Published in J Cell Biol on April 16, 2007
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A (2011) 2.47
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Ku recruits XLF to DNA double-strand breaks. EMBO Rep (2007) 2.00
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol (2010) 1.73
Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res (2009) 1.73
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res (2009) 1.66
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys (2013) 1.57
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks. Nat Struct Mol Biol (2012) 1.49
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. EMBO J (2012) 1.44
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst) (2012) 1.37
Live cell microscopy analysis of radiation-induced DNA double-strand break motion. Proc Natl Acad Sci U S A (2009) 1.35
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) (2008) 1.29
DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst) (2009) 1.27
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. PLoS One (2009) 1.23
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. J Biol Chem (2011) 1.23
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutat Res (2010) 1.20
HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. J Biol Chem (2008) 1.18
Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol Cell Biol (2008) 1.15
A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. Mol Cell (2013) 1.14
A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell (2012) 1.13
FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun (2012) 1.12
Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF. FEBS Lett (2011) 1.11
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair (Amst) (2012) 1.10
CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J Biol Chem (2012) 1.08
hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Res (2010) 1.08
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A (2011) 1.05
A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Res (2014) 1.05
Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond. Front Pharmacol (2013) 1.05
Non-homologous end joining: emerging themes and unanswered questions. DNA Repair (Amst) (2014) 1.05
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem (2011) 1.04
DNA damage response. Cold Spring Harb Perspect Biol (2011) 1.03
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol (2008) 1.03
Rescue of replication failure by Fanconi anaemia proteins. Chromosoma (2011) 1.02
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage. Nucleic Acids Res (2012) 1.01
Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins. Mol Cancer Res (2015) 1.01
PTIP associates with Artemis to dictate DNA repair pathway choice. Genes Dev (2014) 1.01
Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells. DNA Repair (Amst) (2010) 1.00
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res (2008) 0.98
The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation. J Biol Chem (2013) 0.97
Assembly of multiprotein complexes that control genome function. J Cell Biol (2009) 0.96
Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining. Mol Cell (2015) 0.96
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol (2014) 0.96
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK. Nucleic Acids Res (2013) 0.95
Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. PLoS One (2012) 0.95
Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci. Mutagenesis (2010) 0.94
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. Mol Cell Biol (2011) 0.93
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem (2013) 0.93
Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination. Nucleic Acids Res (2007) 0.93
Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks. Cell Cycle (2010) 0.91
Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells. Invest New Drugs (2011) 0.91
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front Genet (2013) 0.90
Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Biosci Rep (2014) 0.90
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) (2009) 0.90
RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. J Biol Chem (2011) 0.90
Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination. PLoS One (2010) 0.89
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol (2013) 0.88
The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability. PLoS Genet (2014) 0.88
Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks. PLoS One (2014) 0.87
Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - when is a DSB not a DSB? Mutat Res (2013) 0.87
Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair (Amst) (2013) 0.86
Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Res (2011) 0.85
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase. BMC Mol Biol (2007) 0.85
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res (2012) 0.84
Enhanced genotoxicity of silver nanoparticles in DNA repair deficient Mammalian cells. Front Genet (2012) 0.84
The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation. Brain Res (2009) 0.83
DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle. Int J Radiat Biol (2010) 0.83
Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Res (2013) 0.83
The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition. Mol Cancer Ther (2015) 0.83
SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products. PLoS Pathog (2014) 0.82
Radiation microbeams as spatial and temporal probes of subcellular and tissue response. Mutat Res (2010) 0.81
Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase. Nucleic Acids Res (2015) 0.81
Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem (2014) 0.80
Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo. Radiat Oncol (2010) 0.80
An ultrasoft X-ray multi-microbeam irradiation system for studies of DNA damage responses by fixed- and live-cell fluorescence microscopy. Eur Biophys J (2009) 0.80
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res (2015) 0.80
SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Biochem Biophys Res Commun (2008) 0.80
MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster. PLoS One (2011) 0.79
Modeling damage complexity-dependent non-homologous end-joining repair pathway. PLoS One (2014) 0.79
Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. Cell Death Dis (2013) 0.79
Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer. PLoS Genet (2016) 0.79
Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway. Oncotarget (2016) 0.78
Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining. J Nucleic Acids (2010) 0.78
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Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet (2001) 6.77
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Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
Repair of DNA double strand breaks by non-homologous end joining. Biochimie (2003) 2.65
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64
In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci U S A (2004) 2.59
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
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ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol (2006) 1.73
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res (2000) 1.65
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
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The endless tale of non-homologous end-joining. Cell Res (2008) 3.03
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem (2005) 3.02
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Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64
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The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst) (2004) 2.18
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) (2004) 2.13
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. EMBO J (2003) 2.12
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell (2003) 2.09
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J (2009) 2.06
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol (2010) 2.03
Ku recruits XLF to DNA double-strand breaks. EMBO Rep (2007) 2.00
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem (2004) 1.96
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc Natl Acad Sci U S A (2002) 1.92
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell (2011) 1.91
Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. PLoS Biol (2006) 1.89
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal (2010) 1.86
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79
A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair. Mol Cell (2010) 1.79
Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure (2004) 1.78
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst) (2006) 1.75
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol (2006) 1.73
Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res (2009) 1.73
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res (2011) 1.72
Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Cancer Res (2007) 1.68
Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc Natl Acad Sci U S A (2011) 1.64
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle (2011) 1.63
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
Aprataxin, a novel protein that protects against genotoxic stress. Hum Mol Genet (2004) 1.60
DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A (2004) 1.60
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. J Biol Chem (2002) 1.60
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev (2011) 1.60
A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest (2005) 1.59
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A (2011) 1.58
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol (2006) 1.55
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res (2005) 1.48
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle (2010) 1.48
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood (2009) 1.42
Room-temperature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays. Anal Chem (2003) 1.40
Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) (2002) 1.40
Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res (2006) 1.38
Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res (2008) 1.37
Retracted DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell (2009) 1.37
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol (2008) 1.36
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res (2009) 1.34
Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J (2002) 1.33
Phosphoproteome profiling of human skin fibroblast cells in response to low- and high-dose irradiation. J Proteome Res (2006) 1.33
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem (2004) 1.32
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet (2009) 1.32
Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer (2003) 1.31
End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. DNA Repair (Amst) (2004) 1.29
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) (2008) 1.29
Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells. J Biol Chem (2004) 1.27
DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst) (2009) 1.27
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res (2010) 1.26
Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinoma cell lines exposed to carbon ions and x-rays. Int J Radiat Oncol Biol Phys (2009) 1.26
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) (2005) 1.25
Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci (2002) 1.24
DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Res (2002) 1.23
Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow. Blood (2002) 1.23
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J (2002) 1.21