Published in J Biol Chem on October 06, 2004
The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors. Proc Natl Acad Sci U S A (2006) 1.64
Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45
Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca2+ release. J Cell Mol Med (2012) 1.40
RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27. Acta Physiol (Oxf) (2008) 1.33
A first look at ARFome: dual-coding genes in mammalian genomes. PLoS Comput Biol (2007) 1.17
Transcriptome landscape of the human placenta. BMC Genomics (2012) 1.05
Direct interaction of tumor suppressor CEACAM1 with beta catenin: identification of key residues in the long cytoplasmic domain. Exp Biol Med (Maywood) (2008) 1.00
MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. J Neurosci (2010) 0.96
Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. J Biol Chem (2012) 0.90
The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila. EMBO Rep (2010) 0.87
Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer. BMC Cancer (2011) 0.85
The physiology of membrane transport and endomembrane-based signalling. EMBO J (2006) 0.83
Rap1 and Rap2 antagonistically control endothelial barrier resistance. PLoS One (2013) 0.83
A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection. Proc Natl Acad Sci U S A (2006) 0.82
A molecular inversion probe assay for detecting alternative splicing. BMC Genomics (2010) 0.79
The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71. PLoS Pathog (2015) 0.78
Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling. PLoS One (2012) 0.77
Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells. Mol Med Rep (2015) 0.76
Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. J Biol Chem (2012) 0.76
The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy. Biol Open (2015) 0.75
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30
Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science (2008) 3.83
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther (2006) 3.46
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res (2010) 2.87
Physics. Learning and scientific reasoning. Science (2009) 2.49
Discovering patterns to extract protein-protein interactions from full texts. Bioinformatics (2004) 2.42
A new algorithm for the evaluation of shotgun peptide sequencing in proteomics: support vector machine classification of peptide MS/MS spectra and SEQUEST scores. J Proteome Res (2003) 2.16
Interferome v2.0: an updated database of annotated interferon-regulated genes. Nucleic Acids Res (2012) 2.08
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet (2007) 2.07
Cyclophilin A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury After Subarachnoid Hemorrhage in Rats. Crit Care Med (2015) 2.01
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol (2007) 1.91
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol (2005) 1.88
Capsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up. Am J Gastroenterol (2012) 1.88
Multiple roles for the receptor tyrosine kinase axl in tumor formation. Cancer Res (2005) 1.87
Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. Am J Hum Genet (2006) 1.85
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83
Fecal lactoferrin in discriminating inflammatory bowel disease from irritable bowel syndrome: a diagnostic meta-analysis. BMC Gastroenterol (2014) 1.82
Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol (2007) 1.81
Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus. Am J Hum Genet (2007) 1.73
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol (2008) 1.70
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. Mol Biol Cell (2005) 1.68
The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area. J Am Soc Nephrol (2004) 1.66
DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A (2004) 1.60
Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem (2002) 1.57
Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol (2006) 1.54
Cross-priming amplification for rapid detection of Mycobacterium tuberculosis in sputum specimens. J Clin Microbiol (2008) 1.47
Diagnosis and treatment of fungal infection after liver transplantation. Chin Med J (Engl) (2011) 1.45
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum (2008) 1.44
Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharm Sci (2011) 1.39
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39
Retracted Gene expression analysis in response to osmotic stimuli in the intervertebral disc with DNA microarray. Eur J Med Res (2013) 1.39
Activation of the PKB/AKT pathway by ICAM-2. Immunity (2002) 1.31
Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly. Am J Hum Genet (2007) 1.26
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. J Biol Chem (2007) 1.25
Functional characterization of human PFTK1 as a cyclin-dependent kinase. Proc Natl Acad Sci U S A (2007) 1.22
Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opin Investig Drugs (2004) 1.20
Structural basis for the unique biological function of small GTPase RHEB. J Biol Chem (2005) 1.19
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem (2013) 1.19
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1. Hum Mol Genet (2009) 1.17
Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol (2011) 1.16
The poxvirus p28 virulence factor is an E3 ubiquitin ligase. J Biol Chem (2004) 1.14
A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem J (2006) 1.14
ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. J Biol Chem (2002) 1.13
The efficacy, safety and durability of selective renal arterial embolization in treating symptomatic and asymptomatic renal angiomyolipoma. Urology (2010) 1.11
Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity. J Biol Chem (2003) 1.10
Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. Nat Struct Mol Biol (2012) 1.08
Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-gamma, and IP3R activation. Aging Cell (2010) 1.08
High speed GeSi electro-absorption modulator at 1550 nm wavelength on SOI waveguide. Opt Express (2012) 1.08
Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. J Immunol (2004) 1.08
Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds. Biomaterials (2008) 1.07
Re: roles played by chemolipiodolization and embolization in chemoembolization for hepatocellular carcinoma: single-blind, randomized trial. J Natl Cancer Inst (2013) 1.06
Retrovirally delivered random cyclic Peptide libraries yield inhibitors of interleukin-4 signaling in human B cells. J Biol Chem (2002) 1.04
A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. J Immunol (2005) 1.04
25Gb/s 1V-driving CMOS ring modulator with integrated thermal tuning. Opt Express (2011) 1.04
Factors impacting compliance with standard precautions in nursing, China. Int J Infect Dis (2010) 1.02
Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats. Respir Res (2010) 1.00
The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim Biophys Acta (2012) 1.00
The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation. Proc Natl Acad Sci U S A (2006) 1.00
Cell cycle regulatory E3 ubiquitin ligases as anticancer targets. Drug Resist Updat (2002) 0.99
Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis. BMC Gastroenterol (2011) 0.98
YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines. World J Gastroenterol (2005) 0.97
Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. Proteomics (2008) 0.96
Effect of distance between decaying (125)I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol (2012) 0.96
Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels. Eur J Pharmacol (2008) 0.95
Observed prevalence of congenital heart defects from a surveillance study in China. J Ultrasound Med (2011) 0.95
The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. PLoS One (2012) 0.95
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. PLoS One (2013) 0.94
Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226. J Immunol (2012) 0.94
WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin. Zhonghua Xue Ye Xue Za Zhi (2002) 0.94
Drug discovery in the ubiquitin regulatory pathway. Drug Discov Today (2003) 0.94
Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology (2009) 0.93
High-throughput screening for inhibitors of the e3 ubiquitin ligase APC. Methods Enzymol (2005) 0.92
Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site. Biochemistry (2002) 0.92
An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results. J Clin Oncol (2005) 0.92
Measurement of carotid wall volume and maximum area with contrast-enhanced 3D MR imaging: initial observations. Radiology (2003) 0.91
H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. Mol Biol Rep (2011) 0.91
Validation of the laparoscopically stapled approach as a standard technique for left lateral segment liver resection. World J Surg (2013) 0.91
Gene expression profile analysis of type 2 diabetic mouse liver. PLoS One (2013) 0.91
Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats. Eur J Pharmacol (2010) 0.90
Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells. Anticancer Drugs (2010) 0.90
Seawater induces apoptosis in alveolar epithelial cells via the Fas/FasL-mediated pathway. Respir Physiol Neurobiol (2012) 0.90
Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice. PLoS One (2011) 0.90
BaNbO(IO3)5: a new polar material with a very large SHG response. J Am Chem Soc (2009) 0.89
Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeeding. PLoS One (2011) 0.89
Technical points of total laparoscopic choledochal cyst excision. Chin Med J (Engl) (2013) 0.88
JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol (2009) 0.88
Application of PCR-LDR-nucleic acid detection strip in detection of YMDD mutation in hepatitis B patients treated with lamivudine. J Med Virol (2010) 0.88
Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis. Eur J Obstet Gynecol Reprod Biol (2013) 0.88
Use of MEDUSA-based data analysis and capillary HPLC-ion-trap mass spectrometry to examine complex immunoaffinity extracts of RBAp48. J Proteome Res (2003) 0.87
A novel role for p21-activated protein kinase 2 in T cell activation. J Immunol (2004) 0.87
International validation of the Chinese university prognostic index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study. Chin J Cancer (2014) 0.87