Published in J Cell Biol on September 01, 2003
Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol (2011) 6.32
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Systems survey of endocytosis by multiparametric image analysis. Nature (2010) 5.03
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol (2004) 4.60
Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol (2009) 3.98
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell (2006) 3.83
α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol (2010) 3.67
Imaging poliovirus entry in live cells. PLoS Biol (2007) 3.40
Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33
Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell (2012) 3.26
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
FCHo proteins are nucleators of clathrin-mediated endocytosis. Science (2010) 2.93
Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol (2009) 2.83
Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc Natl Acad Sci U S A (2004) 2.78
Clathrin is a key regulator of basolateral polarity. Nature (2008) 2.67
Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection. J Cell Biol (2003) 2.65
Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog (2009) 2.59
Clathrin is required for the function of the mitotic spindle. Nature (2005) 2.45
Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules. EMBO J (2006) 2.39
BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell (2006) 2.37
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. Traffic (2008) 2.16
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins. Mol Biol Cell (2005) 1.99
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2008) 1.96
Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol (2003) 1.93
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90
HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. J Biol Chem (2009) 1.89
Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A (2008) 1.88
Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis. EMBO J (2004) 1.87
YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood (2008) 1.86
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis. J Cell Biol (2010) 1.83
Host cell factors and functions involved in vesicular stomatitis virus entry. J Virol (2008) 1.83
Comparative proteomics of clathrin-coated vesicles. J Cell Biol (2006) 1.83
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. Mol Biol Cell (2004) 1.82
Rapid inactivation of proteins by rapamycin-induced rerouting to mitochondria. Dev Cell (2010) 1.82
The role of receptor internalization in CD95 signaling. EMBO J (2006) 1.80
Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch. Science (2014) 1.79
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. Proc Natl Acad Sci U S A (2005) 1.78
EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol (2013) 1.77
A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors. Mol Biol Cell (2006) 1.75
Endophilin marks and controls a clathrin-independent endocytic pathway. Nature (2014) 1.69
Functional analysis of AP-2 alpha and mu2 subunits. Mol Biol Cell (2006) 1.67
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell (2011) 1.66
Internalization and trafficking of cell surface proteoglycans and proteoglycan-binding ligands. Traffic (2007) 1.64
Clathrin-mediated endocytosis in budding yeast. Trends Cell Biol (2011) 1.63
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast. Mol Biol Cell (2009) 1.60
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol Cell Biol (2006) 1.54
Bending a membrane: how clathrin affects budding. Proc Natl Acad Sci U S A (2006) 1.53
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells. J Cell Biol (2007) 1.51
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol Biol Cell (2005) 1.49
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proc Natl Acad Sci U S A (2005) 1.47
Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. Mol Biol Cell (2006) 1.46
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol (2006) 1.46
EpsinR is an adaptor for the SNARE protein Vti1b. Mol Biol Cell (2004) 1.45
Actin dynamics coupled to clathrin-coated vesicle formation at the trans-Golgi network. J Cell Biol (2004) 1.45
The plant endosomal system--its structure and role in signal transduction and plant development. Planta (2004) 1.43
GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin. EMBO J (2006) 1.42
Roles of AP-2 in clathrin-mediated endocytosis. PLoS One (2010) 1.40
Mechanisms of Chlamydia trachomatis entry into nonphagocytic cells. Infect Immun (2007) 1.39
An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol (2007) 1.38
A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. Mol Biol Cell (2006) 1.38
Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots. J Cell Sci (2009) 1.37
Early steps of clathrin-mediated endocytosis involved in phagosomal escape of Fcgamma receptor-targeted adenovirus. J Virol (2005) 1.37
The intracellular trafficking pathway of transferrin. Biochim Biophys Acta (2011) 1.36
The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling. Hum Mol Genet (2009) 1.35
HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2. Mol Biol Cell (2007) 1.32
p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism. Mol Biol Cell (2009) 1.32
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. EMBO J (2009) 1.31
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol (2008) 1.31
Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly. Proc Natl Acad Sci U S A (2007) 1.30
Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27
CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. Dev Cell (2015) 1.27
Epidermal growth factor receptor and cancer: control of oncogenic signalling by endocytosis. J Cell Mol Med (2008) 1.27
Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol (2005) 1.26
Endocytic internalization routes required for delta/notch signaling. Curr Biol (2010) 1.24
Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent. Mol Biol Cell (2004) 1.24
Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol (2006) 1.23
Transport at the recycling endosome. Curr Opin Cell Biol (2010) 1.23
Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology (2010) 1.23
Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J Cell Biol (2010) 1.22
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles. Mol Biol Cell (2009) 1.22
Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis. Traffic (2005) 1.21
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat Cell Biol (2012) 1.21
Highly cooperative control of endocytosis by clathrin. Mol Biol Cell (2005) 1.21
Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis. J Biol Chem (2008) 1.19
The aftiphilin/p200/gamma-synergin complex. Mol Biol Cell (2005) 1.19
The cellular functions of clathrin. Cell Mol Life Sci (2006) 1.17
Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc Natl Acad Sci U S A (2007) 1.17
Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. J Virol (2010) 1.17
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. J Virol (2009) 1.17
Bluetongue virus entry into cells. J Virol (2007) 1.17
Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. J Cell Biol (2004) 1.16
Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta. J Virol (2005) 1.16
Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis. PLoS One (2012) 1.16
Loss of myosin VI no insert isoform (NoI) induces a defect in clathrin-mediated endocytosis and leads to caveolar endocytosis of transferrin receptor. J Biol Chem (2009) 1.15
The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol (1963) 185.56
Regulated portals of entry into the cell. Nature (2003) 15.33
Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem (2003) 13.66
Curvature of clathrin-coated pits driven by epsin. Nature (2002) 8.03
Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science (1995) 7.77
Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science (2001) 5.45
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol (2003) 5.43
A structural explanation for the recognition of tyrosine-based endocytotic signals. Science (1998) 5.03
mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J (2000) 4.06
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat Cell Biol (2002) 3.94
Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization. J Cell Biol (1990) 3.24
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J Cell Biol (1996) 2.78
A novel adaptor-related protein complex. J Cell Biol (1996) 2.69
Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. EMBO J (1999) 2.60
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J (2002) 2.53
Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors. EMBO J (1987) 2.40
Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. Cell (1997) 2.25
Adaptor complex-independent clathrin function in yeast. Mol Biol Cell (1999) 2.10
Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif. J Biol Chem (1996) 2.10
Assembly and function of AP-3 complexes in cells expressing mutant subunits. J Cell Biol (2002) 1.96
Differential requirements for AP-2 in clathrin-mediated endocytosis. J Cell Biol (2003) 1.93
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. J Biol Chem (1993) 1.88
Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J (1999) 1.86
Distinct saturable pathways for the endocytosis of different tyrosine motifs. J Biol Chem (1998) 1.80
Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast. EMBO J (1999) 1.79
The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery. Proc Natl Acad Sci U S A (2002) 1.66
The yeast Epsin Ent1 is recruited to membranes through multiple independent interactions. J Biol Chem (2003) 1.65
Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. J Biol Chem (2001) 1.55
A novel role for clathrin in cytokinesis. Proc Natl Acad Sci U S A (1997) 1.45
Controlled elimination of clathrin heavy-chain expression in DT40 lymphocytes. Science (2002) 1.45
The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation. J Cell Biol (1998) 1.29
Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins. Proc Natl Acad Sci U S A (1995) 1.28
The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites. Traffic (2002) 1.27
Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells. EMBO J (2001) 1.25
Lysosomes: fusion and function. Nat Rev Mol Cell Biol (2007) 5.74
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat Cell Biol (2005) 3.15
The fifth adaptor protein complex. PLoS Biol (2011) 2.94
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell (2005) 2.56
Clathrin is required for the function of the mitotic spindle. Nature (2005) 2.45
EpsinR: an ENTH domain-containing protein that interacts with AP-1. Mol Biol Cell (2003) 2.04
Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners. Hum Mol Genet (2005) 2.01
Assembly and function of AP-3 complexes in cells expressing mutant subunits. J Cell Biol (2002) 1.96
The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci (2010) 1.91
SDPR induces membrane curvature and functions in the formation of caveolae. Nat Cell Biol (2009) 1.84
Comparative proteomics of clathrin-coated vesicles. J Cell Biol (2006) 1.83
Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Curr Biol (2007) 1.75
Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Biochem J (2012) 1.74
Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Nat Struct Mol Biol (2005) 1.71
Functional analysis of AP-2 alpha and mu2 subunits. Mol Biol Cell (2006) 1.67
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell (2011) 1.66
Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO Rep (2004) 1.62
A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. Nature (2007) 1.61
Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. J Cell Biol (2012) 1.59
Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Nat Cell Biol (2012) 1.50
Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment. J Cell Sci (2007) 1.48
EpsinR is an adaptor for the SNARE protein Vti1b. Mol Biol Cell (2004) 1.45
EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval. Traffic (2007) 1.38
Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells. Traffic (2009) 1.33
Structure of Vps26B and mapping of its interaction with the retromer protein complex. Traffic (2007) 1.33
HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2. Mol Biol Cell (2007) 1.32
Structural basis for binding of accessory proteins by the appendage domain of GGAs. Nat Struct Biol (2003) 1.32
Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging (2012) 1.30
Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly. Proc Natl Acad Sci U S A (2007) 1.30
Mistargeting of SH3TC2 away from the recycling endosome causes Charcot-Marie-Tooth disease type 4C. Hum Mol Genet (2009) 1.29
Distinct and overlapping roles for AP-1 and GGAs revealed by the "knocksideways" system. Curr Biol (2012) 1.27
Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Mol Biol Cell (2003) 1.21
The aftiphilin/p200/gamma-synergin complex. Mol Biol Cell (2005) 1.19
The delivery of endocytosed cargo to lysosomes. Biochem Soc Trans (2009) 1.17
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. J Virol (2009) 1.17
A screen for endocytic motifs. Traffic (2010) 1.15
ATP regulation in adult rat cardiomyocytes: time-resolved decoding of rapid mitochondrial calcium spiking imaged with targeted photoproteins. J Biol Chem (2006) 1.14
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15. Mol Biol Cell (2013) 1.12
A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Nat Cell Biol (2013) 1.09
The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function. Biochim Biophys Acta (2012) 1.08
Auxilin depletion causes self-assembly of clathrin into membraneless cages in vivo. Traffic (2008) 1.06
Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem J (2007) 1.05
The role of cargo proteins in GGA recruitment. Traffic (2007) 1.04
An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. J Cell Biol (2013) 1.03
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. Proc Natl Acad Sci U S A (2008) 1.03
Membrane traffic to and from lysosomes. Biochem Soc Symp (2005) 1.03
The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. Nat Struct Mol Biol (2012) 1.01
CVAK104 is a novel regulator of clathrin-mediated SNARE sorting. Traffic (2007) 1.00
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One (2011) 0.99
Endosome-lysosome fusion. Biochem Soc Trans (2010) 0.98
RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci (2014) 0.98
Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling. J Biol Chem (2012) 0.96
The sodium/proton exchanger NHE8 regulates late endosomal morphology and function. Mol Biol Cell (2010) 0.94
Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion. Mamm Genome (2003) 0.93
The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein. Self Nonself (2010) 0.93
Sorting of major cargo glycoproteins into clathrin-coated vesicles. Traffic (2005) 0.93
Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation. PLoS One (2013) 0.87
The lumenal domain of the integral membrane protein phogrin mediates targeting to secretory granules. Traffic (2002) 0.84
ESCRT proteins and the regulation of endocytic delivery to lysosomes. Biochem Soc Trans (2009) 0.80
N-acetylation and phosphorylation of Sec complex subunits in the ER membrane. BMC Cell Biol (2012) 0.79
Evolutionary variations of VPS29, and their implications for the heteropentameric model of retromer. Commun Integr Biol (2011) 0.78
Enhanced SnapShot: endosome-to-golgi retrieval. Cell (2009) 0.76
Endosome sorting: GSE complex minds the Gap. Nat Cell Biol (2006) 0.75