Published in Glycobiology on April 05, 2010
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42
Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors. Curr Opin Struct Biol (2011) 1.29
Structural insights into the mechanism of protein O-fucosylation. PLoS One (2011) 1.06
Systems glycobiology: biochemical reaction networks regulating glycan structure and function. Glycobiology (2011) 0.97
Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology (2015) 0.92
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J Biol Chem (2011) 0.92
The emerging importance of α-L-fucose in human breast cancer: a review. Am J Transl Res (2011) 0.89
A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med (2016) 0.85
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Dev Cell (2016) 0.85
Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patients. PLoS One (2012) 0.83
Glucosamine-induced OGT activation mediates glucose production through cleaved Notch1 and FoxO1, which coordinately contributed to the regulation of maintenance of self-renewal in mouse embryonic stem cells. Stem Cells Dev (2014) 0.81
Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor. Proteomics (2011) 0.80
"Casting" light on the role of glycosylation during embryonic development: insights from zebrafish. Glycoconj J (2012) 0.79
Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling. BMB Rep (2015) 0.78
The multiple roles of epidermal growth factor repeat O-glycans in animal development. Glycobiology (2015) 0.77
Golgi during development. Cold Spring Harb Perspect Biol (2011) 0.77
Extracellular o-linked N-acetylglucosamine is enriched in stem cells derived from human umbilical cord blood. Biores Open Access (2014) 0.76
Glycosylated Notch and Cancer. Front Oncol (2016) 0.75
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
A C-terminal signal prevents secretion of luminal ER proteins. Cell (1987) 14.83
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Character Changes Caused by Mutation of an Entire Region of a Chromosome in Drosophila. Genetics (1919) 13.32
Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 10.06
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature (1996) 8.02
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet (1997) 5.58
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature (1999) 4.64
Notch signaling: the core pathway and its posttranslational regulation. Dev Cell (2009) 4.49
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A (1998) 3.99
Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92
The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell (1983) 3.87
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet (2009) 3.86
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development (1996) 3.84
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
Role of glycosylation in development. Annu Rev Biochem (2004) 3.67
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature (2000) 3.51
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell (1997) 3.48
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol (1995) 3.46
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev (1995) 3.24
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol Cell Biol (1986) 3.02
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol (2006) 2.94
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development (2000) 2.94
Structural basis for autoinhibition of Notch. Nat Struct Mol Biol (2007) 2.89
lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor. Cell (1985) 2.86
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol (2000) 2.83
Notch signaling in stem cell systems. Stem Cells (2006) 2.82
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev (2002) 2.77
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A (2003) 2.69
The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant. J Biol Chem (1981) 2.67
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev (2002) 2.64
Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Science (2005) 2.56
Glycosylation regulates Notch signalling. Nat Rev Mol Cell Biol (2003) 2.48
Fringe modulates Notch-ligand interactions. Nature (1997) 2.44
Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Cell (1996) 2.40
Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate. Hum Mutat (2006) 2.39
Defects in somite formation in lunatic fringe-deficient mice. Nature (1998) 2.37
Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell (2005) 2.31
Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet (2000) 2.28
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development (2004) 2.25
Regulation of notch signaling by o-linked fucose. Cell (2002) 2.24
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules. J Biol Chem (2000) 2.18
LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway. Nature (2000) 2.17
lunatic fringe is an essential mediator of somite segmentation and patterning. Nature (1998) 2.09
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol (2007) 2.09
Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity (2009) 2.03
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol (2009) 1.97
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci (2009) 1.95
Emerging role of Notch in stem cells and cancer. Cancer Lett (2008) 1.88
A Notch updated. J Cell Biol (2009) 1.86
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter. Nat Genet (2001) 1.82
Isolation, characterization, and localization of a capsule-associated gene, CAP10, of Cryptococcus neoformans. J Bacteriol (1999) 1.79
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol (2004) 1.78
Familial Tetralogy of Fallot caused by mutation in the jagged1 gene. Hum Mol Genet (2001) 1.75
A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature (1998) 1.74
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development (2004) 1.74
Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem (2008) 1.71
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell (2004) 1.71
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood (2008) 1.69
Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol (2007) 1.68
Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. J Biol Chem (2003) 1.66
The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci (2008) 1.65
O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors. J Biol Chem (2008) 1.65
Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms. J Thorac Cardiovasc Surg (2007) 1.64
fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell (1994) 1.64
1998 Warkany lecture: signaling pathways in development. Teratology (1999) 1.63
Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet (2001) 1.62
Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell (1995) 1.61
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J Biol Chem (2001) 1.58
The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos. Curr Biol (1998) 1.58
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol (2006) 1.57
Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One (2009) 1.57
Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve. Biochem Biophys Res Commun (2006) 1.56
Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch (2003) 1.55
Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. J Cell Biol (2002) 1.55
A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation. Genome Res (2005) 1.52
Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1. Proc Natl Acad Sci U S A (2001) 1.51
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem (2002) 1.51
Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development (1997) 1.47
Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat Cell Biol (2001) 1.46
The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development. Proc Natl Acad Sci U S A (2008) 1.46
O-fucosylation of notch occurs in the endoplasmic reticulum. J Biol Chem (2005) 1.43
Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region. J Biol Chem (2002) 1.41
Structural and functional properties of the human notch-1 ligand binding region. Structure (2004) 1.40
Notch-dependent control of myelopoiesis is regulated by fucosylation. Blood (2008) 1.40
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38
UDP-sugar transporter implicated in glycosylation and processing of Notch. Nat Cell Biol (2001) 1.38
NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Hum Mol Genet (2008) 1.37
Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. Mol Cell Biol (2006) 1.52
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42
Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function. FASEB J (2011) 1.19
Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability. Mol Cell Biol (2005) 1.07
Negative regulation of notch signaling by xylose. PLoS Genet (2013) 1.07
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development (2011) 1.00
Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor. Genesis (2007) 0.86
Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human. J Steroid Biochem Mol Biol (2006) 0.85
Targeting iCre expression to murine progesterone receptor cell-lineages using bacterial artificial chromosome transgenesis. Genesis (2006) 0.81
A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Mol Endocrinol (2014) 0.75