Published in Nat Cell Biol on May 01, 2003
Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov (2009) 12.46
Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Ubiquitylation and cell signaling. EMBO J (2005) 4.65
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
Heterodimerization and endocytosis of Arabidopsis brassinosteroid receptors BRI1 and AtSERK3 (BAK1). Plant Cell (2004) 3.33
The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol (2012) 3.16
The endocytic matrix. Nature (2010) 3.15
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Signaling on the endocytic pathway. Curr Opin Cell Biol (2007) 2.53
Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron (2006) 2.45
Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest (2004) 2.20
The Arabidopsis thaliana SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES1 and 2 control male sporogenesis. Plant Cell (2005) 2.12
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med (2011) 2.09
Nodal morphogens. Cold Spring Harb Perspect Biol (2009) 2.09
A critical role for endocytosis in Wnt signaling. BMC Cell Biol (2006) 2.09
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell (2009) 2.09
TGF-β: duality of function between tumor prevention and carcinogenesis. J Natl Cancer Inst (2014) 2.08
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res (2008) 2.06
Regulation of raft-dependent endocytosis. J Cell Mol Med (2007) 2.01
Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol (2006) 1.99
HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. J Biol Chem (2009) 1.89
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol (2008) 1.85
Plasma membrane domain organization regulates EGFR signaling in tumor cells. J Cell Biol (2007) 1.82
Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. Mol Biol Cell (2004) 1.82
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol (2007) 1.82
Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol (2009) 1.79
Molecular mechanisms of clathrin-independent endocytosis. J Cell Sci (2009) 1.72
Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP). J Bone Miner Res (2008) 1.72
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains. Mol Biol Cell (2005) 1.67
Endocytosis, actin cytoskeleton, and signaling. Plant Physiol (2004) 1.67
Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell (2005) 1.65
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor. Nat Cell Biol (2012) 1.65
Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation. Nat Neurosci (2005) 1.63
The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal (2015) 1.61
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche. Nat Cell Biol (2009) 1.61
Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction. J Biol Chem (2009) 1.56
Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors. Hepatology (2014) 1.55
Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. Trends Cell Biol (2009) 1.54
Signal processing in the TGF-beta superfamily ligand-receptor network. PLoS Comput Biol (2006) 1.54
Plasticity of B cell receptor internalization upon conditional depletion of clathrin. Mol Biol Cell (2005) 1.49
Compensatory flux changes within an endocytic trafficking network maintain thermal robustness of Notch signaling. Cell (2014) 1.47
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol (2006) 1.46
Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc Natl Acad Sci U S A (2007) 1.42
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res (2008) 1.42
Role of transforming growth factor-beta in hematologic malignancies. Blood (2006) 1.41
Regulation of Smad activities. Biochim Biophys Acta (2006) 1.41
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci (2011) 1.41
Systems biology of vascular endothelial growth factors. Microcirculation (2008) 1.41
Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum (2008) 1.41
TGF-beta signal transduction in chronic kidney disease. Front Biosci (Landmark Ed) (2009) 1.41
Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. Mol Cell Biol (2007) 1.40
A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol (2009) 1.39
Identification of C. elegans DAF-12-binding sites, response elements, and target genes. Genes Dev (2004) 1.39
The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J Cell Biol (2007) 1.38
Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget (2012) 1.37
Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes Dev (2005) 1.36
Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell (2012) 1.34
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem (2010) 1.32
Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. J Clin Invest (2004) 1.32
Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis. Curr Opin Rheumatol (2008) 1.32
Endocytic adaptors--social networking at the plasma membrane. J Cell Sci (2011) 1.29
Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line. Am J Pathol (2005) 1.26
Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. J Clin Invest (2006) 1.26
Inhibitors of clathrin-dependent endocytosis enhance TGFbeta signaling and responses. J Cell Sci (2009) 1.26
The ubiquitination code: a signalling problem. Cell Div (2007) 1.25
Clathrin-independent pathways of endocytosis. Cold Spring Harb Perspect Biol (2014) 1.25
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol (2006) 1.25
Endocytic internalization routes required for delta/notch signaling. Curr Biol (2010) 1.24
Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent. Mol Biol Cell (2004) 1.24
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking. J Cell Biol (2009) 1.23
A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes. Mol Biol Cell (2008) 1.23
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat Cell Biol (2012) 1.21
Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett (2012) 1.21
The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway. J Cell Sci (2009) 1.21
Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway. PLoS One (2007) 1.21
Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol (2009) 1.21
Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival. Curr Protein Pept Sci (2010) 1.21
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment. Cold Spring Harb Perspect Biol (2010) 1.20
Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration. Mol Cell Biol (2007) 1.20
Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci (2007) 1.20
TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J Cell Biol (2005) 1.19
Decoding the quantitative nature of TGF-beta/Smad signaling. Trends Cell Biol (2008) 1.18
Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity. Mol Biol Cell (2008) 1.18
Independent trafficking of Ig-alpha/Ig-beta and mu-heavy chain is facilitated by dissociation of the B cell antigen receptor complex. J Immunol (2005) 1.17
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J (2003) 1.16
Endocytosis of membrane receptors: two pathways are better than one. Proc Natl Acad Sci U S A (2005) 1.15
Ubiquitin-dependent regulation of TGFbeta signaling in cancer. Neoplasia (2006) 1.14
Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow. Blood (2007) 1.14
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. J Natl Cancer Inst (2011) 1.14
Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2. Biochem J (2007) 1.14
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Br J Cancer (2003) 1.14
Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction. Genes Dev (2005) 1.13
A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway. Biophys J (2006) 1.13
Interaction of TGFβ and BMP signaling pathways during chondrogenesis. PLoS One (2011) 1.13
Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci (2009) 1.12
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (2005) 4.70
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol (2005) 4.48
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell (2012) 4.29
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (2004) 3.73
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell (2008) 2.85
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Tissue-specific alternative splicing remodels protein-protein interaction networks. Mol Cell (2012) 2.08
Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays (2005) 1.95
The disparate role of BMP in stem cell biology. Oncogene (2005) 1.92
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (2005) 1.88
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell (2012) 1.72
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
TGF-beta and the Smad signal transduction pathway. Biochem Cell Biol (2002) 1.51
Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem (2005) 1.47
Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Curr Biol (2007) 1.40
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A (2009) 1.29
Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol (2011) 1.23
Degradation of RhoA by Smurf1 ubiquitin ligase. Methods Enzymol (2006) 1.19
Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell (2008) 1.19
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Res (2009) 1.18
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A (2013) 1.16
Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep (2013) 1.15
GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol Cell Biol (2003) 1.15
Regulation of Par6 by extracellular signals. Curr Opin Cell Biol (2006) 1.12
Signaling and endocytosis: a team effort for cell migration. Dev Cell (2005) 1.11
SnapShot: The TGFbeta pathway interactome. Cell (2008) 1.11
Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis. Cancer Res (2013) 1.10
The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans. Science (2007) 1.10
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem (2009) 1.10
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Res (2011) 1.10
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A (2004) 1.10
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity. Proc Natl Acad Sci U S A (2010) 1.08
Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution. PLoS Genet (2012) 1.03
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res (2007) 1.02
Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. J Biol Chem (2008) 1.01
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorg Med Chem Lett (2011) 1.00
An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. J Biol Chem (2006) 1.00
In or out? The dynamics of Smad nucleocytoplasmic shuttling. Trends Cell Biol (2003) 1.00
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci (2009) 1.00
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. EMBO J (2011) 0.99
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med (2010) 0.98
Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. PLoS Genet (2010) 0.96
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol (2009) 0.94
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J (2007) 0.93
Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. Mol Cell Biol (2011) 0.92
Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. J Biol Chem (2004) 0.91
Protein interaction networks in medicine and disease. Proteomics (2012) 0.91
A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling. Mech Dev (2002) 0.90
The TGFβ superfamily in stem cell biology and early mammalian embryonic development. Biochim Biophys Acta (2012) 0.90
AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments. Haematologica (2011) 0.88
The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. Biochem J (2009) 0.87
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis (2008) 0.87
Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget (2011) 0.86
Old DAT and new data: positive direct antiglobulin test identifies a subgroup with poor outcome among chronic lymphocytic leukemia stage A patients. Am J Hematol (2014) 0.86
The TGFbeta-Par6 polarity pathway: linking the Par complex to EMT and breast cancer progression. Cell Cycle (2010) 0.85
No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. Cancer Res (2002) 0.85
C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome. Eur J Hum Genet (2012) 0.84
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest (2016) 0.80
Structural basis for specificity of TGFβ family receptor small molecule inhibitors. Cell Signal (2011) 0.80
Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Res (2006) 0.78
Cell biology: an unexpected social servant. Nature (2004) 0.77
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Mol Cell Proteomics (2013) 0.77
The return of Dr Jekyll in cancer metastasis. EMBO J (2012) 0.75
Structural biology: On the wings of inhibition. Nature (2002) 0.75
Acid-base control of hemilabile proton-responsive protecting devices in dimolybdenum, thiolate-bridged complexes. Inorg Chem (2014) 0.75
A new FeMo complex as a model of heterobimetallic assemblies in natural systems: Mössbauer and density functional theory investigations. Inorg Chem (2014) 0.75
Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev (2015) 0.75