Published in Mol Cell Biol on November 01, 2005
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell (2010) 1.68
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res (2007) 1.48
Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div (2006) 1.47
The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem (2006) 1.45
53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell (2016) 1.44
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. J Exp Med (2007) 1.37
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
BLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination. J Cell Biol (2007) 1.21
Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res (2009) 1.08
Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol (2013) 1.05
p53 suppresses structural chromosome instability after mitotic arrest in human cells. Oncogene (2010) 1.05
The AID-induced DNA damage response in chromatin. Mol Cell (2013) 1.04
Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One (2012) 1.03
The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol (2013) 0.96
Functional overlaps between XLF and the ATM-dependent DNA double strand break response. DNA Repair (Amst) (2014) 0.94
53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma. Mol Cell (2013) 0.93
Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response. Mol Cell Proteomics (2009) 0.93
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet (2010) 0.85
Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. J Biol Chem (2009) 0.84
The role of ATM and 53BP1 as predictive markers in cervical cancer. Int J Cancer (2012) 0.83
Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach. Cancer Inform (2012) 0.82
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma. Cancer Res (2012) 0.82
53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway. Oncol Rep (2012) 0.82
Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci (2009) 0.82
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. Nucleic Acids Res (2014) 0.81
Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reprod Toxicol (2010) 0.80
AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta (2014) 0.79
53BP1 sensitizes breast cancer cells to 5-fluorouracil. PLoS One (2013) 0.79
Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer. Int J Clin Exp Pathol (2015) 0.78
Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene (2014) 0.77
53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway. J Cancer Res Clin Oncol (2016) 0.77
Plk1-mediated stabilization of 53BP1 through USP7 regulates centrosome positioning to maintain bipolarity. Oncogene (2016) 0.75
A New Mode of Mitotic Surveillance. Trends Cell Biol (2017) 0.75
Haploinsufficient tumor suppressor genes. Adv Med Biol (2017) 0.75
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
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Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
Dissecting p53 tumor suppressor functions in vivo. Cancer Cell (2002) 6.24
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell (2003) 4.94
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol (2003) 4.36
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem (2003) 3.34
Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A (1994) 3.30
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol Cell Biol (2001) 3.22
Multicolour spectral karyotyping of mouse chromosomes. Nat Genet (1996) 2.90
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev (2002) 2.26
Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J Biol Chem (1998) 2.07
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem (2003) 2.03
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J (2002) 1.92
S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion. Mol Biol Cell (2004) 1.88
Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1. J Biol Chem (2000) 1.72
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J Cell Sci (2002) 1.61
The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding. Structure (2004) 1.51
No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Mol Cell Biol (1998) 1.45
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev (1999) 1.35
Loss of p53 and centrosome hyperamplification. Oncogene (2002) 1.32
Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol (2004) 1.10
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science (2007) 5.88
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol (2008) 4.82
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol (2004) 4.78
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol (2003) 4.36
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79
Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol (2010) 3.75
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55
Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant. Clin Cancer Res (2002) 3.54
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev (2006) 3.44
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (2006) 3.41
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem (2003) 3.34
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell (2010) 3.33
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem Cell Biol (2003) 3.17
PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol (2009) 3.15
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature (2003) 3.00
PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A (2009) 2.98
Actin-dependent intranuclear repositioning of an active gene locus in vivo. J Cell Biol (2007) 2.93
TET2 promotes histone O-GlcNAcylation during gene transcription. Nature (2012) 2.92
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science (2010) 2.80
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem (2004) 2.72
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol (2009) 2.67
19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J (2007) 2.63
Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res (2007) 2.61
Silence of chromosomal amplifications in colon cancer. Cancer Res (2002) 2.58
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol (2007) 2.55
Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. J Clin Oncol (2009) 2.54
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells (2005) 2.52
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem (2003) 2.50
MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev (2009) 2.49
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol (2007) 2.24
The annealing helicase HARP protects stalled replication forks. Genes Dev (2009) 2.19
A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. Hum Mol Genet (2003) 2.18
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet (2009) 2.14
End-joining, translocations and cancer. Nat Rev Cancer (2013) 2.13
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol (2002) 2.09
Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol (2005) 2.07
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet (2010) 2.06
Human claspin is required for replication checkpoint control. J Biol Chem (2003) 2.02
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem (2003) 2.00
WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol (2011) 2.00
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell (2007) 2.00
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol (2007) 1.98
Chfr is required for tumor suppression and Aurora A regulation. Nat Genet (2005) 1.97
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem (2010) 1.95
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. Genes Chromosomes Cancer (2009) 1.91
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem (2013) 1.86
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med (2010) 1.85