Published in Mol Cell on February 01, 2002
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Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells. Mol Cell Biol (2003) 1.19
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Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A (2003) 1.13
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Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. J Biol Chem (2008) 1.01
Oxygen free radicals and redox biology of organelles. Histochem Cell Biol (2004) 1.00
Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochim Biophys Acta (2014) 1.00
Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry (2013) 0.95
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Transglutaminase 2 inhibits apoptosis induced by calcium- overload through down-regulation of Bax. Exp Mol Med (2010) 0.94
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Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress. Mol Cell Biol (2005) 0.91
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Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases. Gastroenterology (2006) 0.88
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Regulation of caspase-9 activity by differential binding to the apoptosome complex. Front Biosci (2007) 0.86
Insights into novel cellular injury mechanisms by gene expression profiling in nephropathic cystinosis. J Inherit Metab Dis (2010) 0.85
The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage. Cell Death Differ (2010) 0.85
Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis. Nat Protoc (2010) 0.85
A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell (2012) 0.85
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The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am J Pathol (2012) 0.84
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R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell (2005) 6.86
TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell (2005) 6.47
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev (2003) 6.17
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Cytochrome C-mediated apoptosis. Annu Rev Biochem (2004) 5.38
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
WormBase: a comprehensive resource for nematode research. Nucleic Acids Res (2009) 5.20
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell (2007) 5.09
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A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (2004) 4.95
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37
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Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2004) 4.20
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Drosophila Spire is an actin nucleation factor. Nature (2005) 3.64
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A (2004) 3.63
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med (2007) 3.58
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol (2009) 3.55
Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol (2002) 3.34
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol (2007) 3.23
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell (2010) 2.97
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov (2014) 2.79
Indirect emissions from biofuels: how important? Science (2009) 2.71
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro (2005) 2.60
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat Chem Biol (2007) 2.57
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Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem (2003) 2.29
Coordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont. J Biol Chem (2009) 2.21
The role of oxygen during fracture healing. Bone (2012) 2.21
Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic (2006) 2.20
Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc Natl Acad Sci U S A (2005) 2.18
Structure of the mammalian 80S ribosome at 8.7 A resolution. Structure (2008) 2.11
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell (2011) 2.09
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A (2011) 2.06
TorsinA in the nuclear envelope. Proc Natl Acad Sci U S A (2004) 2.06
Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. Blood (2008) 2.04
Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. J Cell Biol (2002) 2.03
Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97
The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus. Structure (2004) 1.96
Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. Dev Cell (2006) 1.95
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol (2003) 1.92
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (2008) 1.90
Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci U S A (2008) 1.81
Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1. Curr Biol (2003) 1.78
Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth. J Clin Invest (2009) 1.78
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol (2008) 1.77
HIV/STD prevalence among men who have sex with men in Chengdu, China and associated risk factors for HIV infection. J Acquir Immune Defic Syndr (2010) 1.76
A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol Biol Cell (2006) 1.75
RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol Biol Cell (2004) 1.74
Cytokines in alcoholic liver disease. Arch Toxicol (2012) 1.74
The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy (2013) 1.71
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
Silica encapsulation of n-octadecane via sol-gel process: a novel microencapsulated phase-change material with enhanced thermal conductivity and performance. J Colloid Interface Sci (2009) 1.67
Visualization of the herpes simplex virus portal in situ by cryo-electron tomography. Virology (2006) 1.63
Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol (2002) 1.61
Autophagy is involved in influenza A virus replication. Autophagy (2009) 1.60
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
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A Bayesian connectivity-based approach to constructing probabilistic gene regulatory networks. Bioinformatics (2004) 1.57
Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system. Nat Cell Biol (2010) 1.55
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (2005) 1.53
Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development (2006) 1.50
Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res (2009) 1.48
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med (2010) 1.47
A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments. Nucleic Acids Res (2008) 1.46
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Mol Cell (2006) 1.46
PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell (2008) 1.44
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. J Mol Biol (2005) 1.43
Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol (2002) 1.43
Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression. Proc Natl Acad Sci U S A (2010) 1.42
Structure of an apoptosome-procaspase-9 CARD complex. Structure (2010) 1.42
Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A (2012) 1.41
Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases. Mol Biol Cell (2003) 1.41
Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. Hepatology (2012) 1.40
The difference in superior adjacent segment pathology after lumbar posterolateral fusion by using 2 different pedicle screw insertion techniques in 9-year minimum follow-up. Spine (Phila Pa 1976) (2014) 1.40
The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J Bacteriol (2004) 1.39
Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. J Biol Chem (2004) 1.34
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest (2013) 1.34
Apoptosome structure, assembly, and procaspase activation. Structure (2013) 1.33