Published in Proc Natl Acad Sci U S A on December 07, 2004
Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26
Structural basis for the enhancement of eIF4A helicase activity by eIF4G. Genes Dev (2005) 1.83
Crystal structure and functional analysis of DEAD-box protein Dhh1p. RNA (2005) 1.70
The ATPase cycle mechanism of the DEAD-box rRNA helicase, DbpA. J Mol Biol (2007) 1.70
Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus. Chromosoma (2008) 1.69
The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. Nat Struct Mol Biol (2009) 1.68
Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase. Proc Natl Acad Sci U S A (2008) 1.58
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell (2012) 1.53
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J (2011) 1.49
Amino acid residue doublet propensity in the protein-RNA interface and its application to RNA interface prediction. Nucleic Acids Res (2006) 1.41
Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol (2009) 1.40
DEAD-box proteins as RNA helicases and chaperones. Wiley Interdiscip Rev RNA (2011) 1.37
ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56. Mol Cell Biol (2007) 1.30
Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev (2008) 1.25
Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proc Natl Acad Sci U S A (2009) 1.25
Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function. Biochemistry (2006) 1.20
RNA helicase proteins as chaperones and remodelers. Annu Rev Biochem (2014) 1.17
Toward a molecular understanding of RNA remodeling by DEAD-box proteins. RNA Biol (2012) 1.16
DEAD-box helicases as integrators of RNA, nucleotide and protein binding. Biochim Biophys Acta (2013) 1.16
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Mol Cell Biol (2006) 1.14
Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain. J Biol Chem (2008) 1.08
Stress-induced Oryza sativa BAT1 dual helicase exhibits unique bipolar translocation. Protoplasma (2015) 1.08
Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Mol Cell Biol (2006) 1.04
ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). J Biol Chem (2012) 1.00
HsdR subunit of the type I restriction-modification enzyme EcoR124I: biophysical characterisation and structural modelling. J Mol Biol (2007) 1.00
RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon. EMBO J (2009) 0.99
A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility. Nucleic Acids Res (2008) 0.98
Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo. J Biol Chem (2011) 0.94
The application of FAST-NMR for the identification of novel drug discovery targets. Drug Discov Today (2008) 0.93
Ddx42p--a human DEAD box protein with RNA chaperone activities. Nucleic Acids Res (2006) 0.91
The fragment structure of a putative HsdR subunit of a type I restriction enzyme from Vibrio vulnificus YJ016: implications for DNA restriction and translocation activity. Nucleic Acids Res (2009) 0.90
Structure of the second domain of the Bacillus subtilis DEAD-box RNA helicase YxiN. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.88
DDX3, a potential target for cancer treatment. Mol Cancer (2015) 0.83
An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway. PLoS One (2011) 0.82
The molecular evolution of PL10 homologs. BMC Evol Biol (2010) 0.81
RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2015) 0.81
Crystallization and preliminary characterization of the Thermus thermophilus RNA helicase Hera C-terminal domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.81
AMP sensing by DEAD-box RNA helicases. J Mol Biol (2013) 0.81
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Nucleic Acids Res (2013) 0.79
Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1. Elife (2017) 0.76
Expression, purification and preliminary crystallographic analysis of recombinant human DEAD-box polypeptide 5. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.76
Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice. J Proteome Res (2013) 0.76
Sexually dimorphic expression of vasa isoforms in the tongue sole (Cynoglossus semilaevis). PLoS One (2014) 0.75
A genomic glance at the components of the mRNA export machinery in Plasmodium falciparum. Commun Integr Biol (2010) 0.75
Structural analyses of the pre-mRNA splicing machinery. Protein Sci (2013) 0.75
Understanding pre-mRNA splicing through crystallography. Methods (2017) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins (1991) 36.69
Raster3D: photorealistic molecular graphics. Methods Enzymol (1997) 27.30
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol (2004) 11.39
Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell (1998) 10.95
Implementation of molecular replacement in AMoRe. Acta Crystallogr D Biol Crystallogr (2001) 8.92
Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. Cell (1999) 6.84
TREX is a conserved complex coupling transcription with messenger RNA export. Nature (2002) 6.53
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure (1998) 5.83
Structure of the recA protein-ADP complex. Nature (1992) 5.33
Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Cell (1997) 4.71
Helicase structure and mechanism. Curr Opin Struct Biol (2002) 4.29
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (2001) 3.94
Structure of the hepatitis C virus RNA helicase domain. Nat Struct Biol (1997) 3.80
Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature (2001) 3.35
Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Proc Natl Acad Sci U S A (2000) 3.01
Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science (2002) 2.72
The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr Biol (2001) 2.70
U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev (1997) 2.67
Coupling transcription, splicing and mRNA export. Curr Opin Cell Biol (2003) 2.54
The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis. Mol Cell (2003) 2.51
Structural basis for recognition of the intron branch site RNA by splicing factor 1. Science (2001) 2.35
Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA. J Biol Chem (1998) 2.35
Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Genes Dev (2001) 2.24
DExD/H-box proteins and their partners: helping RNA helicases unwind. Gene (2003) 2.23
Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair. EMBO J (1999) 2.12
The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol (2001) 1.98
Multiple roles for the yeast SUB2/yUAP56 gene in splicing. Genes Dev (2001) 1.91
A new twist on RNA helicases: DExH/D box proteins as RNPases. Nat Struct Biol (2001) 1.87
Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii. Proc Natl Acad Sci U S A (2001) 1.81
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family. Structure (1999) 1.79
Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J (2003) 1.70
Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56. Genes Dev (2001) 1.60
The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA (2003) 1.58
Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus. Proc Natl Acad Sci U S A (1999) 1.56
UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. RNA (2003) 1.45
Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase. RNA (1999) 1.44
Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair. J Biochem (1999) 1.43
Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export. Structure (2004) 1.33
Molecular biology. RNP remodeling with DExH/D boxes. Science (2001) 0.97
The DEAD-box protein family of RNA helicases. Gene (2005) 6.10
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77
DEAD-box proteins: the driving forces behind RNA metabolism. Nat Rev Mol Cell Biol (2004) 4.87
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science (2007) 4.12
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem (2002) 3.14
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell (2003) 2.86
The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis. Mol Cell (2003) 2.51
Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity. J Biol Chem (2007) 2.38
Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units. Science (2014) 2.37
The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell (2009) 2.27
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Mol Microbiol (2006) 1.92
Making the case for selective use of statins in the primary prevention setting. Arch Intern Med (2011) 1.90
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. J Biol Chem (2006) 1.90
Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J (2002) 1.89
Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev (2011) 1.87
The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3. J Biol Chem (2007) 1.80
The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity. EMBO J (2004) 1.78
Structure of the SET domain histone lysine methyltransferase Clr4. Nat Struct Biol (2002) 1.70
Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. Genes Dev (2010) 1.52
hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA (2006) 1.50
Cartography of methicillin-resistant S. aureus transcripts: detection, orientation and temporal expression during growth phase and stress conditions. PLoS One (2010) 1.46
Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Dev Biol (2005) 1.45
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem (2010) 1.41
A type III-like restriction endonuclease functions as a major barrier to horizontal gene transfer in clinical Staphylococcus aureus strains. Proc Natl Acad Sci U S A (2010) 1.40
Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Mol Microbiol (2004) 1.38
Crystal structure of the Drosophila Mago nashi-Y14 complex. Genes Dev (2003) 1.36
Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.32
A type IV modification-dependent restriction enzyme SauUSI from Staphylococcus aureus subsp. aureus USA300. Nucleic Acids Res (2011) 1.31
Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain. Mol Cell Biol (2006) 1.22
The CodY pleiotropic repressor controls virulence in gram-positive pathogens. FEMS Immunol Med Microbiol (2011) 1.20
Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat Struct Mol Biol (2012) 1.18
Unwinding single RNA molecules using helicases involved in eukaryotic translation initiation. J Mol Biol (2006) 1.17
Structural insights into protein arginine symmetric dimethylation by PRMT5. Proc Natl Acad Sci U S A (2011) 1.14
RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies. Nucleic Acids Res (2004) 1.13
Structural basis for the function of DCN-1 in protein Neddylation. J Biol Chem (2007) 1.11
A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins. Mol Cell Biol (2008) 1.10
Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs. Nucleic Acids Res (2005) 1.09
Structural basis for origin recognition complex 1 protein-silence information regulator 1 protein interaction in epigenetic silencing. Proc Natl Acad Sci U S A (2005) 1.08
Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits. Mol Microbiol (2009) 1.07
An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. RNA (2007) 1.06
Motif III in superfamily 2 "helicases" helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1. J Mol Biol (2009) 1.05
Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. Structure (2006) 1.05
The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus. RNA Biol (2012) 1.05
Structure and function of the BAH domain in chromatin biology. Crit Rev Biochem Mol Biol (2012) 1.02
A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae. Mol Cell (2004) 1.00
Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One (2012) 0.99
New range of vectors with a stringent 5-fluoroorotic acid-based counterselection system for generating mutants by allelic replacement in Staphylococcus aureus. Appl Environ Microbiol (2012) 0.96
Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat Struct Mol Biol (2013) 0.96
Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex. J Biol Chem (2011) 0.95
Therapeutic effect of gene-therapy in combination with local X-irradiation in a mouse malignant melanoma model. Biochem Biophys Res Commun (2005) 0.95
Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Res (2002) 0.93
The C-terminal region of the RNA helicase CshA is required for the interaction with the degradosome and turnover of bulk RNA in the opportunistic pathogen Staphylococcus aureus. RNA Biol (2015) 0.91
Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5. Biochemistry (2013) 0.90
Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells. Curr Genet (2007) 0.90
Analyses of the functional regions of DEAD-box RNA "helicases" with deletion and chimera constructs tested in vivo and in vitro. J Mol Biol (2011) 0.89
The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae. Genetics (2004) 0.89
Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc Natl Acad Sci U S A (2012) 0.89
Structure and assembly of the SF3a splicing factor complex of U2 snRNP. EMBO J (2012) 0.89
Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing. Biochem Biophys Res Commun (2005) 0.88
Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding. Genes Dev (2013) 0.87
Impact of fitness versus obesity on routinely measured cardiometabolic risk in young, healthy adults. Am J Cardiol (2013) 0.86
The distribution of transcutaneous CO2 emission and correlation with the points along the pericardium meridian. J Acupunct Meridian Stud (2009) 0.86
Power of yeast for analysis of eukaryotic translation initiation. J Biol Chem (2010) 0.86
Impact of oleic acid (cis-9-octadecenoic acid) on bacterial viability and biofilm production in Staphylococcus aureus. FEMS Microbiol Lett (2008) 0.86
A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nat Struct Mol Biol (2012) 0.83
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. Eur J Pharmacol (2012) 0.82
DEAD-box RNA helicases in gram-positive RNA decay. Methods Enzymol (2012) 0.81
Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Protein Cell (2015) 0.80
Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast. FEBS J (2006) 0.79
The biology of RNA helicases- modulation for life. Preface. Biochim Biophys Acta (2013) 0.77
Pressure perturbation calorimetry of helical peptides. Proteins (2006) 0.76
Correction: Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation. PLoS Genet (2016) 0.75
A pivotal role of the coiled coil of Sir4. Structure (2003) 0.75
Correction: Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. Elife (2016) 0.75
Protein science research in China. Protein Cell (2010) 0.75
Landmark lipid-lowering trials in the primary prevention of cardiovascular disease. Clin Cardiol (2013) 0.75
Molecular epigenetics: dawn of a new era of biomedical research. Sci China C Life Sci (2009) 0.75