The ADAR protein family.

The ctenophore genome and the evolutionary origins of neural systems. Nature (2014) 2.96

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes. Genome Res (2013) 1.81

Adenosine-to-inosine RNA editing and human disease. Genome Med (2013) 1.40

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome. Genome Biol (2014) 1.26

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. Cell Rep (2015) 1.21

Retrotransposons as regulators of gene expression. Science (2016) 1.09

RNA editing regulates transposon-mediated heterochromatic gene silencing. Nat Commun (2013) 1.07

A genome-wide map of hyper-edited RNA reveals numerous new sites. Nat Commun (2014) 1.04

Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways. Nat Commun (2015) 0.99

Genome-wide analysis of Alu editability. Nucleic Acids Res (2014) 0.92

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease. Adv Exp Med Biol (2014) 0.92

Uncovering RNA Editing Sites in Long Non-Coding RNAs. Front Bioeng Biotechnol (2014) 0.87

Dynamic response of RNA editing to temperature in Drosophila. BMC Biol (2015) 0.87

The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome. Cell Rep (2014) 0.84

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes. Genome Res (2016) 0.82

The Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus. Comput Struct Biotechnol J (2014) 0.80

A-to-I RNA editing independent of ADARs in filamentous fungi. RNA Biol (2016) 0.79

Identification of evolutionarily meaningful information within the mammalian RNA editing landscape. Genome Biol (2014) 0.78

The RBPome: where the brains meet the brawn. Genome Biol (2014) 0.78

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease. RNA (2015) 0.78

Dynamic regulation of RNA editing in human brain development and disease. Nat Neurosci (2016) 0.78

'Z-DNA like' fragments in RNA: a recurring structural motif with implications for folding, RNA/protein recognition and immune response. Nucleic Acids Res (2016) 0.78

Flow-cytometric visualization of C>U mRNA editing reveals the dynamics of the process in live cells. RNA Biol (2015) 0.77

Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript. RNA Biol (2015) 0.77

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J (2014) 0.77

Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain. RNA Biol (2014) 0.77

Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans. RNA (2016) 0.76

Identification of the long, edited dsRNAome of LPS-stimulated immune cells. Genome Res (2016) 0.76

Systems approaches to human autoimmune diseases. Curr Opin Immunol (2013) 0.76

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. PLoS Genet (2015) 0.76

RNA editing by ADAR1 marks dsRNA as "self". Cell Res (2015) 0.76

Complex regulation of ADAR-mediated RNA-editing across tissues. BMC Genomics (2016) 0.76

Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells. Genome Biol (2016) 0.76

Translating the epitranscriptome. Wiley Interdiscip Rev RNA (2016) 0.76

Parallel action of AtDRB2 and RdDM in the control of transposable element expression. BMC Plant Biol (2015) 0.76

Molecular evidence of RNA editing in Bombyx chemosensory protein family. PLoS One (2014) 0.76

Adaptation of A-to-I RNA editing in Drosophila. PLoS Genet (2017) 0.75

Reprogramming, Circular Reasoning and Self versus Non-self: One-Stop Shopping with RNA Editing. Front Genet (2016) 0.75

Single-cell RNA sequencing reveals dynamic changes in A-to-I RNA editome during early human embryogenesis. BMC Genomics (2016) 0.75

ADAR1 restricts LINE-1 retrotransposition. Nucleic Acids Res (2016) 0.75

Diverse selective regimes shape genetic diversity at ADAR genes and at their coding targets. RNA Biol (2015) 0.75

Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma. J Biol Chem (2017) 0.75

Dynamic hyper-editing underlies temperature adaptation in Drosophila. PLoS Genet (2017) 0.75

Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance. Genome Biol (2017) 0.75

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75

RNA interference. Nature (2002) 22.28

The glutamate receptor ion channels. Pharmacol Rev (1999) 15.06

The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85

RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem (2001) 9.66

Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (2008) 8.62

Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature (1997) 7.92

An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (2004) 7.71

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49

Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science (2007) 7.15

Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science (2009) 6.96

Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol (2004) 6.67

Functions and regulation of RNA editing by ADAR deaminases. Annu Rev Biochem (2010) 5.99

RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells. Nature (2008) 5.59

Endogenous RNA interference provides a somatic defense against Drosophila transposons. Curr Biol (2008) 5.22

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21

Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res (2004) 5.14

Regulation of alternative splicing by RNA editing. Nature (1999) 5.00

Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA. EMBO J (1998) 4.87

RNA editing of a miRNA precursor. RNA (2004) 4.43

Nervous system targets of RNA editing identified by comparative genomics. Science (2003) 4.36

RNA editing of human microRNAs. Genome Biol (2006) 4.16

Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Mol Cell Biol (1995) 4.12

A mammalian RNA editing enzyme. Nature (1996) 3.90

A developmentally regulated activity that unwinds RNA duplexes. Cell (1987) 3.79

Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase. EMBO J (1994) 3.75

A-to-I RNA editing and human disease. RNA Biol (2006) 3.32

Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol (2006) 3.31

Behavioural report of single neuron stimulation in somatosensory cortex. Nature (2007) 3.30

A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA (2000) 3.06

Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science (2005) 2.94

NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5. EMBO J (1995) 2.87

Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities. Biochemistry (2000) 2.85

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J (1998) 2.68

Timeline: Z-DNA: the long road to biological function. Nat Rev Genet (2003) 2.65

RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J Biol Chem (1996) 2.64

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63

Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA. Science (1999) 2.54

A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase. Proc Natl Acad Sci U S A (1997) 2.35

RNA editing by base deamination: more enzymes, more targets, new mysteries. Trends Biochem Sci (2001) 2.26

Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol (2004) 2.25

Protein-RNA recognition. Annu Rev Biochem (1995) 2.21

Substrate specificity of the dsRNA unwinding/modifying activity. EMBO J (1991) 2.18

RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J (2002) 2.14

Dynamic association of RNA-editing enzymes with the nucleolus. J Cell Sci (2003) 2.14

Substrate recognition by ADAR1 and ADAR2. RNA (2001) 2.09

Synthetic polynucleotides and the amino acid code. V. Proc Natl Acad Sci U S A (1962) 2.01

Specific cleavage of hyper-edited dsRNAs. EMBO J (2001) 1.98

Editing modifies the GABA(A) receptor subunit alpha3. RNA (2007) 1.96

dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. RNA (2000) 1.95

RNA editing underlies temperature adaptation in K+ channels from polar octopuses. Science (2012) 1.87

RNAi is antagonized by A-->I hyper-editing. EMBO Rep (2001) 1.86

The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing. Neuron (2000) 1.82

ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation. Prog Nucleic Acid Res Mol Biol (2005) 1.78

RNA-editing-mediated exon evolution. Genome Biol (2007) 1.77

Predicting sites of ADAR editing in double-stranded RNA. Nat Commun (2011) 1.74

Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci U S A (2003) 1.73

Burst spiking of a single cortical neuron modifies global brain state. Science (2009) 1.71

RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA (2003) 1.70

RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. Genetics (2000) 1.67

Molecular determinants and guided evolution of species-specific RNA editing. Nature (2005) 1.66

Biased (A-->I) hypermutation of animal RNA virus genomes. Curr Opin Genet Dev (1994) 1.65

Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin2C receptors. J Neurochem (2000) 1.64

CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain. Mol Cell Biol (2001) 1.56

Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria. Am J Hum Genet (2003) 1.55

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature (2008) 1.51

Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome. Nat Chem Biol (2010) 1.49

Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. Proc Natl Acad Sci U S A (2010) 1.47

The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila. Proc Natl Acad Sci U S A (2009) 1.44

Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing. Nat Rev Genet (2010) 1.40

Tuning of RNA editing by ADAR is required in Drosophila. EMBO J (2005) 1.39

tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J (2002) 1.38

Altered RNA editing in mice lacking ADAR2 autoregulation. Mol Cell Biol (2006) 1.36

Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem (2010) 1.34

Extensive editing of mRNAs for the squid delayed rectifier K+ channel regulates subunit tetramerization. Neuron (2002) 1.33

Z-DNA-binding proteins can act as potent effectors of gene expression in vivo. Proc Natl Acad Sci U S A (2002) 1.26

Competition between ADAR and RNAi pathways for an extensive class of RNA targets. Nat Struct Mol Biol (2011) 1.22

RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions. J Biol Chem (2007) 1.21

Origins and evolution of ADAR-mediated RNA editing. IUBMB Life (2009) 1.19

The binding selectivity of ADAR2's dsRBMs contributes to RNA-editing selectivity. Chem Biol (2004) 1.19

RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation. Neuron (2012) 1.15

Spectroscopic characterization of a DNA-binding domain, Z alpha, from the editing enzyme, dsRNA adenosine deaminase: evidence for left-handed Z-DNA in the Z alpha-DNA complex. Biochemistry (1998) 1.13

Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues. PLoS One (2012) 1.11

Regulation of glutamate receptor B pre-mRNA splicing by RNA editing. Nucleic Acids Res (2007) 1.09

Regulated RNA editing and functional epistasis in Shaker potassium channels. J Gen Physiol (2009) 1.07

A-to-I RNA editing alters less-conserved residues of highly conserved coding regions: implications for dual functions in evolution. RNA (2008) 1.01

Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse. Brain Res (2001) 1.00

An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme. RNA (2009) 1.00

A-to-I editing sites are a genomically encoded G: implications for the evolutionary significance and identification of novel editing sites. RNA (2007) 1.00

Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. Nat Commun (2012) 0.99

Editing of human K(V)1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity. Nat Commun (2011) 0.98

The intricate relationship between RNA structure, editing, and splicing. Semin Cell Dev Biol (2011) 0.97

Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system. Nat Methods (2011) 0.95

Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment. J Biol Chem (2012) 0.83

RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue. Channels (Austin) (2012) 0.82

Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A (2004) 3.58

RNA editing in regulating gene expression in the brain. Biochim Biophys Acta (2007) 1.54

Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila. Nat Struct Mol Biol (2013) 1.42

Tuning of RNA editing by ADAR is required in Drosophila. EMBO J (2005) 1.39

Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nat Neurosci (2011) 1.36

Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem (2010) 1.34

RNA editing regulates transposon-mediated heterochromatic gene silencing. Nat Commun (2013) 1.07

Genetic approaches to studying adenosine-to-inosine RNA editing. Methods Enzymol (2007) 1.00

Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. Nat Commun (2012) 0.99

Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem (2009) 0.99

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A (2013) 0.98

The intricate relationship between RNA structure, editing, and splicing. Semin Cell Dev Biol (2011) 0.97

Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system. Nat Methods (2011) 0.95

Tertiary structural elements determine the extent and specificity of messenger RNA editing. Nat Commun (2013) 0.89

Enhancing non-coding RNA information content with ADAR editing. Neurosci Lett (2009) 0.88

Dark matter RNA: an intelligent scaffold for the dynamic regulation of the nuclear information landscape. Front Genet (2012) 0.88

Dynamic response of RNA editing to temperature in Drosophila. BMC Biol (2015) 0.87

Unraveling pleiotropic functions of A-to-I RNA editing in Drosophila. Fly (Austin) (2010) 0.83

RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue. Channels (Austin) (2012) 0.82

Perturbing A-to-I RNA editing using genetics and homologous recombination. Methods Mol Biol (2011) 0.82

Experimental comparison and cross-validation of Affymetrix HT plate and cartridge array gene expression platforms. Genomics (2008) 0.80

Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion. Aging (Albany NY) (2014) 0.80

A model genetic system for testing the in vivo function of peptide toxins. Peptides (2006) 0.79

Identification of evolutionarily meaningful information within the mammalian RNA editing landscape. Genome Biol (2014) 0.78

Mutations to the piRNA pathway component aubergine enhance meiotic drive of segregation distorter in Drosophila melanogaster. Genetics (2012) 0.78

Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging. Fly (Austin) (2012) 0.76

Comparative genomic and bioinformatic approaches for the identification of new adenosine-to-inosine substrates. Methods Enzymol (2007) 0.76

Assessing the validity and reproducibility of genome-scale predictions. Bioinformatics (2013) 0.75