Published in J Biol Chem on November 27, 2001
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87
Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol (2010) 3.36
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest (2003) 2.60
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol (2004) 2.51
Lewy bodies. Proc Natl Acad Sci U S A (2006) 2.15
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13
Neuronal degeneration and mitochondrial dysfunction. J Clin Invest (2003) 2.00
Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation (2005) 1.72
α-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.62
Cell systems and the toxic mechanism(s) of alpha-synuclein. Exp Neurol (2007) 1.59
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect (2003) 1.47
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.47
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci U S A (2003) 1.40
Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta (2008) 1.35
Integrating pathways of Parkinson's disease in a molecular interaction map. Mol Neurobiol (2013) 1.34
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta (2009) 1.26
Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med (2008) 1.25
Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin. Mol Biol Cell (2003) 1.23
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation. J Neurochem (2010) 1.22
Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex. J Virol (2009) 1.22
Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy. J Biol Chem (2013) 1.18
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. J Neurochem (2007) 1.15
The neurodegenerative mitochondriopathies. J Alzheimers Dis (2009) 1.14
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults. Free Radic Biol Med (2008) 1.13
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med (2011) 1.12
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med (2013) 1.12
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci (2014) 1.11
Disruption of protein quality control in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.07
Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci (2010) 1.01
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases. Biochim Biophys Acta (2009) 1.01
Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food Chem Toxicol (2010) 1.01
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis (2011) 0.99
Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death. J Biol Chem (2011) 0.97
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders. Exp Neurobiol (2011) 0.86
Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell (2012) 0.86
Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice. Exp Neurobiol (2011) 0.86
Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection. Parkinsons Dis (2010) 0.86
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proc Natl Acad Sci U S A (2016) 0.82
alpha-Synuclein: a therapeutic target for Parkinson's disease? Pharmacol Res (2008) 0.82
Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra. Cell Death Dis (2012) 0.82
Protein aggregation containing β-amyloid, α-synuclein and hyperphosphorylated τ in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. BMC Neurosci (2010) 0.81
Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation. Exp Mol Med (2015) 0.80
Aggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substrates. J Virol (2013) 0.80
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation. J Biol Chem (2016) 0.79
Alpha-synuclein aggregation is involved in the toxicity induced by ferric iron to SK-N-SH neuroblastoma cells. J Neural Transm (Vienna) (2010) 0.79
Valproic Acid Regulates α-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes. Biomol Ther (Seoul) (2013) 0.78
Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease. Am J Transl Res (2014) 0.78
Histones facilitate α-synuclein aggregation during neuronal apoptosis. Acta Neuropathol (2016) 0.78
Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast. Biomolecules (2015) 0.77
Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification. Exp Mol Med (2017) 0.75
Younger age at onset of sporadic Parkinson's disease among subjects occupationally exposed to metals and pesticides. Interdiscip Toxicol (2014) 0.75
Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep (2017) 0.75
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation. Cell Death Dis (2017) 0.75
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci (2005) 3.93
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol (2008) 2.78
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci (2004) 2.25
Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J Biol Chem (2002) 2.19
Detection of prefracture hip lesions in atypical subtrochanteric fracture with dual-energy x-ray absorptiometry images. Radiology (2013) 2.09
Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. J Biol Chem (2001) 2.03
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry (2002) 1.98
OASIS: online application for the survival analysis of lifespan assays performed in aging research. PLoS One (2011) 1.98
Paricalcitol attenuates cyclosporine-induced kidney injury in rats. Kidney Int (2010) 1.92
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Scoliosis imaging: what radiologists should know. Radiographics (2010) 1.77
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia. Biochem Biophys Res Commun (2008) 1.71
Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis (2003) 1.64
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. J Neurosci (2012) 1.63
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem (2010) 1.60
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
A hybrid approach to estimating national scale spatiotemporal variability of PM2.5 in the contiguous United States. Environ Sci Technol (2013) 1.51
Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells. J Biol Chem (2002) 1.44
Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein. Eur J Neurosci (2006) 1.43
A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J (2004) 1.39
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab (2013) 1.37
Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem (2008) 1.34
Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett (2007) 1.30
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene (2003) 1.27
Biological imaging of HEK293 cells expressing PLCgamma1 using surface-enhanced Raman microscopy. Anal Chem (2007) 1.23
p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res (2008) 1.23
Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene (2004) 1.22
Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas. Oncogene (2004) 1.22
Primary central nervous system lymphoma presenting as an acute massive intracerebral hemorrhage: case report with immunohistochemical study. Surg Neurol (2008) 1.22
TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of CXCR3 ligand chemokines. J Biol Chem (2010) 1.16
Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol Cell Biol (2003) 1.15
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. Am J Pathol (2002) 1.12
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med (2011) 1.12
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med (2013) 1.12
New classification and clinical characteristics of reexpansion pulmonary edema after treatment of spontaneous pneumothorax. Am J Emerg Med (2009) 1.12
The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun (2011) 1.10
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY) (2011) 1.09
Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability. Gastroenterology (2012) 1.09
Clinicopathologic analysis of fine needle aspiration cytology of the thyroid. A review of 1,613 cases and correlation with histopathologic diagnoses. Acta Cytol (2003) 1.08
HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling. Mol Cancer (2010) 1.08
Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin. Cancer Lett (2004) 1.08
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem (2002) 1.06
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis (2013) 1.04
Analysis of fine needle aspiration cytology of the breast: a review of 1,297 cases and correlation with histologic diagnoses. Acta Cytol (2004) 1.03
Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma. Gynecol Oncol (2007) 1.03
Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens. Gynecol Oncol (2010) 1.03
Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats. Am J Physiol Renal Physiol (2009) 1.02
Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene (2004) 1.02
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J (2006) 1.01
Primary testicular osteosarcoma with hydrocele. Virchows Arch (2004) 1.00
Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha. Mol Cancer Res (2010) 1.00
Primary large cell neuroendocrine carcinoma of the urinary bladder. Pathol Int (2006) 1.00
Egr-1 regulates the transcription of the BRCA1 gene by etoposide. BMB Rep (2013) 0.98
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell (2013) 0.98
cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models. J Biochem Mol Biol (2002) 0.98
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (2009) 0.97
A novel mechanism of interaction between alpha-synuclein and biological membranes. J Mol Biol (2006) 0.96
Enzymatic synthesis and properties of highly branched rice starch amylose and amylopectin cluster. J Agric Food Chem (2007) 0.96
Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities. J Neurosci Methods (2011) 0.95
A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. BMC Cell Biol (2010) 0.95
Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1. Gene (2010) 0.95
Brain tumor invasion model system using organotypic brain-slice culture as an alternative to in vivo model. J Cancer Res Clin Oncol (2002) 0.94
Benzochalcones bearing pyrazoline moieties show anti-colorectal cancer activities and selective inhibitory effects on aurora kinases. Bioorg Med Chem (2013) 0.94
Pleckstrin homology domains of phospholipase C-gamma1 directly interact with beta-tubulin for activation of phospholipase C-gamma1 and reciprocal modulation of beta-tubulin function in microtubule assembly. J Biol Chem (2004) 0.94
Preparation of poly(DL-lactide-co-glycolide) microspheres encapsulating all-trans retinoic acid. Int J Pharm (2003) 0.94
Radiation dose reduction via sinogram affirmed iterative reconstruction and automatic tube voltage modulation (CARE kV) in abdominal CT. Korean J Radiol (2013) 0.94
Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. FASEB J (2004) 0.93
Mitochondria and organismal longevity. Curr Genomics (2012) 0.93
Inflammatory myofibroblastic tumor of the kidney misdiagnosed as renal cell carcinoma. J Korean Med Sci (2009) 0.93
Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis. Cancer Biol Ther (2008) 0.93
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
Renal cell carcinoma in South Korea: a multicenter study. Hum Pathol (2004) 0.93
Scrotal primary lipoma with unusual clinical appearance in newborn. Urology (2009) 0.92
Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. Exp Cell Res (2002) 0.92
Regulation of cell proliferation and migration by keratin19-induced nuclear import of early growth response-1 in breast cancer cells. Clin Cancer Res (2013) 0.92
Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Carcinogenesis (2012) 0.92
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet (2012) 0.92
Microsatellite instability at a tetranucleotide repeat in type I endometrial carcinoma. J Exp Clin Cancer Res (2008) 0.92
Relationship between distal screws and femoral arteries in closed hip nailing on computed tomography angiography. Arch Orthop Trauma Surg (2012) 0.92
SERS imaging of HER2-overexpressed MCF7 cells using antibody-conjugated gold nanorods. Phys Chem Chem Phys (2009) 0.92
Dissociation of emotional decision-making from cognitive decision-making in chronic schizophrenia. Psychiatry Res (2007) 0.92
Culture-independent analysis of microbial succession during composting of Swine slurry and mushroom cultural wastes. J Microbiol Biotechnol (2008) 0.91
Porcelain heart: rapid progression of cardiac calcification in a patient with hemodialysis. J Cardiovasc Ultrasound (2012) 0.91
Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence. Langenbecks Arch Surg (2011) 0.91
Incidental unruptured intracranial aneurysms in patients with acute ischemic stroke. Cerebrovasc Dis (2008) 0.91