Published in Mol Biol Cell on December 09, 2004
Chemokine receptor internalization and intracellular trafficking. Cytokine Growth Factor Rev (2005) 1.59
Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts. Mol Biol Cell (2008) 1.30
Differential clathrin binding and subcellular localization of OCRL1 splice isoforms. J Biol Chem (2009) 1.24
Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol (2006) 1.23
Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell (2012) 1.19
Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses. Blood (2006) 1.09
CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One (2012) 1.08
CC chemokine receptor 5 (CCR5) desensitization: cycling receptors accumulate in the trans-Golgi network. J Biol Chem (2010) 1.07
Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progression. Blood (2006) 1.03
Mesenchymal stem cells exhibit firm adhesion, crawling, spreading and transmigration across aortic endothelial cells: effects of chemokines and shear. PLoS One (2011) 1.02
Flat clathrin lattices: stable features of the plasma membrane. Mol Biol Cell (2014) 0.96
RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci (2007) 0.96
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell (2006) 0.96
Antigen stimulation induces HIV envelope gp120-specific CD4(+) T cells to secrete CCR5 ligands and suppress HIV infection. Virology (2007) 0.95
Regarding the amazing choreography of clathrin coats. PLoS Biol (2011) 0.94
Developments in cell biology for quantitative immunoelectron microscopy based on thin sections: a review. Histochem Cell Biol (2008) 0.92
CCR5: From Natural Resistance to a New Anti-HIV Strategy. Viruses (2010) 0.91
New approaches in the treatment of HIV/AIDS - focus on maraviroc and other CCR5 antagonists. Ther Clin Risk Manag (2008) 0.91
CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro. Cell Immunol (2007) 0.91
Mechanisms regulating chemokine receptor activity. Immunology (2011) 0.89
Brain-derived neurotrophic factor modulates expression of chemokine receptors in the brain. Brain Res (2008) 0.88
Selective loss of chemokine receptor expression on leukocytes after cell isolation. PLoS One (2012) 0.88
Constitutive endocytosis of the chemokine CX3CL1 prevents its degradation by cell surface metalloproteases. J Biol Chem (2009) 0.85
CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis. Oncotarget (2014) 0.85
Mapping the distributions and quantifying the labelling intensities of cell compartments by immunoelectron microscopy: progress towards a coherent set of methods. J Anat (2011) 0.81
CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. PLoS One (2014) 0.80
Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells. PLoS One (2011) 0.80
Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver. PLoS One (2015) 0.79
Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5. Genes Immun (2005) 0.76
Real time monitoring of membrane GPCR reconstitution by plasmon waveguide resonance: on the role of lipids. Sci Rep (2016) 0.75
CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells. J Leukoc Biol (2015) 0.75
Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5. Sci Rep (2016) 0.75
Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane. J Virol (2017) 0.75
CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway. J Inflamm (Lond) (2009) 0.75
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science (1995) 17.42
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature (1996) 11.21
The biology of chemokines and their receptors. Annu Rev Immunol (2000) 9.81
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature (1996) 9.25
Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat Cell Biol (2001) 8.93
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell (2004) 6.75
Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol (2003) 6.35
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature (1996) 6.32
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem (1998) 6.26
Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell (1999) 5.16
Spatial control of coated-pit dynamics in living cells. Nat Cell Biol (1999) 4.57
Rapid cycling of lipid raft markers between the cell surface and Golgi complex. J Cell Biol (2001) 4.22
Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci U S A (1999) 3.95
HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med (1997) 3.71
Endocytosis via caveolae. Traffic (2002) 3.41
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway. Mol Cell (2001) 3.25
Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms. Traffic (2003) 3.25
Effects of cytoplasmic acidification on clathrin lattice morphology. J Cell Biol (1989) 3.10
Internalization of cholera toxin by different endocytic mechanisms. J Cell Sci (2001) 3.04
Endocytosis without clathrin coats. Trends Cell Biol (2001) 2.88
Insider information: what viruses tell us about endocytosis. Curr Opin Cell Biol (2003) 2.80
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol (2002) 2.76
Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med (1998) 2.76
Observing FcepsilonRI signaling from the inside of the mast cell membrane. J Cell Biol (2000) 2.69
Caveosomes and endocytosis of lipid rafts. J Cell Sci (2003) 2.44
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol (1997) 2.35
Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. J Biol Chem (1996) 2.32
Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J (1999) 2.32
Lipids as targeting signals: lipid rafts and intracellular trafficking. Traffic (2004) 2.28
Real-time analysis of clathrin-mediated endocytosis during cell migration. J Cell Sci (2003) 2.24
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr Opin Cell Biol (2001) 2.23
Simultaneous visualization of LDL receptor distribution and clathrin lattices on membranes torn from the upper surface of cultured cells. J Histochem Cytochem (1991) 2.22
Cholesterol as modulator of receptor function. Biochemistry (1997) 2.10
HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation. Virology (1997) 2.02
G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there? J Mol Endocrinol (2004) 1.97
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. EMBO J (1997) 1.96
Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol (2004) 1.94
Transferrin receptors promote the formation of clathrin lattices. Cell (1991) 1.91
Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton. J Cell Sci (2002) 1.87
Clathrin-dependent or not: is it still the question? Traffic (2002) 1.85
Chemokine receptors. Cytokine Growth Factor Rev (2001) 1.84
Association of chemokine-mediated block to HIV entry with coreceptor internalization. J Biol Chem (2002) 1.79
Caveolae: anchored, multifunctional platforms in the lipid ocean. Trends Cell Biol (2003) 1.75
Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol (2004) 1.72
Chemokines: attractive mediators of the immune response. Semin Immunol (2003) 1.66
Endocytosis and recycling of the HIV coreceptor CCR5. J Cell Biol (2000) 1.56
Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands. Immunol Rev (2000) 1.54
G protein-coupled receptor/arrestin3 modulation of the endocytic machinery. J Cell Biol (2002) 1.53
Differential regulation of CXCR4 and CCR5 endocytosis. J Cell Sci (1998) 1.49
Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor. Eur J Pharmacol (2004) 1.45
Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4. Mol Biol Cell (2003) 1.44
Recruitment of activated G protein-coupled receptors to pre-existing clathrin-coated pits in living cells. J Biol Chem (2001) 1.44
Regulated endocytosis of G-protein-coupled receptors by a biochemically and functionally distinct subpopulation of clathrin-coated pits. J Biol Chem (1998) 1.42
High-resolution three-dimensional views of membrane-associated clathrin and cytoskeleton in critical-point-dried macrophages. J Cell Biol (1983) 1.42
Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor. J Biol Chem (2001) 1.39
Pathways for internalization and recycling of the chemokine receptor CCR5. Blood (2002) 1.38
Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood (2002) 1.31
Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization. J Biol Chem (2001) 1.31
Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways. J Biol Chem (1997) 1.27
Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway. Traffic (2003) 1.26
HIV-1 entry into T-cells is not dependent on CD4 and CCR5 localization to sphingolipid-enriched, detergent-resistant, raft membrane domains. J Biol Chem (2002) 1.25
Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways. J Biol Chem (2001) 1.24
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem (2003) 1.23
Relative labelling index: a novel stereological approach to test for non-random immunogold labelling of organelles and membranes on transmission electron microscopy thin sections. J Microsc (2002) 1.16
Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression. J Virol (2001) 1.15
Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex. J Immunol (1999) 1.14
Membrane raft microdomains in chemokine receptor function. Semin Immunol (2001) 1.11
Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem (2002) 1.09
Inhibition of chemokine receptor function by membrane cholesterol oxidation. Exp Cell Res (2003) 1.04
Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem (2002) 1.03
Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5). J Leukoc Biol (1999) 0.91
Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms. Biochemistry (2001) 0.88
pH-independent endocytic cycling of the chemokine receptor CCR5. Traffic (2004) 0.87
The ubiquitin-dependent endocytosis motif is required for efficient incorporation of growth hormone receptor in clathrin-coated pits, but not clathrin-coated lattices. J Cell Sci (2001) 0.85
Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization. J Cell Biochem (1998) 0.85
Analysis of chemokine receptor endocytosis and recycling. Methods Mol Biol (2000) 0.80
Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. Exp Cell Res (2003) 0.77
Infectious HIV-1 assembles in late endosomes in primary macrophages. J Cell Biol (2003) 4.68
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med (2009) 3.58
Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains. Nat Cell Biol (2006) 3.08
In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol (2007) 2.68
The on-off story of protein palmitoylation. Trends Cell Biol (2003) 2.58
HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse. Traffic (2005) 2.47
Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions. Biophys J (2004) 2.37
Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. Proc Natl Acad Sci U S A (2009) 2.21
Systemic complement activation in age-related macular degeneration. PLoS One (2008) 2.18
Single-cell analysis of population context advances RNAi screening at multiple levels. Mol Syst Biol (2012) 2.13
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet (2010) 1.95
Endosomes, exosomes and Trojan viruses. Trends Microbiol (2004) 1.84
The cell biology of receptor-mediated virus entry. J Cell Biol (2011) 1.75
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome. Blood (2007) 1.70
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. Traffic (2002) 1.65
Rac regulates endothelial morphogenesis and capillary assembly. Mol Biol Cell (2002) 1.62
Genetic control of the alternative pathway of complement in humans and age-related macular degeneration. Hum Mol Genet (2010) 1.57
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release. Proc Natl Acad Sci U S A (2009) 1.42
A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. Mol Biol Cell (2006) 1.38
HIV interaction with endosomes in macrophages and dendritic cells. Blood Cells Mol Dis (2005) 1.32
Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway. Traffic (2003) 1.26
Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell (2012) 1.19
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. J Biol Chem (2005) 1.19
The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation. PLoS Pathog (2011) 1.18
Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology (2006) 1.18
Bluetongue virus entry into cells. J Virol (2007) 1.17
A revised model for the secretion of tPA and cytokines from cultured endothelial cells. Blood (2010) 1.14
The C-terminus of complement factor H is essential for host cell protection. Mol Immunol (2007) 1.14
The ESCRT machinery is not required for human cytomegalovirus envelopment. Cell Microbiol (2007) 1.13
Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis. Mol Pharmacol (2005) 1.12
Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation. J Biol Chem (2002) 1.11
Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem (2002) 1.09
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype. Mol Pharmacol (2002) 1.08
CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages. J Virol (2008) 1.07
Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome. Nephrol Dial Transplant (2009) 1.06
Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci U S A (2011) 1.06
The role of ubiquitination in lysosomal trafficking of δ-opioid receptors. Traffic (2010) 1.05
Murine leukemia virus particle assembly quantitated by fluorescence microscopy: role of Gag-Gag interactions and membrane association. J Virol (2003) 1.05
Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem (2002) 1.03
P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic (2006) 1.01
HIV assembly and budding in macrophages. Biochem Soc Trans (2009) 0.98
Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog (2011) 0.97
Differential effect of extracellular acidosis on the release and dispersal of soluble and membrane proteins secreted from the Weibel-Palade body. J Biol Chem (2009) 0.96
Misuse of journal impact factors in scientific assessment. Traffic (2013) 0.96
Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M. J Virol (2013) 0.95
HIV's great escape. Nat Med (2003) 0.92
ALIX catches HIV. Cell Host Microbe (2007) 0.92
Protein mobilities and P-selectin storage in Weibel-Palade bodies. J Cell Sci (2010) 0.92
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis. Mol Pharmacol (2005) 0.92
β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages. Traffic (2011) 0.91
Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity. BMC Biochem (2004) 0.89
Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages. BMC Biol (2013) 0.89
pH-independent endocytic cycling of the chemokine receptor CCR5. Traffic (2004) 0.87
Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis. Mol Pharmacol (2008) 0.86
Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor. Biochim Biophys Acta (2008) 0.83
Dynamics of protein kinase C-mediated phosphorylation of the complement C5a receptor on serine 334. J Biol Chem (2006) 0.82
Analysis of chemokine receptor endocytosis and intracellular trafficking. Methods Enzymol (2009) 0.81
Characterization of tetraspanins CD9, CD53, CD63, and CD81 in monocytes and macrophages in HIV-1 infection. J Leukoc Biol (2013) 0.81
Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. J Immunol (2006) 0.81
Casual sex among Australian schoolies. J Sex Res (2003) 0.80
Electron microscopy analysis of viral morphogenesis. Methods Cell Biol (2007) 0.79
Reduced cytokine induction and removal of complement products with synthetic hemodialysis membranes. Blood Purif (2005) 0.77
In vitro CNS tissue analogues formed by self-organisation of reaggregated post-natal brain tissue. J Neurochem (2011) 0.76
Glucocorticoids induce gastroparesis in mice through depletion of l-arginine. Endocrinology (2014) 0.76
IGF-binding protein-3 fragments in plasma of a child with acute renal failure. Pediatr Nephrol (2004) 0.75
Anti-infectives: current challenges and future perspectives. Curr Opin Pharmacol (2010) 0.75