Published in Biochem J on April 15, 2008
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat Struct Mol Biol (2009) 3.37
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep (2009) 2.55
Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem (2011) 1.30
Protein kinase C and toll-like receptor signaling. Enzyme Res (2011) 1.14
The substrates and binding partners of protein kinase Cepsilon. Biochem J (2010) 1.07
Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295. Biochemistry (2009) 0.86
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. EMBO Rep (2014) 0.81
A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts. J Biol Chem (2009) 0.80
Kinetics of PKCε activating and inhibiting llama single chain antibodies and their effect on PKCε translocation in HeLa cells. PLoS One (2012) 0.78
Bacteria induce prolonged PMN survival via a phosphatidylcholine-specific phospholipase C- and protein kinase C-dependent mechanism. PLoS One (2014) 0.77
Short-term regulation of murine colonic NBCe1-B (electrogenic Na+/HCO3(-) cotransporter) membrane expression and activity by protein kinase C. PLoS One (2014) 0.77
New insights into PKC family affairs: three novel phosphorylation sites in PKCepsilon and at least one is regulated by PKCalpha. Biochem J (2008) 0.76
A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ. Biochem J (2015) 0.76
Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology (2016) 0.75
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat Struct Mol Biol (2009) 3.37
Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron (2006) 2.79
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep (2009) 2.55
Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics (2004) 2.43
PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol (2010) 2.41
A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci (2004) 2.33
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol (2010) 2.24
Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect. Proteomics (2003) 2.17
Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol (2009) 2.15
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep (2008) 2.09
Prkcz null mice show normal learning and memory. Nature (2013) 2.06
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol (2003) 1.90
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell (2013) 1.90
The late endosome is essential for mTORC1 signaling. Mol Biol Cell (2010) 1.79
PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J (2005) 1.75
Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem (2006) 1.72
Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J (2003) 1.69
PKC epsilon controls the traffic of beta1 integrins in motile cells. EMBO J (2002) 1.67
PKC-delta promotes renal tubular cell apoptosis associated with proteinuria. J Am Soc Nephrol (2010) 1.67
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J Biol Chem (2003) 1.63
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J (2006) 1.61
The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol (2008) 1.61
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest (2004) 1.58
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell (2004) 1.57
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. Eur J Neurosci (2008) 1.54
PKC controls HGF-dependent c-Met traffic, signalling and cell migration. EMBO J (2004) 1.51
The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol Pharmacol (2004) 1.50
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J Cell Biol (2008) 1.48
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol (2002) 1.45
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem (2007) 1.43
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice. J Neurosci (2002) 1.35
Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. J Clin Invest (2011) 1.35
Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol (2002) 1.35
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol Cell Biol (2006) 1.35
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci (2008) 1.32
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells. PLoS One (2008) 1.31
Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon. J Clin Invest (2002) 1.31
Early editorial manuscript screening versus obligate peer review: a randomized trial. Ann Neurol (2007) 1.23
Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci (2013) 1.20
mTORC2 targets AGC kinases through Sin1-dependent recruitment. Biochem J (2011) 1.18
Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell (2005) 1.16
Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol (2009) 1.14
Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met. J Biol Chem (2003) 1.13
Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer. Cancer Res (2006) 1.12
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival. Int J Cancer (2008) 1.11
Acute functional tolerance to ethanol mediated by protein kinase Cepsilon. Neuropsychopharmacology (2006) 1.11
Protein kinase C intervention: the state of play. Curr Opin Cell Biol (2009) 1.11
Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma. Proteomics (2006) 1.10
Laser capture microdissection and two-dimensional polyacrylamide gel electrophoresis: evaluation of tissue preparation and sample limitations. Am J Pathol (2002) 1.10
Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. Mol Cell Biol (2003) 1.08
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci Signal (2009) 1.08
The substrates and binding partners of protein kinase Cepsilon. Biochem J (2010) 1.07
Protein kinase C isozymes in stroke. Trends Cardiovasc Med (2005) 1.07
A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse. Sci Signal (2011) 1.05
Protein kinases and addiction. Ann N Y Acad Sci (2008) 1.05
Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon. J Neurosci (2005) 1.04
Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides. FEBS Lett (2002) 1.04
Finding the middle ground: how kinetochores power chromosome congression. Cell Mol Life Sci (2010) 1.04
Spatially specific expression of Hoxb4 is dependent on the ubiquitous transcription factor NFY. Development (2002) 1.03
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci U S A (2006) 1.02
Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae. Biochem J (2002) 1.02
Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol (2002) 1.01
PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. PLoS One (2011) 1.00
Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon. Eur J Neurosci (2006) 1.00
The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors. J Biol Chem (2008) 0.99
GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. J Neurosci (2010) 0.99
PIKfyve negatively regulates exocytosis in neurosecretory cells. J Biol Chem (2007) 0.99
Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. PLoS One (2011) 0.99
Alcohol-induced stress in painful alcoholic neuropathy. Eur J Neurosci (2007) 0.98
Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta. Biochem J (2002) 0.98
Mps1 promotes rapid centromere accumulation of Aurora B. EMBO Rep (2012) 0.97
Protein kinase C isozymes and addiction. Mol Neurobiol (2004) 0.97
The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes. J Pharmacol Exp Ther (2009) 0.97
Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ. J Biol Chem (2002) 0.97
PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Nat Cell Biol (2003) 0.97
PLCgamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly. Cell Signal (2006) 0.96
Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res (2013) 0.96
Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase. Chromosoma (2014) 0.95
Approaches to define antigen receptor-induced serine kinase signal transduction pathways. J Biol Chem (2003) 0.95
Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1. J Biol Chem (2003) 0.95
Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry. Mol Cell Biol (2011) 0.94
Use of proteomic methodology for the characterization of human milk fat globular membrane proteins. Anal Biochem (2002) 0.93