Published in EMBO J on September 23, 2004
Amyloid precursor protein trafficking, processing, and function. J Biol Chem (2008) 4.79
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One (2010) 2.78
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron (2007) 2.55
Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci (2011) 2.47
Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol (2007) 2.09
APP processing in Alzheimer's disease. Mol Brain (2011) 2.02
Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J (2005) 1.98
The amyloid precursor protein: beyond amyloid. Mol Neurodegener (2006) 1.98
The Alzheimer's disease beta-secretase enzyme, BACE1. Mol Neurodegener (2007) 1.81
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci (2009) 1.68
The amyloid-beta precursor protein: integrating structure with biological function. EMBO J (2005) 1.68
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol (2005) 1.59
Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J (2005) 1.56
Neurogenesis and Alzheimer's disease: at the crossroads. Exp Neurol (2009) 1.54
The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biol (2013) 1.54
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J (2006) 1.51
Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50
APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. Proc Natl Acad Sci U S A (2007) 1.49
Physiological functions of APP family proteins. Cold Spring Harb Perspect Med (2012) 1.44
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A (2010) 1.38
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem (2014) 1.37
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J (2011) 1.31
A framework for modeling the growth and development of neurons and networks. Front Comput Neurosci (2009) 1.27
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem (2009) 1.25
Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Mol Neurodegener (2006) 1.23
A genetic interaction between the APP and Dab1 genes influences brain development. Mol Cell Neurosci (2007) 1.08
Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res (2011) 1.05
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem (2010) 1.03
Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. PLoS One (2011) 1.03
Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells. J Neuroinflammation (2012) 1.03
APP physiological and pathophysiological functions: insights from animal models. Cell Res (2011) 1.03
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem (2011) 1.01
The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease. Cell Adh Migr (2011) 1.00
Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. J Biol Chem (2010) 0.99
The upside of APP at synapses. CNS Neurosci Ther (2010) 0.98
Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Struct Funct (2009) 0.97
A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching. Mol Cell Neurosci (2007) 0.95
Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression. Acta Neuropathol Commun (2014) 0.95
Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol (2006) 0.94
Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease. Front Aging Neurosci (2013) 0.94
Concise review: Can stem cells be used to treat or model Alzheimer's disease? Stem Cells (2012) 0.93
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging. Exp Brain Res (2011) 0.93
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci (2010) 0.93
The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Exp Brain Res (2011) 0.92
Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices. Mol Cell Biol (2007) 0.91
Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration. Int J Clin Exp Med (2010) 0.91
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase. PLoS One (2011) 0.91
Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. J Biol Chem (2009) 0.90
All in the Family: How the APPs Regulate Neurogenesis. Front Neurosci (2012) 0.90
The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein Go alpha in an identified population of migratory neurons. Dev Biol (2005) 0.90
The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease. Curr Genomics (2007) 0.90
The E2 domains of APP and APLP1 share a conserved mode of dimerization. Biochemistry (2011) 0.89
beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS J (2010) 0.89
Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks. Proc Natl Acad Sci U S A (2009) 0.88
FoxO mediates APP-induced AICD-dependent cell death. Cell Death Dis (2014) 0.88
Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration. J Neurosci (2013) 0.87
APP knockout mice experience acute mortality as the result of ischemia. PLoS One (2012) 0.87
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis (2014) 0.87
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases. Front Genet (2014) 0.86
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Mol Neurodegener (2009) 0.86
Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI. Neuroimage (2012) 0.85
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin. Exp Brain Res (2011) 0.84
An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry (2009) 0.84
The role of lipoprotein receptors on the physiological function of APP. Exp Brain Res (2011) 0.84
How to innervate a simple gut: familiar themes and unique aspects in the formation of the insect enteric nervous system. Dev Dyn (2007) 0.84
Turnover of amyloid precursor protein family members determines their nuclear signaling capability. PLoS One (2013) 0.84
Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget (2015) 0.84
Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proc Natl Acad Sci U S A (2011) 0.84
Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex. BMC Genomics (2011) 0.83
Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance. PLoS One (2013) 0.83
APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression. Front Aging Neurosci (2015) 0.83
Caenorhabditis elegans as a model organism to study APP function. Exp Brain Res (2011) 0.82
APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development. Genetics (2012) 0.81
Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1. Neurobiol Aging (2008) 0.81
Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate. J Biol Chem (2011) 0.81
The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease. Mol Cell Proteomics (2012) 0.81
Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores. Yale J Biol Med (2016) 0.81
APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans. PLoS Genet (2015) 0.81
Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth. PLoS One (2012) 0.81
Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol Cell Neurosci (2012) 0.81
The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimer's disease? Int J Alzheimers Dis (2012) 0.81
Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Struct Funct (2011) 0.81
APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses. Elife (2015) 0.80
Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS One (2013) 0.80
Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci (2014) 0.80
Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO J (2016) 0.80
The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease. Biomed Res Int (2014) 0.79
Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration. J Neurosci (2016) 0.78
Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Dev Biol (2017) 0.77
The physiological functions of the β-amyloid precursor protein APP. Exp Brain Res (2012) 0.77
Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila. PLoS One (2015) 0.77
Impaired structural correlates of memory in Alzheimer's disease mice. Neuroimage Clin (2013) 0.77
The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides. PLoS One (2011) 0.77
Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. J Biol Chem (2014) 0.77
FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. FASEB J (2015) 0.77
Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging. Front Neurol (2016) 0.77
The Role of APP in Structural Spine Plasticity. Front Mol Neurosci (2017) 0.76
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell (1999) 5.52
Silver Impregnation of Reticulum in Paraffin Sections. Am J Pathol (1937) 5.47
Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron (2001) 4.62
Reelin and brain development. Nat Rev Neurosci (2003) 3.97
Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci (2000) 3.38
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell (1995) 3.33
Role of the reelin signaling pathway in central nervous system development. Annu Rev Neurosci (2001) 3.25
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature (2001) 2.84
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem (1998) 2.71
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54
Neuronal migration disorders: from genetic diseases to developmental mechanisms. Trends Neurosci (2000) 2.45
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31
MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sci U S A (1995) 2.01
Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol (1998) 1.95
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J Biol Chem (2001) 1.83
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem (2003) 1.82
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging (1998) 1.81
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). J Biol Chem (1994) 1.74
The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J Cell Biol (2001) 1.67
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell (1994) 1.64
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. J Biol Chem (2004) 1.63
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem (1996) 1.48
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci (1997) 1.46
Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci (1999) 1.45
Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron (2002) 1.43
Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. J Biol Chem (2002) 1.37
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1996) 1.32
Defective glycosylation in congenital muscular dystrophies. Curr Opin Neurol (2004) 1.32
Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. J Neurosci (1997) 1.30
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry (2003) 1.22
beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. Proc Natl Acad Sci U S A (1993) 1.19
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein. Proc Natl Acad Sci U S A (1999) 1.19
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. Cell Death Differ (1998) 1.19
The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic (2002) 1.14
Defective glycosylation in muscular dystrophy. Lancet (2002) 1.10
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Curr Biol (1999) 1.04
Functions of brain chondroitin sulfate proteoglycans during developments: interactions with adhesion molecules. Perspect Dev Neurobiol (1996) 1.04
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. J Neurosci (1999) 1.00
Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behav Brain Res (1998) 1.00
Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development (2003) 0.99
Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. J Neurosci (1998) 0.95
Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components. Brain Res (1996) 0.94
Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice. Exp Neurol (1997) 0.92
Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping. J Neurochem (1997) 0.92
Some morphometric methods for the central nervous system. J Neurol Sci (1975) 0.89
Neuronal migration defects in the Dreher (Lmx1a) mutant mouse: role of disorders of the glial limiting membrane. Cereb Cortex (2001) 0.87
APP processing and synaptic function. Neuron (2003) 8.37
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol (2006) 8.15
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron (2006) 6.76
Real-time imaging reveals the single steps of brain metastasis formation. Nat Med (2009) 3.95
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron (2005) 3.83
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science (2004) 3.38
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature (2005) 3.35
Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci (2007) 3.16
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol (2005) 2.91
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci (2010) 2.79
Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med (2012) 2.56
Constitutional aneuploidy in the normal human brain. J Neurosci (2005) 2.28
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathol (2013) 2.27
Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci (2009) 2.18
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell (2006) 2.16
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development (2004) 2.00
Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J (2005) 1.98
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron (2006) 1.91
Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro. Int J Cancer (2007) 1.85
Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathol (2008) 1.85
Influence of gender of physicians and patients on guideline-recommended treatment of chronic heart failure in a cross-sectional study. Eur J Heart Fail (2009) 1.78
Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet (2002) 1.75
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72
Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation. Am J Hum Genet (2011) 1.70
Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis. Glia (2009) 1.69
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron. Biochem Biophys Res Commun (2009) 1.63
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways. Genome Biol Evol (2010) 1.57
Dendritic pathology in prion disease starts at the synaptic spine. J Neurosci (2007) 1.57
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers. J Biol Chem (2008) 1.56
Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol (2006) 1.56
Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas. J Invest Dermatol (2011) 1.52
Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium. Acta Neuropathol (2008) 1.51
Immunosuppressive therapy in Whipple's disease patients is associated with the appearance of gastrointestinal manifestations. Am J Gastroenterol (2005) 1.45
Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation. Eur J Immunol (2007) 1.45
Metabolic engineering for microbial production of shikimic acid. Metab Eng (2003) 1.40
Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study. J Neuropathol Exp Neurol (2007) 1.38
Effects of antemortem and postmortem variables on human brain mRNA quality: a BrainNet Europe study. J Neuropathol Exp Neurol (2010) 1.36
Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: a BrainNet Europe study. Brain Pathol (2007) 1.36
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. J Neurosci (2009) 1.35
Characterization of the glycinergic input to bipolar cells of the mouse retina. Eur J Neurosci (2006) 1.34
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Genetic Creutzfeldt-Jakob disease and fatal familial insomnia: insights into phenotypic variability and disease pathogenesis. Acta Neuropathol (2010) 1.32
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification. Acta Neuropathol (2009) 1.32
Autocatalytic self-propagation of misfolded prion protein. Proc Natl Acad Sci U S A (2004) 1.30
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. J Clin Invest (2005) 1.30
Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future. Acta Neuropathol (2010) 1.29
Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathol (2009) 1.27
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol (2006) 1.24
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. J Biol Chem (2004) 1.23
Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice. J Clin Invest (2010) 1.21
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. Eur J Neurosci (2008) 1.20
Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J Biol Chem (2002) 1.20
Identification of cyclin D1 mRNA overexpression in B-cell neoplasias by real-time reverse transcription-PCR of microdissected paraffin sections. Clin Cancer Res (2002) 1.19
Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice. J Clin Invest (2006) 1.19
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One (2010) 1.17
Mixed brain pathologies in dementia: the BrainNet Europe consortium experience. Dement Geriatr Cogn Disord (2008) 1.17
Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol (2009) 1.17
Tolerogenic dendritic cells and regulatory T cells: a two-way relationship. J Dermatol Sci (2007) 1.14
Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium. Acta Neuropathol (2008) 1.13
APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci (2009) 1.13
IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival. Cancer (2011) 1.12
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. Hum Mol Genet (2011) 1.12
The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins. Neurodegener Dis (2006) 1.11
Convergence of two independent mental disease genes on the protein level: recruitment of dysbindin to cell-invasive disrupted-in-schizophrenia 1 aggresomes. Biol Psychiatry (2011) 1.11
Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol (2008) 1.08
Methods for studying synaptosomal copper release. J Neurosci Methods (2003) 1.08
Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. PLoS One (2012) 1.07
Dysregulated peripheral and mucosal Th1/Th2 response in Whipple's disease. Gastroenterology (2002) 1.07
Polygalacturonase is a pathogenicity factor in the Claviceps purpurea/rye interaction. Fungal Genet Biol (2002) 1.06
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci (2008) 1.05
In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta Neuropathol (2010) 1.05
Amyloid plaque formation precedes dendritic spine loss. Acta Neuropathol (2012) 1.04
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp Brain Res (2011) 1.03
HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy. Proteomics (2006) 1.02
Lack of Pur-alpha alters postnatal brain development and causes megalencephaly. Hum Mol Genet (2011) 1.02
MiRNA expression patterns predict survival in glioblastoma. Radiat Oncol (2011) 1.01
Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit. J Comp Neurol (2003) 1.01
Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease. Neurobiol Aging (2006) 1.00
Clinical features of rapidly progressive Alzheimer's disease. Dement Geriatr Cogn Disord (2010) 1.00
Skin melanoma development in ret transgenic mice despite the depletion of CD25+Foxp3+ regulatory T cells in lymphoid organs. J Immunol (2009) 1.00
Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. J Neurochem (2006) 0.99
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. J Proteome Res (2012) 0.98
beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res (2007) 0.98
Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. J Biol Chem (2011) 0.98
Brain banking for neurological disorders. Lancet Neurol (2013) 0.97
Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab (2015) 0.96
Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Exp Neurol (2008) 0.96
Diversity of glycine receptors in the mouse retina: localization of the alpha2 subunit. J Comp Neurol (2004) 0.96
Impact of vCJD on blood supply. Biologicals (2007) 0.95