Published in Genome Res on September 01, 2004
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ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol (2008) 2.70
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63
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The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
RNA editing in the human ENCODE RNA-seq data. Genome Res (2012) 2.18
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RNA editing level in the mouse is determined by the genomic repeat repertoire. RNA (2006) 1.75
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Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency. J Biol Chem (2010) 1.59
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Specificity of ADAR-mediated RNA editing in newly identified targets. RNA (2008) 1.51
Prediction of trans-antisense transcripts in Arabidopsis thaliana. Genome Biol (2006) 1.50
Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection. Nucleic Acids Res (2009) 1.49
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Population bottlenecks as a potential major shaping force of human genome architecture. PLoS Genet (2007) 1.47
Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. Proc Natl Acad Sci U S A (2010) 1.47
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RNA editing in Drosophila melanogaster: New targets and functional consequences. RNA (2006) 1.43
Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing. Nat Rev Genet (2010) 1.40
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The ADAR protein family. Genome Biol (2012) 1.39
Genomic gems: SINE RNAs regulate mRNA production. Curr Opin Genet Dev (2010) 1.39
Regulation of circRNA biogenesis. RNA Biol (2015) 1.38
Altered RNA editing in mice lacking ADAR2 autoregulation. Mol Cell Biol (2006) 1.36
Intronic Alus influence alternative splicing. PLoS Genet (2008) 1.35
Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity. Genome Res (2006) 1.35
L1 retrotransposons in human cancers. J Biomed Biotechnol (2006) 1.34
STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev (2013) 1.32
SUMO-1 modification alters ADAR1 editing activity. Mol Biol Cell (2005) 1.32
Hypothesis: RNA editing of microRNA target sites in humans? RNA (2007) 1.30
Mammalian conserved ADAR targets comprise only a small fragment of the human editosome. Genome Biol (2014) 1.26
Deciphering the functions and regulation of brain-enriched A-to-I RNA editing. Nat Neurosci (2013) 1.25
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A (2012) 1.25
InvAluable junk: the cellular impact and function of Alu and B2 RNAs. IUBMB Life (2009) 1.24
Deep and comparative analysis of the mycelium and appressorium transcriptomes of Magnaporthe grisea using MPSS, RL-SAGE, and oligoarray methods. BMC Genomics (2006) 1.24
Competition between ADAR and RNAi pathways for an extensive class of RNA targets. Nat Struct Mol Biol (2011) 1.22
Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Nucleic Acids Res (2012) 1.21
RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions. J Biol Chem (2007) 1.21
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. Cell Rep (2015) 1.21
Letter from the editor: Adenosine-to-inosine RNA editing in Alu repeats in the human genome. EMBO Rep (2005) 1.20
ADAR regulates RNA editing, transcript stability, and gene expression. Cell Rep (2013) 1.19
RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. Mol Cell Biol (2009) 1.18
Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing. Nucleic Acids Res (2008) 1.17
Identification of widespread ultra-edited human RNAs. PLoS Genet (2011) 1.16
Screening of human SNP database identifies recoding sites of A-to-I RNA editing. RNA (2008) 1.16
Alu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing. PLoS One (2010) 1.15
A-to-I editing of coding and non-coding RNAs by ADARs. Nat Rev Mol Cell Biol (2015) 1.14
Identification of RNA editing sites in the SNP database. Nucleic Acids Res (2005) 1.14
An unexpected ending: noncanonical 3' end processing mechanisms. RNA (2009) 1.13
Evidence for large diversity in the human transcriptome created by Alu RNA editing. Nucleic Acids Res (2009) 1.12
Darned in 2013: inclusion of model organisms and linking with Wikipedia. Nucleic Acids Res (2012) 1.12
Adenosine deaminases acting on RNA, RNA editing, and interferon action. J Interferon Cytokine Res (2010) 1.11
A biochemical landscape of A-to-I RNA editing in the human brain transcriptome. Genome Res (2014) 1.09
Characteristics of transposable element exonization within human and mouse. PLoS One (2010) 1.09
Retrotransposons as regulators of gene expression. Science (2016) 1.09
Analysis of microRNA expression in the prepubertal testis. PLoS One (2010) 1.08
Widespread cleavage of A-to-I hyperediting substrates. RNA (2009) 1.06
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc Natl Acad Sci U S A (2008) 1.05
Characterization and comparison of human nuclear and cytosolic editomes. Proc Natl Acad Sci U S A (2013) 1.05
A genome-wide map of hyper-edited RNA reveals numerous new sites. Nat Commun (2014) 1.04
A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. RNA Biol (2013) 1.04
Large-scale analysis of structural, sequence and thermodynamic characteristics of A-to-I RNA editing sites in human Alu repeats. BMC Genomics (2010) 1.02
A-to-I RNA editing alters less-conserved residues of highly conserved coding regions: implications for dual functions in evolution. RNA (2008) 1.01
Extensive adenosine-to-inosine editing detected in Alu repeats of antisense RNAs reveals scarcity of sense-antisense duplex formation. FEBS Lett (2006) 1.01
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr Top Microbiol Immunol (2012) 1.01
Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method. Nucleic Acids Res (2010) 1.00
Regulation of senescence by microRNA biogenesis factors. Ageing Res Rev (2012) 0.99
Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR). RNA (2013) 0.98
A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters. PLoS One (2009) 0.98
SINEs point to abundant editing in the human genome. Genome Biol (2005) 0.97
Reconstruction of Arabidopsis thaliana fully integrated small RNA pathway. Funct Integr Genomics (2009) 0.96
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06
Alu repeats and human genomic diversity. Nat Rev Genet (2002) 12.40
RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem (2001) 9.66
Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res (2004) 8.35
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature (1997) 7.92
Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol (2004) 7.61
LINE-mediated retrotransposition of marked Alu sequences. Nat Genet (2003) 7.32
Alu repeats and human disease. Mol Genet Metab (1999) 6.64
RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62
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Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature (2004) 5.15
Regulation of alternative splicing by RNA editing. Nature (1999) 5.00
The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs. Cell (2001) 4.72
The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Res (2003) 4.21
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RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA. Proc Natl Acad Sci U S A (2002) 3.41
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Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc Natl Acad Sci U S A (2001) 3.14
Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities. Biochemistry (2000) 2.85
RNA truncation by premature polyadenylation attenuates human mobile element activity. Nat Genet (2003) 2.40
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science (2003) 2.34
A-to-I RNA editing: recent news and residual mysteries. J Biol Chem (2002) 2.20
Specific cleavage of hyper-edited dsRNAs. EMBO J (2001) 1.98
HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project. Nucleic Acids Res (2002) 1.98
RNAi is antagonized by A-->I hyper-editing. EMBO Rep (2001) 1.86
Alu repeat analysis in the complete human genome: trends and variations with respect to genomic composition. Bioinformatics (2004) 1.77
Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology (2003) 1.67
Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR. Mol Cell Biol (1998) 1.64
Coordination of editing and splicing of glutamate receptor pre-mRNA. RNA (2003) 1.45
RNA editing activity is associated with splicing factors in lnRNP particles: The nuclear pre-mRNA processing machinery. Proc Natl Acad Sci U S A (2001) 1.42
Human Alu element retrotransposition induced by genotoxic stress. Nat Genet (2003) 1.41
The origins and implications of Aluternative splicing. Trends Genet (2004) 1.35
Pronounced instability of tandem IU base pairs in RNA. Nucleic Acids Res (2004) 1.23
Genomics. Not junk after all. Science (2003) 1.17
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
A second-generation combined linkage physical map of the human genome. Genome Res (2007) 3.60
Age-related macular degeneration--a genome scan in extended families. Am J Hum Genet (2003) 2.99
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genet (2011) 2.13
Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. PLoS Biol (2013) 2.08
Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. Am J Psychiatry (2009) 1.85
Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet (2013) 1.70
A brave new world for an old world pest: Helicoverpa armigera (Lepidoptera: Noctuidae) in Brazil. PLoS One (2013) 1.68
Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study. PLoS One (2012) 1.65
Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae. Genetics (2003) 1.64
Linkage disequilibrium and inference of ancestral recombination in 538 single-nucleotide polymorphism clusters across the human genome. Am J Hum Genet (2003) 1.58
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet (2013) 1.57
Preliminary results of an open label study of heart rate variability biofeedback for the treatment of major depression. Appl Psychophysiol Biofeedback (2007) 1.56
A genome scan for loci shared by autism spectrum disorder and language impairment. Am J Psychiatry (2014) 1.55
New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? Am J Med Genet A (2004) 1.53
Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder. Biol Psychiatry (2011) 1.49
Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atherosclerosis (2013) 1.48
Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study. Arch Intern Med (2006) 1.45
Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. PLoS Med (2005) 1.44
Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Genetics (2007) 1.44
Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative. Genet Epidemiol (2012) 1.42
Raising the bar: PEPFAR and new paradigms for global health. J Acquir Immune Defic Syndr (2012) 1.37
Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium. Diabetes (2012) 1.31
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring) (2013) 1.28
Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet (2013) 1.27
The United States President's Emergency Plan for AIDS Relief: a story of partnerships and smart investments to turn the tide of the global AIDS pandemic. J Acquir Immune Defic Syndr (2012) 1.23
A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia. Appl Psychophysiol Biofeedback (2007) 1.18
Psychiatric comorbidity and other psychological factors in patients with "chronic Lyme disease". Am J Med (2009) 1.14
Bioinformatic prediction, deep sequencing of microRNAs and expression analysis during phenotypic plasticity in the pea aphid, Acyrthosiphon pisum. BMC Genomics (2010) 1.11
When a case is not a case: effects of phenotype misclassification on power and sample size requirements for the transmission disequilibrium test with affected child trios. Hum Hered (2009) 1.08
Expansion of the miRNA pathway in the hemipteran insect Acyrthosiphon pisum. Mol Biol Evol (2010) 1.06
Role of psychiatric comorbidity in chronic Lyme disease. Arthritis Rheum (2008) 1.06
Imputation of coding variants in African Americans: better performance using data from the exome sequencing project. Bioinformatics (2013) 1.05
Reciprocal translocations in Saccharomyces cerevisiae formed by nonhomologous end joining. Genetics (2004) 1.03
Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study. Am J Epidemiol (2013) 1.03
Capture of linear fragments at a double-strand break in yeast. Nucleic Acids Res (2007) 1.00
Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery. Am J Clin Nutr (2005) 0.98
High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor. J Biol Chem (2011) 0.97
The neuropeptide VGF is reduced in human bipolar postmortem brain and contributes to some of the behavioral and molecular effects of lithium. J Neurosci (2010) 0.96
Forum report: issues in clinical trials of empirical antifungal therapy in treating febrile neutropenic patients. Clin Infect Dis (2003) 0.96
Construction of a 5000(rad) whole-genome radiation hybrid panel in the horse and generation of a comprehensive and comparative map for ECA11. Mamm Genome (2002) 0.96
The map problem: a comparison of genetic and sequence-based physical maps. Am J Hum Genet (2001) 0.96
Randomized comparison of rapid ambulation using radial, 4 French femoral access, or femoral access with AngioSeal closure. Catheter Cardiovasc Interv (2004) 0.96
Genetic variant of glutathione peroxidase 1 in autism. Brain Dev (2009) 0.94
Cognitive traits link to human chromosomal regions. Behav Genet (2005) 0.93
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. PLoS One (2013) 0.93
TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data. BMC Bioinformatics (2012) 0.92
Maternal genotype effects can alias case genotype effects in case-control studies. Eur J Hum Genet (2008) 0.90
Pain is associated with short leukocyte telomere length in women with fibromyalgia. J Pain (2012) 0.89
The impact of treatment of depression on quality of life, disability and relapse in patients with Parkinson's disease. Mov Disord (2009) 0.89
The relationship between affect balance style and clinical outcomes in fibromyalgia. Arthritis Rheum (2008) 0.89
Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazole. Pediatr Infect Dis J (2006) 0.89
HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy. Arch Pediatr Adolesc Med (2009) 0.88
Specialist medication review does not benefit short-term outcomes and net costs in continuing-care patients. Age Ageing (2010) 0.88
Gene × gene interaction in shared etiology of autism and specific language impairment. Biol Psychiatry (2012) 0.87
The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes (2013) 0.87
Insights into the role of an active site aspartate in Ty1 reverse transcriptase polymerization. J Biol Chem (2004) 0.86
Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS Genet (2012) 0.86
The incidence and impact of increased body mass index on maternal and fetal morbidity in the low-risk primigravid population. J Matern Fetal Neonatal Med (2007) 0.86
Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study. BMC Genet (2013) 0.86
Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. BMC Med Genet (2013) 0.85
Systematic evaluation of map quality: human chromosome 22. Am J Hum Genet (2002) 0.85
Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia. J Natl Cancer Inst (2014) 0.85
Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity. Kidney Int (2005) 0.85
Associations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study. Circ Cardiovasc Genet (2012) 0.84
Immunomodulation with interferon-gamma and colony-stimulating factors for refractory fungal infections in patients with leukemia. Cancer (2005) 0.84
Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. BMC Med Genet (2013) 0.84
A novel method for analyzing genetic association with longitudinal phenotypes. Stat Appl Genet Mol Biol (2013) 0.83
Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication. Retrovirology (2013) 0.82
Lumbar disc herniation in the Spine Patient Outcomes Research Trial: does educational attainment impact outcome? Spine (Phila Pa 1976) (2011) 0.82
Map error reduction: using genetic and sequence-based physical maps to order closely linked markers. Hum Hered (2002) 0.82
Proofreading activity of DNA polymerase Pol2 mediates 3'-end processing during nonhomologous end joining in yeast. PLoS Genet (2008) 0.81
Development and validation of a short form of the valued life activities disability questionnaire for rheumatoid arthritis. Arthritis Care Res (Hoboken) (2011) 0.81
The impact of umbilical and uterine artery Doppler indices on antenatal course, labor and delivery in a low-risk primigravid population. J Perinat Med (2010) 0.81
Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study. Ann Hum Genet (2013) 0.80
Transmission disequilibrium test power and sample size in the presence of locus heterogeneity. Stat Appl Genet Mol Biol (2009) 0.80
Methods and tools for geographical mapping and analysis in primary health care. Prim Health Care Res Dev (2011) 0.79
NOS1AP protein levels are altered in BA46 and cerebellum of patients with schizophrenia. Schizophr Res (2010) 0.79
Recombinant cytokines in augmentation and immunomodulation of host defenses against Candida spp. Med Mycol (2004) 0.78
Forum report: issues in the evaluation of diagnostic tests, use of historical controls, and merits of the current multicenter collaborative groups. Clin Infect Dis (2003) 0.78
Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast. J Biol Chem (2013) 0.78
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. Hum Genet (2013) 0.78
Why a sex difference in age-adjusted relationship between height and stroke mortality? Stroke (2007) 0.78
Forum report: issues in the design of trials of drugs for the treatment of invasive aspergillosis. Clin Infect Dis (2003) 0.78
Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system. Biochem Biophys Res Commun (2013) 0.77
Follicular dendritic cell tumor of the cervical lymph node. ORL J Otorhinolaryngol Relat Spec (2002) 0.77
Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. Am J Addict (2012) 0.77
Association between blood glucose levels and development of candidemia in hospitalized patients. Endocr Pract (2009) 0.76
The multi-faceted assessment of independence in patients with rheumatoid arthritis: preliminary validation from the ATTAIN study. Curr Med Res Opin (2008) 0.76
Single-variant and multi-variant trend tests for genetic association with next-generation sequencing that are robust to sequencing error. Hum Hered (2013) 0.76