Published in Nat Methods on October 01, 2005
DNA transposons and the evolution of eukaryotic genomes. Annu Rev Genet (2007) 4.99
Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2008) 4.98
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res (2007) 3.09
A hyperactive piggyBac transposase for mammalian applications. Proc Natl Acad Sci U S A (2011) 2.68
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science (2010) 2.31
Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet (2006) 1.84
Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Mamm Genome (2007) 1.51
Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res (2006) 1.48
Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A (2006) 1.48
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther (2008) 1.47
Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives. Genome Biol (2007) 1.29
Sleeping beauty transposase has an affinity for heterochromatin conformation. Mol Cell Biol (2006) 1.23
Genome-wide analysis of Tol2 transposon reintegration in zebrafish. BMC Genomics (2009) 1.20
Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctions. Methods Mol Biol (2008) 1.15
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A (2012) 1.12
High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors. Genome Res (2011) 1.12
Contemporary approaches for modifying the mouse genome. Physiol Genomics (2008) 1.10
Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Mol Cell Biol (2006) 1.09
The expanding universe of transposon technologies for gene and cell engineering. Mob DNA (2010) 1.08
Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. Genome Biol (2007) 1.08
The mouse genetics toolkit: revealing function and mechanism. Genome Biol (2011) 1.05
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol (2006) 1.05
A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice. Nat Genet (2009) 1.03
Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function. PLoS One (2010) 1.03
Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells. Mol Ther (2008) 1.02
Insertional mutagenesis strategies in zebrafish. Genome Biol (2007) 1.02
SMOC1 is essential for ocular and limb development in humans and mice. Am J Hum Genet (2010) 0.97
Efficient transposition of the Tol2 transposable element from a single-copy donor in zebrafish. Proc Natl Acad Sci U S A (2008) 0.95
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One (2010) 0.94
Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes. Genome Biol (2007) 0.94
A mitotic recombination system for mouse chromosome 17. Proc Natl Acad Sci U S A (2008) 0.93
Germline mutagenesis mediated by Sleeping Beauty transposon system in mice. Genome Biol (2007) 0.93
Mutagenesis in rodents using the L1 retrotransposon. Genome Biol (2007) 0.92
Meganuclease and transposon mediated transgenesis in medaka. Genome Biol (2007) 0.90
Suicidal autointegration of sleeping beauty and piggyBac transposons in eukaryotic cells. PLoS Genet (2014) 0.87
Efficient transposition of Tol2 in the mouse germline. Genetics (2009) 0.87
From remote enhancers to gene regulation: charting the genome's regulatory landscapes. Philos Trans R Soc Lond B Biol Sci (2013) 0.86
TRACER: a resource to study the regulatory architecture of the mouse genome. BMC Genomics (2013) 0.85
Transposon mutagenesis in mice. Methods Mol Biol (2009) 0.85
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development (2011) 0.84
Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells. Methods (2010) 0.84
A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. PLoS One (2010) 0.83
Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model. Proc Natl Acad Sci U S A (2013) 0.83
Site-directed integration of transgenes: transposons revisited using DNA-binding-domain technologies. Genetica (2009) 0.82
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells. Nat Protoc (2011) 0.81
Effective gene trapping mediated by Sleeping Beauty transposon. PLoS One (2012) 0.79
Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes. PLoS Genet (2011) 0.79
Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies. Semin Cell Dev Biol (2014) 0.79
Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis. Mob DNA (2011) 0.78
Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. J Biol Chem (2010) 0.78
Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline. Nat Methods (2005) 0.77
Gene targeting in primary human trophoblasts. Placenta (2012) 0.77
Transposable elements in fish functional genomics: technical challenges and perspectives. Genome Biol (2007) 0.77
Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers. Cancer Biol Ther (2015) 0.76
Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression. Proc Natl Acad Sci U S A (2016) 0.76
Controlled somatic and germline copy number variation in the mouse model. Curr Genomics (2010) 0.76
Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World J Gastroenterol (2015) 0.75
Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes. G3 (Bethesda) (2015) 0.75
Chromatin states shape insertion profiles of the piggyBac, Tol2 and Sleeping Beauty transposons and murine leukemia virus. Sci Rep (2017) 0.75
Preclinical and clinical advances in transposon-based gene therapy. Biosci Rep (2017) 0.75
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res (2005) 11.23
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med (2006) 9.68
Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature (2005) 6.20
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet (2003) 5.92
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature (2003) 4.56
RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res (2004) 4.41
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (2009) 4.16
New genes involved in cancer identified by retroviral tagging. Nat Genet (2002) 4.14
Identification of an organelle receptor for myosin-Va. Nat Cell Biol (2002) 4.06
Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell (2010) 4.03
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med (2005) 4.02
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet (2004) 3.78
Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood (2005) 3.71
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest (2004) 3.70
Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat Genet (2010) 3.60
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53
Bcl11a is essential for normal lymphoid development. Nat Immunol (2003) 3.48
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.33
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med (2009) 3.19
Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood (2005) 2.93
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet (2003) 2.78
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science (2010) 2.77
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73
Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature. Hum Mol Genet (2003) 2.64
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J (2004) 2.55
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity (2012) 2.50
The bonobo genome compared with the chimpanzee and human genomes. Nature (2012) 2.49
Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I. Science (2011) 2.47
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46
Harnessing transposons for cancer gene discovery. Nat Rev Cancer (2010) 2.44
Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell (2005) 2.44
Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med (2005) 2.43
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science (2010) 2.31
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. Blood (2005) 2.27
Efficient Cre-loxP-induced mitotic recombination in mouse embryonic stem cells. Nat Genet (2001) 2.14
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
Transposon-tagged mutagenesis in the rat. Nat Methods (2007) 2.06
Gene therapy insertional mutagenesis insights. Science (2004) 1.99
Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Nat Med (2006) 1.97
Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site. Neurobiol Dis (2002) 1.96
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc Res (2012) 1.95
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93
Genetic variants in C5 and poor response to eculizumab. N Engl J Med (2014) 1.91
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. Blood (2005) 1.91
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol (2007) 1.88
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J (2006) 1.88