Published in Nat Med on October 17, 2004
Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology (2010) 1.71
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol (2005) 1.61
Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2. Mol Cancer (2013) 1.02
Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality. Clin Exp Pharmacol Physiol (2012) 0.90
Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun (2015) 0.87
Increased plasma levels of FABP4 and PTEN is associated with more severe insulin resistance in women with gestational diabetes mellitus. Med Sci Monit (2015) 0.86
GOLD.db: genomics of lipid-associated disorders database. BMC Genomics (2004) 0.83
The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep (2005) 0.82
Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway? Adipocyte (2013) 0.77
Akt activation protects liver cells from apoptosis in rats during acute cold exposure. Int J Biol Sci (2013) 0.76
TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice. Cardiovasc Diabetol (2016) 0.75
Retracted Turning up the heat in the fat cell. Nat Med (2004) 0.75
Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest (2004) 13.42
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature (2008) 10.11
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med (2002) 8.95
A novel class of small RNAs bind to MILI protein in mouse testes. Nature (2006) 8.80
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Characterization of the piRNA complex from rat testes. Science (2006) 7.86
Retracted Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2004) 7.21
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes (2007) 6.81
Orangutan cultures and the evolution of material culture. Science (2003) 6.06
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun (2011) 5.66
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development (2004) 5.47
Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol (2003) 4.86
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity (2010) 4.13
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med (2005) 4.02
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem (2003) 3.86
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation (2002) 3.81
Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol (2003) 3.78
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest (2004) 3.70
Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med (2002) 3.55
PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol (2006) 3.54
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes (2003) 3.28
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot (2010) 3.11
Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem (2002) 3.05
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell (2009) 2.96
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat Methods (2005) 2.70
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity (2012) 2.50
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes (2002) 2.49
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation (2002) 2.40
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature (2012) 2.38
Stella is a maternal effect gene required for normal early development in mice. Curr Biol (2003) 2.38
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension (2006) 2.24
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology (2009) 2.23
Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest (2010) 2.23
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (2011) 2.17
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
Major issues and challenges of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2008) 2.16
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev (2012) 2.10
Transposon-tagged mutagenesis in the rat. Nat Methods (2007) 2.06
Pluripotential competence of cells associated with Nanog activity. Mech Dev (2005) 2.01
High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan: a cross-sectional study. Clin J Am Soc Nephrol (2011) 1.98
Enterovirus 68 among children with severe acute respiratory infection, the Philippines. Emerg Infect Dis (2011) 1.96
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Mech Dev (2002) 1.94
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem (2008) 1.93
Adiponectin acts as an endogenous antithrombotic factor. Arterioscler Thromb Vasc Biol (2005) 1.88
Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol (2006) 1.87
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Effect of adiponectin on murine colitis induced by dextran sulfate sodium. Gastroenterology (2006) 1.86
In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice. Genesis (2006) 1.85
MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev (2010) 1.84
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res (2005) 1.84
Target-site preferences of Sleeping Beauty transposons. J Mol Biol (2004) 1.83
High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. Am J Physiol Cell Physiol (2009) 1.82
Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease. Circ J (2008) 1.81
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80
Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun (2005) 1.80