Published in J Clin Invest on November 01, 2004
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Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66
A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev (2007) 1.39
Differential p53 engagement in response to oxidative and oncogenic stresses in Fanconi anemia mice. Cancer Res (2008) 1.07
Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood (2010) 1.04
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Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration. Arthritis Res Ther (2008) 1.00
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Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span. Aging Cell (2017) 0.75
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A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
Ink4a/Arf expression is a biomarker of aging. J Clin Invest (2004) 8.30
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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol (2004) 4.87
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Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp Cell Res (2000) 1.95
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev (2004) 1.84
Telomeres, aging and cancer: in search of a happy ending. Oncogene (2002) 1.69
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev (2002) 1.65
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Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell (2002) 1.44
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Caloric restriction in primates. Ann N Y Acad Sci (2001) 1.33
Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol Cell Biol (2004) 1.25
p16(INK4a) and the control of cellular proliferative life span. Carcinogenesis (1999) 1.08
Activation of the DNA damage response by telomere attrition: a passage to cellular senescence. Cell Cycle (2004) 0.94
Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology (2007) 26.78
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A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell (2012) 3.21
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J (2002) 2.96
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med (2007) 2.41
DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell (2007) 1.96
Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. J Natl Cancer Inst (2014) 1.96
Telomerase gene mutations are associated with cirrhosis formation. Hepatology (2011) 1.67
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65
Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. Gastroenterology (2012) 1.63
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell (2012) 1.61
The role of telomeres in stem cells and cancer. Cell (2013) 1.50
Aging in the lympho-hematopoietic stem cell compartment. Trends Immunol (2009) 1.47
Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction. Hypertension (2010) 1.39
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet (2009) 1.33
Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology (2004) 1.19
Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) (2010) 1.17
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo. EMBO Rep (2005) 1.16
Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci U S A (2004) 1.14
Telomeres and telomerase: a dual role in hepatocarcinogenesis. Hepatology (2004) 1.10
Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use? Exp Gerontol (2008) 1.08
Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology (2007) 1.08
A dual role of p21 in stem cell aging. Ann N Y Acad Sci (2007) 1.05
Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology (2005) 1.04
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol (2011) 1.02
Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice. Blood (2009) 1.02
Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma. Hepatology (2005) 0.98
ROS induced DNA damage and checkpoint responses: influences on aging? Cell Cycle (2010) 0.95
Immunoaging induced by hematopoietic stem cell aging. Curr Opin Immunol (2011) 0.95
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis. J Clin Invest (2012) 0.95
Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma. J Hepatol (2004) 0.94
Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice. Cell Cycle (2004) 0.91
Telomere shortening in leukocyte subpopulations in depression. BMC Psychiatry (2014) 0.91
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Ann Neurol (2014) 0.90
The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems. Ann N Y Acad Sci (2012) 0.90
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Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy. J Gastroenterol Hepatol (2005) 0.87
Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice. J Tissue Eng Regen Med (2011) 0.87
Merging models of hepatitis C virus pathogenesis. Semin Liver Dis (2005) 0.85
Are aging biomarkers clinically relevant in oncogeriatrics? Crit Rev Oncol Hematol (2012) 0.85
Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function. Aging Cell (2012) 0.84
Keeping your senescent cells under control. Aging (Albany NY) (2009) 0.83
Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice. Aging (Albany NY) (2009) 0.83
Telomeres, telomerase and cancer: an endless search to target the ends. Cell Cycle (2004) 0.81
Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers. J Proteomics (2013) 0.79
Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status. Exp Gerontol (2008) 0.79
Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion. Neuroreport (2014) 0.78
Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin. Exp Hematol (2008) 0.78
CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells. EMBO Rep (2010) 0.76
[[Cancer and aging--biological mechanisms]. Onkologie (2009) 0.75
The GAPs between hepatocellular carcinoma and RAS. J Hepatol (2010) 0.75
Lineage-specific pleiotropy in immune aging. Blood (2011) 0.75
Improve organ health by chewing up old proteins? Hepatology (2009) 0.75
Telomere stability--Wnt it or lose it. EMBO Rep (2013) 0.75
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage. Cell (2014) 0.75
Telomere shortening is associated with reduced duodenal HCOFormula secretory but normal gastric acid secretory capacity in aging mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.75
Telomere structural dynamics in genome integrity control and carcinogenesis. Adv Exp Med Biol (2005) 0.75