Published in Endocrinology on October 21, 2004
Comparison of class A and D G protein-coupled receptors: common features in structure and activation. Biochemistry (2005) 1.05
Novel insights on thyroid-stimulating hormone receptor signal transduction. Endocr Rev (2013) 0.97
Current loss-of-function mutations in the thyrotropin receptor gene: when to investigate, clinical effects, and treatment. J Clin Res Pediatr Endocrinol (2012) 0.92
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. PLoS One (2010) 0.87
An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3. Endocrinology (2007) 0.86
Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy. Curr Pharm Des (2009) 0.84
An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety. J Biol Chem (2014) 0.83
Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy. Graefes Arch Clin Exp Ophthalmol (2013) 0.77
Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor. PLoS One (2015) 0.75
Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain. Biophys J (2016) 0.75
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work. Front Endocrinol (Lausanne) (2017) 0.75
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
The management of thyroid nodules: a retrospective analysis of health insurance data. Dtsch Arztebl Int (2013) 2.97
American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and EuropeanThyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules. Endocr Pract (2010) 2.97
Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43
Pituitary adenoma predisposition caused by germline mutations in the AIP gene. Science (2006) 2.24
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology (2008) 2.03
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun (2002) 1.86
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun (2003) 1.82
Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol (2006) 1.76
General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem (2006) 1.71
Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. J Mol Biol (2004) 1.68
Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes. Diabetes Care (2006) 1.63
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci (2003) 1.46
The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem (2004) 1.42
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). J Biol Chem (2006) 1.38
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33
Molecular pathogenesis of euthyroid and toxic multinodular goiter. Endocr Rev (2004) 1.33
Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. J Clin Endocrinol Metab (2010) 1.24
Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev (2009) 1.24
Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol Cell Endocrinol (2005) 1.20
Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes. Diabetes Care (2003) 1.17
Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. Proc Natl Acad Sci U S A (2007) 1.16
Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab (2005) 1.15
Pancreatic neuroendocrine tumor with ectopic adrenocorticotropin production upon second recurrence. J Clin Endocrinol Metab (2004) 1.14
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem (2004) 1.14
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol (2005) 1.13
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One (2009) 1.12
Hypercalcemia as a result of sarcoidosis with normal serum concentrations of vitamin D. Med Sci Monit (2007) 1.11
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor. J Biol Chem (2006) 1.08
Primary and secondary thyroid hormone transporters. Thyroid Res (2011) 1.07
Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun (2004) 1.07
Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. J Cell Biol (2007) 1.06
Current state and future perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules. J Clin Endocrinol Metab (2011) 1.06
Comparative structural and energetic analysis of WW domain-peptide interactions. J Mol Biol (2004) 1.06
Adiponectin, obesity, and cardiovascular disease. Biochimie (2004) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane. J Biol Chem (2002) 1.04
Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem (2008) 1.03
Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns. Mol Cell Endocrinol (2010) 1.02
Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res (2007) 1.02
Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes. FEBS Lett (2004) 1.00
Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor. J Mol Med (Berl) (2006) 0.98
Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands. Mol Cell Endocrinol (2012) 0.97
Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. J Endocrinol (2005) 0.97
Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors. Nat Clin Pract Endocrinol Metab (2007) 0.97
Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms: role of G protein-coupled receptor kinases, protein kinase C and beta-arrestins. Endocrinology (2007) 0.97
Impact of molecular screening for point mutations and rearrangements in routine air-dried fine-needle aspiration samples of thyroid nodules. Thyroid (2013) 0.97
Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem (2010) 0.97
Ectopic Cushing' syndrome caused by a neuroendocrine carcinoma of the mesentery. BMC Cancer (2006) 0.96
Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource. Mol Endocrinol (2006) 0.96
The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor. J Biol Chem (2009) 0.96
Analysis options for high-throughput sequencing in miRNA expression profiling. BMC Res Notes (2014) 0.96
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. Blood (2013) 0.96
Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor. J Biol Chem (2006) 0.95
Perspectives and limitations of microarray-based gene expression profiling of thyroid tumors. Endocr Rev (2007) 0.95
A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping. Endocr Relat Cancer (2007) 0.95
Research resource: Update and extension of a glycoprotein hormone receptors web application. Mol Endocrinol (2011) 0.95
Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils. J Mol Biol (2005) 0.95
Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. FASEB J (2010) 0.94
The human thyrotropin receptor is predominantly internalized by beta-arrestin 2. Endocrinology (2006) 0.93
Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma. BMC Cancer (2006) 0.93
Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor. FASEB J (2008) 0.93
The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding. FEBS Lett (2005) 0.93
Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey. Eur J Endocrinol (2006) 0.93
Selenium and goiter prevalence in borderline iodine sufficiency. Eur J Endocrinol (2006) 0.93
Evaluation of a computer based interactive diabetes education program designed to train the estimation of the energy or carbohydrate contents of foods. Patient Educ Couns (2002) 0.92
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem (2011) 0.92
Large genomic deletions in AIP in pituitary adenoma predisposition. J Clin Endocrinol Metab (2008) 0.92
The hinge region: an important receptor component for GPHR function. Trends Endocrinol Metab (2009) 0.91
Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice. Biochem Biophys Res Commun (2005) 0.91
GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models. BMC Bioinformatics (2011) 0.91
Is there a place for thyroidectomy in older patients with thyrotoxic storm and cardiorespiratory failure? Thyroid (2003) 0.91
Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans. Eur J Endocrinol (2007) 0.90
On the interaction of Clostridium perfringens enterotoxin with claudins. Toxins (Basel) (2010) 0.90
Perspectives for improved and more accurate classification of thyroid epithelial tumors. J Clin Endocrinol Metab (2008) 0.90
Modulation of TSHR signaling by posttranslational modifications. Trends Endocrinol Metab (2007) 0.89
Functional significance of the thyrotropin receptor germline polymorphism D727E. Biochem Biophys Res Commun (2003) 0.89
Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl (2006) 0.88
A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. Endocrinology (2005) 0.88
Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes. FEBS Lett (2004) 0.88
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl (2013) 0.88
Impaired enteral levothyroxine absorption in hypothyroidism refractory to oral therapy after thyroid ablation for papillary thyroid cancer: case report and kinetic studies. Thyroid (2006) 0.87
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. PLoS One (2010) 0.87
Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules. Thyroid (2005) 0.87