Published in Mol Pharmacol on November 17, 2004
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Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence. Neuropsychopharmacology (2011) 0.95
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Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma. J Neurosci (2013) 0.91
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Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia. J Cereb Blood Flow Metab (2013) 0.86
Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addict Biol (2014) 0.85
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. Alcohol Clin Exp Res (2012) 0.85
Glutamatergic transmission in drug reward: implications for drug addiction. Front Neurosci (2015) 0.84
(-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking. Addict Biol (2011) 0.83
Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats. Behav Brain Funct (2013) 0.82
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol (2013) 0.81
Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl) (2013) 0.81
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A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference. J Biol Chem (2015) 0.77
The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol. Pharmacogenet Genomics (2010) 0.76
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Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. Prog Mol Biol Transl Sci (2015) 0.75
Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective. F1000Res (2017) 0.75
Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5. eNeuro (2016) 0.75
Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder. Neurosci Biobehav Rev (2017) 0.75
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. J Med Chem (2011) 0.75
Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens. J Neurosci Res (2016) 0.75
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A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci (2004) 2.33
Prkcz null mice show normal learning and memory. Nature (2013) 2.06
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Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. FASEB J (2008) 1.87
GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice. Psychopharmacology (Berl) (2004) 1.78
Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake. Pharmacol Biochem Behav (2002) 1.75
The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. Biochem J (2008) 1.74
Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci (2007) 1.72
PKC-delta promotes renal tubular cell apoptosis associated with proteinuria. J Am Soc Nephrol (2010) 1.67
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J Biol Chem (2003) 1.63
Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci (2009) 1.62
Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum. Biol Psychiatry (2012) 1.61
Context is a trigger for relapse to alcohol. Behav Brain Res (2005) 1.58
Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest (2004) 1.58
RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci (2004) 1.55
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. Eur J Neurosci (2008) 1.54
The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berl) (2005) 1.49
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol (2002) 1.45
Inactivation of the lateral but not medial dorsal striatum eliminates the excitatory impact of Pavlovian stimuli on instrumental responding. J Neurosci (2007) 1.44
CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Neuropsychopharmacology (2010) 1.44
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem (2007) 1.43
Amygdala neurons differentially encode motivation and reinforcement. J Neurosci (2007) 1.41
Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A (2008) 1.41
Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP. Neuropharmacology (2008) 1.38
Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal. Proc Natl Acad Sci U S A (2009) 1.38
Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci (2006) 1.36
Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking. Neuropsychopharmacology (2009) 1.36
Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice. J Neurosci (2002) 1.35
Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. J Clin Invest (2011) 1.35
GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci U S A (2008) 1.35
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats. Psychopharmacology (Berl) (2009) 1.32
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci (2008) 1.32
Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon. J Clin Invest (2002) 1.31
Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning. Eur J Neurosci (2010) 1.30
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci (2013) 1.29
betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell (2002) 1.26
Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes. Psychopharmacology (Berl) (2006) 1.24
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Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. Biol Psychiatry (2009) 1.22
Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol. Neuropsychopharmacology (2005) 1.21
Amygdala neural encoding of the absence of reward during extinction. J Neurosci (2010) 1.21
Ethanol-associated cues produce general pavlovian-instrumental transfer. Alcohol Clin Exp Res (2007) 1.20
Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci (2013) 1.20
Context-induced relapse of conditioned behavioral responding to ethanol cues in rats. Biol Psychiatry (2008) 1.19
Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice. Neuropsychopharmacology (2008) 1.19
Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect. Alcohol Clin Exp Res (2006) 1.18
Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcohol Clin Exp Res (2007) 1.16
The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci (2006) 1.15
Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. Behav Brain Res (2010) 1.15
Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol (2009) 1.14
Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem (2009) 1.13
Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res (2009) 1.13
Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core. Eur J Neurosci (2008) 1.13
Ethanol operant self-administration in rats is regulated by adenosine A2 receptors. Alcohol Clin Exp Res (2004) 1.13
Safety encoding in the basal amygdala. J Neurosci (2013) 1.13
The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach. Behav Brain Res (2008) 1.12
Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci U S A (2011) 1.12
Acute functional tolerance to ethanol mediated by protein kinase Cepsilon. Neuropsychopharmacology (2006) 1.11
mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats. Eur J Pharmacol (2006) 1.11
Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice. Psychopharmacology (Berl) (2007) 1.09
Methylphenidate facilitates learning-induced amygdala plasticity. Nat Neurosci (2010) 1.09
Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. J Neurosci (2009) 1.08
Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci (2009) 1.08
The substrates and binding partners of protein kinase Cepsilon. Biochem J (2010) 1.07
Protein kinase C isozymes in stroke. Trends Cardiovasc Med (2005) 1.07
Alcohol seeking in C57BL/6 mice induced by conditioned cues and contexts in the extinction-reinstatement model. Alcohol (2006) 1.07
Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J Neurosci (2005) 1.07
Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice. Eur J Pharmacol (2003) 1.05
Protein kinases and addiction. Ann N Y Acad Sci (2008) 1.05
Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon. J Neurosci (2005) 1.04
Ethanol preexposure increases ethanol self-administration in C57BL/6J and DBA/2J mice. Pharmacol Biochem Behav (2004) 1.03
Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats. Psychopharmacology (Berl) (2003) 1.03
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci U S A (2006) 1.02
GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res (2009) 1.02
Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. Psychopharmacology (Berl) (2009) 1.02
Alcohol, cocaine, and brain stimulation-reward in C57Bl6/J and DBA2/J mice. Alcohol Clin Exp Res (2009) 1.01
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcohol Clin Exp Res (2003) 1.01
Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol (2002) 1.01
Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach. Neurobiol Learn Mem (2007) 1.00
Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon. Eur J Neurosci (2006) 1.00
GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. J Neurosci (2010) 0.99
A role for corticotropin releasing factor (CRF) in ethanol consumption, sensitivity, and reward as revealed by CRF-deficient mice. Psychopharmacology (Berl) (2002) 0.99
Alcohol-induced stress in painful alcoholic neuropathy. Eur J Neurosci (2007) 0.98
Intra-amygdala infusion of the NPY Y1 receptor antagonist BIBP 3226 attenuates operant ethanol self-administration. Alcohol Clin Exp Res (2003) 0.98
GDNF and addiction. Rev Neurosci (2005) 0.98
Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. J Clin Invest (2012) 0.97