Published in Development on October 01, 2004
Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci (2006) 7.18
Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Trends Cardiovasc Med (2007) 1.56
Cardiovascular actions of neurotrophins. Physiol Rev (2009) 1.45
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J (2009) 1.41
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat Med (2013) 1.25
TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov (2014) 1.19
NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. PLoS One (2009) 1.01
The role of thioredoxin reductases in brain development. PLoS One (2008) 0.95
Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions. Proc Natl Acad Sci U S A (2008) 0.93
CD36 as a therapeutic target for endothelial dysfunction in stroke. Curr Pharm Des (2012) 0.90
Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons. Biol Trace Elem Res (2014) 0.83
Trkb signaling in pericytes is required for cardiac microvessel stabilization. PLoS One (2014) 0.82
Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs. Am J Physiol Lung Cell Mol Physiol (2010) 0.81
Thymocyte depletion affects neurotrophin receptor expression in thymic stromal cells. J Anat (2006) 0.80
The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo. Mol Cell Biol (2006) 0.79
Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis. PLoS One (2011) 0.78
Loss of Ikbkap Causes Slow, Progressive Retinal Degeneration in a Mouse Model of Familial Dysautonomia. eNeuro (2016) 0.78
Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun (2017) 0.75
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (2009) 4.16
Cdk2 knockout mice are viable. Curr Biol (2003) 3.92
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55
Bcl11a is essential for normal lymphoid development. Nat Immunol (2003) 3.48
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol (2005) 3.44
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem Cell Biol (2003) 3.17
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest (2005) 2.91
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest (2012) 2.66
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J (2004) 2.55
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
Neuronal release of proBDNF. Nat Neurosci (2009) 2.36
Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity (2005) 2.35
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol (2008) 2.29
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst (2008) 2.25
Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment. Eur J Neurosci (2006) 2.15
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet (2009) 2.14
End-joining, translocations and cancer. Nat Rev Cancer (2013) 2.13
Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle (2003) 2.06
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One (2008) 1.86
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med (2010) 1.85
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A (2010) 1.84
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res (2005) 1.83
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci (2012) 1.82
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature (2006) 1.82
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. J Immunol (2003) 1.77
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A (2002) 1.70
Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance. Prog Brain Res (2004) 1.66
In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron (2006) 1.64
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nat Cell Biol (2008) 1.63
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet (2002) 1.60
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol (2005) 1.56
The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity (2008) 1.55
BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development (2003) 1.55
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A (2012) 1.55
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53
Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A (2013) 1.48
Genetic background and the dilemma of translating mouse studies to humans. Immunity (2008) 1.47
Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol (2004) 1.46
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res (2003) 1.46
Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism. Plant J (2014) 1.44
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A (2004) 1.42
Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest (2014) 1.42
Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells. Proc Natl Acad Sci U S A (2011) 1.41
Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol Cell Biol (2003) 1.41
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J (2009) 1.41
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A (2011) 1.41
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet (2008) 1.37
Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency. Laryngoscope (2009) 1.35
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med (2007) 1.32
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A (2004) 1.31
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J Exp Med (2002) 1.30
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29
Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J Immunol (2009) 1.28
H2AX regulates meiotic telomere clustering. J Cell Biol (2003) 1.27
Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res (2009) 1.27
Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons. Proc Natl Acad Sci U S A (2006) 1.27
A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses. J Immunol (2010) 1.26
Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. J Neurosci Methods (2004) 1.25
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat Med (2013) 1.25
Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci (2002) 1.24
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol (2006) 1.24
ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci U S A (2007) 1.21
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nat Neurosci (2013) 1.18
Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. Oncogene (2003) 1.18
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development. Blood (2012) 1.17
Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis. J Allergy Clin Immunol (2011) 1.17
Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain. Hear Res (2005) 1.15
Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo. J Neurosci (2009) 1.13