Published in Crit Rev Oncol Hematol on September 02, 2012
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Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat Cell Biol (2002) 3.16
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J (2002) 2.96
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med (2007) 2.41
DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell (2007) 1.96
Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. J Natl Cancer Inst (2014) 1.96
The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr Biol (2006) 1.95
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep (2002) 1.79
Telomerase gene mutations are associated with cirrhosis formation. Hepatology (2011) 1.67
A topological mechanism for TRF2-enhanced strand invasion. Nat Struct Mol Biol (2007) 1.65
RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet (2003) 1.65
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65
Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. Gastroenterology (2012) 1.63
CST meets shelterin to keep telomeres in check. Mol Cell (2010) 1.63
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell (2012) 1.61
Telomeric position effect: from the yeast paradigm to human pathologies? Biochimie (2007) 1.57
A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol (2009) 1.51
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell (2010) 1.50
The role of telomeres in stem cells and cancer. Cell (2013) 1.50
Aging in the lympho-hematopoietic stem cell compartment. Trends Immunol (2009) 1.47
TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J (2009) 1.42
General regulatory factors (GRFs) as genome partitioners. J Biol Chem (2002) 1.39
Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction. Hypertension (2010) 1.39
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest (2007) 1.39
The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. J Biol Chem (2005) 1.37
The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. PLoS Genet (2009) 1.37
The DNA damage response at eroded telomeres and tethering to the nuclear pore complex. Nat Cell Biol (2009) 1.36
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet (2009) 1.33
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J (2010) 1.32
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway. Nucleic Acids Res (2009) 1.29
Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Blood (2007) 1.28
Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. Cell Res (2011) 1.25
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms. EMBO J (2003) 1.21
Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology (2004) 1.19
Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) (2010) 1.17
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo. EMBO Rep (2005) 1.16
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J (2008) 1.15
Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci U S A (2004) 1.14
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol (2013) 1.12
Insulator dynamics and the setting of chromatin domains. Bioessays (2004) 1.11
Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF. EMBO J (2009) 1.11
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
Subtelomeric proteins negatively regulate telomere elongation in budding yeast. EMBO J (2006) 1.11
Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells. Cancer Res (2009) 1.11
Telomeres and telomerase: a dual role in hepatocarcinogenesis. Hepatology (2004) 1.10
Protosilencers as building blocks for heterochromatin. Bioessays (2002) 1.09
Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use? Exp Gerontol (2008) 1.08
Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology (2007) 1.08
A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells. Nucleic Acids Res (2009) 1.07
Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet (2010) 1.06
The vertebrate protein CTCF functions as an insulator in Saccharomyces cerevisiae. Nucleic Acids Res (2002) 1.05
A dual role of p21 in stem cell aging. Ann N Y Acad Sci (2007) 1.05
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells. Eur J Cancer (2006) 1.04
The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA. Nucleic Acids Res (2011) 1.04
Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology (2005) 1.04
p16 and ARF: activation of teenage proteins in old age. J Clin Invest (2004) 1.04
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol (2011) 1.02
Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice. Blood (2009) 1.02
Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation. EMBO J (2006) 1.00
CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation. J Biol Chem (2010) 1.00
Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Clin Cancer Res (2003) 0.98
Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma. Hepatology (2005) 0.98
Telomeric RNA enters the game. Nat Cell Biol (2008) 0.97
Chromatin domain boundaries delimited by a histone-binding protein in yeast. J Biol Chem (2004) 0.97
G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors. Clin Cancer Res (2008) 0.97
The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation. Nat Struct Mol Biol (2006) 0.97
ROS induced DNA damage and checkpoint responses: influences on aging? Cell Cycle (2010) 0.95
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Rep (2013) 0.95
Biology of cancer and aging: a complex association with cellular senescence. J Clin Oncol (2014) 0.95
Immunoaging induced by hematopoietic stem cell aging. Curr Opin Immunol (2011) 0.95
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis. J Clin Invest (2012) 0.95
Structural identity of telomeric complexes. FEBS Lett (2010) 0.94
Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma. J Hepatol (2004) 0.94
D4Z4 as a prototype of CTCF and lamins-dependent insulator in human cells. Nucleus (2011) 0.93
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Blood (2011) 0.92
One identity or more for telomeres? Front Oncol (2013) 0.91
Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice. Cell Cycle (2004) 0.91
Telomere shortening in leukocyte subpopulations in depression. BMC Psychiatry (2014) 0.91
The telomerase cycle: normal and pathological aspects. J Mol Med (Berl) (2005) 0.90
Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis. Nucleic Acids Res (2013) 0.90
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Ann Neurol (2014) 0.90
A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast. Mol Cell Biol (2003) 0.90
The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems. Ann N Y Acad Sci (2012) 0.90
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle (2014) 0.89
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner. PLoS One (2012) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Global analysis of DNA methylation and transcription of human repetitive sequences. Epigenetics (2009) 0.89
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents. Clin Cancer Res (2011) 0.88
Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy. J Gastroenterol Hepatol (2005) 0.87
Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice. J Tissue Eng Regen Med (2011) 0.87
RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts. EMBO J (2012) 0.86
Merging models of hepatitis C virus pathogenesis. Semin Liver Dis (2005) 0.85
Dynamics of telomeric chromatin at the crossroads of aging and cancer. Essays Biochem (2010) 0.84
Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias. Exp Hematol (2010) 0.84