Published in Nucleic Acids Res on February 18, 2006
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res (2008) 0.98
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
Phosphorylation: the molecular switch of double-strand break repair. Int J Proteomics (2011) 0.87
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Res (2011) 0.84
Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates. J Mol Recognit (2009) 0.83
Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex. Nucleic Acids Res (2016) 0.77
Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? Genome Integr (2012) 0.76
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell (1992) 4.41
Mechanism of interaction between Ku protein and DNA. J Biol Chem (1986) 4.22
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83
Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex. Cell (2002) 3.21
A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell (2004) 3.01
The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J Biol Chem (1996) 2.92
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol (1999) 2.86
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol (2003) 2.74
Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J (2002) 2.62
The life and death of DNA-PK. Oncogene (2005) 2.62
DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats. Genes Dev (1992) 2.56
DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. EMBO J (1999) 2.38
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol (2005) 2.37
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc Natl Acad Sci U S A (1998) 2.30
The DNA-dependent protein kinase: the director at the end. Immunol Rev (2004) 2.20
The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst) (2004) 2.18
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) (2004) 2.13
Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J Biol Chem (1993) 2.08
Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. Nucleic Acids Res (1999) 1.96
The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J Biol Chem (1998) 1.87
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis. J Biol Chem (2005) 1.84
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res (2004) 1.77
Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J Biol Chem (2004) 1.76
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature (1998) 1.68
Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end. J Biol Chem (1999) 1.65
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Structure (2005) 1.62
Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol Cell Biol (1998) 1.51
Interactive competition between homologous recombination and non-homologous end joining. Mol Cancer Res (2003) 1.49
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment. J Mol Biol (2003) 1.48
Activation of DNA-dependent protein kinase by single-stranded DNA ends. J Biol Chem (2000) 1.40
Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) (2002) 1.40
On the mechanisms of Ku protein binding to DNA. Biochem Biophys Res Commun (1992) 1.39
Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J (2005) 1.38
Production and characterization of recombinant human Ku antigen. Nucleic Acids Res (1994) 1.32
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc Natl Acad Sci U S A (2000) 1.27
The RAG proteins in V(D)J recombination: more than just a nuclease. Nucleic Acids Res (2001) 1.24
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proc Natl Acad Sci U S A (2005) 1.23
Differential activation of DNA-PK based on DNA strand orientation and sequence bias. Nucleic Acids Res (2005) 1.12
New insights into the mechanism of homologous recombination in yeast. Mutat Res (2004) 1.11
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J Biol Chem (2004) 1.10
Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. DNA Repair (Amst) (2004) 1.08
DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends. J Biol Chem (2001) 1.02
Differential etoposide sensitivity of cells deficient in the Ku and DNA-PKcs components of the DNA-dependent protein kinase. Carcinogenesis (1998) 0.94
Electron microscopy studies on DNA recognition by DNA-PK. Micron (2004) 0.89
A method to detect particle-specific antibodies against Ku and the DNA-dependent protein kinase catalytic subunit in autoimmune sera. J Immunol Methods (2001) 0.86
Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins. Proc Natl Acad Sci U S A (2001) 0.86
Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination. Mol Cell Biol (1998) 0.85
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res (2004) 2.33
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res (2002) 1.52
Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. J Biol Chem (2004) 1.46
Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance. Nucleic Acids Res (2009) 1.27
Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites. Mol Cell Biol (2002) 1.23
DNA damage response and Ku80 function in the vertebrate embryo. Nucleic Acids Res (2005) 1.11
Human papillomavirus-active head and neck cancer and ethnic health disparities. Laryngoscope (2010) 1.10
Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. DNA Repair (Amst) (2004) 1.08
Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer. Neoplasia (2009) 1.02
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation. J Biol Chem (2003) 1.01
Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells. DNA Repair (Amst) (2010) 1.00
Saturation labeling with cysteine-reactive cyanine fluorescent dyes provides increased sensitivity for protein expression profiling of laser-microdissected clinical specimens. Proteomics (2005) 0.97
Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase. Nucleic Acids Res (2003) 0.95
Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region. J Immunol (2002) 0.94
Quantifiable biomarkers of normal aging in the Japanese medaka fish (Oryzias latipes). PLoS One (2010) 0.91
Characterization of Molecular Markers Indicative of Cervical Cancer Progression. Proteomics Clin Appl (2009) 0.91
Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications. Nanomedicine (2009) 0.89
Quantification of ionizing radiation-induced cell death in situ in a vertebrate embryo. Radiat Res (2007) 0.89
Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis. Neurosci Lett (2007) 0.88
Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic Acids Res (2013) 0.86
Use of combination proteomic analysis to demonstrate molecular similarity of head and neck squamous cell carcinoma arising from different subsites. Arch Otolaryngol Head Neck Surg (2009) 0.83
E. coli expression of a soluble, active single-chain antibody variable fragment containing a nuclear localization signal. Protein Expr Purif (2009) 0.83
The current state of proteomics in GI oncology. Dig Dis Sci (2008) 0.81
Biological effects of high-energy neutrons measured in vivo using a vertebrate model. Radiat Res (2009) 0.81
Effects of low-dose ionizing radiation and menadione, an inducer of oxidative stress, alone and in combination in a vertebrate embryo model. Radiat Res (2012) 0.79
Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit. Int J Radiat Oncol Biol Phys (2011) 0.78
2D-DIGE proteomic characterization of head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg (2009) 0.78
Significance of HSPB1 expression in head and neck squamous cell carcinoma: a meta-analysis of published literatures. Laryngoscope (2010) 0.77
Long-term effects of ionizing radiation on gene expression in a zebrafish model. PLoS One (2013) 0.76
Use of a microscope stage-mounted Nickel-63 microirradiator for real-time observation of the DNA double-strand break response. Nucleic Acids Res (2010) 0.75
Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res (2013) 0.75
Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiat Res (2014) 0.75
Multi-spectral imaging analysis of HSPB1 expression in head and neck squamous cell carcinoma. Laryngoscope (2010) 0.75