Published in J Biol Chem on November 22, 2004
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure. Genome Res (2007) 1.68
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific. BMC Genomics (2007) 1.15
The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes. Mol Biochem Parasitol (2010) 1.15
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity. Proc Natl Acad Sci U S A (2013) 1.06
Quiescin sulfhydryl oxidase from Trypanosoma brucei: catalytic activity and mechanism of a QSOX family member with a single thioredoxin domain. Biochemistry (2010) 0.95
Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei. PLoS Pathog (2012) 0.94
The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation. PLoS Pathog (2009) 0.89
Life and times: synthesis, trafficking, and evolution of VSG. Trends Parasitol (2014) 0.88
T-cell responses to the trypanosome variant surface glycoprotein are not limited to hypervariable subregions. Infect Immun (2008) 0.86
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Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families. Protein Sci (2014) 0.85
Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity. Front Immunol (2016) 0.78
Mapping of VSG similarities in Trypanosoma brucei. Mol Biochem Parasitol (2011) 0.78
Maintaining the protective variant surface glycoprotein coat of African trypanosomes. Biochem Soc Trans (2005) 0.76
Redox-assisted protein folding systems in eukaryotic parasites. Antioxid Redox Signal (2012) 0.75
Efficient production of (2)H, (13)C, (15)N-enriched industrial enzyme Rhizopus chinensis lipase with native disulfide bonds. Microb Cell Fact (2016) 0.75
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature (2002) 6.09
TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79
Role of intermolecular forces in defining material properties of protein nanofibrils. Science (2007) 2.94
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J (2004) 2.79
Sleeping sickness in Uganda: a thin line between two fatal diseases. BMJ (2005) 2.53
Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy. Nat Struct Mol Biol (2010) 2.17
The trypanosome flagellar pocket. Nat Rev Microbiol (2009) 2.07
The structure of docking domains in modular polyketide synthases. Chem Biol (2003) 1.98
Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96
GeneDB--an annotation database for pathogens. Nucleic Acids Res (2011) 1.82
Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism. PLoS Negl Trop Dis (2009) 1.79
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol (2005) 1.74
Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci (2008) 1.64
The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. J Biol Chem (2006) 1.62
The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly. Trends Parasitol (2009) 1.54
Fast multidimensional NMR spectroscopy using compressed sensing. Angew Chem Int Ed Engl (2011) 1.52
Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. Eukaryot Cell (2006) 1.47
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells. Nucleic Acids Res (2008) 1.46
Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Protist (2007) 1.43
The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Mol Cell Biol (2004) 1.43
Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes. Proc Natl Acad Sci U S A (2009) 1.38
Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly. Proc Natl Acad Sci U S A (2011) 1.31
Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids. Trends Parasitol (2010) 1.27
Biochemical and structural studies of the interaction of Cdc37 with Hsp90. J Mol Biol (2004) 1.25
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific. BMC Genomics (2007) 1.15
Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei. Proteomics (2008) 1.15
The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes. Mol Biochem Parasitol (2010) 1.15
A multiplex PCR that discriminates between Trypanosoma brucei brucei and zoonotic T. b. rhodesiense. Exp Parasitol (2007) 1.14
Detergent-free mass spectrometry of membrane protein complexes. Nat Methods (2013) 1.14
Intracellular membrane transport systems in Trypanosoma brucei. Traffic (2004) 1.13
The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol (2002) 1.12
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. Biochemistry (2009) 1.12
Structure of the chromo barrel domain from the MOF acetyltransferase. J Biol Chem (2005) 1.12
Solution structure and backbone dynamics of the KH-QUA2 region of the Xenopus STAR/GSG quaking protein. J Mol Biol (2005) 1.11
Bloodstream form Trypanosome plasma membrane proteins: antigenic variation and invariant antigens. Parasitology (2010) 1.11
In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense. Mol Biochem Parasitol (2003) 1.09
The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci (2010) 1.06
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity. Proc Natl Acad Sci U S A (2013) 1.06
Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes. Eukaryot Cell (2007) 1.05
Ubiquitylation is required for degradation of transmembrane surface proteins in trypanosomes. Traffic (2008) 1.05
The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol (2002) 1.05
Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK). Biochemistry (2005) 1.04
Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM. J Biol Chem (2003) 1.04
Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device. PLoS Negl Trop Dis (2013) 1.04
Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction (2004) 1.03
The Rac1 polybasic region is required for interaction with its effector PRK1. J Biol Chem (2007) 1.03
The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem (2007) 1.03
Ubiquitylation and developmental regulation of invariant surface protein expression in trypanosomes. Eukaryot Cell (2011) 1.03
Cytoplasmic targeting signals in transmembrane invariant surface glycoproteins of trypanosomes. J Biol Chem (2004) 1.03
Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor. Nucleic Acids Res (2005) 1.03
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties. Mol Biochem Parasitol (2010) 0.99
Rapid synthesis of a register-specific heterotrimeric type I collagen helix encompassing the integrin alpha2beta1 binding site. J Mol Biol (2006) 0.98
A new generation of T7 RNA polymerase-independent inducible expression plasmids for Trypanosoma brucei. PLoS One (2012) 0.98
Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. BMC Genomics (2010) 0.98
The two eIF4A helicases in Trypanosoma brucei are functionally distinct. Nucleic Acids Res (2006) 0.98
Whole-genome analysis of animal A- and B-type cyclins. Genome Biol (2002) 0.97
Macromolecular trafficking and immune evasion in african trypanosomes. Int Rev Cell Mol Biol (2009) 0.97
Solution-state NMR spectroscopy of a seven-helix transmembrane protein receptor: backbone assignment, secondary structure, and dynamics. Angew Chem Int Ed Engl (2008) 0.97
Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry. Biochemistry (2002) 0.95
Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS One (2009) 0.94
Compressed sensing reconstruction of undersampled 3D NOESY spectra: application to large membrane proteins. J Biomol NMR (2012) 0.94
Multienzyme docking in hybrid megasynthetases. Nat Chem Biol (2007) 0.94
The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions. J Biol Chem (2010) 0.93
A novel method for the biosynthesis of deuterated proteins with selective protonation at the aromatic rings of Phe, Tyr and Trp. J Biomol NMR (2003) 0.92
VSG structure: similar N-terminal domains can form functional VSGs with different types of C-terminal domain. Mol Biochem Parasitol (2003) 0.92
NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J Biol Chem (2010) 0.92
Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution. J Am Chem Soc (2010) 0.91
VSGdb: a database for trypanosome variant surface glycoproteins, a large and diverse family of coiled coil proteins. BMC Bioinformatics (2007) 0.91
Specificity determinants on Cdc42 for binding its effector protein ACK. Biochemistry (2005) 0.91
Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). J Biol Chem (2003) 0.91
Functional characterization of three leishmania poly(a) binding protein homologues with distinct binding properties to RNA and protein partners. Eukaryot Cell (2010) 0.91
Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. PLoS One (2010) 0.90
Functional characterization of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages. Mol Microbiol (2008) 0.90
The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction. Structure (2010) 0.90
How do trypanosomes change gene expression in response to the environment? Protoplasma (2011) 0.90
Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate. J Cell Sci (2012) 0.90
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei. Biochim Biophys Acta (2012) 0.89
The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation. PLoS Pathog (2009) 0.89
Ultra-high resolution 3D NMR spectra from limited-size data sets. J Magn Reson (2004) 0.88
Is there a classical nonsense-mediated decay pathway in trypanosomes? PLoS One (2011) 0.88
Candidate protein selection for diagnostic markers of African trypanosomiasis. Trends Parasitol (2004) 0.87
Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. J Biol Chem (2003) 0.87