Published in J Immunol on December 15, 2004
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol (2005) 6.95
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 3.76
Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest (2005) 3.73
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med (2005) 3.70
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Antigen-specific peripheral shaping of the natural regulatory T cell population. J Exp Med (2008) 2.68
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med (2005) 2.61
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci U S A (2005) 2.57
OX40 costimulation turns off Foxp3+ Tregs. Blood (2007) 2.52
Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut (2005) 2.37
Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A (2010) 2.30
Unique maturation program of the IgE response in vivo. Immunity (2007) 2.15
TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med (2007) 2.15
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunol Rev (2011) 2.02
A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol (2009) 2.01
An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme. Neuro Oncol (2006) 1.92
Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci U S A (2005) 1.90
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A (2007) 1.90
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol (2011) 1.89
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2. J Immunother (2005) 1.78
Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. J Immunol (2007) 1.78
Soluble IL-2Rα facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. Blood (2011) 1.75
Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol (2010) 1.72
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med (2009) 1.69
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Proc Natl Acad Sci U S A (2007) 1.64
IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol (2011) 1.56
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J Immunol (2006) 1.43
Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc Natl Acad Sci U S A (2007) 1.42
Control of homeostatic proliferation by regulatory T cells. J Clin Invest (2005) 1.40
FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly. PLoS Negl Trop Dis (2016) 1.39
Regulation of adaptive immunity; the role of interleukin-10. Front Immunol (2013) 1.38
Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection. J Exp Med (2007) 1.36
Regulatory T cells in many flavors control asthma. Mucosal Immunol (2010) 1.28
Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol (2006) 1.27
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice. J Exp Med (2010) 1.27
Peripherally induced tregs - role in immune homeostasis and autoimmunity. Front Immunol (2013) 1.24
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One (2009) 1.23
More stories on Th17 cells. Cell Res (2009) 1.14
Generation and function of induced regulatory T cells. Front Immunol (2013) 1.12
Stimulation of anti-tumor immunity by photodynamic therapy. Expert Rev Clin Immunol (2011) 1.11
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol (2012) 1.11
Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO. J Cereb Blood Flow Metab (2012) 1.11
CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells. J Immunol (2012) 1.10
Influenza A virus infection results in a robust, antigen-responsive, and widely disseminated Foxp3+ regulatory T cell response. J Virol (2011) 1.09
Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response. J Immunol (2006) 1.09
Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma. Proc Natl Acad Sci U S A (2010) 1.08
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat Immunol (2015) 1.06
The role of virus-induced regulatory T cells in immunopathology. Springer Semin Immunopathol (2006) 1.05
Th17 cells and Tregs: unlikely allies. J Leukoc Biol (2014) 1.03
From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine. Semin Immunol (2008) 0.99
Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model. Front Immunol (2012) 0.99
Regulatory T cells in radiotherapeutic responses. Front Oncol (2012) 0.98
Natural regulatory T cells in autoimmunity. Autoimmunity (2010) 0.94
Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem (2010) 0.94
In vivo expansion of regulatory T cells with IL-2/IL-2 mAb complexes prevents anti-factor VIII immune responses in hemophilia A mice treated with factor VIII plasmid-mediated gene therapy. Mol Ther (2011) 0.94
Molecular signature of recent thymic selection events on effector and regulatory CD4+ T lymphocytes. J Immunol (2005) 0.93
Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells. Eur J Immunol (2011) 0.92
Expansion of CD4+ CD25+ Foxp3+ T cells by bone marrow-derived dendritic cells. Immunology (2009) 0.91
A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model. Mol Immunol (2007) 0.90
Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection. PLoS One (2011) 0.90
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells. Front Immunol (2013) 0.90
Mechanisms of tolerance and allergic sensitization in the airways and the lungs. Curr Opin Immunol (2010) 0.90
The impact of aging on regulatory T-cells. Front Immunol (2013) 0.89
Cellular and molecular determinants for the development of natural and induced regulatory T cells. Hum Immunol (2012) 0.88
Human adipose-tissue derived mesenchymal stem cells induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA. Clin Exp Immunol (2013) 0.88
Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells. Virology (2009) 0.88
T lymphocytes and normal tissue responses to radiation. Front Oncol (2012) 0.86
Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models. Front Immunol (2013) 0.86
IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection. J Immunol (2013) 0.86
Tumor necrosis factor-related apoptosis-inducing ligand inhibits experimental autoimmune thyroiditis by the expansion of CD4+CD25+ regulatory T cells. Endocrinology (2008) 0.86
Peripheral induction of tolerance by retinal antigen expression. J Immunol (2009) 0.86
Can TNF-α boost regulatory T cells? J Clin Invest (2010) 0.85
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells. Inflamm Res (2012) 0.85
G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol (2007) 0.85
Regulation of CD8(+) T Cell Responses to Retinal Antigen by Local FoxP3(+) Regulatory T Cells. Front Immunol (2012) 0.84
Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features. Front Immunol (2013) 0.84
HSP60: issues and insights on its therapeutic use as an immunoregulatory agent. Front Immunol (2012) 0.83
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development. Pediatr Rheumatol Online J (2008) 0.83
PD-1 regulates extrathymic regulatory T-cell differentiation. Eur J Immunol (2014) 0.83
Local "on-demand" generation and function of antigen-specific Foxp3+ regulatory T cells. J Immunol (2013) 0.82
Foxp3(+) regulatory T cells in mouse models of type 1 diabetes. J Diabetes Res (2013) 0.82
Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS One (2012) 0.81
Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis. Mucosal Immunol (2012) 0.81
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms. Cell Immunol (2010) 0.81
Susceptibility of neonatal T cells and adult thymocytes to peripheral tolerance to allogeneic stimuli. Immunology (2008) 0.81
Stable activity of diabetogenic cells with age in NOD mice: dynamics of reconstitution and adoptive diabetes transfer in immunocompromised mice. Immunology (2014) 0.81
Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis. Am J Pathol (2005) 0.81
Phenotype and function of regulatory T cells in the genital tract. Curr Trends Immunol (2011) 0.80
Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome. Pediatr Nephrol (2012) 0.80
Origin of Foxp3(+) cells during pregnancy. Am J Clin Exp Immunol (2013) 0.80
Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective. Immunol Cell Biol (2015) 0.80
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity (2009) 6.11
Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med (2002) 3.94
Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest (2005) 3.73
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature (2011) 3.37
Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity (2008) 3.33
Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (2010) 3.31
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu Rev Immunol (2012) 2.71
Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nat Med (2008) 2.52
CD4(+) regulatory T cells in autoimmunity and allergy. Curr Opin Immunol (2002) 2.25
TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J Exp Med (2009) 2.18
Unique maturation program of the IgE response in vivo. Immunity (2007) 2.15
Sequential class switching is required for the generation of high affinity IgE antibodies. J Exp Med (2012) 1.66
IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol (2005) 1.56
Control of homeostatic proliferation by regulatory T cells. J Clin Invest (2005) 1.40
Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods (2009) 1.29
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J Exp Med (2013) 1.26
Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice. Eur J Immunol (2002) 1.25
Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med (2011) 1.23
Pillars article: High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 1994. 78: 399-408. J Immunol (2013) 1.07
On the differentiation of mouse IgE⁺ cells. Nat Immunol (2012) 1.06
Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis. J Immunol (2008) 1.06
The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. Cell Rep (2012) 1.01
Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Proc Natl Acad Sci U S A (2013) 1.00
Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria. J Immunol (2003) 0.96
Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization. J Immunol (2010) 0.96
Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proc Natl Acad Sci U S A (2012) 0.95
Biology of IgE production: IgE cell differentiation and the memory of IgE responses. Curr Top Microbiol Immunol (2015) 0.91
Mechanisms of tolerance and allergic sensitization in the airways and the lungs. Curr Opin Immunol (2010) 0.90
Can TNF-α boost regulatory T cells? J Clin Invest (2010) 0.85
Do regulatory T cells play a role in the control of homeostatic proliferation? Int Rev Immunol (2005) 0.85
Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood (2007) 0.84
Maternal-fetal immune tolerance, block by block. Cell (2012) 0.83
Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10. Blood (2013) 0.83
CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood (2012) 0.83
It takes two to tango. Immunity (2011) 0.83
What is unique about the IgE response? Adv Immunol (2012) 0.82
Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis. Am J Pathol (2005) 0.81
The role of regulatory T cells in allergy. Springer Semin Immunopathol (2003) 0.80
Corrigendum: A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers. Sci Rep (2016) 0.75
Reaginic antibodies. Curr Top Microbiol Immunol (2015) 0.75
Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis. J Leukoc Biol (2005) 0.75