Published in J Biol Chem on October 20, 2004
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell (2013) 3.10
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect (2006) 1.33
A mathematical model of glutathione metabolism. Theor Biol Med Model (2008) 1.30
Use of pathway information in molecular epidemiology. Hum Genomics (2009) 1.22
A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr (2008) 1.22
Trafficking of intracellular folates. Adv Nutr (2011) 1.15
In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model (2006) 1.10
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS One (2011) 1.08
Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells. PLoS Comput Biol (2010) 1.07
One-carbon metabolism and breast cancer: an epidemiological perspective. J Genet Genomics (2009) 1.02
Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. PLoS One (2012) 1.00
A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life. Proc Natl Acad Sci U S A (2010) 0.98
Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children. Diabetologia (2013) 0.98
Biomarkers of Nutrition for Development-Folate Review. J Nutr (2015) 0.98
A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis. PLoS One (2011) 0.96
Modeling cellular compartmentation in one-carbon metabolism. Wiley Interdiscip Rev Syst Biol Med (2013) 0.94
Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. Theor Biol Med Model (2009) 0.93
Folic acid supplementation promotes mammary tumor progression in a rat model. PLoS One (2014) 0.92
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. J Nutr (2009) 0.92
Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. J Bacteriol (2007) 0.89
Genomic and epigenomic instability, fragile sites, schizophrenia and autism. Curr Genomics (2010) 0.89
Mathematical model insights into arsenic detoxification. Theor Biol Med Model (2011) 0.89
Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers. Cancer Epidemiol Biomarkers Prev (2011) 0.86
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. Mol Nutr Food Res (2012) 0.85
Aluminum-induced entropy in biological systems: implications for neurological disease. J Toxicol (2014) 0.84
Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells. Am J Physiol Endocrinol Metab (2014) 0.82
Vitamin B-12 and Perinatal Health. Adv Nutr (2015) 0.82
The challenges for molecular nutrition research 4: the "nutritional systems biology level". Genes Nutr (2008) 0.81
A population model of folate-mediated one-carbon metabolism. Nutrients (2013) 0.81
Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial. PLoS One (2009) 0.81
Bacterial conversion of folinic acid is required for antifolate resistance. J Biol Chem (2011) 0.81
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation. Mol Med (2011) 0.80
Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. Eur J Nutr (2015) 0.78
Mathematical modeling of folate metabolism. Wiley Interdiscip Rev Syst Biol Med (2013) 0.76
The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level. Genes Nutr (2008) 0.76
Homeostasis, singularities, and networks. J Math Biol (2016) 0.76
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. PLoS Pathog (2016) 0.76
Robustness, flexibility, and sensitivity in a multifunctional motor control model. Biol Cybern (2016) 0.75
Mathematical Modeling of Glutathione Status in Type 2 Diabetics with Vitamin B12 Deficiency. Front Cell Dev Biol (2016) 0.75
Mathematical analysis of the regulation of competing methyltransferases. BMC Syst Biol (2015) 0.75
Using mathematical models to understand metabolism, genes, and disease. BMC Biol (2015) 0.75
Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev (2002) 5.04
Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol (2009) 3.58
Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA (2003) 3.22
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA (2008) 2.73
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57
Moderate-intensity exercise reduces the incidence of colds among postmenopausal women. Am J Med (2006) 2.53
Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet (2011) 2.35
Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr (2006) 2.25
Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol (2008) 2.15
Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res (2004) 2.14
Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev (2002) 2.08
Singularity in polarization: rewiring yeast cells to make two buds. Cell (2009) 2.00
Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst (2010) 1.99
Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal women. Menopause (2004) 1.97
Dietary weight loss and exercise effects on insulin resistance in postmenopausal women. Am J Prev Med (2011) 1.90
Folate and cancer--timing is everything. JAMA (2007) 1.88
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr (2006) 1.82
5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol (2003) 1.64
Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects. J Am Diet Assoc (2004) 1.61
Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature. Mol Carcinog (2005) 1.61
Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors. Breast Cancer Res Treat (2008) 1.60
Characterization of gene-environment interactions for colorectal cancer susceptibility loci. Cancer Res (2012) 1.58
Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking. Am J Gastroenterol (2006) 1.56
Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue. Cancer Immunol Immunother (2013) 1.53
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology (2009) 1.50
Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. Cancer Res (2012) 1.50
Folate and cancer prevention: a closer look at a complex picture. Am J Clin Nutr (2007) 1.43
History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women. Metabolism (2012) 1.43
Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors. Am J Clin Nutr (2008) 1.41
Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. Obes Res (2005) 1.37
Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women. Cancer Epidemiol Biomarkers Prev (2004) 1.35
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect (2006) 1.33
Managed care and primary physician satisfaction. J Am Board Fam Pract (2003) 1.31
Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation. J Natl Cancer Inst (2010) 1.30
Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomarkers Prev (2004) 1.30
A mathematical model of glutathione metabolism. Theor Biol Med Model (2008) 1.30
Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women. Prev Med (2004) 1.29
Mailing strategies and recruitment into an intervention trial of the exercise effect on breast cancer biomarkers. Cancer Epidemiol Biomarkers Prev (2002) 1.29
Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis (2007) 1.28
PharmGKB summary: methotrexate pathway. Pharmacogenet Genomics (2011) 1.27
A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc (2009) 1.26
Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am J Clin Nutr (2008) 1.26
Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women. Cancer Epidemiol Biomarkers Prev (2005) 1.26
Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer. Cancer Causes Control (2011) 1.25
Postdiagnosis diet quality is inversely related to a biomarker of inflammation among breast cancer survivors. Cancer Epidemiol Biomarkers Prev (2010) 1.25
Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation. Blood (2010) 1.24
Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women. Sleep (2003) 1.23
Effect of exercise on oxidative stress: a 12-month randomized, controlled trial. Med Sci Sports Exerc (2010) 1.22
Impact of resistance training in cancer survivors: a meta-analysis. Med Sci Sports Exerc (2013) 1.22
Use of pathway information in molecular epidemiology. Hum Genomics (2009) 1.22
Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer. Gut (2010) 1.20
Associations between healthy eating patterns and immune function or inflammation in overweight or obese postmenopausal women. Am J Clin Nutr (2007) 1.14
Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.13
MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.12
Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate. Epigenetics (2006) 1.11
Randomized controlled pilot trial of yoga in overweight and obese breast cancer survivors: effects on quality of life and anthropometric measures. Support Care Cancer (2011) 1.10
A mathematical model of the methionine cycle. J Theor Biol (2004) 1.10
In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor Biol Med Model (2006) 1.10
The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer. Genes Chromosomes Cancer (2008) 1.10
No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomarkers Prev (2005) 1.09
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev (2008) 1.08
Fatigue, inflammation, and ω-3 and ω-6 fatty acid intake among breast cancer survivors. J Clin Oncol (2012) 1.05
UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. Breast Cancer Res (2004) 1.05
Leveraging epidemiology and clinical studies of cancer outcomes: recommendations and opportunities for translational research. J Natl Cancer Inst (2012) 1.04
Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations. Cancer Epidemiol Biomarkers Prev (2004) 1.04
The effects of obesity and obesity-related conditions on colorectal cancer prognosis. Cancer Control (2010) 1.04
Review of mass spectrometry-based metabolomics in cancer research. Cancer Epidemiol Biomarkers Prev (2013) 1.03
Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. Cancer Epidemiol Biomarkers Prev (2010) 1.03
Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival. Int J Cancer (2010) 1.02
Isolation and characterization of ellagitannins as the major polyphenolic components of Longan (Dimocarpus longan Lour) seeds. Phytochemistry (2012) 1.01
Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia. J Clin Oncol (2004) 1.00
MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res (2009) 1.00
Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions. Cancer Epidemiol Biomarkers Prev (2008) 1.00
A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 0.99
Cohorts and consortia conference: a summary report (Banff, Canada, June 17-19, 2009). Cancer Causes Control (2011) 0.99
Genetic variation in calcium-sensing receptor and risk for colon cancer. Cancer Epidemiol Biomarkers Prev (2008) 0.99
Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, area. Environ Health Perspect (2008) 0.98
A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH. Theor Biol Med Model (2004) 0.98
Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. Int J Cancer (2012) 0.97
Predictors of diet quality among overweight and obese postmenopausal women. J Am Diet Assoc (2008) 0.97
Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22. Cancer Res (2010) 0.96
Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. Cancer Epidemiol Biomarkers Prev (2006) 0.96
Modeling folate, one-carbon metabolism, and DNA methylation. Nutr Rev (2008) 0.96
Genome-wide search for gene-gene interactions in colorectal cancer. PLoS One (2012) 0.96
IκBKβ and NFκB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry. Carcinogenesis (2012) 0.95
B vitamin intakes and incidence of colorectal cancer: results from the Women's Health Initiative Observational Study cohort. Am J Clin Nutr (2012) 0.95
Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women. Nutr Res (2010) 0.95
Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps. Carcinogenesis (2007) 0.95
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev (2010) 0.94
Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev (2004) 0.94
DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. Cancer Epidemiol Biomarkers Prev (2005) 0.93
Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. Theor Biol Med Model (2009) 0.93
Homocysteine, cysteine, and risk of incident colorectal cancer in the Women's Health Initiative observational cohort. Am J Clin Nutr (2013) 0.92
COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. Cancer Causes Control (2013) 0.92
Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. Nutr Cancer (2011) 0.92
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. J Nutr (2009) 0.92