Published in J Am Chem Soc on October 27, 2004
Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis. Bioorg Med Chem (2008) 0.81
Mapping the kinetic barriers of a Large RNA molecule's folding landscape. PLoS One (2014) 0.77
Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry. J Org Chem (2011) 0.75
Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations. J Am Chem Soc (2015) 0.75
Selective stabilization of natively folded RNA structure by DNA constraints. J Am Chem Soc (2008) 0.75
General acid catalysis by the hepatitis delta virus ribozyme. Nat Chem Biol (2005) 2.88
The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity (2010) 2.02
RNA catalyses nuclear pre-mRNA splicing. Nature (2013) 1.86
Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine. Nucleic Acids Res (2007) 1.66
Structural inference of native and partially folded RNA by high-throughput contact mapping. Proc Natl Acad Sci U S A (2008) 1.54
New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis. Chem Biol (2004) 1.53
Synthetic antibodies for specific recognition and crystallization of structured RNA. Proc Natl Acad Sci U S A (2007) 1.51
Molecular mechanisms of protein and lipid targeting to ciliary membranes. J Cell Sci (2010) 1.43
A second divalent metal ion in the group II intron reaction center. Chem Biol (2007) 1.29
Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science (2009) 1.27
The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins. Nat Struct Mol Biol (2006) 1.26
The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. Mol Cell (2010) 1.23
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol (2010) 1.18
Identification of catalytic metal ion ligands in ribozymes. Methods (2009) 1.18
Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme. Proc Natl Acad Sci U S A (2010) 1.18
A systematic, ligation-based approach to study RNA modifications. RNA (2006) 1.10
Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base. J Am Chem Soc (2010) 1.07
Functional identification of catalytic metal ion binding sites within RNA. PLoS Biol (2005) 1.05
General acid-base catalysis mediated by nucleobases in the hairpin ribozyme. J Am Chem Soc (2012) 1.05
Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation. Proc Natl Acad Sci U S A (2013) 1.05
Identification of an active site ligand for a group I ribozyme catalytic metal ion. Biochemistry (2002) 1.05
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design. Proc Natl Acad Sci U S A (2011) 1.03
Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins. RNA (2007) 1.02
Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment. Angew Chem Int Ed Engl (2011) 1.02
Nucleotide analogues to investigate RNA structure and function. Curr Opin Chem Biol (2005) 1.01
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem (2010) 0.98
Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin. Biochemistry (2007) 0.98
Functional identification of ligands for a catalytic metal ion in group I introns. Biochemistry (2008) 0.98
Synthesis of the phosphoramidite derivatives of 2'-deoxy-2'-C-alpha-methylcytidine and 2'-deoxy-2'-C-alpha-hydroxymethylcytidine: analogues for chemical dissection of RNA's 2'-hydroxyl group. J Org Chem (2004) 0.96
Separation of RNA phosphorothioate oligonucleotides by HPLC. Methods Enzymol (2009) 0.95
Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding. RNA (2012) 0.92
Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis. J Org Chem (2007) 0.91
Isotope edited internal standard method for quantitative surface-enhanced Raman spectroscopy. Anal Chem (2005) 0.89
Synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites for probing cytosine function in RNA. J Org Chem (2009) 0.89
Structure and function converge to identify a hydrogen bond in a group I ribozyme active site. Angew Chem Int Ed Engl (2009) 0.87
The mechanism of RNA strand scission: an experimental measure of the Brønsted coefficient, beta nuc. Angew Chem Int Ed Engl (2007) 0.87
Sin resolvase catalytic activity and oligomerization state are tightly coupled. J Mol Biol (2010) 0.87
2'-mercaptonucleotide interference reveals regions of close packing within folded RNA molecules. J Am Chem Soc (2003) 0.86
Efficient synthesis of 2'-C-beta-methylguanosine. J Org Chem (2006) 0.86
'Turning on' riboswitches to their antibacterial potential. Nat Chem Biol (2007) 0.85
A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage. Nucleic Acids Res (2010) 0.84
Synthesis of 2'-C-beta-methyl-2'-deoxyguanosine. J Org Chem (2009) 0.84
Chemical origins of life: Prebiotic RNA unstuck. Nat Chem (2013) 0.83
Efficient chemical synthesis of AppDNA by adenylation of immobilized DNA-5'-monophosphate. Org Lett (2009) 0.83
A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site. Biochemistry (2010) 0.83
The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction. Biochemistry (2008) 0.83
Reactions of phosphate and phosphorothiolate diesters with nucleophiles: comparison of transition state structures. Org Biomol Chem (2007) 0.82
Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage. Acc Chem Res (2011) 0.82
2'-amino-modified ribonucleotides as probes for local interactions within RNA. Methods Enzymol (2009) 0.82
Syntheses of (2')3'-15N-amino-(2')3'-deoxyguanosine and determination of their pKa values by 15N NMR spectroscopy. Org Lett (2007) 0.82
Improved synthesis of 2'-amino-2'-deoxyguanosine and its phosphoramidite. Bioorg Med Chem (2005) 0.81
Tightening of active site interactions en route to the transition state revealed by single-atom substitution in the guanosine-binding site of the Tetrahymena group I ribozyme. J Am Chem Soc (2011) 0.81
2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA. Chem Biol (2011) 0.81
A packing-density metric for exploring the interior of folded RNA molecules. Angew Chem Int Ed Engl (2004) 0.81
Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate. Biochemistry (2008) 0.81
Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis. Bioorg Med Chem (2008) 0.81
Modulation of individual steps in group I intron catalysis by a peripheral metal ion. RNA (2007) 0.80
Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage. J Biol Chem (2013) 0.80
Synthesis of the phosphoramidite derivative of 2'-deoxy-2'-C-beta-methylcytidine. J Org Chem (2003) 0.78
Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site. ACS Chem Biol (2011) 0.78
The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues. Biochemistry (2011) 0.77
Synthesis of 2'-C-difluoromethylribonucleosides and their enzymatic incorporation into oligonucleotides. J Org Chem (2005) 0.77
Highly stereocontrolled total synthesis of β-D-mannosyl phosphomycoketide: a natural product from Mycobacterium tuberculosis. J Org Chem (2013) 0.77
Synthesis of 2'-C-beta-fluoromethyluridine. Org Lett (2003) 0.77
Synthesis of 2'-O-photocaged ribonucleoside phosphoramidites. Nucleosides Nucleotides Nucleic Acids (2015) 0.76
Spinach RNA aptamer detects lead(II) with high selectivity. Chem Commun (Camb) (2015) 0.76
Automated solid-phase synthesis of RNA oligonucleotides containing a nonbridging phosphorodithioate linkage via phosphorothioamidites. J Org Chem (2012) 0.75
Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations. J Am Chem Soc (2015) 0.75
Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry. J Org Chem (2011) 0.75
Quantification of isotope encoded proteins in 2-D gels using surface enhanced resonance Raman. Bioconjug Chem (2008) 0.75
Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis. J Org Chem (2014) 0.75
Unusual high rate of asymptomatic maternal parvovirus B19 infection associated with severe fetal outcome. J Matern Fetal Neonatal Med (2010) 0.75
Efficient Synthetic Approach to Linear Dasatinib-DNA Conjugates by Click Chemistry. Bioconjug Chem (2016) 0.75
Efficient synthesis of 2',3'-dideoxy-2'-amino-3'-thiouridine. Org Lett (2004) 0.75
Efficient synthesis of methyl 3,5-di-O-benzyl-alpha-D-ribofuranoside and application to the synthesis of 2'-C-beta-alkoxymethyluridines. Org Lett (2007) 0.75
Synthesis of 2'-C-alpha-(hydroxyalkyl) and 2'-C-alpha-alkylcytidine phosphoramidites: analogues for probing solvent interactions with RNA. J Org Chem (2007) 0.75
Efficient synthesis of 2'-C-α-aminomethyl-2'-deoxynucleosides. Chem Commun (Camb) (2012) 0.75
Synthesis of 5´-Thio-3´-O-Ribonucleoside Phosphoramidites. J Org Chem (2017) 0.75