The cell biology of touch.

Imprinting, latchment and displacement: a mini review of early instinctual behaviour in newborn infants influencing breastfeeding success. Acta Paediatr (2015) 3.07

Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat Rev Neurosci (2011) 2.12

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature (2012) 2.07

DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor. Neuron (2011) 1.90

Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell (2015) 1.66

Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. J Neurosci (2013) 1.30

Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28

Anatomical pathways involved in generating and sensing rhythmic whisker movements. Front Integr Neurosci (2011) 1.17

Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol (2012) 1.16

How does morphology relate to function in sensory arbors? Trends Neurosci (2011) 1.03

Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol (2013) 1.03

The touch dome defines an epidermal niche specialized for mechanosensory signaling. Cell Rep (2013) 1.01

A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO J (2012) 1.01

Neurosensory mechanotransduction through acid-sensing ion channels. J Cell Mol Med (2013) 0.97

The organization of submodality-specific touch afferent inputs in the vibrissa column. Cell Rep (2013) 0.97

Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs. Cell Rep (2015) 0.94

Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor. Development (2012) 0.92

Genetics and neurobiology of aggression in Drosophila. Fly (Austin) (2012) 0.91

The star-nosed mole reveals clues to the molecular basis of mammalian touch. PLoS One (2013) 0.91

The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles. Elife (2014) 0.90

Perspectives on: information and coding in mammalian sensory physiology: probing mammalian touch transduction. J Gen Physiol (2011) 0.89

Merkel cells and neurons keep in touch. Trends Cell Biol (2014) 0.88

The role of Atonal transcription factors in the development of mechanosensitive cells. Semin Cell Dev Biol (2013) 0.85

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. J Physiol (2013) 0.84

Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network. Development (2014) 0.84

Tissue mechanics govern the rapidly adapting and symmetrical response to touch. Proc Natl Acad Sci U S A (2015) 0.83

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet (2016) 0.82

Developmental and architectural principles of the lateral-line neural map. Front Neural Circuits (2013) 0.82

Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation. Pflugers Arch (2014) 0.81

Mechanotransduction in the endothelium: role of membrane proteins and reactive oxygen species in sensing, transduction, and transmission of the signal with altered blood flow. Antioxid Redox Signal (2014) 0.81

Investigation of mechanosensation in C. elegans using light field calcium imaging. Biomed Opt Express (2016) 0.77

In touch - the molecular basis of mechanosensory transduction. Biochem (Lond) (2011) 0.76

Bedding Material Affects Mechanical Thresholds, Heat Thresholds, and Texture Preference. J Pain (2015) 0.76

The microtubule-based cytoskeleton is a component of a mechanical signaling pathway in fly campaniform receptors. Biophys J (2014) 0.76

Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons. Elife (2016) 0.75

Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects. PLoS One (2014) 0.75

ASIC2 is present in human mechanosensory neurons of the dorsal root ganglia and in mechanoreceptors of the glabrous skin. Histochem Cell Biol (2014) 0.75

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature (2007) 8.04

Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol (1986) 7.71

An SCN9A channelopathy causes congenital inability to experience pain. Nature (2006) 7.01

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29

C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron (2000) 6.00

Cellular mechanotransduction: putting all the pieces together again. FASEB J (2006) 5.84

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73

Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev Biol (1981) 4.93

painless, a Drosophila gene essential for nociception. Cell (2003) 4.93

A Drosophila mechanosensory transduction channel. Science (2000) 4.81

The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat Neurosci (2004) 4.52

Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol (2007) 4.07

OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci (1997) 4.06

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A (2009) 3.98

The roles and functions of cutaneous mechanoreceptors. Curr Opin Neurobiol (2001) 3.88

Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A (2003) 3.87

A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature (1999) 3.74

Dopaminergic neurons in the nematode Caenorhabditis elegans. J Comp Neurol (1975) 3.68

Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57

The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron (2001) 3.56

Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron (2005) 3.54

Mechanisms of sensory transduction in the skin. Nature (2007) 3.53

A TRPV family ion channel required for hearing in Drosophila. Nature (2003) 3.53

Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns (2003) 3.42

Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron (1991) 3.39

The mammalian sodium channel BNC1 is required for normal touch sensation. Nature (2000) 3.30

A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue. Nature (2006) 3.20

Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Neuron (2002) 3.17

A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1993) 3.15

Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (1996) 3.15

A possible unifying principle for mechanosensation. Nature (2005) 3.09

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2004) 3.07

Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci (2002) 3.02

The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types. Genes Dev (1989) 3.00

C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron (2010) 2.89

A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron (2007) 2.83

Genetic dissection of mechanosensory transduction: mechanoreception-defective mutations of Drosophila. Neuron (1994) 2.75

Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science (1989) 2.73

Neurosensory mechanotransduction. Nat Rev Mol Cell Biol (2009) 2.73

Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci (2004) 2.66

Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells. Proc Natl Acad Sci U S A (1989) 2.56

Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods (2010) 2.50

The structure and function of the slowly adapting type II mechanoreceptor in hairy skin. Q J Exp Physiol Cogn Med Sci (1972) 2.50

In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron (2003) 2.49

Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (2004) 2.48

Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature (2009) 2.45

The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron (2010) 2.44

Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci (2002) 2.40

Identification of genes expressed in C. elegans touch receptor neurons. Nature (2002) 2.39

Organization of neuronal microtubules in the nematode Caenorhabditis elegans. J Cell Biol (1979) 2.34

mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans. Genes Dev (1989) 2.33

NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science (2003) 2.31

Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci (2009) 2.30

Multiple mechanosensitive ion channels from Escherichia coli, activated at different thresholds of applied pressure. J Membr Biol (1996) 2.30

Review series: The cell biology of hearing. J Cell Biol (2010) 2.29

The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol (2001) 2.27

MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature (2002) 2.27

Sensory regulation of male mating behavior in Caenorhabditis elegans. Neuron (1995) 2.26

Merkel cells are essential for light-touch responses. Science (2009) 2.24

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol (2009) 2.24

Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr Biol (2010) 2.20

Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci (2007) 2.19

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature (1994) 2.17

The micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci (2007) 2.17

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16

Mechanosensitive currents in the neurites of cultured mouse sensory neurones. J Physiol (2006) 2.16

Mechanotransduction and auditory transduction in Drosophila. Pflugers Arch (2007) 2.12

Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett (1999) 2.11

A stomatin-domain protein essential for touch sensation in the mouse. Nature (2006) 2.08

TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07

Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. J Child Psychol Psychiatry (2007) 2.00

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Nature (2002) 2.00

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J (2009) 1.98

Friedrich Sigmund Merkel and his "Merkel cell", morphology, development, and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol (2003) 1.96

Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat Neurosci (2010) 1.92

Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron (2009) 1.88

Response latency of vertebrate hair cells. Biophys J (1979) 1.84

Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J Cell Biol (1998) 1.82

Neuropathic pain: a practical guide for the clinician. CMAJ (2006) 1.79

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nat Neurosci (2007) 1.78

Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A (2004) 1.77

The role of fingerprints in the coding of tactile information probed with a biomimetic sensor. Science (2009) 1.76

Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2005) 1.72

nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Neuron (2001) 1.71

Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans. J Cell Biol (1982) 1.70

Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions. Development (2001) 1.65

Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. J Neurosci (1999) 1.63

COMPONENTS OF RECEPTOR ADAPTATION IN A PACINIAN CORPUSCLE. J Physiol (1965) 1.61

Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Dev Biol (2010) 1.60

A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster. Proc Natl Acad Sci U S A (1997) 1.59

MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans. J Cell Sci (1999) 1.59

Mammalian Merkel cells are descended from the epidermal lineage. Dev Biol (2009) 1.58

The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons. EMBO J (1992) 1.55

Neural coding mechanisms underlying perceived roughness of finely textured surfaces. J Neurosci (2001) 1.54

Mechanosensation. WormBook (2006) 1.49

Extracellular proteins needed for C. elegans mechanosensation. Neuron (1996) 1.49

Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells. J Neurosci (2004) 1.48

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Curr Biol (2004) 1.47

Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci (2009) 1.46

Nociceptors: a phylogenetic view. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2009) 1.44

Merkel cells are essential for light-touch responses. Science (2009) 2.24

The ion channel TRPA1 is required for chronic itch. J Neurosci (2013) 1.41

Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors. Elife (2014) 1.19

Hyperelastic Material Properties of Mouse Skin under Compression. PLoS One (2013) 0.88

DEG/ENaCs lead by a nose: mechanotransduction in a polymodal sensory neuron. Neuron (2011) 0.76