Published in Genome Res on July 01, 2002
An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A (2004) 13.66
The impact of retrotransposons on human genome evolution. Nat Rev Genet (2009) 8.08
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol (2004) 6.67
Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res (2004) 5.14
Intronic sequences flanking alternatively spliced exons are conserved between human and mouse. Genome Res (2003) 5.01
Alternative splicing and evolution: diversification, exon definition and function. Nat Rev Genet (2010) 4.30
Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47
Transcription-mediated gene fusion in the human genome. Genome Res (2005) 3.19
Different levels of alternative splicing among eukaryotes. Nucleic Acids Res (2006) 3.07
Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls. J Biol Chem (2003) 2.69
Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. Cell (2013) 2.67
Naturally occurring antisense: transcriptional leakage or real overlap? Genome Res (2005) 2.39
Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol (2007) 2.35
Alu elements as regulators of gene expression. Nucleic Acids Res (2006) 2.31
A non-EST-based method for exon-skipping prediction. Genome Res (2004) 2.15
Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs. PLoS Genet (2013) 2.07
Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutat Res (2006) 2.00
Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons. Proc Natl Acad Sci U S A (2006) 1.97
A novel algorithm for computational identification of contaminated EST libraries. Nucleic Acids Res (2003) 1.96
Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Res (2005) 1.96
Retrocopy contributions to the evolution of the human genome. BMC Genomics (2008) 1.95
LINE-1 RNA splicing and influences on mammalian gene expression. Nucleic Acids Res (2006) 1.94
Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences. Proc Natl Acad Sci U S A (2005) 1.88
Alu elements: know the SINEs. Genome Biol (2011) 1.81
Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes. RNA (2007) 1.75
The birth of new exons: mechanisms and evolutionary consequences. RNA (2007) 1.72
Improved repeat identification and masking in Dipterans. Gene (2006) 1.70
Transposable elements re-wire and fine-tune the transcriptome. PLoS Genet (2013) 1.70
Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms. Gene (2006) 1.68
Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene. PLoS Genet (2007) 1.67
Silencer elements as possible inhibitors of pseudoexon splicing. Nucleic Acids Res (2004) 1.65
The struggle for life of the genome's selfish architects. Biol Direct (2011) 1.64
Origin and evolution of new exons in rodents. Genome Res (2005) 1.57
Short interspersed elements (SINEs) are a major source of canine genomic diversity. Genome Res (2005) 1.57
C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts. Nucleic Acids Res (2009) 1.55
Possible involvement of SINEs in mammalian-specific brain formation. Proc Natl Acad Sci U S A (2008) 1.54
Diverse splicing patterns of exonized Alu elements in human tissues. PLoS Genet (2008) 1.52
All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol (2010) 1.52
Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features. Orphanet J Rare Dis (2014) 1.47
Transposable elements donate lineage-specific regulatory sequences to host genomes. Cytogenet Genome Res (2005) 1.44
Exon-trapping mediated by the human retrotransposon SVA. Genome Res (2009) 1.44
5'-Transducing SVA retrotransposon groups spread efficiently throughout the human genome. Genome Res (2009) 1.43
Widespread establishment and regulatory impact of Alu exons in human genes. Proc Natl Acad Sci U S A (2011) 1.40
Genomic gems: SINE RNAs regulate mRNA production. Curr Opin Genet Dev (2010) 1.39
Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Genome Res (2007) 1.36
Intronic Alus influence alternative splicing. PLoS Genet (2008) 1.35
LINE dancing in the human genome: transposable elements and disease. Genome Med (2009) 1.33
TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates. Nucleic Acids Res (2007) 1.30
The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. Genome Biol (2010) 1.29
Transposable elements in disease-associated cryptic exons. Hum Genet (2009) 1.28
Characteristics and regulatory elements defining constitutive splicing and different modes of alternative splicing in human and mouse. RNA (2005) 1.28
Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution. BMC Genomics (2007) 1.27
The "alternative" choice of constitutive exons throughout evolution. PLoS Genet (2007) 1.27
InvAluable junk: the cellular impact and function of Alu and B2 RNAs. IUBMB Life (2009) 1.24
Comparative cross-species alternative splicing in plants. Plant Physiol (2007) 1.21
Alu exonization events reveal features required for precise recognition of exons by the splicing machinery. PLoS Comput Biol (2009) 1.20
SVA retrotransposons: Evolution and genetic instability. Semin Cancer Biol (2010) 1.20
AluGene: a database of Alu elements incorporated within protein-coding genes. Nucleic Acids Res (2004) 1.19
Coding sequences of functioning human genes derived entirely from mobile element sequences. Proc Natl Acad Sci U S A (2004) 1.18
Global mapping of transposon location. PLoS Genet (2006) 1.16
New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts. PLoS Genet (2006) 1.14
Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes. Genome Res (2006) 1.13
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J (2009) 1.13
Multifactorial interplay controls the splicing profile of Alu-derived exons. Mol Cell Biol (2008) 1.12
Distributions of transposable elements reveal hazardous zones in mammalian introns. PLoS Comput Biol (2011) 1.12
Global discovery of primate-specific genes in the human genome. Proc Natl Acad Sci U S A (2009) 1.11
Alternative splicing of Alu exons--two arms are better than one. Nucleic Acids Res (2008) 1.11
Where do introns come from? PLoS Biol (2008) 1.10
Characteristics of transposable element exonization within human and mouse. PLoS One (2010) 1.09
Retrotransposons as regulators of gene expression. Science (2016) 1.09
The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution. PLoS Genet (2009) 1.07
Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns. Genome Biol (2006) 1.07
The effect of intron length on exon creation ratios during the evolution of mammalian genomes. RNA (2008) 1.07
Comprehensive analysis of two Alu Yd subfamilies. J Mol Evol (2003) 1.06
The biased distribution of Alus in human isochores might be driven by recombination. J Mol Evol (2005) 1.05
Evaluating the protein coding potential of exonized transposable element sequences. Biol Direct (2007) 1.05
SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements. BMC Genet (2007) 1.05
The origins, evolution, and functional potential of alternative splicing in vertebrates. Mol Biol Evol (2011) 1.05
Exonization of AluYa5 in the human ACE gene requires mutations in both 3' and 5' splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Res (2005) 1.02
Modern origin of numerous alternatively spliced human introns from tandem arrays. Proc Natl Acad Sci U S A (2007) 1.01
Misfolded human tRNA isodecoder binds and neutralizes a 3' UTR-embedded Alu element. Proc Natl Acad Sci U S A (2011) 1.01
Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform. Arch Biochem Biophys (2008) 1.01
Paucity of chimeric gene-transposable element transcripts in the Drosophila melanogaster genome. BMC Biol (2005) 1.00
Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates. Mob DNA (2011) 1.00
Transposable elements modulate human RNA abundance and splicing via specific RNA-protein interactions. Genome Biol (2014) 1.00
Genomic fossils as a snapshot of the human transcriptome. Proc Natl Acad Sci U S A (2006) 0.99
Exonization of the LTR transposable elements in human genome. BMC Genomics (2007) 0.99
Large-scale analysis of exonized mammalian-wide interspersed repeats in primate genomes. Hum Mol Genet (2009) 0.99
Exon creation and establishment in human genes. Genome Biol (2008) 0.98
A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters. PLoS One (2009) 0.98
Evolution of the exon-intron structure and alternative splicing of the MAGE-A family of cancer/testis antigens. J Mol Evol (2004) 0.97
Identification of splicing silencers and enhancers in sense Alus: a role for pseudoacceptors in splice site repression. Mol Cell Biol (2005) 0.97
LINEs and SINEs of primate evolution. Evol Anthropol (2010) 0.96
De novo insertion of an Alu sequence in the coding region of the CLCN5 gene results in Dent's disease. Hum Genet (2003) 0.95
Expressing genes do not forget their LINEs: transposable elements and gene expression. Front Biosci (Landmark Ed) (2012) 0.94
Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. Mol Genet Genomics (2005) 0.93
Roles for retrotransposon insertions in human disease. Mob DNA (2016) 0.92
Alternative splicing of anciently exonized 5S rRNA regulates plant transcription factor TFIIIA. Genome Res (2009) 0.92
Editing efficiency of a Drosophila gene correlates with a distant splice site selection. RNA (2005) 0.92
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A computer program for aligning a cDNA sequence with a genomic DNA sequence. Genome Res (1998) 22.69
Evolutionary analyses of the human genome. Nature (2001) 4.13
Transposable elements are found in a large number of human protein-coding genes. Trends Genet (2001) 3.89
Intron-exon structures of eukaryotic model organisms. Nucleic Acids Res (1999) 3.84
Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature (1987) 3.62
Reconstruction and analysis of human Alu genes. J Mol Evol (1991) 2.87
The age of Alu subfamilies. J Mol Evol (1996) 2.85
Alu sequences in the coding regions of mRNA: a source of protein variability. Trends Genet (1994) 2.49
Alu: structure, origin, evolution, significance and function of one-tenth of human DNA. Prog Nucleic Acid Res Mol Biol (1996) 2.29
Standardized nomenclature for Alu repeats. J Mol Evol (1996) 2.00
Biased distribution of inverted and direct Alus in the human genome: implications for insertion, exclusion, and genome stability. Genome Res (2001) 1.97
The frequency and position of Alu repeats in cDNAs, as determined by database searching. Genomics (1995) 1.87
Genomic scrap yard: how genomes utilize all that junk. Gene (2000) 1.84
The contribution of exon-skipping events on chromosome 22 to protein coding diversity. Genome Res (2001) 1.83
Alu sequences. FEBS Lett (1997) 1.81
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev (1996) 1.60
Splice-mediated insertion of an Alu sequence inactivates ornithine delta-aminotransferase: a role for Alu elements in human mutation. Proc Natl Acad Sci U S A (1991) 1.56
Origin and phylogenetic distribution of Alu DNA repeats: irreversible events in the evolution of primates. J Mol Biol (1999) 1.45
Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. Mol Cell Biol (1993) 1.31
Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Genomics (2001) 1.23
Alu alert. Nature (1994) 1.18
Effects of Alu insertions on gene function. Electrophoresis (1998) 1.04
Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Genomics (1996) 0.97
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Chromatin organization marks exon-intron structure. Nat Struct Mol Biol (2009) 5.90
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. Science (2010) 5.56
The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons. Science (2003) 5.04
Intronic sequences flanking alternatively spliced exons are conserved between human and mouse. Genome Res (2003) 5.01
Alternative splicing and evolution: diversification, exon definition and function. Nat Rev Genet (2010) 4.30
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. Mol Cell (2006) 4.11
How prevalent is functional alternative splicing in the human genome? Trends Genet (2004) 3.81
Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior. Mol Biol Evol (2004) 3.62
Different levels of alternative splicing among eukaryotes. Nucleic Acids Res (2006) 3.07
GUIDANCE: a web server for assessing alignment confidence scores. Nucleic Acids Res (2010) 2.95
Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle. Proc Natl Acad Sci U S A (2010) 2.76
Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control. OMICS (2004) 2.40
An alignment confidence score capturing robustness to guide tree uncertainty. Mol Biol Evol (2010) 2.39
Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol (2007) 2.35
GC composition of the human genome: in search of isochores. Mol Biol Evol (2005) 2.25
Public control could be a nightmare for researchers. Nature (2007) 2.24
Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB. Nat Struct Mol Biol (2010) 2.19
The genome sequence of the leaf-cutter ant Atta cephalotes reveals insights into its obligate symbiotic lifestyle. PLoS Genet (2011) 2.16
A non-EST-based method for exon-skipping prediction. Genome Res (2004) 2.15
Heads or tails: a simple reliability check for multiple sequence alignments. Mol Biol Evol (2007) 2.04
Alternative splicing: current perspectives. Bioessays (2008) 1.95
Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile). Proc Natl Acad Sci U S A (2011) 1.94
Minimal conditions for exonization of intronic sequences: 5' splice site formation in alu exons. Mol Cell (2004) 1.93
Comparative analysis detects dependencies among the 5' splice-site positions. RNA (2004) 1.91
Detection and removal of biases in the analysis of next-generation sequencing reads. PLoS One (2011) 1.91
Draft genome of the red harvester ant Pogonomyrmex barbatus. Proc Natl Acad Sci U S A (2011) 1.88
Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes. Genome Res (2007) 1.86
Can GC content at third-codon positions be used as a proxy for isochore composition? Mol Biol Evol (2009) 1.80
Insights into the connection between cancer and alternative splicing. Trends Genet (2007) 1.78
RNA-editing-mediated exon evolution. Genome Biol (2007) 1.77
Human-mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation. Hum Mol Genet (2005) 1.71
Ratios of radical to conservative amino acid replacement are affected by mutational and compositional factors and may not be indicative of positive Darwinian selection. Mol Biol Evol (2002) 1.60
Bacterial type III secretion systems are ancient and evolved by multiple horizontal-transfer events. Gene (2003) 1.60
Estimates of positive Darwinian selection are inflated by errors in sequencing, annotation, and alignment. Genome Biol Evol (2009) 1.57
'Genome order index' should not be used for defining compositional constraints in nucleotide sequences. Comput Biol Chem (2007) 1.54
Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing. EMBO J (2010) 1.53
Finding the missing honey bee genes: lessons learned from a genome upgrade. BMC Genomics (2014) 1.46
Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res (2013) 1.45
DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure. Genome Res (2013) 1.44
Differential GC content between exons and introns establishes distinct strategies of splice-site recognition. Cell Rep (2012) 1.41
In search of the vertebrate phylotypic stage: a molecular examination of the developmental hourglass model and von Baer's third law. J Exp Zool B Mol Dev Evol (2005) 1.36
Intronic Alus influence alternative splicing. PLoS Genet (2008) 1.35
Playing chicken (Gallus gallus): methodological inconsistencies of molecular divergence date estimates due to secondary calibration points. Gene (2002) 1.34
SROOGLE: webserver for integrative, user-friendly visualization of splicing signals. Nucleic Acids Res (2009) 1.32
TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates. Nucleic Acids Res (2007) 1.30
The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. Genome Biol (2010) 1.29
The importance of being divisible by three in alternative splicing. Nucleic Acids Res (2005) 1.29
A method for the simultaneous estimation of selection intensities in overlapping genes. PLoS One (2008) 1.28
The "inverse relationship between evolutionary rate and age of mammalian genes" is an artifact of increased genetic distance with rate of evolution and time of divergence. Mol Biol Evol (2005) 1.27
The "alternative" choice of constitutive exons throughout evolution. PLoS Genet (2007) 1.27
Regulation of alternative splicing through coupling with transcription and chromatin structure. Annu Rev Biochem (2015) 1.26
Evolutionary dynamics of large numts in the human genome: rarity of independent insertions and abundance of post-insertion duplications. J Mol Evol (2003) 1.24
A comparative analysis of numt evolution in human and chimpanzee. Mol Biol Evol (2006) 1.24
The "domino theory" of gene death: gradual and mass gene extinction events in three lineages of obligate symbiotic bacterial pathogens. Mol Biol Evol (2005) 1.21
Alu exonization events reveal features required for precise recognition of exons by the splicing machinery. PLoS Comput Biol (2009) 1.20
AluGene: a database of Alu elements incorporated within protein-coding genes. Nucleic Acids Res (2004) 1.19
SR proteins: a foot on the exon before the transition from intron to exon definition. Trends Genet (2006) 1.15
The emergence of alternative 3' and 5' splice site exons from constitutive exons. PLoS Comput Biol (2007) 1.15
Multifactorial interplay controls the splicing profile of Alu-derived exons. Mol Cell Biol (2008) 1.12
Characterization of pairwise and multiple sequence alignment errors. Gene (2008) 1.11
Alternative splicing of Alu exons--two arms are better than one. Nucleic Acids Res (2008) 1.11
Local reliability measures from sets of co-optimal multiple sequence alignments. Pac Symp Biocomput (2008) 1.11
A branch-and-bound algorithm for the inference of ancestral amino-acid sequences when the replacement rate varies among sites: Application to the evolution of five gene families. Bioinformatics (2002) 1.11
Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons. Genome Res (2011) 1.10
The U1 snRNP base pairs with the 5' splice site within a penta-snRNP complex. Mol Cell Biol (2003) 1.10
Characteristics of transposable element exonization within human and mouse. PLoS One (2010) 1.09
The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution. PLoS Genet (2009) 1.07
SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements. BMC Genet (2007) 1.05
Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. Mol Cell (2013) 1.03
IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination. Hum Mol Genet (2007) 1.01
Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells. PLoS One (2010) 0.98
A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives. Virol J (2009) 0.97
IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia. Hum Mol Genet (2011) 0.96
Neutral evolution of robustness in Drosophila microRNA precursors. Mol Biol Evol (2011) 0.95
Identifying compositionally homogeneous and nonhomogeneous domains within the human genome using a novel segmentation algorithm. Nucleic Acids Res (2010) 0.94
Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model. Hum Mol Genet (2013) 0.92
Alternative approach to a heavy weight problem. Genome Res (2007) 0.92
Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene. BMC Mol Biol (2007) 0.91
Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. J Cell Sci (2005) 0.91
Inferring the pattern of spontaneous mutation from the pattern of substitution in unitary pseudogenes of Mycobacterium leprae and a comparison of mutation patterns among distantly related organisms. J Mol Evol (2005) 0.91
Alternative splicing and disease. RNA Biol (2008) 0.89
Same-strand overlapping genes in bacteria: compositional determinants of phase bias. Biol Direct (2008) 0.88
Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements. Nucleic Acids Res (2009) 0.88
Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing. Nucleic Acids Res (2002) 0.87
Bioactivation of carbamate-based 20(S)-camptothecin prodrugs. Bioorg Med Chem (2004) 0.86
Detecting excess radical replacements in phylogenetic trees. Gene (2003) 0.85
Comparative testing of DNA segmentation algorithms using benchmark simulations. Mol Biol Evol (2009) 0.85
Detection of functional overlapping genes: simulation and case studies. J Mol Evol (2010) 0.85
A computational tool for the genomic identification of regions of unusual compositional properties and its utilization in the detection of horizontally transferred sequences. Mol Biol Evol (2006) 0.84
The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates. J Mol Evol (2002) 0.84
Pre-mRNA splicing is a determinant of nucleosome organization. PLoS One (2013) 0.82
Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. RNA (2007) 0.82
When epigenetics meets alternative splicing: the roles of DNA methylation and GC architecture. Epigenomics (2013) 0.81
Is there a twelfth protein-coding gene in the genome of influenza A? A selection-based approach to the detection of overlapping genes in closely related sequences. J Mol Evol (2011) 0.81
Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. Mol Biol Cell (2004) 0.80