Published in Mol Cell Biol on December 01, 2004
Bmp2 transcription in osteoblast progenitors is regulated by a distant 3' enhancer located 156.3 kilobases from the promoter. Mol Cell Biol (2007) 1.66
Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. J Clin Invest (2012) 1.41
Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche. Proc Natl Acad Sci U S A (2006) 1.34
Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet (2008) 1.27
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell (2014) 1.27
Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation. Mol Cell Biol (2008) 1.17
An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene. Mol Cell Biol (2011) 1.04
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet (2013) 1.02
Shared long-range regulatory elements coordinate expression of a gene cluster encoding nicotinic receptor heteromeric subtypes. Mol Cell Biol (2006) 1.01
BAC transgenic analysis reveals enhancers sufficient for Hoxa13 and neighborhood gene expression in mouse embryonic distal limbs and genital bud. Evol Dev (2008) 0.94
Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes. BMC Dev Biol (2011) 0.93
Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer. Dev Biol (2006) 0.91
Inferring time-varying network topologies from gene expression data. EURASIP J Bioinform Syst Biol (2007) 0.88
Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene. J Biol Chem (2008) 0.87
GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. Mol Cell Biol (2014) 0.84
UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice. Mol Cell Biol (2012) 0.81
Fishing for function: zebrafish BAC transgenics for functional genomics. Mol Biosyst (2011) 0.80
Progenitor stage-specific activity of a cis-acting double GATA motif for Gata1 gene expression. Mol Cell Biol (2014) 0.80
A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish. BMC Dev Biol (2007) 0.78
Motif discovery in tissue-specific regulatory sequences using directed information. EURASIP J Bioinform Syst Biol (2007) 0.77
Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect. Mol Cell Biol (2016) 0.76
Reducing inflammatory cytokine production from renal collecting duct cells by inhibiting GATA2 ameliorates acute kidney injury. Mol Cell Biol (2017) 0.75
PipMaker--a web server for aligning two genomic DNA sequences. Genome Res (2000) 17.46
An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A (2000) 17.30
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell (2004) 16.15
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics (2001) 15.03
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science (2000) 10.14
Scanning human gene deserts for long-range enhancers. Science (2003) 9.75
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
High throughput fingerprint analysis of large-insert clones. Genome Res (1997) 6.91
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev (1997) 6.52
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet (1998) 5.95
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev (1990) 5.25
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly. Proc Natl Acad Sci U S A (2002) 5.18
Bacterial artificial chromosome libraries for mouse sequencing and functional analysis. Genome Res (2000) 5.13
A physical map of the mouse genome. Nature (2002) 4.97
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev (1998) 4.72
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat Genet (1995) 4.39
An SV40 "enhancer trap" incorporates exogenous enhancers or generates enhancers from its own sequences. Cell (1984) 3.61
Development of hematopoietic cells lacking transcription factor GATA-1. Development (1995) 2.78
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet (2000) 2.53
A modular, positive selection bacterial artificial chromosome vector with multiple cloning sites. Genomics (1999) 2.17
Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes Dev (1993) 2.03
A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet (2000) 1.95
Embryonic expression and cloning of the murine GATA-3 gene. Development (1994) 1.84
A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene. Mol Cell Biol (2000) 1.58
Alternative promoters regulate transcription of the mouse GATA-2 gene. J Biol Chem (1998) 1.53
A general approach for identifying distant regulatory elements applied to the Gdf6 gene. Genome Res (2003) 1.49
The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region. Blood (1999) 1.44
Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J (1998) 1.41
Identification of ribophorins in rough microsomal membranes from different organs of several species. Eur J Biochem (1982) 1.35
Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes. Proc Natl Acad Sci U S A (2000) 1.31
GATA2 is required for the generation of V2 interneurons. Development (2000) 1.29
Abnormalities of the genitourinary tract in female mice lacking GATA5. Mol Cell Biol (2000) 1.26
Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points. Neuron (2003) 1.19
GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. EMBO J (2002) 1.16
Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus. Mol Cell Biol (1999) 1.16
Pulsed field separation of large supercoiled and open-circular DNAs and its application to bacterial artificial chromosome cloning. Electrophoresis (1995) 1.07
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol (2004) 8.94
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet (2003) 6.69
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell (2006) 6.09
Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med (2004) 5.88
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci U S A (2008) 5.18
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells (2003) 4.47
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest (2006) 4.41
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med (2005) 4.31
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal (2005) 4.20
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem (2002) 4.14
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul (2006) 3.90
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell (2012) 3.90
Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast. Nat Cell Biol (2002) 3.85
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells (2011) 3.76
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res (2008) 3.56
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene (2002) 3.33
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol (2006) 3.27
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem J (2003) 3.13
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med (2004) 3.09
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J (2002) 3.06
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci U S A (2004) 2.94
MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol (2005) 2.85
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun (2005) 2.85
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol (2002) 2.82
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther (2007) 2.71
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology (2008) 2.70
Distinct cohesin complexes organize meiotic chromosome domains. Science (2003) 2.68
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. J Biol Chem (2006) 2.66
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J (2007) 2.65
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature (2006) 2.64
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol Chem (2006) 2.61
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol (2008) 2.57
GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol (2005) 2.55
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells (2002) 2.43
The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J (2004) 2.43
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun (2006) 2.37
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol (2010) 2.32
HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J (2003) 2.28
Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci (2013) 2.26
Meiosis-specific noncoding RNA mediates robust pairing of homologous chromosomes in meiosis. Science (2012) 2.26
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol Cell Biol (2004) 2.25
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res (2004) 2.23
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther (2012) 2.22
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol (2003) 2.19
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells (2005) 2.18
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol (2008) 2.15
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest (2011) 2.13
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11
The transcriptional programme of antibody class switching involves the repressor Bach2. Nature (2004) 2.09
Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A (2007) 2.06
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res (2009) 2.04
The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol (2008) 2.03
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts. Biochem Biophys Res Commun (2003) 2.01
Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J Biol Chem (2002) 2.00
Essential and instructive roles of GATA factors in eosinophil development. J Exp Med (2002) 1.98
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res (2004) 1.95
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell (2008) 1.94
Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. Am J Respir Crit Care Med (2005) 1.94
Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate. Nat Chem Biol (2007) 1.93
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem (2007) 1.90
Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development (2003) 1.90
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol (2009) 1.90
Thalassaemia. Lancet (2011) 1.89
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A (2004) 1.88
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol (2006) 1.86
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Mol Cell Biol (2007) 1.86
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis (2009) 1.85
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J Biol Chem (2004) 1.81
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema. J Immunol (2005) 1.79
Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal (2010) 1.76
Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med (2005) 1.76
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med (2007) 1.73
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem (2008) 1.73
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells (2008) 1.72
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol (2007) 1.71
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys (2005) 1.71