PubRank

Gerd Krause

Author PubWeight™ 75.63‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol 2002 5.02
2 Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J 2007 2.43
3 A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology 2008 2.03
4 General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A 2006 1.72
5 Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem 2006 1.71
6 Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. J Mol Biol 2004 1.68
7 Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A 2009 1.61
8 WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci 2003 1.46
9 The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem 2004 1.42
10 A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). J Biol Chem 2006 1.38
11 Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem 2004 1.33
12 Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev 2009 1.24
13 Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem 2004 1.14
14 Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol 2005 1.13
15 Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 2009 1.12
16 Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem 2009 1.11
17 Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor. J Biol Chem 2006 1.08
18 Primary and secondary thyroid hormone transporters. Thyroid Res 2011 1.07
19 Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. J Cell Biol 2007 1.06
20 Comparative structural and energetic analysis of WW domain-peptide interactions. J Mol Biol 2004 1.06
21 High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J 2006 1.04
22 The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane. J Biol Chem 2002 1.04
23 Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem 2008 1.03
24 Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res 2007 1.02
25 Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor. J Mol Med (Berl) 2006 0.98
26 Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands. Mol Cell Endocrinol 2012 0.97
27 Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem 2010 0.97
28 Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource. Mol Endocrinol 2006 0.96
29 The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor. J Biol Chem 2009 0.96
30 Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor. J Biol Chem 2006 0.95
31 Research resource: Update and extension of a glycoprotein hormone receptors web application. Mol Endocrinol 2011 0.95
32 Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils. J Mol Biol 2005 0.95
33 Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. FASEB J 2010 0.94
34 The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding. FEBS Lett 2005 0.93
35 Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor. FASEB J 2008 0.93
36 Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem 2011 0.92
37 GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models. BMC Bioinformatics 2011 0.91
38 On the interaction of Clostridium perfringens enterotoxin with claudins. Toxins (Basel) 2010 0.90
39 A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. Endocrinology 2005 0.88
40 Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl 2006 0.88
41 Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl 2013 0.88
42 Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. PLoS One 2010 0.87
43 Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments. J Biol Chem 2014 0.86
44 Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. Cell Mol Life Sci 2010 0.86
45 From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs). J Biol Chem 2011 0.86
46 Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB. J Pept Sci 2009 0.86
47 Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1. Regul Pept 2005 0.85
48 Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity. Mol Endocrinol 2002 0.85
49 TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5. J Endocrinol 2005 0.85
50 Structural substrate conditions required for neutral endopeptidase-mediated natriuretic Peptide degradation. J Mol Biol 2009 0.85
51 A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6. J Clin Endocrinol Metab 2010 0.85
52 Functional significance of cleavable signal peptides of G protein-coupled receptors. Eur J Cell Biol 2011 0.85
53 An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors. Hum Mutat 2010 0.84
54 Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor. Endocrinology 2004 0.84
55 Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8). Endocrinology 2013 0.84
56 Defining structural and functional dimensions of the extracellular thyrotropin receptor region. J Biol Chem 2011 0.83
57 A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R. Obes Facts 2008 0.83
58 Using ortholog sequence data to predict the functional relevance of mutations in G-protein-coupled receptors. FASEB J 2012 0.83
59 Domain Interaction Footprint: a multi-classification approach to predict domain-peptide interactions. Bioinformatics 2009 0.83
60 The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. J Struct Funct Genomics 2007 0.82
61 Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists. Biochem Soc Trans 2013 0.82
62 HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo. PLoS One 2008 0.82
63 Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain. ChemMedChem 2011 0.82
64 Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling. PLoS One 2011 0.81
65 Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation. FEBS J 2014 0.81
66 The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization. J Biol Chem 2012 0.80
67 Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor. Hum Reprod Update 2013 0.80
68 Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5. Cell Mol Life Sci 2014 0.79
69 The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology. FEBS Lett 2005 0.77
70 Research resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses. Mol Endocrinol 2013 0.77
71 Determinants contributing to claudin ion channel formation. Ann N Y Acad Sci 2012 0.76
72 Small-molecule inhibitors of AF6 PDZ-mediated protein-protein interactions. ChemMedChem 2014 0.75
73 [Causes of selectivity, activation and inhibition. Molecular mechanisms of endothelin-receptor recognition]. Pharm Unserer Zeit 2010 0.75