Published in J Biol Chem on August 26, 2004
G protein-coupled receptor rhodopsin. Annu Rev Biochem (2006) 4.95
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol (2007) 3.86
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem (2007) 2.31
Phototransduction in mouse rods and cones. Pflugers Arch (2007) 2.23
Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry (2004) 2.03
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol (2007) 1.92
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
Chemistry and biology of vision. J Biol Chem (2011) 1.73
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Functional and structural characterization of rhodopsin oligomers. J Biol Chem (2006) 1.39
CNTF and retina. Prog Retin Eye Res (2011) 1.34
Chemistry of the retinoid (visual) cycle. Chem Rev (2013) 1.28
Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol (2008) 1.28
Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry (2011) 1.24
Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J (2010) 1.23
The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol (2005) 1.23
Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme. Exp Eye Res (2006) 1.23
Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda) (2010) 1.20
Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers. J Am Chem Soc (2012) 1.20
Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci (2010) 1.18
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J (2009) 1.18
Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev (2008) 1.14
Protein sorting, targeting and trafficking in photoreceptor cells. Prog Retin Eye Res (2013) 1.13
Molecular properties of rhodopsin and rod function. J Biol Chem (2006) 1.12
Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery. Vision Res (2007) 1.12
Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? Life Sci (2009) 1.09
Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction. Biophys J (2008) 1.07
Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy. Hum Gene Ther (2013) 1.06
Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A (2014) 1.03
Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry (2009) 1.02
Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry (2006) 1.02
Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant. PLoS One (2012) 1.00
Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol (2014) 0.99
Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res (2011) 0.95
Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest (2012) 0.95
Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One (2012) 0.93
P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet (2013) 0.93
Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters. IET Syst Biol (2010) 0.92
An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesis. J Neurosci (2012) 0.91
Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. J Cell Sci (2014) 0.91
From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci (2013) 0.90
Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem (2006) 0.89
Nanodomain organization of rhodopsin in native human and murine rod outer segment disc membranes. Biochim Biophys Acta (2014) 0.89
Barriers for retinal gene therapy: separating fact from fiction. Vision Res (2008) 0.88
Initiation of rod outer segment disc formation requires RDS. PLoS One (2014) 0.88
Molecular basis for photoreceptor outer segment architecture. Prog Retin Eye Res (2016) 0.87
Genomic DNA nanoparticles rescue rhodopsin-associated retinitis pigmentosa phenotype. FASEB J (2015) 0.87
Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci (2008) 0.86
Progress in elucidating the structural and dynamic character of G Protein-Coupled Receptor oligomers for use in drug discovery. Curr Pharm Des (2009) 0.85
Impact of reduced rhodopsin expression on the structure of rod outer segment disc membranes. Biochemistry (2015) 0.83
Proteomic analysis of the retina: removal of RPE alters outer segment assembly and retinal protein expression. Glia (2009) 0.82
The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death. J Biol Chem (2013) 0.80
Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. Elife (2015) 0.80
Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem (2016) 0.79
Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci (2014) 0.79
Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. PLoS One (2014) 0.78
Rhodopsin Forms Nanodomains in Rod Outer Segment Disc Membranes of the Cold-Blooded Xenopus laevis. PLoS One (2015) 0.78
Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods (2011) 0.78
A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Invest Ophthalmol Vis Sci (2015) 0.78
Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem (2010) 0.78
The G protein-coupled receptor rhodopsin: a historical perspective. Methods Mol Biol (2015) 0.78
Visual sensorial impairments in neurodevelopmental disorders: evidence for a retinal phenotype in Fragile X Syndrome. PLoS One (2014) 0.77
Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa. Gene Ther (2012) 0.77
Extended duration of transgene expression from pegylated POD nanoparticles enables attenuation of photoreceptor degeneration. PLoS One (2013) 0.77
Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration. Invest Ophthalmol Vis Sci (2016) 0.76
Signalling beyond photon absorption: extracellular retinoids and growth factors modulate rod photoreceptor sensitivity. J Physiol (2016) 0.75
Crystal structure of rhodopsin: A G protein-coupled receptor. Science (2000) 28.60
Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (2003) 5.85
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev (2000) 4.98
Amplification and kinetics of the activation steps in phototransduction. Biochim Biophys Acta (1993) 4.80
Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet (1997) 4.50
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc Natl Acad Sci U S A (2002) 4.12
Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem (2003) 3.90
Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy. J Comp Neurol (1979) 3.86
Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proc Natl Acad Sci U S A (1999) 3.71
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry (2001) 3.62
Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res (2001) 3.46
Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol (2002) 3.45
Roles of G-protein-coupled receptor dimerization. EMBO Rep (2004) 3.33
Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci (2001) 3.04
Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A (2000) 2.60
Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J Mol Biol (2003) 2.57
Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A (2001) 2.44
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry (2003) 2.42
Rods and cones in the mouse retina. II. Autoradiographic analysis of cell generation using tritiated thymidine. J Comp Neurol (1979) 2.35
Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci (1996) 2.24
The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett (2004) 2.19
G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol Ther (2002) 2.18
Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem (1996) 2.17
Identification of amino acid residues crucial for chemokine receptor dimerization. Nat Immunol (2004) 2.09
G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol (2002) 2.08
Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry (1999) 2.07
Membrane protein diffusion sets the speed of rod phototransduction. Nature (2001) 2.03
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol (2000) 1.88
Adsorption of biological molecules to a solid support for scanning probe microscopy. J Struct Biol (1997) 1.79
Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins. J Biol Chem (1979) 1.72
Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays (2000) 1.69
G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling. Circ Res (2004) 1.66
Photoreceptor membrane proteins, phototransduction, and retinal degenerative diseases. The Friedenwald Lecture. Invest Ophthalmol Vis Sci (1998) 1.58
GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J (2002) 1.49
Phototransduction: crystal clear. Trends Biochem Sci (2003) 1.45
Biophysics: is rhodopsin dimeric in native retinal rods? Nature (2003) 1.43
Dimerization of G-protein-coupled receptors: roles in signal transduction. Cell Signal (2004) 1.43
Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol (2001) 1.33
Dimerization of G-protein-coupled receptors. J Med Chem (2001) 1.16
A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments. Exp Eye Res (1979) 1.11
The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy. J Biol Chem (2003) 1.05
Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Eng (2002) 1.03
Rhodopsin photoproducts in 2D crystals. J Mol Biol (2004) 1.01
Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution. Biochemistry (2003) 1.00
The hydrodynamic properties of dark- and light-activated states of n-dodecyl beta-D-maltoside-solubilized bovine rhodopsin support the dimeric structure of both conformations. J Biol Chem (2004) 0.99
Rhodopsin structure, function, and topography the Friedenwald lecture. Invest Ophthalmol Vis Sci (2001) 0.99
Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. Proc Natl Acad Sci U S A (1993) 0.95
Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature (2003) 5.85
Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther (2005) 4.74
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A (2006) 4.33
Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A (2005) 4.04
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol (2007) 3.86
Aquaporin water channels--from atomic structure to clinical medicine. J Physiol (2002) 3.70
Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem (2003) 3.16
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Science (2005) 2.90
Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci (2004) 2.72
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62
Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci (2004) 2.62
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59
Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Hum Gene Ther (2006) 2.59
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol (2013) 2.53
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry (2003) 2.42
Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem (2008) 2.35
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem (2007) 2.31
Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem (2005) 2.28
Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol (2004) 2.24
Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A (2007) 2.21
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A (2003) 2.21
Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda) (2010) 2.18
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem (2005) 2.15
Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem (2002) 2.11
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol Cell (2005) 2.09
G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol (2002) 2.08
Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol (2006) 2.03
Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry (2004) 2.03
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A (2009) 2.01
Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem (2009) 2.01
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol (2007) 1.92
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci (2004) 1.92
Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci (2002) 1.86
Conformational changes in surface structures of isolated connexin 26 gap junctions. EMBO J (2002) 1.84
Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med (2005) 1.83
Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A (2005) 1.83
Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci (2008) 1.76
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A (2002) 1.72
ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet (2008) 1.69
Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A (2009) 1.65
RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab (2008) 1.64
Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem (2008) 1.62
Structure and assembly of the pseudopilin PulG. Mol Microbiol (2004) 1.61
Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem (2005) 1.58
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem (2006) 1.58
Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express (2010) 1.58
Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem (2004) 1.57
Aquaporins: Phylogeny, Structure, and Physiology of Water Channels. News Physiol Sci (1999) 1.56
Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55
Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem (2011) 1.55
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem (2011) 1.55
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A (2009) 1.54
Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A (2007) 1.53
Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci (2002) 1.52
Bacterial outer membrane secretin PulD assembles and inserts into the inner membrane in the absence of its pilotin. EMBO J (2006) 1.52
Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun (2002) 1.51
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem (2008) 1.51
Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure (2007) 1.51
Structural insights into the secretin PulD and its trypsin-resistant core. J Biol Chem (2005) 1.50
GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J (2002) 1.49
Structure of the dodecameric Yersinia enterocolitica secretin YscC and its trypsin-resistant core. Structure (2013) 1.49
Molecular architecture of photosynthetic membranes in Rhodobacter sphaeroides: the role of PufX. EMBO J (2004) 1.47