Published in DNA Repair (Amst) on November 02, 2004
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases. Proc Natl Acad Sci U S A (2008) 6.59
Mechanisms for human genomic rearrangements. Pathogenetics (2008) 4.54
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology. Nucleic Acids Res (2010) 2.61
ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev (2008) 2.17
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
Ku recruits XLF to DNA double-strand breaks. EMBO Rep (2007) 2.00
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J (2006) 1.36
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genet (2006) 1.31
Exonuclease function of human Mre11 promotes deletional nonhomologous end joining. J Biol Chem (2009) 1.16
Evolution in health and medicine Sackler colloquium: Genomic disorders: a window into human gene and genome evolution. Proc Natl Acad Sci U S A (2010) 1.11
Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair. Biochemistry (2011) 1.10
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis. Nucleic Acids Res (2006) 1.04
DNA damage response. Cold Spring Harb Perspect Biol (2011) 1.03
RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function? Chromosome Res (2009) 1.01
Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology. DNA Repair (Amst) (2007) 0.98
Identifying the mechanisms of intron gain: progress and trends. Biol Direct (2012) 0.98
The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation. J Biol Chem (2013) 0.97
End-to-end attraction of duplex DNA. Nucleic Acids Res (2012) 0.96
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. PLoS Genet (2009) 0.93
Comprehensive analysis of pathogenic deletion variants in Fanconi anemia genes. Hum Mutat (2014) 0.91
DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun (2009) 0.89
Rqh1 blocks recombination between sister chromatids during double strand break repair, independent of its helicase activity. Proc Natl Acad Sci U S A (2006) 0.89
The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer Lett (2006) 0.89
Efficient repair of DNA double-strand breaks in malignant cells with structural instability. Mutat Res (2010) 0.88
CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma. Mol Cancer Res (2012) 0.87
Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF). J Biol Chem (2013) 0.86
Aberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene. Genome Res (2011) 0.86
Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining. Mutagenesis (2010) 0.86
Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo. PLoS One (2011) 0.86
Linear group II intron RNAs can retrohome in eukaryotes and may use nonhomologous end-joining for cDNA ligation. Proc Natl Acad Sci U S A (2009) 0.85
Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. Mol Cell Biol (2007) 0.85
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase. BMC Mol Biol (2007) 0.85
Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe. Genetics (2006) 0.84
Inhibition of DNA damage repair by artificial activation of PARP with siDNA. Nucleic Acids Res (2013) 0.84
Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Res (2013) 0.83
Tissue-specific differences in the accumulation of sequence rearrangements with age. DNA Repair (Amst) (2008) 0.83
Replicative mechanisms of CNV formation preferentially occur as intrachromosomal events: evidence from Potocki-Lupski duplication syndrome. Hum Mol Genet (2012) 0.82
XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination. Blood (2016) 0.81
Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. PLoS One (2014) 0.79
Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. Cell Death Dis (2013) 0.79
Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo. Oncol Lett (2012) 0.79
Strategies for B-cell receptor repertoire analysis in primary immunodeficiencies: from severe combined immunodeficiency to common variable immunodeficiency. Front Immunol (2015) 0.79
Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy. Front Oncol (2015) 0.78
Genetic Susceptibility to Rhodococcus equi. J Vet Intern Med (2015) 0.77
Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications. Curr Genomics (2010) 0.77
Phosphorylation of Ku70 subunit by cell cycle kinases modulates the replication related function of Ku heterodimer. Nucleic Acids Res (2016) 0.77
BRCA1 silencing is associated with failure of DNA repairing in retinal neurocytes. PLoS One (2014) 0.76
Insertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome Maintenance. Front Genet (2016) 0.75
53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks. PLoS Genet (2016) 0.75
DNA repair mechanisms and human cytomegalovirus (HCMV) infection. Folia Microbiol (Praha) (2014) 0.75
DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. EMBO J (2003) 2.12
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J (2009) 2.06
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev (2011) 1.60
A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest (2005) 1.59
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood (2009) 1.42
Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res (2006) 1.38
End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. DNA Repair (Amst) (2004) 1.29
DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Res (2002) 1.23
Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow. Blood (2002) 1.23
Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches. Eur J Immunol (2007) 1.09
Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol (2005) 1.09
MicroRNAs, the DNA damage response and cancer. Mutat Res (2011) 1.03
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol (2008) 1.03
An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. J Clin Endocrinol Metab (2015) 0.99
Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle. Mutat Res (2006) 0.95
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest (2016) 0.94
MicroRNA responses and stress granule formation modulate the DNA damage response. Cell Cycle (2009) 0.93
DNA-PKcs deficiency in human: long predicted, finally found. Curr Opin Allergy Clin Immunol (2009) 0.91
A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination. J Exp Med (2013) 0.91
Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities. Hum Mutat (2013) 0.87
The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response. FASEB J (2010) 0.86
NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78
Spatiotemporal aspects of MicroRNA-mediated gene regulation. Adv Exp Med Biol (2011) 0.77
DNA double strand break repair: zooming in on the focus. Cell Cycle (2009) 0.76
A novel radiosensitive SCID patient with a pronounced G(2)/M sensitivity. DNA Repair (Amst) (2010) 0.75