Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet (2014) 1.03

The importance of Src signaling in sarcoma. Oncol Lett (2015) 0.82

Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Mol Cell Proteomics (2012) 0.82

Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells. Oncotarget (2015) 0.82

Drugs for solid cancer: the productivity crisis prompts a rethink. Onco Targets Ther (2013) 0.78

The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer. Oncotarget (2016) 0.77

MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway. Oncotarget (2017) 0.75

Epithelial regeneration and cancer: news from the Src front. EMBO J (2014) 0.75

YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. Am J Cancer Res (2015) 0.75

Protein Kinases and Parkinson's Disease. Int J Mol Sci (2016) 0.75

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41

Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol (1997) 11.36

Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94

Targeting MET in cancer: rationale and progress. Nat Rev Cancer (2012) 6.43

A renaissance for SRC. Nat Rev Cancer (2004) 6.27

STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell (2010) 5.67

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature (2011) 5.49

Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24

Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev (2003) 4.62

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24

Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol (2009) 4.07

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature (2000) 4.01

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature (1991) 3.97

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol (1995) 3.85

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell (2004) 3.63

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol (2004) 3.47

Structure and regulation of Src family kinases. Oncogene (2004) 3.44

The interplay between Src family kinases and receptor tyrosine kinases. Oncogene (2004) 3.36

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc Natl Acad Sci U S A (2001) 3.29

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell (1993) 3.08

P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell (2006) 3.04

Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet (1999) 2.84

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell (2004) 2.82

Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell (2011) 2.77

Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell (1993) 2.75

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med (2000) 2.75

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62

Newest findings on the oldest oncogene; how activated src does it. J Cell Sci (2004) 2.51

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50

Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth. Mol Cell Biol (2005) 2.38

EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell (2002) 2.31

MicroRNA-143 and -145 in colon cancer. DNA Cell Biol (2007) 2.24

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. J Clin Invest (2011) 2.20

Selected glimpses into the activation and function of Src kinase. Oncogene (2000) 2.16

Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol (2000) 2.04

Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer (2002) 2.03

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol (2009) 1.97

Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment. Cancer Res (2010) 1.95

Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol (2004) 1.92

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. Oncogene (2010) 1.88

WNT signaling in the normal intestine and colorectal cancer. Front Biosci (2007) 1.79

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proc Natl Acad Sci U S A (1990) 1.76

Src activation regulates anoikis in human colon tumor cell lines. Oncogene (2002) 1.70

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther (2006) 1.66

Elevated c-yes tyrosine kinase activity in premalignant lesions of the colon. Gastroenterology (1995) 1.66

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J (2006) 1.64

MicroRNA-145 targets YES and STAT1 in colon cancer cells. PLoS One (2010) 1.64

Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin Cancer Res (2002) 1.60

Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer Res (2008) 1.56

Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. Cancer Res (2009) 1.54

Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J (1997) 1.53

Src continues aging: current and future clinical directions. Clin Cancer Res (2007) 1.50

The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. Mol Cell (2008) 1.48

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene (1997) 1.48

Association of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J (2005) 1.45

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res (2005) 1.45

PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. Cancer Res (2007) 1.43

Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis. Clin Cancer Res (2012) 1.39

pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line. J Cell Biol (1995) 1.37

c-Yes tyrosine kinase activity in human colon carcinoma. Oncogene (1993) 1.35

Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J (2011) 1.33

Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. Cancer Res (2002) 1.33

SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res (2005) 1.29

Dormant liver metastases: an experimental study. Br J Surg (1992) 1.28

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A (2010) 1.27

Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. Cancer Res (2009) 1.25

SRC gene expression in human cancer: the role of transcriptional activation. Biochem Cell Biol (2004) 1.23

Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol (2004) 1.18

The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. Cancer Cell (2009) 1.14

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells. Proc Natl Acad Sci U S A (2008) 1.13

The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. Discov Med (2011) 1.12

The role of Eph receptors and ephrin ligands in colorectal cancer. Int J Cancer (2010) 1.12

Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells. Blood (2011) 1.11

Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene (2011) 1.11

Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. J Cell Sci (2006) 1.11

Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain. Mol Cell Biol (2009) 1.10

TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer. Ann Surg Oncol (2008) 1.06

Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. Int J Cancer (2008) 1.06

Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol (2006) 1.05

c-Src differentially regulates the functions of microtentacles and invadopodia. Oncogene (2010) 1.05

Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer Res (2007) 1.04

Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. Clin Cancer Res (1996) 1.04

SRC transcriptional activation in a subset of human colon cancer cell lines. FEBS Lett (2001) 1.03

A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. Blood (2007) 1.02

Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Oncogene (2009) 1.01

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis. Oncogene (2007) 0.99

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood (2007) 0.99

Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest (1998) 0.97

Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells. Int J Cancer (2011) 0.97

No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese. Cancer Lett (2000) 0.97

Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer. Clin Cancer Res (2010) 0.96

A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Oncogene (2003) 0.95

Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway. J Biol Chem (2011) 0.94

Reduced C-terminal Src kinase activity is correlated inversely with pp60(c-src) activity in colorectal carcinoma. Cancer (2001) 0.93

Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. Cancer Res (1999) 0.93

The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities. Mol Cell Biol (2007) 0.92

Regulation of FynT function by dual domain docking on PAG/Cbp. J Biol Chem (2007) 0.91

Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer Res (2008) 1.56

Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell (2008) 1.52

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. J Biol Chem (2002) 1.49

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J (2002) 1.41

Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells. Cancer Res (2009) 1.25

Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity. Blood (2003) 1.22

Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells. Blood (2011) 1.11

Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. J Cell Sci (2006) 1.11

Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors. J Cell Sci (2005) 1.09

The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol Cell Biol (2006) 1.07

Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. J Cell Sci (2003) 1.07

The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton. J Cell Sci (2009) 1.00

Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene (2002) 1.00

Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. J Biol Chem (2002) 0.99

The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities. Mol Cell Biol (2007) 0.92

A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling. Cell Signal (2010) 0.92

Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells. PLoS One (2011) 0.90

The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. J Cell Biol (2008) 0.86

Cyclin E and cyclin A are likely targets of Src for PDGF-induced DNA synthesis in fibroblasts. FEBS Lett (2002) 0.85

Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Mol Cell Proteomics (2012) 0.82

Contribution of phosphoproteomics in understanding SRC signaling in normal and tumor cells. Proteomics (2015) 0.80