Published in Nature on November 25, 2004
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
De novo cardiomyocytes from within the activated adult heart after injury. Nature (2011) 5.17
Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest (2005) 4.25
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A (2005) 4.13
Gene expression analysis of zebrafish heart regeneration. PLoS Biol (2006) 3.00
Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest (2005) 2.80
Death begets failure in the heart. J Clin Invest (2005) 2.72
The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest (2005) 2.62
Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures. Am J Physiol Heart Circ Physiol (2006) 2.37
Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev (2006) 2.29
miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med (2011) 2.24
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol (2009) 1.88
Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev (2006) 1.80
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation (2008) 1.77
Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol (2011) 1.77
Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76
Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol (2012) 1.70
Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest (2009) 1.69
Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation (2008) 1.68
The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell (2009) 1.62
Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res (2012) 1.57
Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease. Circulation (2012) 1.53
Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials (2009) 1.50
An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50
Reverse remodeling in heart failure--mechanisms and therapeutic opportunities. Nat Rev Cardiol (2011) 1.49
Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res (2008) 1.42
Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One (2014) 1.39
Importance of the SDF-1:CXCR4 axis in myocardial repair. Circ Res (2009) 1.37
Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair (2008) 1.37
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol (2005) 1.27
Enhancing repair of the mammalian heart. Circ Res (2007) 1.21
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol (2007) 1.18
From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. J Cell Biol (2009) 1.17
Cardiac regeneration. Curr Top Dev Biol (2012) 1.17
Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration. Dev Cell (2009) 1.14
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol (2009) 1.14
Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus. J Proteome Res (2009) 1.13
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest (2010) 1.09
Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke. Neuroscience (2010) 1.09
Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy. PLoS One (2011) 1.09
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation (2009) 1.08
Gene manipulated peritoneal cell patch repairs infarcted myocardium. J Mol Cell Cardiol (2009) 1.08
Importance of myocyte-nonmyocyte interactions in cardiac development and disease. Circ Res (2012) 1.07
Zebrafish models in cardiac development and congenital heart birth defects. Differentiation (2012) 1.07
Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res (2011) 1.05
Perfusable branching microvessel bed for vascularization of engineered tissues. Proc Natl Acad Sci U S A (2012) 1.04
Neurological functional recovery after thymosin beta4 treatment in mice with experimental auto encephalomyelitis. Neuroscience (2009) 1.03
Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int (2013) 1.03
Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circ Res (2013) 1.02
Coronary vessel development and insight towards neovascular therapy. Int J Exp Pathol (2009) 1.00
Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J Biol Chem (2008) 0.99
Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts. PLoS One (2011) 0.98
Learning from failure: congestive heart failure in the postgenomic age. J Clin Invest (2005) 0.98
Gender-based differences in cardiac remodeling and ILK expression after myocardial infarction. Arq Bras Cardiol (2014) 0.98
PAI-1 and kidney fibrosis. Front Biosci (Landmark Ed) (2009) 0.97
Protein therapeutics for cardiac regeneration after myocardial infarction. J Cardiovasc Transl Res (2010) 0.97
Treatment of traumatic brain injury with thymosin β₄ in rats. J Neurosurg (2010) 0.96
Stemming heart failure with cardiac- or reprogrammed-stem cells. J Cell Mol Med (2008) 0.96
Thymosin beta(4) and beta(10) levels in pre-term newborn oral cavity and foetal salivary glands evidence a switch of secretion during foetal development. PLoS One (2009) 0.95
Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency. Am J Pathol (2007) 0.95
Thymosin beta 4 protects cardiomyocytes from oxidative stress by targeting anti-oxidative enzymes and anti-apoptotic genes. PLoS One (2012) 0.93
Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell (2009) 0.93
Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair. Drug Discov Today Dis Models (2007) 0.93
Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart. Ann N Y Acad Sci (2012) 0.93
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing. Nat Commun (2013) 0.93
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J (2011) 0.92
Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium. Circ Res (2005) 0.92
Regenerating functional heart tissue for myocardial repair. Cell Mol Life Sci (2012) 0.92
Stem cell therapy: pieces of the puzzle. J Cardiovasc Transl Res (2009) 0.91
Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats. J Neurosurg (2012) 0.91
Intramyocardial administration of chimeric ephrinA1-Fc promotes tissue salvage following myocardial infarction in mice. J Physiol (2011) 0.91
Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PLoS One (2010) 0.90
The role of thymosin beta 4 on odontogenic differentiation in human dental pulp cells. PLoS One (2013) 0.89
Cardiomyocyte-specific role of miR-24 in promoting cell survival. J Cell Mol Med (2014) 0.89
Thymosin β 4 mediates oligodendrocyte differentiation by upregulating p38 MAPK. Glia (2012) 0.89
Expression pattern of thymosin beta 4 in the adult human liver. Eur J Histochem (2011) 0.89
Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells. Am J Pathol (2011) 0.88
Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure. Cardiovasc Res (2010) 0.88
Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors. Fibrogenesis Tissue Repair (2011) 0.87
Application of peripheral-blood-derived endothelial progenitor cell for treating ischemia-reperfusion injury and infarction: a preclinical study in rat models. J Cardiothorac Surg (2013) 0.87
Thymosin β4 increases the potency of transplanted mesenchymal stem cells for myocardial repair. Circulation (2013) 0.87
Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a. Stem Cells Dev (2013) 0.87
N-acetyl-seryl-aspartyl-lysyl-proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes. Front Pharmacol (2014) 0.86
Thymosin β4 is not required for embryonic viability or vascular development. Circ Res (2013) 0.86
Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia. Ann N Y Acad Sci (2010) 0.86
Thymosin β4 promotes the recovery of peripheral neuropathy in type II diabetic mice. Neurobiol Dis (2012) 0.86
Cardiac repair by embryonic stem-derived cells. Handb Exp Pharmacol (2006) 0.85
Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner. FASEB J (2011) 0.85
The epicardium as a candidate for heart regeneration. Future Cardiol (2012) 0.85
Thymosin beta4 and Ac-SDKP: tools to mend a broken heart. J Mol Med (Berl) (2007) 0.85
A dose-response study of thymosin β4 for the treatment of acute stroke. J Neurol Sci (2014) 0.85
Thymosin β4 overexpression regulates neuron production and spatial distribution in the developing avian optic tectum. Histochem Cell Biol (2016) 0.84
Thymosin beta4: a candidate for treatment of stroke? Ann N Y Acad Sci (2010) 0.84
Snapshot peptidomics of the regulated secretory pathway. Mol Cell Proteomics (2009) 0.84
Rsu1 contributes to regulation of cell adhesion and spreading by PINCH1-dependent and - independent mechanisms. J Cell Commun Signal (2013) 0.84
Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility. Histochem Cell Biol (2006) 0.84
Cardioprotective signaling by endothelin. Trends Cardiovasc Med (2008) 0.84
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature (2009) 10.26
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature (2003) 6.40
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res (2004) 5.57
A developmental view of microRNA function. Trends Biochem Sci (2007) 4.75
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell (2008) 4.70
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22
Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell (2009) 4.21
MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A (2005) 3.78
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development (2004) 2.61
MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell (2010) 2.57
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A (2007) 2.56
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science (2011) 2.46
MicroRNA regulation of cardiovascular development. Circ Res (2009) 2.42
Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet (2002) 2.27
miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med (2011) 2.24
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev (2003) 2.01
Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res (2010) 2.00
Genetics of human cardiovascular disease. Cell (2012) 1.90
Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol (2009) 1.88
microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci U S A (2008) 1.80
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development (2004) 1.75
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol (2009) 1.73
Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol (2007) 1.71
Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol (2008) 1.69
Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation (2008) 1.68
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol (2011) 1.66
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66
Chromosomal haplotypes by genetic phasing of human families. Am J Hum Genet (2011) 1.58
MicroRNAs: opening a new vein in angiogenesis research. Sci Signal (2009) 1.58
MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res (2012) 1.56
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development (2006) 1.56
A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes Dev (2011) 1.48
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet (2005) 1.47
Technique for branched thoracic stent-graft repair of a chronic type a aortic dissection in a patient with multiple prior sternotomies. J Endovasc Ther (2011) 1.47
Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol (2004) 1.47
Endovascular repair of acute traumatic thoracic aortic transection with laser-assisted in-situ fenestration of a stent-graft covering the left subclavian artery. J Endovasc Ther (2009) 1.46
Thoracic endovascular repair (TEVAR) in the management of aortic arch pathology. Ann Vasc Surg (2012) 1.45
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A (2007) 1.42
Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A (2008) 1.39
Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36
Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell (2012) 1.35
Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol (2009) 1.32
Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nat Protoc (2013) 1.31
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (2011) 1.31
Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells (2013) 1.29
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol (2008) 1.29
Elevated miR-499 levels blunt the cardiac stress response. PLoS One (2011) 1.28
Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome. Mol Microbiol (2006) 1.26
Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem (2004) 1.24
Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem (2009) 1.20
Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor. Am J Physiol Heart Circ Physiol (2003) 1.19
The paradoxical patent ductus arteriosus. J Clin Invest (2006) 1.18
microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife (2013) 1.18
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome. Trends Mol Med (2003) 1.16
Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. Am J Med Genet A (2007) 1.13
Critical factors for cardiac reprogramming. Circ Res (2012) 1.12
Identification of GATA6 sequence variants in patients with congenital heart defects. Pediatr Res (2010) 1.10
Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis (2010) 1.10
Stem cell therapy for cardiac disease. Pediatr Res (2012) 1.10
Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury. Am J Physiol Heart Circ Physiol (2004) 1.09
Japanese encephalitis (JE). Part I: clinical profile of 1,282 adult acute cases of four epidemics. J Neurol (2011) 1.07
Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT. J Cell Biol (2013) 1.06
Cellular and molecular regulation of skeletal muscle side population cells. Stem Cells (2004) 1.05
Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle (2008) 1.05
Impact of percutaneous coronary intervention performance reporting on cardiac resuscitation centers: a scientific statement from the American Heart Association. Circulation (2013) 1.04
Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circ Res (2010) 1.04
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet (2012) 1.03
The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn (2011) 1.03
Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circ Res (2013) 1.02
MicroRNAs in cardiac development. Pediatr Cardiol (2010) 1.01
Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol (2003) 1.01
Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem Biophys Res Commun (2006) 1.01
The genetics of cardiac birth defects. Semin Cell Dev Biol (2006) 0.99
Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin. J Thorac Cardiovasc Surg (2003) 0.99
Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol (2010) 0.99
Theory of transport of long polymer molecules through carbon nanotube channels. Phys Rev Lett (2003) 0.99
Transcriptional regulation during development of the ductus arteriosus. Circ Res (2008) 0.96
Reparative myocardial mechanisms in adult C57BL/6 and MRL mice following injury. Physiol Genomics (2007) 0.96
Volumetric analysis of type B aortic dissections treated with thoracic endovascular aortic repair. J Vasc Surg (2011) 0.96
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol (2011) 0.95
Thymosin beta4 is cardioprotective after myocardial infarction. Ann N Y Acad Sci (2007) 0.95
Fibronectin mediates mesendodermal cell fate decisions. Development (2013) 0.95
The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development (2010) 0.94
A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Dev Cell (2011) 0.93