Published in Biochemistry on November 09, 2004
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase. PLoS Pathog (2005) 1.20
A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis. Proc Natl Acad Sci U S A (2005) 1.20
Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus. J Exp Med (2005) 1.04
A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. J Biol Chem (2007) 1.01
Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases. J Biol Chem (2013) 0.91
Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype. J Bacteriol (2005) 0.90
Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases. Biochim Biophys Acta (2013) 0.87
High resolution structure of an M23 peptidase with a substrate analogue. Sci Rep (2015) 0.82
The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes. BMC Microbiol (2012) 0.76
Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. J Biol Chem (2014) 0.75
New method for typing Staphylococcus aureus strains: multiple-locus variable-number tandem repeat analysis of polymorphism and genetic relationships of clinical isolates. J Clin Microbiol (2003) 2.96
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum (2010) 2.53
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother (2004) 2.34
Comparison of multiple-locus variable-number tandem-repeat analysis with pulsed-field gel electrophoresis, spa typing, and multilocus sequence typing for clonal characterization of Staphylococcus aureus isolates. J Clin Microbiol (2005) 2.16
A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. PLoS One (2008) 2.12
Molecular machines for protein degradation. Chembiochem (2005) 1.81
The role and regulation of the extracellular proteases of Staphylococcus aureus. Microbiology (2004) 1.70
Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000 (2010) 1.65
Latent LytM at 1.3A resolution. J Mol Biol (2004) 1.64
Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence. Nucleic Acids Res (2007) 1.60
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria? J Bacteriol (2006) 1.56
Crystal structures of active LytM. J Mol Biol (2005) 1.52
Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J Immunol (2007) 1.50
Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD). Hum Mutat (2010) 1.49
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proc Natl Acad Sci U S A (2005) 1.47
Role of rubrerythrin in the oxidative stress response of Porphyromonas gingivalis. Mol Microbiol (2002) 1.42
Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One (2009) 1.41
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog (2006) 1.35
Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem (2003) 1.27
On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator. J Biol Chem (2004) 1.25
Folds and activities of peptidoglycan amidases. FEMS Microbiol Rev (2007) 1.22
Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog (2013) 1.22
Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells. Infect Immun (2005) 1.21
The biphasic virulence activities of gingipains: activation and inactivation of host proteins. Curr Protein Pept Sci (2003) 1.21
The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep (2014) 1.20
Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses. PLoS One (2008) 1.19
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis (2013) 1.18
Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases. Mol Microbiol (2003) 1.17
Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus. J Bacteriol (2006) 1.17
Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73. Cell Cycle (2010) 1.17
Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis. J Periodontol (2011) 1.17
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PLoS Pathog (2009) 1.16
Crystal structure of a fragment of mouse ubiquitin-activating enzyme. J Biol Chem (2005) 1.16
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15
High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism. J Innate Immun (2008) 1.15
Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis. J Immunol (2008) 1.14
Crystal structure of the beta beta alpha-Me type II restriction endonuclease Hpy99I with target DNA. Nucleic Acids Res (2009) 1.13
NsaRS is a cell-envelope-stress-sensing two-component system of Staphylococcus aureus. Microbiology (2011) 1.13
Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun (2002) 1.12
Pseudomonas aeruginosa LD-carboxypeptidase, a serine peptidase with a Ser-His-Glu triad and a nucleophilic elbow. J Biol Chem (2005) 1.11
A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes. J Innate Immun (2008) 1.10
Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis. Microbiology (2009) 1.09
Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY). Proc Natl Acad Sci U S A (2002) 1.08
A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037. Biol Chem (2010) 1.08
Porphyromonas gingivalis HmuY and HmuR: further characterization of a novel mechanism of heme utilization. Arch Microbiol (2007) 1.08
A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system. J Immunol (2012) 1.07
Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance. J Biol Chem (2003) 1.07
Central base pair flipping and discrimination by PspGI. Nucleic Acids Res (2008) 1.04
Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus. J Exp Med (2005) 1.04
Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis. Infect Immun (2006) 1.03
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther (2010) 1.03
DIBER: protein, DNA or both? Acta Crystallogr D Biol Crystallogr (2010) 1.02
Staphylococcal proteases aid in evasion of the human complement system. J Innate Immun (2013) 1.02
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production. Infect Immun (2002) 1.02
A new autocatalytic activation mechanism for cysteine proteases revealed by Prevotella intermedia interpain A. J Biol Chem (2007) 1.01
Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis. Infect Immun (2005) 1.01
Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. J Immunol (2007) 1.01
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB). J Biol Chem (2013) 1.01
Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA. J Mol Biol (2007) 1.00
Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism. BMC Microbiol (2009) 1.00
Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus. Microbes Infect (2012) 0.99
The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease. J Biol Chem (2003) 0.99
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem (2004) 0.99
Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis. PLoS Pathog (2009) 0.98
Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically. Nucleic Acids Res (2007) 0.98
Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages. Biol Chem (2009) 0.97
Papain-like proteases of Staphylococcus aureus. Adv Exp Med Biol (2011) 0.96
Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin. Arch Biochem Biophys (2007) 0.96
The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities. Mol Microbiol (2004) 0.96
The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases. Mol Microbiol (2010) 0.95
Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. J Immunol (2011) 0.95
The Clostridium ramosum IgA proteinase represents a novel type of metalloendopeptidase. J Biol Chem (2002) 0.95
Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI. Nucleic Acids Res (2012) 0.95
Functional and structural characterization of Spl proteases from Staphylococcus aureus. J Mol Biol (2006) 0.95
Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin. Biochem J (2009) 0.95
Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis. Mol Microbiol (2013) 0.94
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis. J Immunol (2009) 0.94
HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis. PLoS One (2011) 0.94
Protease-dependent mechanisms of complement evasion by bacterial pathogens. Biol Chem (2012) 0.94
The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition. Adv Exp Med Biol (2011) 0.93
Proteolytic inactivation of LL-37 by karilysin, a novel virulence mechanism of Tannerella forsythia. J Innate Immun (2010) 0.93
Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus. Microbiology (2010) 0.93
Proteinase-mediated release of epithelial cell-associated CD44. Extracellular CD44 complexes with components of cellular matrices. J Biol Chem (2002) 0.92
Molecular diversity of a putative virulence factor: purification and characterization of isoforms of an extracellular serine glutamyl endopeptidase of Enterococcus faecalis with different enzymatic activities. J Bacteriol (2005) 0.92
Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage. Biol Chem (2009) 0.92
Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis. FASEB J (2011) 0.91
Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases. J Biol Chem (2013) 0.91
Genome Sequence of Porphyromonas gingivalis Strain HG66 (DSM 28984). Genome Announc (2014) 0.91
Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis. Anal Biochem (2011) 0.91
Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis. Nucleic Acids Res (2010) 0.90
Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype. J Bacteriol (2005) 0.90
Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage. Infect Immun (2012) 0.90
Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis. Biol Chem (2008) 0.90
Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms. Infect Immun (2010) 0.90
Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans. FEBS J (2014) 0.90
The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin. Biochem J (2008) 0.90