Published in J Biol Chem on December 05, 2004
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood (2006) 1.48
Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell (2007) 1.10
Structure of the split PH domain and distinct lipid-binding properties of the PH-PDZ supramodule of alpha-syntrophin. EMBO J (2005) 1.03
BAG3: a new player in the heart failure paradigm. Heart Fail Rev (2015) 0.98
Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. J Biol Chem (2010) 0.97
Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity. J Biol Chem (2009) 0.93
Inhibition of phospholipase C disrupts cytoskeletal organization and gravitropic growth in Arabidopsis roots. Planta (2010) 0.81
The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis. Exp Mol Med (2013) 0.80
Centaurin-α₂ interacts with β-tubulin and stabilizes microtubules. PLoS One (2012) 0.78
Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative. Cancer Cell Int (2016) 0.76
A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation. Exp Mol Med (2010) 0.76
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 3.07
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling. J Natl Cancer Inst (2014) 2.96
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem (2003) 2.94
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Nat Cell Biol (2006) 2.23
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. J Biol Chem (2003) 2.14
Detection of prefracture hip lesions in atypical subtrochanteric fracture with dual-energy x-ray absorptiometry images. Radiology (2013) 2.09
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol (2006) 2.00
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem (2006) 1.94
Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol (2002) 1.90
Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem (2001) 1.85
Scoliosis imaging: what radiologists should know. Radiographics (2010) 1.77
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71
Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase. Mol Microbiol (2006) 1.70
Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol (2003) 1.67
Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis (2003) 1.64
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc Natl Acad Sci U S A (2012) 1.53
An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One (2007) 1.53
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell (2012) 1.49
Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. J Biol Chem (2005) 1.42
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol Cell Biol (2004) 1.37
Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene (2005) 1.34
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood (2008) 1.30
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett (2007) 1.30
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J Immunol (2006) 1.30
Changes in IP3 receptor are associated with altered calcium response to cholecystokinin in diabetic rat pancreatic acini. Pancreas (2004) 1.29
Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A (2010) 1.28
Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene (2003) 1.27
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol Cell Biol (2009) 1.25
Biological imaging of HEK293 cells expressing PLCgamma1 using surface-enhanced Raman microscopy. Anal Chem (2007) 1.23
Crystal structure of SEDL and its implications for a genetic disease spondyloepiphyseal dysplasia tarda. J Biol Chem (2002) 1.23
o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells. Cell Signal (2007) 1.23
p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res (2008) 1.23
Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene (2004) 1.22
Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways. Carcinogenesis (2009) 1.20
Parkin ubiquitinates and promotes the degradation of RanBP2. J Biol Chem (2005) 1.19
Electroacupuncture preconditioning reduces cerebral ischemic injury via BDNF and SDF-1α in mice. BMC Complement Altern Med (2013) 1.18
TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of CXCR3 ligand chemokines. J Biol Chem (2010) 1.16
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev (2011) 1.15
Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol Cell Biol (2003) 1.15
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood (2008) 1.15
Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med (2009) 1.13
Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. J Biol Chem (2007) 1.13
New classification and clinical characteristics of reexpansion pulmonary edema after treatment of spontaneous pneumothorax. Am J Emerg Med (2009) 1.12
Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem (2003) 1.11
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal (2006) 1.11
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun (2011) 1.10
Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin. Cancer Lett (2004) 1.08
Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol (2008) 1.07
Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha. Biochem Biophys Res Commun (2008) 1.07
Electroacupuncture acutely improves cerebral blood flow and attenuates moderate ischemic injury via an endothelial mechanism in mice. PLoS One (2013) 1.07
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem (2002) 1.06
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria. J Biol Chem (2006) 1.06
Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells. J Biol Chem (2008) 1.06
Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis. Mol Ther (2013) 1.06
Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase. J Cell Physiol (2012) 1.05
The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. J Biol Chem (2005) 1.05
α-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization. Arterioscler Thromb Vasc Biol (2010) 1.05
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis (2013) 1.04
Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. J Biol Chem (2009) 1.04
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem (2006) 1.03
Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis. Oncogene (2004) 1.03
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci U S A (2008) 1.02
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. Mol Biol Cell (2002) 1.02
Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene (2004) 1.02
Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Biochem J (2005) 1.02
CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia (2014) 1.01
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J (2006) 1.01
Phospholipase D meets Wnt signaling: a new target for cancer therapy. Cancer Res (2011) 1.01
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem (2002) 1.01
Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis. Cancer Res (2010) 1.00
Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha. Mol Cancer Res (2010) 1.00
Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J Cell Sci (2004) 0.99
Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. J Cell Physiol (2010) 0.99
Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis. Proteomics (2010) 0.98
Egr-1 regulates the transcription of the BRCA1 gene by etoposide. BMB Rep (2013) 0.98
RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. J Biol Chem (2002) 0.98
cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models. J Biochem Mol Biol (2002) 0.98
Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C. Biochim Biophys Acta (2004) 0.98
4-Hydroxynonenal induces vascular smooth muscle cell apoptosis through mitochondrial generation of reactive oxygen species. Toxicol Lett (2006) 0.98
Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun (2010) 0.98
Differential activation of formyl peptide receptor signaling by peptide ligands. Mol Pharmacol (2003) 0.98
Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin. J Biol Chem (2004) 0.98
Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation. Biochem Biophys Res Commun (2011) 0.97
Alterations in cell proliferation related gene expressions in gastric cancer. Crit Rev Eukaryot Gene Expr (2011) 0.97
Phospholipase D2 directly interacts with aldolase via Its PH domain. Biochemistry (2002) 0.97
Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity. Exp Mol Med (2007) 0.97