Published in Curr Biol on November 09, 2004
Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Dev Biol (2005) 2.45
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat Neurosci (2010) 1.92
Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Dev Biol (2010) 1.60
Mechanosensation. WormBook (2006) 1.49
The cell biology of touch. J Cell Biol (2010) 1.45
Touch sensitivity in Caenorhabditis elegans. Pflugers Arch (2007) 1.38
Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway. Proc Natl Acad Sci U S A (2011) 1.25
The multipurpose 15-protofilament microtubules in C. elegans have specific roles in mechanosensation. Curr Biol (2009) 1.18
Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch. Nat Commun (2014) 1.12
The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons. J Neurosci (2011) 1.10
Signaling from the podocyte intercellular junction to the actin cytoskeleton. Semin Nephrol (2012) 1.07
MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity. J Gen Physiol (2008) 1.04
Stiffened lipid platforms at molecular force foci. Proc Natl Acad Sci U S A (2013) 0.97
Fusion and fission, the evolution of sterol carrier protein-2. J Mol Evol (2006) 0.97
Neurosensory mechanotransduction through acid-sensing ion channels. J Cell Mol Med (2013) 0.97
Shared gene expression in distinct neurons expressing common selector genes. Proc Natl Acad Sci U S A (2011) 0.96
Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. Open Biol (2012) 0.95
The genetic architecture of degenerin/epithelial sodium channels in Drosophila. G3 (Bethesda) (2013) 0.94
Schistosoma mansoni Stomatin like protein-2 is located in the tegument and induces partial protection against challenge infection. PLoS Negl Trop Dis (2010) 0.94
Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation. Cell Rep (2014) 0.93
The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites. Elife (2014) 0.93
Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans. Nat Methods (2010) 0.93
Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity. J Physiol (2013) 0.92
Modulation of T cell activation by stomatin-like protein 2. J Immunol (2008) 0.91
Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes. J Biol Chem (2009) 0.91
mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development. Genetics (2009) 0.90
Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Adv Genet (2011) 0.88
Sensory mechanotransduction at membrane-matrix interfaces. Pflugers Arch (2014) 0.87
Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2015) 0.85
Primary processes in sensory cells: current advances. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2008) 0.81
Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons. Nat Commun (2015) 0.81
Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Mol Biol Cell (2016) 0.80
Assaying mechanosensation. WormBook (2014) 0.80
A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin. J Biol Chem (2014) 0.79
The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet (2012) 0.79
NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels. J Biol Chem (2014) 0.78
A Proteomics Approach Highlights a Myriad of Transporters in the Arabidopsis thaliana Vacuolar Membrane. Plant Signal Behav (2007) 0.77
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet (2016) 0.76
Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels. Am J Physiol Cell Physiol (2016) 0.75
Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference. G3 (Bethesda) (2015) 0.75
The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ. PLoS One (2012) 0.75
Forces applied during classical touch assays for Caenorhabditis elegans. PLoS One (2017) 0.75
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science (2007) 8.07
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell (2011) 6.23
The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat Neurosci (2004) 4.52
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet (2009) 3.59
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. Development (2011) 2.99
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66
Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods (2010) 2.50
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J Neurosci (2005) 2.50
Virtual histology of transgenic mouse embryos for high-throughput phenotyping. PLoS Genet (2006) 2.45
Identification of genes expressed in C. elegans touch receptor neurons. Nature (2002) 2.39
Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J (2009) 2.31
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature (2002) 2.27
Eukaryotic mechanosensitive channels. Annu Rev Biophys (2010) 2.23
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci U S A (2008) 2.09
Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell (2010) 2.03
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Nature (2002) 2.00
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J Neurosci (2006) 1.98
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell (2011) 1.96
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (2013) 1.85
Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization. Curr Biol (2012) 1.83
Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A (2014) 1.79
Combinatorial marking of cells and organelles with reconstituted fluorescent proteins. Cell (2004) 1.73
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72
Genetics of sensory mechanotransduction. Annu Rev Genet (2002) 1.72
WormBook: the online review of Caenorhabditis elegans biology. Nucleic Acids Res (2006) 1.71
Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors. Mol Imaging (2005) 1.65
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain (2008) 1.61
Targeted cell killing by reconstituted caspases. Proc Natl Acad Sci U S A (2007) 1.61
NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest (2013) 1.60
Overcoming autopsy barriers in pediatric cancer research. Pediatr Blood Cancer (2012) 1.47
Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells. Mol Cell Biol (2012) 1.47
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Hum Mol Genet (2004) 1.42
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Touch sensitivity in Caenorhabditis elegans. Pflugers Arch (2007) 1.38
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res (2009) 1.37
Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion. Mol Biol Cell (2009) 1.34
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. Dis Model Mech (2010) 1.33
Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biol (2006) 1.32
Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Neuron (2004) 1.32
Generation of stable transgenic C. elegans using microinjection. J Vis Exp (2008) 1.29
Lysosomal impairment in Parkinson's disease. Mov Disord (2013) 1.27
Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway. Proc Natl Acad Sci U S A (2011) 1.25
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum Mol Genet (2011) 1.21
Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci (2003) 1.21
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol (2009) 1.19
The multipurpose 15-protofilament microtubules in C. elegans have specific roles in mechanosensation. Curr Biol (2009) 1.18
TorsinA participates in endoplasmic reticulum-associated degradation. Nat Commun (2011) 1.18
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity. Hum Mol Genet (2012) 1.15
Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain. Nat Struct Mol Biol (2013) 1.14
The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Hum Mol Genet (2010) 1.13
BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev Biol (2009) 1.11
Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med (2014) 1.10
The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons. J Neurosci (2011) 1.10
Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Mol Cancer Ther (2011) 1.07
Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. J Neurochem (2010) 1.07
Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria. PLoS One (2010) 1.06
Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the Children's Oncology Group. Pediatr Blood Cancer (2006) 1.06
Modulation of C. elegans touch sensitivity is integrated at multiple levels. J Neurosci (2014) 1.05
A new approach for prediction of tumor sensitivity to targeted drugs based on functional data. BMC Bioinformatics (2013) 1.05
Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression. Proc Natl Acad Sci U S A (2011) 1.04
MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells. Stem Cells (2011) 1.04
Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem (2011) 1.04
Pax7 expressing cells contribute to dermal wound repair, regulating scar size through a β-catenin mediated process. Stem Cells (2011) 1.03
Images in cardiovascular medicine: Microscopic computed tomography-based virtual histology for visualization and morphometry of atherosclerosis in diabetic apolipoprotein e mutant mice. Circulation (2009) 1.03
Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet (2009) 1.02
miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal (2013) 1.02
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro. Cell Stress Chaperones (2010) 1.01
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis (2009) 1.00
Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol Cancer Ther (2010) 1.00
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neurosci Lett (2008) 0.99
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Dev Dyn (2010) 0.99
The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3. Development (2003) 0.99
A Postnatal Pax7 Progenitor Gives Rise to Pituitary Adenomas. Genes Cancer (2010) 0.99
A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans. Genes Dev (2013) 0.97
Shared gene expression in distinct neurons expressing common selector genes. Proc Natl Acad Sci U S A (2011) 0.96
Rb1 gene inactivation expands satellite cell and postnatal myoblast pools. J Biol Chem (2011) 0.96
Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes. J Vis Exp (2008) 0.95
Near-infrared imaging of injured tissue in living subjects using IR-820. Mol Imaging (2009) 0.95
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res (2006) 0.95
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration. PLoS One (2009) 0.95
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. PLoS Genet (2013) 0.94
Mechanosensation in Caenorhabditis elegans. Int Rev Neurobiol (2006) 0.93
IGF-1 receptor inhibition by picropodophyllin in medulloblastoma. Biochem Biophys Res Commun (2010) 0.93
Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans. Nat Methods (2010) 0.93
Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells. Dev Biol (2013) 0.93
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. J Neurosci (2012) 0.92
High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. Cancer Epidemiol Biomarkers Prev (2004) 0.92
Functional evaluation of therapeutic response for a mouse model of medulloblastoma. Transgenic Res (2010) 0.92
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med (2015) 0.91
Low-grade myofibrosarcoma of the head and neck: importance of surgical therapy. J Pediatr Hematol Oncol (2004) 0.91
IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clin Cancer Res (2011) 0.91
Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces. Proc Natl Acad Sci U S A (2014) 0.90