' exonuclease. Nucleic Acids Res (2000) 1.46
A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture. J Cell Physiol (1977) 1.43
Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc Natl Acad Sci U S A (2000) 1.42
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem (2004) 1.36
Junction of RecQ helicase biochemistry and human disease. J Biol Chem (2004) 1.34
Current advances in unraveling the function of the Werner syndrome protein. Mutat Res (2005) 1.32
Pathways and functions of the Werner syndrome protein. Mech Ageing Dev (2005) 1.23
Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp Gerontol (1982) 1.18
Altered frequency of initiation sites of DNA replication in Werner's syndrome cells. Hum Genet (1982) 1.04
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) (2004) 0.99
Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication? Bioessays (2004) 0.90
Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. Front Biosci (2006) 0.88
Detection of ultra-rare mutations by next-generation sequencing. Proc Natl Acad Sci U S A (2012) 5.53
Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet (2007) 3.53
Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11
Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A (2004) 3.07
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation (2009) 2.96
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet (2008) 2.77
Spatial and temporal cellular responses to single-strand breaks in human cells. Mol Cell Biol (2003) 2.70
In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci U S A (2004) 2.59
Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol (2004) 2.58
Environmental and chemical carcinogenesis. Semin Cancer Biol (2004) 2.50
Fractal analysis of mammographic parenchymal patterns in breast cancer risk assessment. Acad Radiol (2007) 2.16
Computerized interpretation of breast MRI: investigation of enhancement-variance dynamics. Med Phys (2004) 2.14
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest (2006) 2.14
Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol (2010) 2.02
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem (2005) 1.94
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J Biol Chem (2002) 1.89
Quantification of random genomic mutations. Nat Methods (2005) 1.88
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol (2007) 1.74
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.73
In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. J Biol Chem (2003) 1.73
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. Proc Natl Acad Sci U S A (2003) 1.67
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J (2007) 1.65
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J Biol Chem (2005) 1.63
Cancerous breast lesions on dynamic contrast-enhanced MR images: computerized characterization for image-based prognostic markers. Radiology (2010) 1.60
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell (2010) 1.57
The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions. DNA Repair (Amst) (2005) 1.57
Computerized analysis of mammographic parenchymal patterns for assessing breast cancer risk: effect of ROI size and location. Med Phys (2004) 1.57
Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A (2009) 1.56
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev (2002) 1.56
Cancer genome sequencing--an interim analysis. Cancer Res (2009) 1.52
On mitochondria, mutations, and methodology. Cell Metab (2009) 1.52
The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas. Clin Cancer Res (2006) 1.51
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet (2013) 1.51
HMGB1 is a cofactor in mammalian base excision repair. Mol Cell (2007) 1.49
Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms. Acad Radiol (2005) 1.49
A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell. Nucleic Acids Res (2008) 1.47
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat Genet (2012) 1.42
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol (2007) 1.41
Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev (2011) 1.39
Clinical and pathological characteristics of homogeneous and nonhomogeneous tissue of in-stent restenosis visualized by optical coherence tomography. Coron Artery Dis (2015) 1.39
Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol (2005) 1.39
Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei. Curr Biol (2002) 1.36
Genetic instability in cancer: theory and experiment. Semin Cancer Biol (2005) 1.34
The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells. Mol Cell (2011) 1.34
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc Natl Acad Sci U S A (2009) 1.34
Current advances in unraveling the function of the Werner syndrome protein. Mutat Res (2005) 1.32
Human DNA polymerase iota protects cells against oxidative stress. EMBO J (2008) 1.31
Classification of breast lesions with multimodality computer-aided diagnosis: observer study results on an independent clinical data set. Radiology (2006) 1.29
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols. EMBO J (2002) 1.28
Optimization of DNA polymerase mutation rates during bacterial evolution. Proc Natl Acad Sci U S A (2009) 1.28
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol (2012) 1.27
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res (2002) 1.27
Lethal mutagenesis of HIV. Virus Res (2005) 1.26
Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci U S A (2006) 1.25
Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain. Lab Invest (2005) 1.22
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
High fidelity and lesion bypass capability of human DNA polymerase delta. Biochimie (2009) 1.22
Replication-dependent and -independent responses of RAD18 to DNA damage in human cells. J Biol Chem (2006) 1.21
BLM is an early responder to DNA double-strand breaks. Biochem Biophys Res Commun (2006) 1.21
Recruitment of mismatch repair proteins to the site of DNA damage in human cells. J Cell Sci (2008) 1.19
Generation of mutator mutants during carcinogenesis. DNA Repair (Amst) (2005) 1.18
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. J Biol Chem (2008) 1.18
Evaluation of computer-aided diagnosis on a large clinical full-field digital mammographic dataset. Acad Radiol (2008) 1.17
Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine. J Biol Rhythms (2008) 1.17
Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci U S A (2009) 1.17
Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. J Biol Chem (2007) 1.15
Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol Cell Biol (2008) 1.15
DNA single-strand break repair is impaired in aprataxin-related ataxia. Ann Neurol (2007) 1.14
Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells. DNA Repair (Amst) (2004) 1.14
Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family. Nucleic Acids Res (2004) 1.14
Quantification of random mutations in the mitochondrial genome. Methods (2008) 1.14
Negative clonal selection in tumor evolution. Genetics (2005) 1.13