PubRank

B G Spratt

Author PubWeight™ 440.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A 1998 39.20
2 Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 2000 34.08
3 How clonal are bacteria? Proc Natl Acad Sci U S A 1993 18.19
4 Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A 1975 18.13
5 A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology 1998 17.05
6 Properties of the penicillin-binding proteins of Escherichia coli K12,. Eur J Biochem 1977 16.26
7 Penicillin-binding proteins and cell shape in E. coli. Nature 1975 10.20
8 Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature 2000 9.86
9 Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9. Gene 1986 7.97
10 Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences. Proc Natl Acad Sci U S A 2001 7.90
11 Multilocus sequence typing. Trends Microbiol 1999 7.00
12 Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis 1991 6.69
13 Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol 2001 6.66
14 Versatile low-copy-number plasmid vectors for cloning in Escherichia coli. Gene 1982 6.62
15 The relative contributions of recombination and mutation to the divergence of clones of Neisseria meningitidis. Mol Biol Evol 1999 6.23
16 Localized sex in bacteria. Nature 1991 6.03
17 Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A 1989 5.65
18 Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae. Mol Microbiol 1991 5.45
19 Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone. Infect Immun 2001 5.27
20 Recombination and the population structures of bacterial pathogens. Annu Rev Microbiol 2001 5.14
21 Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae. Mol Microbiol 1998 5.12
22 Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 1995 4.93
23 Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Mol Microbiol 1991 4.85
24 Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae. Mol Microbiol 1989 4.78
25 Temperature-sensitive cell division mutants of Escherichia coli with thermolabile penicillin-binding proteins. J Bacteriol 1977 4.78
26 Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data. Genetics 2000 4.61
27 Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12. Antimicrob Agents Chemother 1977 4.45
28 Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species. Mol Microbiol 1997 3.83
29 Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae. Mol Microbiol 1992 3.58
30 Retracted A link between virulence and ecological abundance in natural populations of Staphylococcus aureus. Science 2001 3.44
31 Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture. J Gen Microbiol 1983 3.41
32 Identification of three major clones of multiply antibiotic-resistant Streptococcus pneumoniae in Taiwanese hospitals by multilocus sequence typing. J Clin Microbiol 1998 3.36
33 Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol 1994 3.12
34 Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics. Trends Microbiol 1994 2.99
35 Lysis of Escherichia coli by beta-lactam antibiotics: deletion analysis of the role of penicillin-binding proteins 1A and 1B. J Gen Microbiol 1985 2.93
36 Escherichia coli resistance to beta-lactam antibiotics through a decrease in the affinity of a target for lethality. Nature 1978 2.92
37 Identification of the major penicillin-binding proteins of Escherichia coli as D-alanine carboxypeptidase IA. J Bacteriol 1976 2.85
38 Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein. J Biol Chem 1986 2.84
39 Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae. Proc Natl Acad Sci U S A 1990 2.82
40 The mechanism of action of mecillinam. J Antimicrob Chemother 1977 2.68
41 Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins. Antimicrob Agents Chemother 1995 2.64
42 The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain. J Clin Microbiol 1999 2.56
43 Mutants of Escherichia coli which lack a component of penicillin-binding protein 1 are viable. FEBS Lett 1977 2.56
44 The plasmid of Salmonella typhimurium LT2. Mol Gen Genet 1973 2.54
45 Defective and plaque-forming lambda transducing bacteriophage carrying penicillin-binding protein-cell shape genes: genetic and physical mapping and identification of gene products from the lip-dacA-rodA-pbpA-leuS region of the Escherichia coli chromosome. J Bacteriol 1980 2.51
46 Database-driven multi locus sequence typing (MLST) of bacterial pathogens. Bioinformatics 2001 2.45
47 Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob Agents Chemother 1993 2.44
48 Extensive variation in the ddl gene of penicillin-resistant Streptococcus pneumoniae results from a hitchhiking effect driven by the penicillin-binding protein 2b gene. Mol Biol Evol 1999 2.26
49 A vector for the construction of translational fusions to TEM beta-lactamase and the analysis of protein export signals and membrane protein topology. Gene 1986 2.21
50 The nucleotide sequences of the ponA and ponB genes encoding penicillin-binding protein 1A and 1B of Escherichia coli K12. Eur J Biochem 1985 2.14
51 Estimating the relative contributions of mutation and recombination to clonal diversification: a comparison between Neisseria meningitidis and Streptococcus pneumoniae. Res Microbiol 2000 2.14
52 Biochemical and genetical approaches to the mechanism of action of penicillin. Philos Trans R Soc Lond B Biol Sci 1980 2.11
53 Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species. Mol Biol Evol 1999 2.10
54 Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation. J Bacteriol 1994 2.10
55 Deletion of the penicillin-binding protein 6 gene of Escherichia coli. J Bacteriol 1982 2.10
56 Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae. Mol Microbiol 1989 2.09
57 The balance between different peptidoglycan precursors determines whether Escherichia coli cells will elongate or divide. J Bacteriol 1990 2.07
58 Serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region. Microbiology 1999 2.07
59 Spherical E. coli due to elevated levels of D-alanine carboxypeptidase. Nature 1982 2.02
60 Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae. Mol Microbiol 1990 1.97
61 Meningococcal conjugate vaccines: new opportunities and new challenges. Lancet 1999 1.93
62 Comparison of the binding properties of two 6 beta-amidinopenicillanic acid derivatives that differ in their physiological effects on Escherichia coli. Antimicrob Agents Chemother 1977 1.91
63 Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6. Nucleic Acids Res 1989 1.91
64 Sequence diversity within the argF, fbp and recA genes of natural isolates of Neisseria meningitidis: interspecies recombination within the argF gene. Mol Microbiol 1992 1.90
65 Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli. J Bacteriol 1986 1.89
66 Identification of the major Spanish clones of penicillin-resistant pneumococci via the Internet using multilocus sequence typing. J Clin Microbiol 2000 1.88
67 Resistance to beta-lactam antibiotics by re-modelling the active site of an E. coli penicillin-binding protein. Nature 1986 1.87
68 Opa-typing: a high-resolution tool for studying the epidemiology of gonorrhoea. Mol Microbiol 1995 1.86
69 WebACT--an online companion for the Artemis Comparison Tool. Bioinformatics 2005 1.78
70 Precursor forms of penicillin-binding proteins 5 and 6 of E. coli cytoplasmic membrane. Nature 1981 1.76
71 Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya. Infect Immun 1993 1.74
72 Membrane topology of penicillin-binding protein 3 of Escherichia coli. Mol Microbiol 1989 1.70
73 Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F. Microbiology 1996 1.69
74 Production of thiol-penicillin-binding protein 3 of Escherichia coli using a two primer method of site-directed mutagenesis. EMBO J 1985 1.65
75 A comparison of the nucleotide sequences of the adk and recA genes of pathogenic and commensal Neisseria species: evidence for extensive interspecies recombination within adk. J Mol Evol 1996 1.65
76 Sequence evolution of the porB gene of Neisseria gonorrhoeae and Neisseria meningitidis: evidence of positive Darwinian selection. Mol Biol Evol 1995 1.65
77 Deletion of the penicillin-binding protein 5 gene of Escherichia coli. J Bacteriol 1980 1.63
78 Retracted Directional gene movement from human-pathogenic to commensal-like streptococci. Infect Immun 2001 1.61
79 Genetics and molecular biology of beta-lactam-resistant pneumococci. Microb Drug Resist 1995 1.61
80 Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins. Biochem J 1991 1.57
81 A mecillinam-sensitive peptidoglycan crosslinking reaction in Escherichia coli. Biochem Biophys Res Commun 1982 1.56
82 Deletion analysis of the essentiality of penicillin-binding proteins 1A, 2B and 2X of Streptococcus pneumoniae. FEMS Microbiol Lett 1993 1.55
83 Organization and subcloning of the dacA-rodA-pbpA cluster of cell shape genes in Escherichia coli. J Bacteriol 1983 1.54
84 Identification of the rodA gene product of Escherichia coli. J Bacteriol 1983 1.54
85 Amino acid substitutions that reduce the affinity of penicillin-binding protein 3 of Escherichia coli for cephalexin. Eur J Biochem 1985 1.49
86 Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae. Microb Drug Resist 1998 1.49
87 Electrophoretic variation in adenylate kinase of Neisseria meningitidis is due to inter- and intraspecies recombination. Proc Natl Acad Sci U S A 1995 1.48
88 Dynamics of penicillin-susceptible clones in invasive pneumococcal disease. J Infect Dis 2001 1.47
89 Genetic diversity of penicillin-binding protein 2 genes of penicillin-resistant strains of Neisseria meningitidis revealed by fingerprinting of amplified DNA. Antimicrob Agents Chemother 1990 1.44
90 Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone of Streptococcus pneumoniae in South Africa. Eur J Clin Microbiol Infect Dis 1994 1.42
91 Monofunctional biosynthetic peptidoglycan transglycosylases. Mol Microbiol 1996 1.39
92 A gene fusion that localises the penicillin-binding domain of penicillin-binding protein 3 of Escherichia coli. FEBS Lett 1984 1.35
93 Penicillin-resistant isolates of Neisseria lactamica produce altered forms of penicillin-binding protein 2 that arose by interspecies horizontal gene transfer. Antimicrob Agents Chemother 1991 1.32
94 Nucleotide sequences of the penicillin-binding protein 5 and 6 genes of Escherichia coli. Nucleic Acids Res 1988 1.32
95 Ecological separation and genetic isolation of Neisseria gonorrhoeae and Neisseria meningitidis. Curr Biol 1993 1.26
96 A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus. J Clin Microbiol 2006 1.25
97 Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis. FEMS Microbiol Lett 1993 1.24
98 Use of a beta-lactamase fusion vector to investigate the organization of penicillin-binding protein 1B in the cytoplasmic membrane of Escherichia coli. Mol Microbiol 1987 1.23
99 Further evidence for the non-clonal population structure of Neisseria gonorrhoeae: extensive genetic diversity within isolates of the same electrophoretic type. Microbiology 1994 1.22
100 Sequences of the active-site peptides of three of the high-Mr penicillin-binding proteins of Escherichia coli K-12. Proc Natl Acad Sci U S A 1985 1.21
101 The mechanism of action of penicillin. Sci Prog 1978 1.19
102 Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeae. Microbiology 1998 1.18
103 Molecular and genetic characterization of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F. Microbiology 1999 1.16
104 Interspecies recombination in nature: a meningococcus that has acquired a gonococcal PIB porin. Mol Microbiol 1995 1.15
105 Molecular typing of bacteria directly from cerebrospinal fluid. Eur J Clin Microbiol Infect Dis 2000 1.13
106 An amino acid substitution in penicillin-binding protein 3 creates pointed polar caps in Escherichia coli. J Bacteriol 1988 1.13
107 Cell division in a mutant of Salmonella typhimurium which is temperature-sensitive for DNA synthesis. J Gen Microbiol 1971 1.10
108 An amino acid substitution that blocks the deacylation step in the enzyme mechanism of penicillin-binding protein 5 of Escherichia coli. FEBS Lett 1984 1.08
109 The epidemiology of ciprofloxacin resistant isolates of Neisseria gonorrhoeae in Scotland 2002: a comparison of phenotypic and genotypic analysis. Sex Transm Infect 2005 1.03
110 Physiological and genetical studies on a mutant of Salmonella typhimurium which is temperature-sensitive for DNA synthesis. Mol Gen Genet 1972 1.02
111 Genetic diversity of penicillin-resistant Neisseria meningitidis. J Infect Dis 1992 1.01
112 Preparation and characterization of monoclonal antibodies against native membrane-bound penicillin-binding protein 1B of Escherichia coli. J Bacteriol 1989 1.00
113 The mutation Lys234His yields a class A beta-lactamase with a novel pH-dependence. Biochem J 1991 1.00
114 Nucleotide sequence of the penicillin-binding protein 2 gene of Neisseria meningitidis. Nucleic Acids Res 1989 0.98
115 Arginine-, hypoxanthine-, uracil-requiring isolates of Neisseria gonorrhoeae are a clonal lineage with a non-clonal population. Microbiology 1997 0.98
116 Two major groups of colicin factors: their evolutionary significance. Mol Gen Genet 1973 0.98
117 A mutant in the initiation of DNA synthesis in Salmonella typhimurium. J Gen Microbiol 1970 0.96
118 Cell division and the production of cells lacking nuclear bodies in a mutant of Salmonella typhimurium. Mol Gen Genet 1972 0.96
119 Replication of extrachromosomal elements in a DNA synthesis initiation mutant of Salmonella typhimurium. Biochem Biophys Res Commun 1972 0.94
120 Expression and purification of a soluble form of penicillin-binding protein 2 from both penicillin-susceptible and penicillin-resistant Neisseria gonorrhoeae. Protein Expr Purif 1992 0.94
121 Multiple antibiotic resistance in Streptococcus pneumoniae. Br Med Bull 1998 0.92
122 Representational difference analysis of cDNA for the detection of differential gene expression in bacteria: development using a model of iron-regulated gene expression in Neisseria meningitidis. Microbiology 1999 0.90
123 Mecillinam resistance in Escherichia coli: dissociation of growth inhibition and morphologic change. J Infect Dis 1981 0.88
124 Necrotizing fasciitis in captive juvenile Crocodylus porosus caused by Streptococcus agalactiae: an outbreak and review of the animal and human literature. Epidemiol Infect 2007 0.84
125 DNA polymorphisms and variant penicillin-binding proteins as evidence that relatively penicillin-resistant pneumococci in western Canada are clonally related. J Infect Dis 1996 0.84
126 Mapping of conformational epitopes of monoclonal antibodies against Escherichia coli penicillin-binding protein 1B (PBP 1B) by means of hybrid protein analysis: implications for the tertiary structure of PBP 1B. J Bacteriol 1990 0.80
127 A simple method for maximizing the yields of membrane and exported proteins expressed in Escherichia coli. Mol Microbiol 1989 0.76
128 Production of DNA-less cells in a mutant of Salmonella typhimurium. J Gen Microbiol 1970 0.75
129 A mutant in the initiation of DNA synthesis in Salmonella typhimurium. J Gen Microbiol 1970 0.75