Published in J Biol Chem on October 15, 2004
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. Hum Genet (2006) 1.47
Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Semin Cancer Biol (2010) 1.44
Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements. Mol Syndromol (2015) 1.13
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res (2006) 1.05
Disease-causing missense mutations in human DNA helicase disorders. Mutat Res (2012) 0.95
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures. PLoS One (2012) 0.92
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3. Aging (Albany NY) (2009) 0.92
From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing. Cell Mol Life Sci (2007) 0.89
Functional deficit associated with a missense Werner syndrome mutation. DNA Repair (Amst) (2013) 0.87
WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects. Hum Mutat (2016) 0.86
Werner syndrome gene variants in human sarcomas. Mol Carcinog (2010) 0.84
Delineation of WRN helicase function with EXO1 in the replicational stress response. DNA Repair (Amst) (2010) 0.82
Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population. Age (Dordr) (2013) 0.81
The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling. Nucleic Acids Res (2007) 0.80
Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia. Neurobiol Dis (2010) 0.79
The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds. Cancer Chemother Pharmacol (2008) 0.79
Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced gammaH2A.X Foci. J Cancer Epidemiol (2009) 0.75
Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal. Nucleic Acids Res (2014) 0.75
Recombine and Associate to Prevent Genomic Instability and Premature Aging. Mol Syndromol (2016) 0.75
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype. Sci Rep (2017) 0.75
Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer. Int J Mol Sci (2015) 0.75
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities. Oncotarget (2016) 0.75
Detection of ultra-rare mutations by next-generation sequencing. Proc Natl Acad Sci U S A (2012) 5.53
Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet (2007) 3.53
Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11
Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A (2004) 3.07
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation (2009) 2.96
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet (2008) 2.77
DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc Natl Acad Sci U S A (2002) 2.58
Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol (2004) 2.58
Environmental and chemical carcinogenesis. Semin Cancer Biol (2004) 2.50
Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol (2010) 2.02
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem (2005) 1.94
Quantification of random genomic mutations. Nat Methods (2005) 1.88
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol (2007) 1.74
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. Proc Natl Acad Sci U S A (2003) 1.67
On mitochondria, mutations, and methodology. Cell Metab (2009) 1.52
Cancer genome sequencing--an interim analysis. Cancer Res (2009) 1.52
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet (2013) 1.51
Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol (2007) 1.41
Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev (2011) 1.39
Genetic instability in cancer: theory and experiment. Semin Cancer Biol (2005) 1.34
Current advances in unraveling the function of the Werner syndrome protein. Mutat Res (2005) 1.32
Optimization of DNA polymerase mutation rates during bacterial evolution. Proc Natl Acad Sci U S A (2009) 1.28
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res (2002) 1.27
Lethal mutagenesis of HIV. Virus Res (2005) 1.26
Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci U S A (2006) 1.25
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
High fidelity and lesion bypass capability of human DNA polymerase delta. Biochimie (2009) 1.22
Generation of mutator mutants during carcinogenesis. DNA Repair (Amst) (2005) 1.18
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. J Biol Chem (2008) 1.18
Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci U S A (2009) 1.17
Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. J Biol Chem (2007) 1.15
Werner syndrome protein interacts functionally with translesion DNA polymerases. Proc Natl Acad Sci U S A (2007) 1.15
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. Hum Mol Genet (2005) 1.15
Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis. J Biol Chem (2006) 1.15
Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family. Nucleic Acids Res (2004) 1.14
Quantification of random mutations in the mitochondrial genome. Methods (2008) 1.14
Negative clonal selection in tumor evolution. Genetics (2005) 1.13
Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas. Mol Cancer (2009) 1.12
APOBEC3B mutagenesis in cancer. Nat Genet (2013) 1.09
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet (2013) 1.09
Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461. PLoS One (2011) 1.08
Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. Mol Cell (2010) 1.07
Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen (2005) 1.06
Lethal mutagenesis: targeting the mutator phenotype in cancer. Semin Cancer Biol (2010) 1.05
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem (2002) 1.04
DNA polymerase delta in DNA replication and genome maintenance. Environ Mol Mutagen (2012) 1.02
Implications of genetic heterogeneity in cancer. Ann N Y Acad Sci (2012) 1.02
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev (2003) 1.01
Critical role of R-loops in processing replication blocks. Front Biosci (2005) 1.01
Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria. Arch Biochem Biophys (2007) 1.01
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) (2004) 0.99
Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression. J Biol Chem (2010) 0.99
Incorporation of reporter-labeled nucleotides by DNA polymerases. Biotechniques (2005) 0.98
1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site. Proteins (2002) 0.98
Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase. Nucleic Acids Res (2003) 0.98
Mutator phenotype in cancer: origin and consequences. Semin Cancer Biol (2010) 0.98
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ. J Biol Chem (2012) 0.96
Do mutator mutations fuel tumorigenesis? Cancer Metastasis Rev (2013) 0.96
The mutator phenotype in cancer: molecular mechanisms and targeting strategies. Curr Drug Targets (2010) 0.95
Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication. Nucleic Acids Res (2011) 0.94
Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea. J Biol Chem (2004) 0.93
Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases. DNA Repair (Amst) (2005) 0.92
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. J Biol Chem (2003) 0.92
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures. PLoS One (2012) 0.92
Ageing: mice and mitochondria. Nature (2004) 0.88
Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers. Transl Oncol (2013) 0.87
Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst) (2005) 0.87
A random mutation capture assay to detect genomic point mutations in mouse tissue. Nucleic Acids Res (2011) 0.86
Tumbling down a different pathway to genetic instability. J Clin Invest (2003) 0.86
Chloroplast His-to-Asp signal transduction: a potential mechanism for plastid gene regulation in Heterosigma akashiwo (Raphidophyceae). BMC Evol Biol (2007) 0.85
Werner syndrome gene variants in human sarcomas. Mol Carcinog (2010) 0.84
When pol I goes into high gear: processive DNA synthesis by pol I in the cell. Cell Cycle (2004) 0.84
53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes. Gynecol Oncol (2012) 0.83
Use of Pol I-deficient E. coli for functional complementation of DNA polymerase. Methods Mol Biol (2003) 0.83
Limits to the Human Cancer Genome Project? Science (2007) 0.81
Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA Repair (Amst) (2008) 0.80
A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site. J Biol Chem (2013) 0.80
Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis. Inflamm Bowel Dis (2013) 0.80
Accuracy of Next Generation Sequencing Platforms. Next Gener Seq Appl (2015) 0.80
LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends Genet (2007) 0.80
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. Int J Cancer (2006) 0.79
E2F3b over-expression in ovarian carcinomas and in BRCA1 haploinsufficient fallopian tube epithelium. Genes Chromosomes Cancer (2012) 0.79
Identification of a preneoplastic gene expression profile in tubal epithelium of BRCA1 mutation carriers. Neoplasia (2010) 0.79
Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects. J Mol Med (Berl) (2010) 0.79
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther (2006) 0.78
The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum. J Mol Biol (2011) 0.78
Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells. Hum Gene Ther (2009) 0.78
Endogenous mutagenesis and cancer. Mutat Res (2002) 0.77
In vitro production and screening of DNA polymerase eta mutants for catalytic diversity. Biotechniques (2002) 0.77
Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site. J Biol Chem (2003) 0.77
Mutagenicity assessment of acrylate and methacrylate compounds and implications for regulatory toxicology requirements. Regul Toxicol Pharmacol (2008) 0.77
Genetic complementation protocols. Methods Mol Biol (2003) 0.76
Reply: Is There Any Genetic Instability in Human Cancer? DNA Repair (Amst) (2010) 0.76
Allele-specific transcriptional elongation regulates monoallelic expression of the IGF2BP1 gene. Epigenetics Chromatin (2011) 0.76
Random oligonucleotide mutagenesis. Methods Mol Biol (2003) 0.75
XPG and WRN: an unexpected partnership. Cell Cycle (2011) 0.75
Angiogenic alterations associated with circulating neoplastic DNA in ovarian carcinoma. Transl Oncol (2012) 0.75
The multiplicity of mutations in human cancers. Adv Exp Med Biol (2005) 0.75