Published in Oncogene on October 18, 2004
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med (2011) 6.21
Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab. Cancer Biol Ther (2009) 2.37
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity (2010) 2.22
Global impact of oncogenic Src on a phosphotyrosine proteome. J Proteome Res (2008) 1.94
SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol (2007) 1.79
Management of breast cancer with targeted agents: importance of heterogeneity. [corrected]. Nat Rev Clin Oncol (2010) 1.69
VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci (2006) 1.65
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J (2006) 1.64
MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol (2010) 1.64
RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry. PLoS Pathog (2008) 1.63
Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res (2008) 1.63
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene (2008) 1.57
Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth. Clin Cancer Res (2011) 1.55
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
Src inhibition ameliorates polycystic kidney disease. J Am Soc Nephrol (2008) 1.43
Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Res (2010) 1.38
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
Regulation of SRC family kinases in human cancers. J Signal Transduct (2011) 1.32
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol (2007) 1.32
SRC-family tyrosine kinases in wound- and ligand-induced epidermal growth factor receptor activation in human corneal epithelial cells. Invest Ophthalmol Vis Sci (2006) 1.23
ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J Cell Sci (2010) 1.22
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J (2006) 1.22
The dual kinase complex FAK-Src as a promising therapeutic target in cancer. Onco Targets Ther (2010) 1.22
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne) (2012) 1.17
The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene (2009) 1.16
Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp Eye Res (2006) 1.14
The secret life of kinases: functions beyond catalysis. Cell Commun Signal (2011) 1.13
Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation. Mol Cell Biol (2005) 1.12
Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene (2011) 1.11
Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem (2010) 1.10
Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice. Diabetes (2013) 1.09
A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nat Chem Biol (2011) 1.09
Lessons from the endothelial junctional mechanosensory complex. F1000 Biol Rep (2012) 1.08
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol Cell Biol (2006) 1.07
Treatment options for patients with triple-negative breast cancer. J Hematol Oncol (2010) 1.07
Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Mol Endocrinol (2010) 1.06
Lyn kinase promotes erythroblast expansion and late-stage development. Blood (2006) 1.06
Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor. Oncogene (2012) 1.06
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol (2006) 1.05
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2). Endocrinology (2006) 1.05
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells. J Clin Invest (2013) 1.04
Lipid rafts are required for Kit survival and proliferation signals. Blood (2007) 1.03
Localized activation of Src-family protein kinases in the mouse egg. Dev Biol (2007) 1.03
RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.02
Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol Biol Cell (2005) 1.00
Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress. Oncotarget (2014) 0.99
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer. Cancer Discov (2013) 0.98
ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS One (2013) 0.98
Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells. Mol Cell Biol (2011) 0.97
Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events. J Proteome Res (2010) 0.97
Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells. J Biol Chem (2009) 0.97
Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc Natl Acad Sci U S A (2014) 0.96
Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer. Clin Cancer Res (2010) 0.96
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases. Mol Endocrinol (2005) 0.96
Regulation of Xenopus gastrulation by ErbB signaling. Dev Biol (2006) 0.96
A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells. Exp Cell Res (2007) 0.96
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene (2011) 0.96
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J (2009) 0.95
Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. Eur J Cancer (2013) 0.95
Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle. FEBS J (2009) 0.95
Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines. Eur J Cancer (2012) 0.94
Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions. Proteome Sci (2011) 0.94
Implications of bone-only metastases in breast cancer: favorable preference with excellent outcomes of hormone receptor positive breast cancer. Cancer Res Treat (2011) 0.93
A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy. Cancer Prev Res (Phila) (2008) 0.92
The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities. Mol Cell Biol (2007) 0.92
Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization. J Biol Chem (2008) 0.92
The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget (2015) 0.91
Characterization of the Src/Abl hybrid kinase SmTK6 of Schistosoma mansoni. J Biol Chem (2011) 0.90
Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells. PLoS One (2011) 0.90
The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells. Endocrinology (2008) 0.89
Subcellular localization of total and activated Src kinase in African American and Caucasian breast cancer. PLoS One (2012) 0.89
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. J Exp Med (2010) 0.89
Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer. Am J Cancer Res (2012) 0.89
Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One (2010) 0.89
Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex. Mol Reprod Dev (2009) 0.89
Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases. Am J Respir Cell Mol Biol (2009) 0.88
Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia (2012) 0.88
Pathways driving the endocytosis of mutant and wild-type EGFR in cancer. Oncoscience (2014) 0.87
Protein tyrosine kinase signaling during oocyte maturation and fertilization. Mol Reprod Dev (2011) 0.87
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets. Oncotarget (2015) 0.87
Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis. Mol Cell Biol (2015) 0.87
The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer. MAbs (2013) 0.86
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling. Mol Oncol (2012) 0.86
Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms. Am J Physiol Renal Physiol (2008) 0.86
Src signaling pathways in prostate cancer. Cancer Metastasis Rev (2014) 0.86
Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem (2012) 0.86
Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis. Oncotarget (2015) 0.86
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. J Cell Biol (2008) 0.86
Role of Fyn kinase in oocyte developmental potential. Reprod Fertil Dev (2010) 0.86
Venus kinase receptors: prospects in signaling and biological functions of these invertebrate kinases. Front Endocrinol (Lausanne) (2014) 0.85
Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila. PLoS Biol (2008) 0.85
YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention. Oncotarget (2011) 0.85
Wrangling phosphoproteomic data to elucidate cancer signaling pathways. PLoS One (2013) 0.85
Mutations of the lutropin/choriogonadotropin receptor that do not activate the phosphoinositide cascade allow hCG to induce aromatase expression in immature rat granulosa cells. Mol Cell Endocrinol (2008) 0.85
Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma. Oncotarget (2015) 0.84
Wiskott-Aldrich syndrome protein is an effector of Kit signaling. Blood (2009) 0.84
How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism. Front Immunol (2012) 0.84
Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells. J Biol Chem (2011) 0.84
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev (2003) 4.47
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest (2010) 4.22
Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol (2008) 3.26
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A (2012) 3.21
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res (2011) 3.18
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell (2005) 2.91
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res (2013) 2.27
The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem (2003) 2.08
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res (2010) 1.96
Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat (2009) 1.77
The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation. Mol Biol Cell (2009) 1.68
A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. Eur J Cell Biol (2008) 1.65
MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol (2010) 1.64
Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal (2009) 1.56
The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2. J Biol Chem (2002) 1.52
Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation. J Cell Sci (2009) 1.51
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet (2012) 1.38
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1. Mol Biol Cell (2008) 1.37
Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal (2009) 1.29
The hepatitis E virus open reading frame 3 protein activates ERK through binding and inhibition of the MAPK phosphatase. J Biol Chem (2004) 1.24
A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion. Sci Signal (2011) 1.20
Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. Am J Hum Genet (2010) 1.18
A Src-Tks5 pathway is required for neural crest cell migration during embryonic development. PLoS One (2011) 1.16
Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Med (2012) 1.12
Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol (2013) 1.10
Hepatitis viruses and the MAPK pathway: is this a survival strategy? Virus Res (2003) 1.09
Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation. Exp Cell Res (2009) 1.08
Cancer stem cells: nature versus nurture. Nat Cell Biol (2010) 0.92
Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells. Prostate (2013) 0.92
The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly. J Cell Sci (2003) 0.91
Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts. J Biol Chem (2005) 0.90
Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. Mol Cancer Ther (2015) 0.89
Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer. Cell Cycle (2012) 0.86
Cancer: Escape from inhibition. Nature (2003) 0.85
Podosomal proteins as causes of human syndromes: a role in craniofacial development? Genesis (2011) 0.85
[The cancer stem cell: the breast cancer driver]. Med Sci (Paris) (2007) 0.85
Inflammation and autophagy conspire to promote tumor growth. Cell Cycle (2011) 0.84
The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics). Clin Cancer Res (2008) 0.81
Redox signaling at invasive microdomains in cancer cells. Free Radic Biol Med (2011) 0.79