Published in Biophys J on October 01, 2004
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A (2006) 2.81
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances. Arch Toxicol (2011) 1.82
Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain. Proc Natl Acad Sci U S A (2007) 1.24
Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophys J (2005) 1.13
S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels. Proc Natl Acad Sci U S A (2005) 1.13
Down-state model of the voltage-sensing domain of a potassium channel. Biophys J (2010) 1.06
Models of voltage-dependent conformational changes in NaChBac channels. Biophys J (2008) 1.05
Membrane mechanics as a probe of ion-channel gating mechanisms. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.00
Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling. Biophys J (2007) 0.99
Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel. Biophys J (2008) 0.98
Properties of shaker-type potassium channels in higher plants. J Membr Biol (2006) 0.93
Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. J Gen Physiol (2005) 0.88
Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels. Proteins (2010) 0.87
Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function. J Biol Chem (2011) 0.84
Structural models of TREK channels and their gating mechanism. Channels (Austin) (2011) 0.82
Kinetics and thermodynamics of membrane protein folding. Biomolecules (2014) 0.78
Normal mode dynamics of voltage-gated K(+) channels: gating principle, opening mechanism, and inhibition. J Comput Neurosci (2014) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86
Position-based sequence weights. J Mol Biol (1994) 24.41
X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature (2001) 13.76
Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes. J Mol Biol (1987) 10.85
Crystal structure and mechanism of a calcium-gated potassium channel. Nature (2002) 10.03
Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature. Biophys J (1997) 9.60
Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron (1996) 8.11
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science (1998) 7.51
Crystal structure of the potassium channel KirBac1.1 in the closed state. Science (2003) 7.46
The principle of gating charge movement in a voltage-dependent K+ channel. Nature (2003) 6.94
Molecular basis of charge movement in voltage-gated sodium channels. Neuron (1996) 6.61
Transmembrane movement of the shaker K+ channel S4. Neuron (1996) 6.61
The size of gating charge in wild-type and mutant Shaker potassium channels. Science (1992) 6.42
A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature (2004) 5.66
Molecular model of the action potential sodium channel. Proc Natl Acad Sci U S A (1986) 4.61
Characterizing voltage-dependent conformational changes in the Shaker K+ channel with fluorescence. Neuron (1997) 4.08
PHAT: a transmembrane-specific substitution matrix. Predicted hydrophobic and transmembrane. Bioinformatics (2000) 3.66
The gating mechanism of the large mechanosensitive channel MscL. Nature (2001) 3.43
Ion conduction pore is conserved among potassium channels. Nature (2001) 3.01
Hydrophobic interactions of peptides with membrane interfaces. Biochim Biophys Acta (1998) 2.79
Hydrophobic organization of membrane proteins. Science (1989) 2.74
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J Mol Biol (1997) 2.66
Structural models of the MscL gating mechanism. Biophys J (2001) 2.58
Helix packing in membrane proteins. J Mol Biol (1997) 2.47
alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 2.46
Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J Gen Physiol (2001) 2.43
Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature (2003) 2.42
Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron (2003) 2.41
Identification of a translocated protein segment in a voltage-dependent channel. Nature (1994) 2.36
Voltage-dependent structural interactions in the Shaker K(+) channel. J Gen Physiol (2000) 2.31
Effective energy function for proteins in lipid membranes. Proteins (2003) 2.27
Helical structure and packing orientation of the S2 segment in the Shaker K+ channel. J Gen Physiol (1999) 2.10
A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel. Neuron (2000) 2.05
The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron (2003) 1.96
Comparison of helix interactions in membrane and soluble alpha-bundle proteins. Biophys J (2002) 1.88
The lipid-protein interface of a Shaker K(+) channel. J Gen Physiol (2000) 1.85
S4 charges move close to residues in the pore domain during activation in a K channel. J Gen Physiol (2001) 1.65
Structural models of the KtrB, TrkH, and Trk1,2 symporters based on the structure of the KcsA K(+) channel. Biophys J (1999) 1.64
Voltage sensor movements. J Gen Physiol (2002) 1.59
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
Glycosylation of shaker potassium channel protein in insect cell culture and in Xenopus oocytes. Biochemistry (1994) 1.51
Structural models of the transmembrane region of voltage-gated and other K+ channels in open, closed, and inactivated conformations. J Struct Biol (1998) 1.47
Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes. Eur J Pharmacol (1992) 1.42
Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel. Biophys J (2000) 1.42
Answers and questions from the KvAP structures. Neuron (2003) 1.30
Modeling the ion channel structure of cecropin. Biophys J (1992) 1.22
A peptide segment critical for sodium channel inactivation functions as an inactivation gate in a potassium channel. Neuron (1993) 1.22
Family ties of gated pores: evolution of the sensor module. FASEB J (2002) 1.20
Localization of the extracellular end of the voltage sensor S4 in a potassium channel. Biophys J (2001) 1.20
A family of putative Kir potassium channels in prokaryotes. BMC Evol Biol (2001) 1.03
Using sequence homology to analyze the structure and function of voltage-gated ion channel proteins. Soc Gen Physiol Ser (1994) 0.94
Models of delta-hemolysin membrane channels and crystal structures. Proteins (1990) 0.94
Neuroscience. The puzzling portrait of a pore. Science (2003) 0.92
KcsA closed and open: modelling and simulation studies. Eur Biophys J (2003) 0.92
A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0. FEBS Lett (2003) 0.82
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension. Nat Struct Biol (2002) 2.70
Membrane fusion. Chem Rev (2003) 1.69
Relating molecular flexibility to function: a case study of tubulin. Biophys J (2002) 1.62
On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL. J Gen Physiol (2003) 1.42
A common architecture for K+ channels and ionotropic glutamate receptors? Trends Neurosci (2003) 1.41
Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions. J Am Chem Soc (2006) 1.31
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure (2009) 1.28
Models of the structure and voltage-gating mechanism of the shaker K+ channel. Biophys J (2004) 1.24
Substrate specificity of the human protein phosphatase 2Cdelta, Wip1. Biochemistry (2005) 1.23
Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds. Nat Commun (2012) 1.06
Structural and functional insights into the HIV-1 maturation inhibitor binding pocket. PLoS Pathog (2012) 1.06
p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis (2012) 1.06
Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1. Biochemistry (2006) 1.06
Models of voltage-dependent conformational changes in NaChBac channels. Biophys J (2008) 1.05
The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases. Biochemistry (2007) 1.04
Specificity of acyl transfer from 2-mercaptobenzamide thioesters to the HIV-1 nucleocapsid protein. J Am Chem Soc (2007) 1.03
Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution. Org Lett (2007) 1.00
Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling. Biophys J (2007) 0.99
Structural model of the Ca V 1.2 pore. Channels (Austin) (2008) 0.98
Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer. Biochemistry (2006) 0.98
Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel. Biophys J (2008) 0.98
Models of membrane-bound Alzheimer's Abeta peptide assemblies. Proteins (2010) 0.98
Role of positively charged amino acids in the M2D transmembrane helix of Ktr/Trk/HKT type cation transporters. Channels (Austin) (2007) 0.97
N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorg Med Chem (2009) 0.95
Stability tests on known and misfolded structures with discrete and all atom molecular dynamics simulations. J Mol Graph Model (2010) 0.95
Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry (2011) 0.89
Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils. Proteins (2010) 0.88
Pore stability and gating in voltage-activated calcium channels. Channels (Austin) (2008) 0.87
Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels. Proteins (2010) 0.87
Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2. Channels (Austin) (2008) 0.85
STAM: simple transmembrane alignment method. Bioinformatics (2004) 0.85
Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites. Biochemistry (2011) 0.83
Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters. J Am Chem Soc (2006) 0.83
Structural models of TREK channels and their gating mechanism. Channels (Austin) (2011) 0.82
A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases. BMC Struct Biol (2003) 0.81
The KtrA and KtrE subunits are required for Na+-dependent K+ uptake by KtrB across the plasma membrane in Synechocystis sp. strain PCC 6803. J Bacteriol (2010) 0.81
A small molecular scaffold for selective inhibition of Wip1 phosphatase. ChemMedChem (2008) 0.81
Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models. Channels (Austin) (2011) 0.80
Polyhistidine peptide inhibitor of the Abeta calcium channel potently blocks the Abeta-induced calcium response in cells. Theoretical modeling suggests a cooperative binding process. Biochemistry (2010) 0.80
Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects. J Am Chem Soc (2014) 0.79
Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity. Biochemistry (2013) 0.78
Structure-function studies of the outer mouth and voltage sensor domain of hERG. Novartis Found Symp (2005) 0.77
Analysis of the stabilities of hexameric amyloid-β(1-42) models using discrete molecular dynamics simulations. J Mol Graph Model (2010) 0.75
Transmembrane interactions of alpha/beta integrin signaling. Structure (2005) 0.75
Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange - Mass Spectrometry. Biochemistry (2017) 0.75
5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4. Integr Biol (Camb) (2016) 0.75