On the interaction of Clostridium perfringens enterotoxin with claudins.

PubWeight™: 0.90‹?›

🔗 View Article (PMC 3153257)

Published in Toxins (Basel) on June 08, 2010

Authors

Anna Veshnyakova1, Jonas Protze, Jan Rossa, Ingolf E Blasig, Gerd Krause, Joerg Piontek

Author Affiliations

1: Leibniz-Institut für molekulare Pharmakologie, Robert-Rössle-Str.10, 13125 Berlin, Germany. veshnyakova@fmp-berlin.de

Articles citing this

Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment: Opportunities and Challenges. J Toxicol (2011) 0.92

Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin. MBio (2013) 0.92

Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem (2011) 0.92

Host cell-induced signaling causes Clostridium perfringens to upregulate production of toxins important for intestinal infections. Gut Microbes (2013) 0.87

Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections. Microbes Infect (2012) 0.79

Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79

The interaction of Clostridium perfringens enterotoxin with receptor claudins. Anaerobe (2016) 0.78

Trends in drug delivery through tissue barriers containing tight junctions. Tissue Barriers (2013) 0.78

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin. Sci Rep (2016) 0.77

A synthetic peptide corresponding to the extracellular loop 2 region of claudin-4 protects against Clostridium perfringens enterotoxin in vitro and in vivo. Infect Immun (2014) 0.77

Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin. Pflugers Arch (2016) 0.76

Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens. Toxins (Basel) (2017) 0.75

Transcriptional Profile during Deoxycholate-Induced Sporulation in a Clostridium perfringens Isolate Causing Foodborne Illness. Appl Environ Microbiol (2016) 0.75

Articles cited by this

Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol (1993) 10.65

Structure and function of intercellular junctions. Int Rev Cytol (1974) 8.14

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A (1999) 5.54

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol (2002) 5.51

ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell (2006) 4.61

Tight junction proteins. Prog Biophys Mol Biol (2003) 3.98

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol (2005) 3.05

Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol (1999) 3.02

Virulence genes of Clostridium perfringens. Annu Rev Microbiol (1998) 3.01

Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops. Mol Microbiol (1999) 2.99

Structure and function of claudins. Biochim Biophys Acta (2007) 2.98

Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res (2005) 2.92

Rabbit ileal loop response to strains of Clostridium perfringens. J Bacteriol (1968) 2.80

Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43

Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. J Cell Biol (1997) 2.25

Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli. Infect Immun (1993) 2.05

Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem (1997) 1.91

Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol (2009) 1.91

Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene. Infect Immun (2001) 1.87

Impact of drug transporter studies on drug discovery and development. Pharmacol Rev (2003) 1.83

Crystal structure of the mosquito-larvicidal toxin Cry4Ba and its biological implications. J Mol Biol (2005) 1.75

Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology (2001) 1.75

Clostridium perfringens Type A Food Poisoning II. Response of the Rabbit Ileum as an Indication of Enteropathogenicity of Strains of Clostridium perfringens in Human Beings. Infect Immun (1971) 1.73

Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett (2000) 1.69

Experimental Diarrhoea in human volunteers following oral administration of Clostridium perfringens enterotoxin. J Appl Bacteriol (1977) 1.66

The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus. J Virol (2008) 1.63

Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model. Infect Immun (2006) 1.49

Regulation of heterotypic claudin compatibility. J Biol Chem (2007) 1.48

A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation. EMBO J (2003) 1.45

Clostridium perfringens alpha-toxin: characterization and mode of action. J Biochem (2004) 1.45

Intestinal permeation enhancers. J Pharm Sci (2000) 1.44

The effects of Clostridium perfringens enterotoxin on morphology, viability, and macromolecular synthesis in Vero cells. J Cell Physiol (1979) 1.44

Evidence that an approximately 50-kDa mammalian plasma membrane protein with receptor-like properties mediates the amphiphilicity of specifically bound Clostridium perfringens enterotoxin. J Biol Chem (1994) 1.43

Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev (2006) 1.42

Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells. J Biol Chem (2003) 1.41

Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides. The 30 C-terminal amino acids define a functional binding region. J Biol Chem (1991) 1.40

Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomes. J Biol Chem (2002) 1.36

Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. J Biol Chem (2007) 1.32

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. BMC Cell Biol (2009) 1.32

Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin. Cancer Res (2005) 1.28

Identification of a prepore large-complex stage in the mechanism of action of Clostridium perfringens enterotoxin. Infect Immun (2007) 1.23

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proc Natl Acad Sci U S A (2010) 1.17

Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants. Cell Microbiol (2007) 1.17

Deletion analysis of the Clostridium perfringens enterotoxin. Infect Immun (1997) 1.16

Clostridium perfringens epsilon toxin induces a rapid change of cell membrane permeability to ions and forms channels in artificial lipid bilayers. J Biol Chem (2001) 1.15

A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol Pharmacol (2004) 1.11

Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11

Calcium-independent and dependent steps in action of Clostridium perfringens enterotoxin on HeLa and Vero cells. Biochem Biophys Res Commun (1979) 1.11

The importance of calcium influx, calpain and calmodulin for the activation of CaCo-2 cell death pathways by Clostridium perfringens enterotoxin. Cell Microbiol (2005) 1.11

The complex interactions between Clostridium perfringens enterotoxin and epithelial tight junctions. Toxicon (2001) 1.10

Structural constraints for the binding of short peptides to claudin-4 revealed by surface plasmon resonance. J Biol Chem (2008) 1.09

Clostridium perfringens type A enterotoxin induces tissue damage and fluid accumulation in rabbit ileum. J Diarrhoeal Dis Res (1994) 1.08

The effects of Clostridium perfringens enterotoxin on rat and rabbit ileum: an electron microscopic study. Lab Invest (1978) 1.08

Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules. Cell Mol Life Sci (2010) 1.07

Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer Res (2007) 1.07

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol (2008) 1.05

Identification of a Clostridium perfringens enterotoxin region required for large complex formation and cytotoxicity by random mutagenesis. Infect Immun (1999) 1.05

Molecular construction of Clostridium botulinum type C progenitor toxin and its gene organization. Biochem Biophys Res Commun (1994) 1.05

Comparative biochemical and immunocytochemical studies reveal differences in the effects of Clostridium perfringens enterotoxin on polarized CaCo-2 cells versus Vero cells. J Biol Chem (2001) 1.04

Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE). Cancer (2007) 1.02

Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol (2006) 1.02

Clostridium perfringens epsilon toxin rapidly decreases membrane barrier permeability of polarized MDCK cells. Cell Microbiol (2003) 1.01

Fine mapping of the N-terminal cytotoxicity region of Clostridium perfringens enterotoxin by site-directed mutagenesis. Infect Immun (2004) 1.01

Characterization of a parasporal inclusion body from sporulating, enterotoxin-positive Clostridium perfringens type A. J Bacteriol (1986) 1.00

SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily. Gene (1999) 1.00

Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin. Infect Immun (2009) 0.98

Structure and function of extracellular claudin domains. Ann N Y Acad Sci (2009) 0.97

Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors. Mol Cancer Ther (2009) 0.97

Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4. J Control Release (2005) 0.97

Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane. J Pharm Pharmacol (1996) 0.96

Clostridium perfringens enterotoxin damages the human intestine in vitro. Infect Immun (2005) 0.95

Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin. J Pharmacol Exp Ther (2005) 0.93

Characterization of membrane-associated Clostridium perfringens enterotoxin following pronase treatment. Infect Immun (1998) 0.92

Fluid secretory response of bovine Thiry jejunal fistula to enterotoxin of Clostridium perfringens. Infect Immun (1973) 0.92

Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction. J Biol Chem (2009) 0.91

A novel strategy for a drug delivery system using a claudin modulator. Biol Pharm Bull (2006) 0.90

A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide. Biochem Pharmacol (2010) 0.88

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction. Biochem Pharmacol (2006) 0.87

Claudin proteins in ovarian cancer. Dis Markers (2007) 0.87

Targeted therapy of cancer using diphtheria toxin-derived immunotoxins. Drug Discov Today (2008) 0.82

Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin. Eur J Pharm Biopharm (2010) 0.81

Immunotoxins in the treatment of refractory hairy cell leukemia. Hematol Oncol Clin North Am (2006) 0.78

A strategy for enrichment of claudins based on their affinity to Clostridium perfringens enterotoxin. BMC Mol Biol (2009) 0.78

Articles by these authors

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02

Structure and function of claudins. Biochim Biophys Acta (2007) 2.98

Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43

A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology (2008) 2.03

General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. J Med Chem (2006) 1.71

Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. J Mol Biol (2004) 1.68

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J (2007) 1.63

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61

WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci (2003) 1.46

The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem (2004) 1.42

A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). J Biol Chem (2006) 1.38

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J Biol Chem (2004) 1.33

Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev (2009) 1.24

Serum markers support disease-specific glial pathology in major depression. J Affect Disord (2008) 1.18

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proc Natl Acad Sci U S A (2010) 1.17

Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem (2004) 1.14

Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol (2005) 1.13

Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell Mol Life Sci (2011) 1.12

Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One (2009) 1.12

Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11

Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor. J Biol Chem (2006) 1.08

Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules. Cell Mol Life Sci (2010) 1.07

Primary and secondary thyroid hormone transporters. Thyroid Res (2011) 1.07

Comparative structural and energetic analysis of WW domain-peptide interactions. J Mol Biol (2004) 1.06

Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. J Cell Biol (2007) 1.06

High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04

The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane. J Biol Chem (2002) 1.04

Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reoxygenation. Proteomics (2006) 1.04

Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem (2008) 1.03

Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res (2007) 1.02

S100B is increased in mood disorders and may be reduced by antidepressive treatment. Neuroreport (2002) 0.99

Neuron-specific enolase is unaltered whereas S100B is elevated in serum of patients with schizophrenia--original research and meta-analysis. Psychiatry Res (2009) 0.99

Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor. J Mol Med (Berl) (2006) 0.98

Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands. Mol Cell Endocrinol (2012) 0.97

Uptake and trafficking of liposomes to the endoplasmic reticulum. FASEB J (2010) 0.97

Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem (2010) 0.97

Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource. Mol Endocrinol (2006) 0.96

The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor. J Biol Chem (2009) 0.96

Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor. J Biol Chem (2006) 0.95

Transient opening of the perineurial barrier for analgesic drug delivery. Proc Natl Acad Sci U S A (2012) 0.95

Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. Int J Biochem Cell Biol (2005) 0.95

Research resource: Update and extension of a glycoprotein hormone receptors web application. Mol Endocrinol (2011) 0.95

Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils. J Mol Biol (2005) 0.95

Serum S100B is increased during early treatment with antipsychotics and in deficit schizophrenia. Schizophr Res (2003) 0.95

Visualization and quantitative analysis of reconstituted tight junctions using localization microscopy. PLoS One (2012) 0.94

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. FASEB J (2010) 0.94

Protein markers of ischemic insult in brain endothelial cells identified using 2D gel electrophoresis and ICAT-based quantitative proteomics. J Proteome Res (2007) 0.94

Mood disorders are glial disorders: evidence from in vivo studies. Cardiovasc Psychiatry Neurol (2010) 0.93

Redox-sensitivity of the dimerization of occludin. Cell Mol Life Sci (2009) 0.93

Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor. FASEB J (2008) 0.93

The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding. FEBS Lett (2005) 0.93

The oligomerization of the coiled coil-domain of occludin is redox sensitive. Ann N Y Acad Sci (2009) 0.93

Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem (2011) 0.92

GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models. BMC Bioinformatics (2011) 0.91

New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients. J Proteome Res (2011) 0.90

Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase. Free Radic Biol Med (2006) 0.90

Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study. PLoS One (2012) 0.88

Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl (2006) 0.88

A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. Endocrinology (2005) 0.88

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl (2013) 0.88

Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. PLoS One (2010) 0.87

Protective effects of peroxiredoxin-1 at the injured blood-brain barrier. Free Radic Biol Med (2008) 0.87

Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments. J Biol Chem (2014) 0.86

CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity. Cell Commun Signal (2013) 0.86

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. Cell Mol Life Sci (2010) 0.86

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs). J Biol Chem (2011) 0.86

Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB. J Pept Sci (2009) 0.86

Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1. Regul Pept (2005) 0.85

Functional significance of cleavable signal peptides of G protein-coupled receptors. Eur J Cell Biol (2011) 0.85

Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity. Mol Endocrinol (2002) 0.85

TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5. J Endocrinol (2005) 0.85

Structural substrate conditions required for neutral endopeptidase-mediated natriuretic Peptide degradation. J Mol Biol (2009) 0.85

A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6. J Clin Endocrinol Metab (2010) 0.85

An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors. Hum Mutat (2010) 0.84

Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor. Endocrinology (2004) 0.84

Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8). Endocrinology (2013) 0.84

A peptidomimetic tight junction modulator to improve regional analgesia. Mol Pharm (2012) 0.84

Domain Interaction Footprint: a multi-classification approach to predict domain-peptide interactions. Bioinformatics (2009) 0.83

Using ortholog sequence data to predict the functional relevance of mutations in G-protein-coupled receptors. FASEB J (2012) 0.83

Substrate pathways and mechanisms of inhibition in the sulfur oxygenase reductase of acidianus ambivalens. Front Microbiol (2011) 0.83

Defining structural and functional dimensions of the extracellular thyrotropin receptor region. J Biol Chem (2011) 0.83

Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell Mol Life Sci (2010) 0.83

A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R. Obes Facts (2008) 0.83

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. J Struct Funct Genomics (2007) 0.82

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists. Biochem Soc Trans (2013) 0.82

Protein delivery of caspase-3 induces cell death in malignant C6 glioma, primary astrocytes and immortalized and primary brain capillary endothelial cells. J Neurooncol (2005) 0.82

HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo. PLoS One (2008) 0.82

Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain. ChemMedChem (2011) 0.82

Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling. PLoS One (2011) 0.81

The hinge region of the scaffolding protein of cell contacts, zonula occludens protein 1, regulates interacting with various signaling proteins. J Cell Biochem (2012) 0.81

Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation. FEBS J (2014) 0.81

Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor. Hum Reprod Update (2013) 0.80

The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization. J Biol Chem (2012) 0.80