Published in Mol Cell Biol on December 01, 2004
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest (2007) 2.39
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol (2005) 2.11
The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood (2011) 1.93
Advances in the understanding of haemoglobin switching. Br J Haematol (2010) 1.74
Regulation of human fetal hemoglobin: new players, new complexities. Blood (2005) 1.60
Novel role for EKLF in megakaryocyte lineage commitment. Blood (2007) 1.53
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood (2011) 1.50
Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther (2010) 1.45
Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Mol Cell Biol (2006) 1.26
Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol (2007) 1.20
Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol (2013) 1.18
Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res (2012) 1.13
Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors. EMBO J (2006) 1.10
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci U S A (2011) 1.06
Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf. Blood (2010) 1.03
Non-random subcellular distribution of variant EKLF in erythroid cells. Exp Cell Res (2008) 1.01
EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Mol Cell Biol (2012) 0.98
EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. Mol Cell Biol (2010) 0.97
Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus. Mol Cell Biol (2008) 0.95
Solution structure of the mSin3A PAH2-Pf1 SID1 complex: a Mad1/Mxd1-like interaction disrupted by MRG15 in the Rpd3S/Sin3S complex. J Mol Biol (2011) 0.94
Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ. J Biol Chem (2012) 0.83
Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression. Proc Natl Acad Sci U S A (2014) 0.81
Tissue-restricted transcription from a conserved intragenic CpG island in the Klf1 gene in mice. Biol Reprod (2012) 0.81
Solution NMR studies of apo-mSin3A and -mSin3B reveal that the PAH1 and PAH2 domains are structurally independent. Protein Sci (2007) 0.79
Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3). J Biol Chem (2015) 0.76
Coordinated Transcriptional Control of Adipocyte Triglyceride Lipase (Atgl) by transcription factors Sp1 and PPARγ during Adipocyte Differentiation. J Biol Chem (2017) 0.75
Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly. FASEB J (2017) 0.75
The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature (1997) 9.71
Transcription regulation and animal diversity. Nature (2003) 9.22
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell (1997) 8.99
The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol (2000) 8.47
Combinatorial control of gene expression by nuclear receptors and coregulators. Cell (2002) 8.01
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell (1997) 7.64
A unified theory of gene expression. Cell (2002) 7.61
Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science (2001) 6.79
DNA binding of the glucocorticoid receptor is not essential for survival. Cell (1998) 6.40
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A (1996) 6.29
Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell (1997) 6.27
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell (1991) 6.14
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol (1993) 5.70
The structure and function of proline-rich regions in proteins. Biochem J (1994) 5.39
Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev (1997) 5.21
Krüppel-like factors: three fingers in many pies. J Biol Chem (2001) 5.05
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (1995) 4.97
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature (1995) 4.80
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Signal transduction and the control of gene expression. Science (2002) 4.38
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37
Regulation of E2F1 activity by acetylation. EMBO J (2000) 4.18
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol (2001) 4.11
Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell (1999) 3.82
Protein motifs 5. Zinc fingers. FASEB J (1995) 3.46
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood (2002) 3.21
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A (1998) 3.13
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell (1998) 2.99
A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature (1997) 2.78
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev (2002) 2.77
Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol (2001) 2.72
The role of EKLF in human beta-globin gene competition. Genes Dev (1996) 2.72
Metal-dependent folding of a single zinc finger from transcription factor IIIA. Proc Natl Acad Sci U S A (1987) 2.53
GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol (2003) 2.52
Recognition of DNA by Cys2,His2 zinc fingers. Science (1991) 2.27
A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J (2001) 2.23
Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem (1994) 2.22
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev (1996) 2.18
Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev (2000) 2.07
Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics. Nat Struct Mol Biol (2003) 2.00
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol (2001) 1.93
Activation of the beta-globin locus control region precedes commitment to the erythroid lineage. Proc Natl Acad Sci U S A (1992) 1.87
Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development (1999) 1.80
Maintenance of chromatin states: an open-and-shut case. Curr Opin Cell Biol (2003) 1.72
Transcriptional coregulators in development. Science (1999) 1.72
The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter. Mol Cell Biol (1995) 1.61
Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn (1996) 1.59
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes Dev (1998) 1.48
Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice. Blood (2001) 1.34
Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J (1996) 1.33
Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expression. Nucleic Acids Res (1994) 1.32
Erythroid Kruppel like factor: from fishing expedition to gourmet meal. Int J Biochem Cell Biol (1999) 1.32
A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. Blood (1997) 1.26
A 13-amino acid amphipathic alpha-helix is required for the functional interaction between the transcriptional repressor Mad1 and mSin3A. J Biol Chem (1999) 1.22
Krüppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Krüppel-like factor. J Biol Chem (2002) 1.21
Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter. Mol Cell Biol (2002) 1.17
Unanticipated repression function linked to erythroid Krüppel-like factor. Mol Cell Biol (2001) 1.14
Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Blood (2000) 1.09
CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions. J Biol Chem (2003) 1.07
The function of individual zinc fingers in sequence-specific DNA recognition by transcription factor IIIA. J Mol Biol (1993) 1.07
Overexpression of HOX11 leads to the immortalization of embryonic precursors with both primitive and definitive hematopoietic potential. Blood (1998) 1.02
Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A. FEBS Lett (2003) 0.93
Unicellular-unilineage erythropoietic cultures: molecular analysis of regulatory gene expression at sibling cell level. Blood (1999) 0.85
Epo-induced hemoglobinization of SKT6 cells is mediated by minimal cytoplasmic domains of the Epo or prolactin receptors without modulation of GATA-1 or EKLF. Growth Factors (1997) 0.82
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat Genet (2009) 6.39
Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci U S A (2005) 1.96
The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood (2011) 1.93
Novel role for EKLF in megakaryocyte lineage commitment. Blood (2007) 1.53
Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A (2010) 1.34
The erythroblastic island. Curr Top Dev Biol (2008) 1.32
The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media. Development (2002) 1.30
Krüppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Krüppel-like factor. J Biol Chem (2002) 1.21
Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment. Development (2008) 1.20
Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol (2007) 1.20
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci U S A (2011) 1.06
Non-random subcellular distribution of variant EKLF in erythroid cells. Exp Cell Res (2008) 1.01
EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Mol Cell Biol (2012) 0.98
EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. Mol Cell Biol (2010) 0.97
Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development. Blood (2004) 0.95
Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus. Mol Cell Biol (2008) 0.95
Distinct modes of gene regulation by a cell-specific transcriptional activator. Proc Natl Acad Sci U S A (2009) 0.94
EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome. FEBS Lett (2006) 0.93
Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives. Eur J Haematol (2009) 0.93
Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. J Biol Chem (2004) 0.92
Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm. Blood Cells Mol Dis (2013) 0.91
Putting a finger on the switch. Nat Genet (2010) 0.91
Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol (2007) 0.86
T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem (2012) 0.86
GATA2 finds its macrophage niche. Blood (2011) 0.84
Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ. J Biol Chem (2012) 0.83
Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo. Proc Natl Acad Sci U S A (2010) 0.78
Orchestration of late events in erythropoiesis by KLF1/EKLF. Curr Opin Hematol (2017) 0.76
Red cell development. Preface. Curr Top Dev Biol (2008) 0.75