Published in Cell on June 28, 2007
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci U S A (2009) 2.73
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
IgH chain class switch recombination: mechanism and regulation. J Immunol (2014) 2.27
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell (2012) 2.21
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med (2008) 2.10
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science (2010) 2.05
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity (2011) 1.77
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res (2009) 1.66
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med (2008) 1.47
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med (2008) 1.44
Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages. Microbiology (2011) 1.40
Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med (2009) 1.40
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature (2014) 1.37
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med (2010) 1.36
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med (2010) 1.33
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24
The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature (2011) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. Immunity (2012) 1.19
Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks. Clin Cancer Res (2010) 1.18
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res (2010) 1.17
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood (2013) 1.16
How does DNA break during chromosomal translocations? Nucleic Acids Res (2011) 1.14
RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med (2016) 1.12
The ATM signaling network in development and disease. Front Genet (2013) 1.09
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood (2009) 1.08
ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma. Cancer Cell (2011) 1.03
Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade. J Virol (2008) 1.01
ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks. PLoS Genet (2010) 0.99
Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle (2010) 0.98
Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A (2016) 0.96
Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination. J Biol Chem (2008) 0.95
Ataxia-telangiectasia: future prospects. Appl Clin Genet (2014) 0.94
It takes two: communication between homologous alleles preserves genomic stability during V(D)J recombination. Nucleus (2011) 0.94
Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci U S A (2014) 0.93
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. EMBO J (2012) 0.92
The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage. Nat Commun (2013) 0.92
Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers. Cell Rep (2013) 0.90
Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice. Oncotarget (2016) 0.90
RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'. Nucleic Acids Res (2014) 0.90
Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunol Res (2014) 0.86
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet (2010) 0.85
Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. Genetics (2012) 0.85
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nat Commun (2016) 0.83
ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. PLoS One (2010) 0.83
Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia. Cell Cycle (2014) 0.83
Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci (2009) 0.82
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. Nucleic Acids Res (2014) 0.81
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes. Nucleic Acids Res (2013) 0.81
53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation. Mol Cancer Res (2013) 0.81
AID-initiated DNA lesions are differentially processed in distinct B cell populations. J Immunol (2014) 0.81
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRβ and IgH allelic exclusion. J Immunol (2014) 0.80
Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia. BMC Pulm Med (2014) 0.79
ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol (2014) 0.79
Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions. Clin Cancer Res (2012) 0.79
Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice. Leukemia (2015) 0.78
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol (2016) 0.77
DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS Genet (2015) 0.77
Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. J Immunol (2016) 0.76
Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease. Immunology (2015) 0.76
Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1. Sci Rep (2017) 0.75
The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep (2017) 0.75
Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks. J Immunol (2017) 0.75
The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining. J Immunol (2015) 0.75
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency. Proc Natl Acad Sci U S A (2017) 0.75
The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends. J Immunol (2016) 0.75
The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes. Int J Mol Sci (2017) 0.75
Corrupting the DNA damage response: a critical role for Rad52 in tumor cell survival. Aging (Albany NY) (2017) 0.75
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
H2AX: the histone guardian of the genome. DNA Repair (Amst) (2004) 6.65
In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
Blimp1 is a critical determinant of the germ cell lineage in mice. Nature (2005) 5.49
Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol (2007) 5.31
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature (2005) 5.15
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol (2008) 4.86
The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med (2009) 4.79
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 3.58
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55
Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant. Clin Cancer Res (2002) 3.54
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol (2005) 3.44
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (2012) 3.41
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem Cell Biol (2003) 3.17
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02
Actin-dependent intranuclear repositioning of an active gene locus in vivo. J Cell Biol (2007) 2.93
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80
Chromatin dynamics and the preservation of genetic information. Nature (2007) 2.80
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
Silence of chromosomal amplifications in colon cancer. Cancer Res (2002) 2.58
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol (2007) 2.55
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells (2005) 2.52
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell (2011) 2.46
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev (2009) 2.44
Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann N Y Acad Sci (2003) 2.36
ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med (2004) 2.30
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature (2007) 2.30
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell (2012) 2.21
Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep (2013) 2.15
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet (2009) 2.14
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med (2008) 2.10
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol (2005) 2.07
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet (2010) 2.06
Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle (2003) 2.06
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science (2010) 2.05
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell (2007) 2.00