Modulation of T cell activation by stomatin-like protein 2.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 2913160)

Published in J Immunol on August 01, 2008

Authors

Mark G Kirchhof1, Luan A Chau, Caitlin D Lemke, Santosh Vardhana, Peter J Darlington, Maria E Márquez, Roy Taylor, Kamilia Rizkalla, Isaac Blanca, Michael L Dustin, Joaquín Madrenas

Author Affiliations

1: FOCIS Centre for Clinical Immunology and Immunotherapeutics, Robarts Research Institute, and Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.

Articles citing this

Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. Mol Cell Biol (2011) 1.10

A robust method for quantitative high-throughput analysis of proteomes by 18O labeling. Mol Cell Proteomics (2010) 1.03

Schistosoma mansoni Stomatin like protein-2 is located in the tegument and induces partial protection against challenge infection. PLoS Negl Trop Dis (2010) 0.94

Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation. PLoS One (2012) 0.89

Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates. Parasitol Res (2010) 0.89

Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes. J Biol Chem (2011) 0.89

Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Mol Cell Biol (2015) 0.82

Caveolin-1 Promotes the Imbalance of Th17/Treg in Patients with Chronic Obstructive Pulmonary Disease. Inflammation (2016) 0.76

Identification of STOML2 as a putative novel asthma risk gene associated with IL6R. Allergy (2016) 0.75

Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling. Mol Cell Proteomics (2015) 0.75

The plasma membrane as a capacitor for energy and metabolism. Am J Physiol Cell Physiol (2015) 0.75

Proteomics identifies differentially expressed proteins in neonatal murine thymus compared with adults. Proteome Sci (2012) 0.75

Stomatin-like protein 2 deficiency results in impaired mitochondrial translation. PLoS One (2017) 0.75

Articles cited by this

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell (2003) 6.77

Mitochondria: more than just a powerhouse. Curr Biol (2006) 6.76

The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity (1998) 4.56

T cell receptor signaling precedes immunological synapse formation. Science (2002) 4.56

Altered TCR signaling from geometrically repatterned immunological synapses. Science (2005) 3.94

T cell fitness determined by signal strength. Nat Immunol (2003) 3.65

Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol (2007) 3.19

The SPFH domain-containing proteins: more than lipid raft markers. Trends Cell Biol (2007) 2.49

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol (2005) 2.41

Identification of genes expressed in C. elegans touch receptor neurons. Nature (2002) 2.39

MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature (2002) 2.27

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16

Orchestration of lymphocyte chemotaxis by mitochondrial dynamics. J Exp Med (2006) 2.10

A stomatin-domain protein essential for touch sensation in the mouse. Nature (2006) 2.08

T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A (2007) 2.06

Scaffolding microdomains and beyond: the function of reggie/flotillin proteins. Cell Mol Life Sci (2005) 2.01

Flotillins and the PHB domain protein family: rafts, worms and anaesthetics. Traffic (2005) 2.01

A stomatin-like protein necessary for mechanosensation in C. elegans. Nature (1995) 2.00

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Nature (2002) 2.00

The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. Trends Biochem Sci (1999) 1.97

Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem (2003) 1.86

Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. Blood (2001) 1.81

Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins. Nat Rev Immunol (2007) 1.72

Stop and go traffic to tune T cell responses. Immunity (2004) 1.71

Immunological synapses are versatile structures enabling selective T cell polarization. Immunity (2005) 1.65

Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr Opin Immunol (2006) 1.49

Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc Natl Acad Sci U S A (2003) 1.48

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Curr Biol (2004) 1.47

From synapses to immunological memory: the role of sustained T cell stimulation. Curr Opin Immunol (2000) 1.46

Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2. J Biol Chem (2006) 1.36

PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction. FASEB J (2004) 1.28

Identification of a stomatin orthologue in vacuoles induced in human erythrocytes by malaria parasites. A role for microbial raft proteins in apicomplexan vacuole biogenesis. J Biol Chem (2003) 1.27

Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity (2006) 1.26

Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J Exp Med (2002) 1.24

T-cell-receptor-dependent actin regulatory mechanisms. J Cell Sci (2007) 1.20

Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma. Clin Cancer Res (2006) 1.19

The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem (2005) 1.18

Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues. J Biol Chem (2000) 1.18

Molecular interactions at the T cell-antigen-presenting cell interface. Curr Opin Immunol (2004) 1.15

Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes. Blood (1992) 1.15

LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. Bioessays (2004) 1.13

The distal pole complex: a novel membrane domain distal to the immunological synapse. Immunol Rev (2002) 1.12

Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Proteomics (2006) 1.12

Merging complexes: properties of membrane raft assembly during lymphocyte signaling. Trends Immunol (2005) 1.09

Unc-1: a stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 1.06

Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry. Electrophoresis (2004) 1.06

Stomatin: a putative cation transport regulator in the red cell membrane. Biochim Biophys Acta (1993) 1.05

Proteomic analysis of isolated membrane fractions from superinvasive cancer cells. Biochim Biophys Acta (2006) 1.03

Eukaryotic and prokaryotic stomatins: the proteolytic link. Blood Cells Mol Dis (2004) 1.02

The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation. Clin Immunol (2003) 1.00

High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival. Am J Clin Pathol (2007) 0.98

Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24. Gene (1998) 0.97

The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol (2000) 0.96

Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma. Oncol Rep (2007) 0.93

Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray. Hum Pathol (2007) 0.92

Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation. Mol Cell Biol (2001) 0.92

Structure, organization, and expression of the human band 7.2b gene, a candidate gene for hereditary hydrocytosis. J Biol Chem (1995) 0.89

A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1. Cytogenet Cell Genet (2001) 0.87

Regulation of T-cell activation by phosphodiesterase 4B2 requires its dynamic redistribution during immunological synapse formation. Mol Cell Biol (2003) 0.85

Articles by these authors

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease. BMJ (2008) 7.47

Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol (2005) 6.48

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med (2005) 5.55

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49

The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (2011) 4.76

T cell receptor signaling precedes immunological synapse formation. Science (2002) 4.56

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01

Altered TCR signaling from geometrically repatterned immunological synapses. Science (2005) 3.94

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57

Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (2010) 3.31

Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol (2006) 3.31

Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell (2008) 3.29

Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol (2001) 3.24

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13

Modernising medical careers, medical training application service, and the postgraduate medical education and training board: time for the emperors to don their clothes. Lancet (2007) 3.12

Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A (2007) 3.11

Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol (2005) 2.89

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature (2008) 2.87

A molecular perspective of CTLA-4 function. Annu Rev Immunol (2006) 2.71

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol (2008) 2.61

LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity (2004) 2.47

Development and migration of plasma cells in the mouse lymph node. Immunity (2010) 2.44

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity (2008) 2.42

Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut (2011) 2.38

Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity (2007) 2.19

T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol (2009) 2.17

What is the importance of the immunological synapse? Trends Immunol (2004) 2.02

Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity (2009) 1.98

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med (2011) 1.97

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol (2010) 1.97

Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol (2013) 1.96

Supported planar bilayers in studies on immune cell adhesion and communication. J Immunol Methods (2003) 1.95

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature (2009) 1.94

T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation. Biophys J (2008) 1.92

Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol (2007) 1.90

Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol (2011) 1.89

Lateral membrane waves constitute a universal dynamic pattern of motile cells. Phys Rev Lett (2006) 1.85

Identification of transcriptional regulators in the mouse immune system. Nat Immunol (2013) 1.79

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78

Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity (2009) 1.74

Cytotoxic T lymphocytes form an antigen-independent ring junction. J Clin Invest (2004) 1.72

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol (2007) 1.72

Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology. Hepatology (2008) 1.72

Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. J Hepatol (2012) 1.70

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proc Natl Acad Sci U S A (2011) 1.61

The transcriptional landscape of αβ T cell differentiation. Nat Immunol (2013) 1.61

Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A (2006) 1.58

Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol (2010) 1.58

Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity (2010) 1.56

ICAM-1 co-stimulates target cells to facilitate antigen presentation. Curr Opin Immunol (2005) 1.55

Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest (2012) 1.55

Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proc Natl Acad Sci U S A (2008) 1.55

The critical role of agrin in the hematopoietic stem cell niche. Blood (2011) 1.54

Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (2005) 1.51

Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity (2002) 1.50

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med (2013) 1.48

Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol (2007) 1.48

The immunological synapse: integrins take the stage. Immunol Rev (2002) 1.47

TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function. J Immunol (2011) 1.47

Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. J Leukoc Biol (2012) 1.47

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med (2011) 1.43

Mycoplasma hominis and Ureaplasma urealyticum in midtrimester amniotic fluid: association with amniotic fluid cytokine levels and pregnancy outcome. Am J Obstet Gynecol (2004) 1.43

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev (2007) 1.42

WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity (2002) 1.41

Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker. Hepatology (2014) 1.41

T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol (2008) 1.41

Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. J Immunol (2008) 1.38

Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med (2012) 1.38

Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J Immunol (2010) 1.38

The second-meal phenomenon in type 2 diabetes. Diabetes Care (2009) 1.38

Innate response to focal necrotic injury inside the blood-brain barrier. J Immunol (2006) 1.31

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods (2009) 1.29

Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med (2009) 1.29

Measuring diffusion and binding kinetics by contact area FRAP. Biophys J (2008) 1.26

Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity (2006) 1.26

Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophys J (2006) 1.25

Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J Immunol (2008) 1.24

Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J Exp Med (2002) 1.24

Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends Immunol (2002) 1.24

The second-meal phenomenon is associated with enhanced muscle glycogen storage in humans. Clin Sci (Lond) (2009) 1.24

Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology (2008) 1.23

In silico models for cellular and molecular immunology: successes, promises and challenges. Nat Immunol (2003) 1.21

Mechanosensing in T lymphocyte activation. Biophys J (2012) 1.21

CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J Immunol (2005) 1.20

Nanoparticle delivery systems in cancer vaccines. Pharm Res (2010) 1.20

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol (2009) 1.20

Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol (2002) 1.18