Published in Nucleic Acids Res on May 10, 2006
Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96
Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci (2008) 1.64
Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia. Plant Cell (2009) 1.29
Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in Leishmania. Eukaryot Cell (2006) 1.01
The DEAD-box helicase eIF4A: paradigm or the odd one out? RNA Biol (2012) 0.95
Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS One (2009) 0.94
Functional characterization of three leishmania poly(a) binding protein homologues with distinct binding properties to RNA and protein partners. Eukaryot Cell (2010) 0.91
A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways. Nucleic Acids Res (2011) 0.90
The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis. Mol Microbiol (2008) 0.88
Evolutionary conservation and diversification of the translation initiation apparatus in trypanosomatids. Comp Funct Genomics (2012) 0.84
Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog. Eukaryot Cell (2014) 0.83
RNA Granules Living a Post-transcriptional Life: the Trypanosomes' Case. Curr Chem Biol (2011) 0.82
An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway. PLoS One (2011) 0.82
SCD6 induces ribonucleoprotein granule formation in trypanosomes in a translation-independent manner, regulated by its Lsm and RGG domains. Mol Biol Cell (2013) 0.82
Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation. RNA Biol (2015) 0.80
The eIF3 complex of Typanosoma brucei: composition conservation does not imply the conservation of structural assembly and subunits function. RNA (2016) 0.75
DEAD/DExH-Box RNA Helicases in Selected Human Parasites. Korean J Parasitol (2015) 0.75
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59
A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol (1999) 11.77
The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64
Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J Parasitol (1989) 7.06
Molecular mechanisms of translation initiation in eukaryotes. Proc Natl Acad Sci U S A (2001) 5.80
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev (2002) 4.96
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell (2001) 4.92
DEAD-box proteins: the driving forces behind RNA metabolism. Nat Rev Mol Cell Biol (2004) 4.87
Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol (2005) 4.45
Helicase structure and mechanism. Curr Opin Struct Biol (2002) 4.29
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol (2005) 3.99
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA (2001) 3.65
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J (1988) 3.17
Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Proc Natl Acad Sci U S A (2000) 3.01
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature (2004) 2.95
trans and cis splicing in trypanosomatids: mechanism, factors, and regulation. Eukaryot Cell (2003) 2.91
Expression of a polypeptide containing a dipeptide repeat is confined to the insect stage of Trypanosoma brucei. Nature (1987) 2.86
The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J (2002) 2.76
Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei. Mol Biochem Parasitol (2002) 2.74
Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol (2003) 2.63
The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis. Mol Cell (2003) 2.51
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Mol Cell (2001) 2.43
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol (2005) 2.40
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol (2004) 2.38
Trypanosome mRNAs have unusual "cap 4" structures acquired by addition of a spliced leader. Proc Natl Acad Sci U S A (1987) 2.31
A conserved role of a DEAD box helicase in mRNA masking. RNA (2001) 2.20
Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae. Mol Cell Biol (1997) 2.05
Starting the protein synthesis machine: eukaryotic translation initiation. Bioessays (2003) 2.00
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA (2005) 1.96
eIF4A3 is a novel component of the exon junction complex. RNA (2004) 1.93
The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. J Biol Chem (1993) 1.92
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol Cell Biol (1999) 1.85
Structural basis for the enhancement of eIF4A helicase activity by eIF4G. Genes Dev (2005) 1.83
A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J Exp Med (1995) 1.81
Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii. Proc Natl Acad Sci U S A (2001) 1.81
A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA. RNA (2000) 1.79
The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity. EMBO J (2004) 1.78
Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function. Mol Microbiol (2002) 1.71
Crystal structure and functional analysis of DEAD-box protein Dhh1p. RNA (2005) 1.70
Transcription in kinetoplastid protozoa: why be normal? Microbes Infect (2003) 1.67
RNA-binding domain proteins in Kinetoplastids: a comparative analysis. Eukaryot Cell (2005) 1.52
Yeast RNA helicases of the DEAD-box family involved in translation initiation. Biol Cell (2003) 1.42
LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile. J Immunol (1998) 1.31
The structure and transcription of an element interspersed between tandem arrays of mini-exon donor RNA genes in Trypanosoma brucei. Nucleic Acids Res (1987) 1.13
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. RNA (2006) 1.13
Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues. Mol Biochem Parasitol (2005) 1.09
Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor. Nucleic Acids Res (2005) 1.03
Novel and essential subunits in the 300-kilodalton nuclear cap binding complex of Trypanosoma brucei. Mol Cell Biol (2005) 1.01
A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. Biochem Biophys Res Commun (2000) 0.92
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
How do microRNAs regulate gene expression? Sci STKE (2007) 4.64
TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79
Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1. Nat Neurosci (2006) 3.74
Sleeping sickness in Uganda: a thin line between two fatal diseases. BMJ (2005) 2.53
The trypanosome flagellar pocket. Nat Rev Microbiol (2009) 2.07
Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol (2007) 1.96
GeneDB--an annotation database for pathogens. Nucleic Acids Res (2011) 1.82
The active form of Xp54 RNA helicase in translational repression is an RNA-mediated oligomer. Nucleic Acids Res (2004) 1.79
CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes. J Biol Chem (2007) 1.79
Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism. PLoS Negl Trop Dis (2009) 1.79
Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci (2008) 1.64
The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly. Trends Parasitol (2009) 1.54
Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. Eukaryot Cell (2006) 1.47
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells. Nucleic Acids Res (2008) 1.46
Asymmetric cell division as a route to reduction in cell length and change in cell morphology in trypanosomes. Protist (2007) 1.43
The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Mol Cell Biol (2004) 1.43
Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes. Proc Natl Acad Sci U S A (2009) 1.38
Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. Mol Biol Cell (2009) 1.36
RNA-binding proteins in early development. Crit Rev Biochem Mol Biol (2005) 1.33
Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly. Proc Natl Acad Sci U S A (2011) 1.31
Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids. Trends Parasitol (2010) 1.27
The KH domains of Xenopus Vg1RBP mediate RNA binding and self-association. RNA (2002) 1.26
Identification of a C-terminal poly(A)-binding protein (PABP)-PABP interaction domain: role in cooperative binding to poly (A) and efficient cap distal translational repression. J Biol Chem (2003) 1.23
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating. Nat Struct Mol Biol (2012) 1.18
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. J Biol Chem (2010) 1.17
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific. BMC Genomics (2007) 1.15
The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes. Mol Biochem Parasitol (2010) 1.15
A multiplex PCR that discriminates between Trypanosoma brucei brucei and zoonotic T. b. rhodesiense. Exp Parasitol (2007) 1.14
Intracellular membrane transport systems in Trypanosoma brucei. Traffic (2004) 1.13
The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol (2002) 1.12
Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis. Genome Res (2009) 1.12
Solution structure and backbone dynamics of the KH-QUA2 region of the Xenopus STAR/GSG quaking protein. J Mol Biol (2005) 1.11
Bloodstream form Trypanosome plasma membrane proteins: antigenic variation and invariant antigens. Parasitology (2010) 1.11
Multiple binding of repressed mRNAs by the P-body protein Rck/p54. RNA (2012) 1.10
Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues. Mol Biochem Parasitol (2005) 1.09
The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense. Mol Biochem Parasitol (2003) 1.09
Two distinct Staufen isoforms in Xenopus are vegetally localized during oogenesis. RNA (2004) 1.07
The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci (2010) 1.06
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity. Proc Natl Acad Sci U S A (2013) 1.06
Distinct functions of maternal and somatic Pat1 protein paralogs. RNA (2010) 1.06
Two Piwi proteins, Xiwi and Xili, are expressed in the Xenopus female germline. RNA (2009) 1.05
Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes. Eukaryot Cell (2007) 1.05
The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol (2002) 1.05
Ubiquitylation is required for degradation of transmembrane surface proteins in trypanosomes. Traffic (2008) 1.05
Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device. PLoS Negl Trop Dis (2013) 1.04
Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction (2004) 1.03
Cytoplasmic targeting signals in transmembrane invariant surface glycoproteins of trypanosomes. J Biol Chem (2004) 1.03
Ubiquitylation and developmental regulation of invariant surface protein expression in trypanosomes. Eukaryot Cell (2011) 1.03
Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor. Nucleic Acids Res (2005) 1.03
Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2. J Biol Chem (2004) 1.01
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties. Mol Biochem Parasitol (2010) 0.99
Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. BMC Genomics (2010) 0.98
A new generation of T7 RNA polymerase-independent inducible expression plasmids for Trypanosoma brucei. PLoS One (2012) 0.98
Pat1 proteins: a life in translation, translation repression and mRNA decay. Biochem Soc Trans (2010) 0.98
Whole-genome analysis of animal A- and B-type cyclins. Genome Biol (2002) 0.97
The Xenopus ELAV protein ElrB represses Vg1 mRNA translation during oogenesis. Mol Cell Biol (2005) 0.96
Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS One (2009) 0.94
VSG structure: similar N-terminal domains can form functional VSGs with different types of C-terminal domain. Mol Biochem Parasitol (2003) 0.92
Functional characterization of three leishmania poly(a) binding protein homologues with distinct binding properties to RNA and protein partners. Eukaryot Cell (2010) 0.91
Molecular mechanism of peroxisome proliferator-activated receptor α activation by WY14643: a new mode of ligand recognition and receptor stabilization. J Mol Biol (2013) 0.91
VSGdb: a database for trypanosome variant surface glycoproteins, a large and diverse family of coiled coil proteins. BMC Bioinformatics (2007) 0.91
Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. PLoS One (2010) 0.90
RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor. Mol Biol Cell (2011) 0.90
How do trypanosomes change gene expression in response to the environment? Protoplasma (2011) 0.90
Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate. J Cell Sci (2012) 0.90
Functional characterization of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages. Mol Microbiol (2008) 0.90
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei. Biochim Biophys Acta (2012) 0.89
Role of cdc2 kinase phosphorylation and conserved N-terminal proteolysis motifs in cytoplasmic polyadenylation-element-binding protein (CPEB) complex dissociation and degradation. Biochem J (2003) 0.89
Disease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer. Curr Med Res Opin (2014) 0.89
The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation. PLoS Pathog (2009) 0.89
Is there a classical nonsense-mediated decay pathway in trypanosomes? PLoS One (2011) 0.88
Characterization of novel Leishmania infantum recombinant proteins encoded by genes from five families with distinct capacities for serodiagnosis of canine and human visceral leishmaniasis. Am J Trop Med Hyg (2011) 0.87
Candidate protein selection for diagnostic markers of African trypanosomiasis. Trends Parasitol (2004) 0.87
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis. BMC Genomics (2014) 0.86
Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Nucleic Acids Res (2013) 0.86
Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families. Protein Sci (2014) 0.85
Yeast-based automated high-throughput screens to identify anti-parasitic lead compounds. Open Biol (2013) 0.85
The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule. PLoS One (2012) 0.85
Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein. J Biol Chem (2007) 0.85
The Ontology for Parasite Lifecycle (OPL): towards a consistent vocabulary of lifecycle stages in parasitic organisms. J Biomed Semantics (2012) 0.85
Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells. PLoS One (2013) 0.85
Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA pools. PLoS One (2013) 0.84
Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. Proteins (2009) 0.84
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms. Protein Sci (2010) 0.83
Alterations in DRBD3 ribonucleoprotein complexes in response to stress in Trypanosoma brucei. PLoS One (2012) 0.83