Published in Am J Hum Genet on August 13, 2004
The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev (2011) 2.44
Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci. Am J Hum Genet (2004) 2.31
Genomewide linkage scan for opioid dependence and related traits. Am J Hum Genet (2006) 2.15
Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment. J Neurodev Disord (2009) 1.57
New complexities in the genetics of stuttering: significant sex-specific linkage signals. Am J Hum Genet (2006) 1.46
A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. Am J Hum Genet (2005) 1.43
A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood (2007) 1.32
Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays. Am J Hum Genet (2008) 1.28
Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes (2008) 1.27
Finding common susceptibility variants for complex disease: past, present and future. Brief Funct Genomic Proteomic (2009) 1.20
Comparing single-nucleotide polymorphism marker-based and microsatellite marker-based linkage analyses. BMC Genet (2005) 1.15
A comparison of SNPs and microsatellites as linkage mapping markers: lessons from the zebra finch (Taeniopygia guttata). BMC Genomics (2010) 1.10
The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees. BMC Genet (2005) 1.08
A genetic linkage map and comparative genome analysis of common carp (Cyprinus carpio L.) using microsatellites and SNPs. Mol Genet Genomics (2011) 1.08
Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait. Am J Hum Genet (2008) 1.07
Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. Biol Psychiatry (2008) 1.03
Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies. BMC Genomics (2007) 1.01
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects. Eur J Hum Genet (2008) 0.98
Multiple subsampling of dense SNP data localizes disease genes with increased precision. Hum Hered (2009) 0.97
Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene. Pharmacogenomics J (2008) 0.96
SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data. BMC Bioinformatics (2009) 0.94
Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis. BMC Genet (2005) 0.91
Parent-of-origin effects in autism identified through genome-wide linkage analysis of 16,000 SNPs. PLoS One (2010) 0.89
A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility. Neurogenetics (2012) 0.88
A system for exact and approximate genetic linkage analysis of SNP data in large pedigrees. Bioinformatics (2012) 0.87
Genome-wide linkage analysis of QTL for growth and body composition employing the PorcineSNP60 BeadChip. BMC Genet (2012) 0.86
Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data. Genet Epidemiol (2008) 0.85
Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14. Epilepsy Res (2009) 0.84
Influence of genotyping error in linkage mapping for complex traits--an analytic study. BMC Genet (2008) 0.83
Genome-wide high-density SNP-based linkage analysis of infantile hypertrophic pyloric stenosis identifies loci on chromosomes 11q14-q22 and Xq23. Am J Hum Genet (2008) 0.82
Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: significant evidence for linkage at chromosome 14q24.3. J Med Genet (2008) 0.82
Identification and prioritization of NUAK1 and PPP1CC as positional candidate loci for skeletal muscle strength phenotypes. Physiol Genomics (2011) 0.81
A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Metab (2012) 0.81
Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study. Physiol Genomics (2008) 0.81
Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families. BMC Dermatol (2007) 0.80
The advantages of dense marker sets for linkage analysis with very large families. Hum Genet (2007) 0.80
A novel locus for autosomal dominant cone-rod dystrophy maps to chromosome 10q. Eur J Hum Genet (2012) 0.79
Obtaining accurate p values from a dense SNP linkage scan. Hum Hered (2012) 0.79
High-density single nucleotide polymorphism screen in a large multiplex neural tube defect family refines linkage to loci at 7p21.1-pter and 2q33.1-q35. Birth Defects Res A Clin Mol Teratol (2006) 0.78
Microsatellites and SNPs linkage analysis in a Sardinian genetic isolate confirms several essential hypertension loci previously identified in different populations. BMC Med Genet (2009) 0.77
Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays. BMC Genet (2005) 0.77
The genetic basis of the comorbidity between cannabis use and major depression. Addiction (2016) 0.75
A comparison between microsatellite and single-nucleotide polymorphism markers with respect to two measures of information content. BMC Genet (2005) 0.75
Estimation of linkage disequilibrium and effective population size in New Zealand sheep using three different methods to create genetic maps. BMC Genet (2017) 0.75
Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature (1996) 27.61
Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet (1998) 19.35
Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet (1995) 12.78
Large-scale genotyping of complex DNA. Nat Biotechnol (2003) 10.00
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
The use of a genetic map of biallelic markers in linkage studies. Nat Genet (1997) 6.62
BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques (2002) 5.98
Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. Genome Res (2004) 5.59
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat Genet (2003) 5.03
Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites. Am J Hum Genet (2004) 4.76
Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet (2001) 3.70
A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. Am J Hum Genet (2000) 3.22
From QTL to gene: the harvest begins. Nat Genet (2002) 2.79
The impact of SNP density on fine-scale patterns of linkage disequilibrium. Hum Mol Genet (2004) 2.78
Caution on pedigree haplotype inference with software that assumes linkage equilibrium. Am J Hum Genet (2002) 2.51
Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet (2004) 2.41
Bias in multipoint linkage analysis arising from map misspecification. Genet Epidemiol (2000) 2.21
The impact of genotyping error on family-based analysis of quantitative traits. Eur J Hum Genet (2001) 2.12
Power of variance component linkage analysis to detect quantitative trait loci. Ann Hum Genet (1999) 2.10
Characteristics of genetic markers and maps for cost-effective genome screens using diallelic markers. Genet Epidemiol (2002) 1.44
Equivalence of single- and multilocus markers: power to detect linkage with composite markers derived from biallelic loci. Am J Hum Genet (2000) 1.31
A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL. Behav Genet (1999) 1.08
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Replicating genotype-phenotype associations. Nature (2007) 16.11
The effects of human population structure on large genetic association studies. Nat Genet (2004) 14.88
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Evaluating coverage of genome-wide association studies. Nat Genet (2006) 11.40
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet (2007) 8.50
Thousands of chemical starting points for antimalarial lead identification. Nature (2010) 8.28
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
Two-stage two-locus models in genome-wide association. PLoS Genet (2006) 5.60
The complex interplay among factors that influence allelic association. Nat Rev Genet (2004) 5.26
Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes. Am J Hum Genet (2004) 4.44
Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms. Am J Hum Genet (2008) 4.28
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A (2004) 3.73
Data quality control in genetic case-control association studies. Nat Protoc (2010) 3.68
Measures of human population structure show heterogeneity among genomic regions. Genome Res (2005) 3.68
Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet (2008) 3.65
A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 2.85
The impact of SNP density on fine-scale patterns of linkage disequilibrium. Hum Mol Genet (2004) 2.78
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA (2008) 2.73
An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets. Nat Genet (2005) 2.66
GOLDsurfer: three dimensional display of linkage disequilibrium. Bioinformatics (2004) 2.61
Efficient selective screening of haplotype tag SNPs. Bioinformatics (2003) 2.57
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab (2011) 2.52
Use of genome-wide association studies for drug repositioning. Nat Biotechnol (2012) 2.51
The impact of genotyping error on haplotype reconstruction and frequency estimation. Eur J Hum Genet (2002) 2.51
Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. Nat Genet (2001) 2.48
Designing candidate gene and genome-wide case-control association studies. Nat Protoc (2007) 2.42
The portability of tagSNPs across populations: a worldwide survey. Genome Res (2006) 1.99
Basic statistical analysis in genetic case-control studies. Nat Protoc (2011) 1.86
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Am J Hum Genet (2004) 1.76
Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors. Hum Mol Genet (2002) 1.76
Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature (2006) 1.75
A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations. Am J Hum Genet (2005) 1.75
TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology (2006) 1.73
Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet (2005) 1.67
Fine mapping versus replication in whole-genome association studies. Am J Hum Genet (2007) 1.64
Use of multivariate linkage analysis for dissection of a complex cognitive trait. Am J Hum Genet (2003) 1.62
HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol (2011) 1.60
What makes a good case-control study? Design issues for complex traits such as endometriosis. Hum Reprod (2002) 1.59
Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. J Clin Oncol (2011) 1.56
Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis (2007) 1.47
Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples. Hum Mol Genet (2004) 1.41
Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes. Am J Hum Genet (2001) 1.32
Evaluating the results of genomewide linkage scans of complex traits by locus counting. Am J Hum Genet (2002) 1.30
Site and gender specificity of inheritance of bone mineral density. J Bone Miner Res (2003) 1.30
The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset. Ann Hum Genet (2006) 1.26
Genetically indistinguishable SNPs and their influence on inferring the location of disease-associated variants. Genome Res (2005) 1.25
The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am J Hum Genet (2004) 1.24
To what extent do scans of non-synonymous SNPs complement denser genome-wide association studies? Eur J Hum Genet (2008) 1.24
Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. Am J Med Genet (2002) 1.22
Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Hum Reprod (2004) 1.18
Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype. Inflamm Bowel Dis (2007) 1.18
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. PLoS One (2011) 1.18
Genotype prediction using a dense map of SNPs. Genet Epidemiol (2004) 1.16
Marker selection for genetic case-control association studies. Nat Protoc (2009) 1.12
Prospects and pitfalls in whole genome association studies. Philos Trans R Soc Lond B Biol Sci (2005) 1.09
Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs. Proc Natl Acad Sci U S A (2003) 1.07
Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. Genet Epidemiol (2008) 1.06
GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs. BMC Bioinformatics (2009) 1.03
Novelty in the target landscape of the pharmaceutical industry. Nat Rev Drug Discov (2013) 1.03
Aspects of observing and claiming allele flips in association studies. Genet Epidemiol (2010) 1.01
Disentangling linkage disequilibrium and linkage from dense single-nucleotide polymorphism trio data. Genetics (2005) 1.01
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation. Diabetes (2012) 1.00
Goldsurfer2 (Gs2): a comprehensive tool for the analysis and visualization of genome wide association studies. BMC Bioinformatics (2008) 1.00
Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group. Genet Epidemiol (2010) 0.99
The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. Hum Mol Genet (2003) 0.99
Genome-wide association: a promising start to a long race. Trends Genet (2006) 0.96
A comparison of tagging methods and their tagging space. Hum Mol Genet (2005) 0.96
Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24. Diabetes (2004) 0.94
Singleton SNPs in the human genome and implications for genome-wide association studies. Eur J Hum Genet (2008) 0.94
Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15. Hum Reprod (2006) 0.93
Multivariate genetic analysis of chronic pelvic pain and associated phenotypes. Behav Genet (2005) 0.87
How useful is the fine-scale mapping of complex trait linkage peaks? Evaluating the impact of additional microsatellite genotyping on the posterior probability of linkage. Genet Epidemiol (2005) 0.86
Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. J Hepatol (2011) 0.86
Fine mapping of the IBD1 locus did not identify Crohn disease-associated NOD2 variants: implications for complex disease genetics. Am J Med Genet (2002) 0.85
Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe. Hum Mutat (2012) 0.83
Fine-scale map of encyclopedia of DNA elements regions in the Korean population. Genetics (2006) 0.82
The application of genetics to the discovery of better medicines. Pharmacogenomics (2002) 0.80
Reply to Rational drug repositioning by medical genetics. Nat Biotechnol (2013) 0.78
Characterization of ADME gene variation in 21 populations by exome sequencing. Pharmacogenet Genomics (2016) 0.75
Impact of genetically supported target selection on R&D productivity. Nat Rev Drug Discov (2016) 0.75