Published in J Biol Chem on January 14, 1994
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res (1999) 3.68
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol (1995) 3.39
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A (1998) 3.13
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. EMBO J (1998) 3.06
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet (2010) 2.50
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol Cell Biol (1995) 2.41
Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res (2000) 2.34
Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol (1996) 2.31
A global role for EKLF in definitive and primitive erythropoiesis. Blood (2005) 2.24
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol (2005) 2.11
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res (2010) 2.02
Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A (1996) 1.99
Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A (2006) 1.95
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol (2001) 1.93
The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood (2011) 1.93
The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J (2005) 1.83
A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. J Biol Chem (2008) 1.72
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev (2000) 1.64
The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter. Mol Cell Biol (1995) 1.61
Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. Blood (2012) 1.58
A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia. Am J Hum Genet (2010) 1.50
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes Dev (1998) 1.48
Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells. Mol Cell Biol (2007) 1.45
Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. J Virol (2004) 1.35
Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture. BMC Genomics (2007) 1.34
Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A (2010) 1.34
Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J (1996) 1.33
Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Mol Cell Biol (2006) 1.26
Stage-specific repression by the EKLF transcriptional activator. Mol Cell Biol (2004) 1.21
Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol (2007) 1.20
Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol (2013) 1.18
Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter. Mol Cell Biol (2002) 1.17
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor. Genome Biol (2014) 1.17
Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood (2009) 1.15
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem (2009) 1.13
Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res (2012) 1.13
Adult stage gamma-globin silencing is mediated by a promoter direct repeat element. Mol Cell Biol (2005) 1.10
Activation of beta-globin promoter by erythroid Krüppel-like factor. Mol Cell Biol (1998) 1.08
Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci U S A (2011) 1.06
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells. Blood (2013) 1.04
Erythroid phenotypes associated with KLF1 mutations. Haematologica (2011) 0.99
Erythropoiesis: development and differentiation. Cold Spring Harb Perspect Med (2013) 0.98
EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Mol Cell Biol (2012) 0.98
EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. Mol Cell Biol (2010) 0.97
The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Mol Cell Biol (2012) 0.93
Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol (2012) 0.93
ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. J Biol Chem (2012) 0.93
Human fetal globin gene expression is regulated by LYAR. Nucleic Acids Res (2014) 0.93
Isolation of a differentially regulated splicing isoform of human NF-E2. Proc Natl Acad Sci U S A (1995) 0.89
Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis. Mol Cell Biol (2011) 0.86
Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol (2007) 0.86
Intronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene. Mol Cell Biol (1996) 0.85
Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development. Mol Cell Biol (2010) 0.82
Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants. Blood (2016) 0.82
Tissue-restricted transcription from a conserved intragenic CpG island in the Klf1 gene in mice. Biol Reprod (2012) 0.81
KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes. Genome Biol Evol (2015) 0.78
Erythroid Krüppel-like transcription factor (Eklf) maps to a region of mouse chromosome 8 syntenic with human chromosome 19. Mamm Genome (1998) 0.78
A functional mutation at position -155 in porcine APOE promoter affects gene expression. BMC Genet (2011) 0.77
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol (1993) 5.70
CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell (1999) 3.39
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A (1998) 3.13
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell (1998) 2.99
Formation of a rate-limiting intermediate in 5S RNA gene transcription. Cell (1985) 2.94
Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching. J Biol Chem (1995) 2.51
Physical properties and DNA-binding stoichiometry of a 5 S gene-specific transcription factor. J Biol Chem (1984) 2.00
Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol (2001) 1.93
The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter. Mol Cell Biol (1995) 1.61
Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn (1996) 1.59
Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease. J Cell Biol (1998) 1.53
Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters. Blood (1996) 1.45
Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J (1996) 1.33
A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. Blood (1997) 1.26
Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem (1994) 1.22
Unanticipated repression function linked to erythroid Krüppel-like factor. Mol Cell Biol (2001) 1.14
Expression of two nonallelic type II procollagen genes during Xenopus laevis embryogenesis is characterized by stage-specific production of alternatively spliced transcripts. J Cell Biol (1991) 1.07
Regulation of erythroid Krüppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain. J Biol Chem (1998) 1.06
Genetic transformation of Saccharomyces cerevisiae with single-stranded circular DNA vectors. Gene (1982) 1.04
The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci (2000) 1.04
Chromatin structure and transcriptional control elements of the erythroid Krüppel-like factor (EKLF) gene. J Biol Chem (1998) 0.89
Transcription factor erythroid Krüppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation. J Biol Chem (1998) 0.86
Characterization of the nucleotide requirement for elimination of the rate-limiting step in 5 S RNA gene transcription. J Biol Chem (1986) 0.86
Erythroid Krüppel-like transcription factor (Eklf) maps to a region of mouse chromosome 8 syntenic with human chromosome 19. Mamm Genome (1998) 0.78
The single-strands of yeast autonomously replicating DNA segments are not recognized as origins of replication by Escherichia coli DNA replication proteins. Biochem Biophys Res Commun (1981) 0.75
An easy, quantitative method for detection of endonuclease activity. Anal Biochem (1980) 0.75